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Tytuł :
Chemical composition, cytotoxicity, and antibacterial activity of propolis from Africanized honeybees and three different Meliponini species.
Autorzy :
Surek M; Post-Graduate Program in Pharmaceutical Sciences, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil; Laboratory of Physiology and Cell Signalling, Department of Clinical Analysis, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil.
Fachi MM; Post-Graduate Program in Pharmaceutical Sciences, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil.
de Fátima Cobre A; Post-Graduate Program in Pharmaceutical Sciences, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil.
de Oliveira FF; Laboratory of Bionomy, Biogeography and Insect Systematics (BIOSIS), Federal University of Bahia, St. Barão de Jeremoabo, S/N, 40170-115, Salvador, BA, Brazil.
Pontarolo R; Post-Graduate Program in Pharmaceutical Sciences, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil.
Crisma AR; Laboratory of Physiology and Cell Signalling, Department of Clinical Analysis, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil.
de Souza WM; Post-Graduate Program in Pharmaceutical Sciences, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil.
Felipe KB; Post-Graduate Program in Pharmaceutical Sciences, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil; Laboratory of Physiology and Cell Signalling, Department of Clinical Analysis, Federal University of Paraná, Av. Prefeito Lothário Meissner 632, 80210-170, Curitiba, PR, Brazil. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 06; Vol. 269, pp. 113662. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Anti-Bacterial Agents/*pharmacology
Antibiotics, Antineoplastic/*chemistry
Antibiotics, Antineoplastic/*pharmacology
Propolis/*chemistry
Propolis/*pharmacology
Animals ; Anti-Bacterial Agents/isolation & purification ; Antibiotics, Antineoplastic/isolation & purification ; Bees ; Cell Survival/drug effects ; Cell Survival/physiology ; Chromatography, High Pressure Liquid/methods ; Dose-Response Relationship, Drug ; HeLa Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Propolis/isolation & purification ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Enzyme-Triggered Disassembly of Polymeric Micelles by Controlled Depolymerization via Cascade Cyclization for Anticancer Drug Delivery.
Autorzy :
Park J; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea.
Jo S; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, POSTECH, Pohang 37673, South Korea.
Lee YM; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, POSTECH, Pohang 37673, South Korea.
Saravanakumar G; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, POSTECH, Pohang 37673, South Korea.; OmniaMed Co., Ltd., Pohang 37673, South Korea.
Lee J; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, POSTECH, Pohang 37673, South Korea.; OmniaMed Co., Ltd., Pohang 37673, South Korea.
Park D; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, POSTECH, Pohang 37673, South Korea.
Kim WJ; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea.; Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, POSTECH, Pohang 37673, South Korea.; OmniaMed Co., Ltd., Pohang 37673, South Korea.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Feb 24; Vol. 13 (7), pp. 8060-8070. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Antibiotics, Antineoplastic/*pharmacology
Doxorubicin/*pharmacology
Lung Neoplasms/*drug therapy
NAD(P)H Dehydrogenase (Quinone)/*metabolism
Polymers/*metabolism
Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/metabolism ; Benzoquinones/chemistry ; Benzoquinones/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclization ; Doxorubicin/chemistry ; Doxorubicin/metabolism ; Drug Liberation ; Drug Screening Assays, Antitumor ; Humans ; Hydrophobic and Hydrophilic Interactions ; Lactones/chemistry ; Lactones/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Micelles ; Molecular Structure ; NAD(P)H Dehydrogenase (Quinone)/chemistry ; Particle Size ; Polymerization ; Polymers/chemistry ; Propionates/chemistry ; Propionates/metabolism ; Surface Properties ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Tumor Microenvironment-Responsive Nanococktails for Synergistic Enhancement of Cancer Treatment via Cascade Reactions.
Autorzy :
Chen Q; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.; Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.
Ma Y; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.
Bai P; Department of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, 37 Guoxuexiang, Chengdu, Sichuan 610041, P. R. China.
Li Q; Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.
Canup BSB; Center for Diagnostics and Therapeutics, Georgia State University, 100 Piedmont Avenue, Atlanta, Georgia 30303, United States.
Long D; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.
Ke B; Department of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, 37 Guoxuexiang, Chengdu, Sichuan 610041, P. R. China.
Dai F; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.
Xiao B; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass Sciences, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.; Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.
Li C; Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, 2 Tiansheng Road, Beibei, Chongqing 400715, P. R. China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Feb 03; Vol. 13 (4), pp. 4861-4873. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*administration & dosage
Doxorubicin/*administration & dosage
Manganese/*administration & dosage
Neoplasms/*drug therapy
Photosensitizing Agents/*administration & dosage
Phycocyanin/*administration & dosage
Animals ; Antibiotics, Antineoplastic/pharmacology ; Antibiotics, Antineoplastic/therapeutic use ; Bombyx/chemistry ; Cations, Divalent/administration & dosage ; Cations, Divalent/pharmacology ; Cations, Divalent/therapeutic use ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Carriers/chemistry ; Fibroins/chemistry ; Glutathione/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrogen-Ion Concentration ; Manganese/pharmacology ; Manganese/therapeutic use ; Mice ; Nanoparticles/chemistry ; Neoplasms/metabolism ; Neoplasms/pathology ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Phycocyanin/pharmacology ; Phycocyanin/therapeutic use ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
Autorzy :
Khaledian B; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.; Division of Advanced Cancer Diagnostics, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Taguchi A; Division of Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.; Division of Advanced Cancer Diagnostics, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shin-Ya K; National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Kondo-Ida L; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kagaya N; National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Suzuki M; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Molecular Oncology, Fujita Health University School of Medicine, Toyoake, Japan.
Kajino T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.; Division of Advanced Cancer Diagnostics, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yamaguchi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto, Japan.
Shimada Y; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Division of Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.; Division of Advanced Cancer Diagnostics, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahashi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Aichi Cancer Center, Nagoya, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Mar; Vol. 112 (3), pp. 1225-1234. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*drug therapy
Antibiotics, Antineoplastic/*pharmacology
HSP90 Heat-Shock Proteins/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
Receptor Tyrosine Kinase-like Orphan Receptors/*metabolism
Adenocarcinoma of Lung/pathology ; Antibiotics, Antineoplastic/therapeutic use ; Benzoquinones/pharmacology ; Benzoquinones/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Gene Knockdown Techniques ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; High-Throughput Screening Assays ; Humans ; Lactams, Macrocyclic/pharmacology ; Lactams, Macrocyclic/therapeutic use ; Lung Neoplasms/pathology ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis/drug effects ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
CRISPR-dCas9-Guided and Telomerase-Responsive Nanosystem for Precise Anti-Cancer Drug Delivery.
Autorzy :
Ma Y; Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen 518055, China.; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Mao G; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Wu G; Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen 518055, China.
Cui Z; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Zhang XE; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; National Key Laboratory of Biomacromolecules, CAS Center for Biological Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Huang W; Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen 518055, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Feb 24; Vol. 13 (7), pp. 7890-7896. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Antibiotics, Antineoplastic/*pharmacology
CRISPR-Associated Protein 9/*chemistry
Doxorubicin/*pharmacology
Nanoparticles/*chemistry
Telomerase/*chemistry
Antibiotics, Antineoplastic/chemistry ; CRISPR-Associated Protein 9/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Doxorubicin/chemistry ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; Molecular Structure ; Nanoparticles/metabolism ; Optical Imaging ; Particle Size ; Porosity ; Surface Properties ; Telomerase/metabolism
Czasopismo naukowe
Tytuł :
Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis.
Autorzy :
Zifodya JS; Department of Medicine, Section of Pulmonary, Critical Care, & Environmental Medicine , Tulane University, New Orleans, LA, USA.
Kreniske JS; Department of Internal Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Schiller I; Centre for Outcomes Research, McGill University Health Centre - Research Institute, Montreal, Canada.
Kohli M; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Dendukuri N; Centre for Outcomes Research, McGill University Health Centre - Research Institute, Montreal, Canada.
Schumacher SG; FIND, Geneva , Switzerland.
Ochodo EA; Centre for Evidence-based Health Care, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Haraka F; Elizabeth Glaser Pediatric AIDS Foundation, Dar es Salaam, Tanzania.; Ifakara Health Institute, Bagamoyo, Tanzania.
Zwerling AA; School of Epidemiology & Public Health, University of Ottawa, Ottawa, Canada.
Pai M; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Steingart KR; Honorary Research Fellow, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Horne DJ; Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Firland Northwest TB Center, University of Washington, Seattle, WA, USA.
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Źródło :
The Cochrane database of systematic reviews [Cochrane Database Syst Rev] 2021 Feb 22; Vol. 2. Cochrane AN: CD009593. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Antibiotics, Antitubercular*/pharmacology
Drug Resistance, Bacterial*
Mycobacterium tuberculosis*/drug effects
Rifampin*/pharmacology
Tuberculosis, Pulmonary*/diagnosis
Tuberculosis, Pulmonary*/drug therapy
Diagnostic Errors ; Extensively Drug-Resistant Tuberculosis/diagnosis ; Extensively Drug-Resistant Tuberculosis/drug therapy ; False Negative Reactions ; False Positive Reactions ; Humans ; Microbial Sensitivity Tests ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses.
Autorzy :
Liu J; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, QLD 4072, Australia.
Sun L; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, QLD 4072, Australia.
Li L; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, QLD 4072, Australia.
Zhang R; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, QLD 4072, Australia.
Xu ZP; Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, QLD 4072, Australia.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Feb 17; Vol. 13 (6), pp. 7115-7126. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Photochemotherapy*
Antibiotics, Antineoplastic/*pharmacology
Doxorubicin/*pharmacology
Hydroxides/*pharmacology
Melanoma/*therapy
Skin Neoplasms/*therapy
Animals ; Antibiotics, Antineoplastic/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Copper/chemistry ; Copper/pharmacology ; Dose-Response Relationship, Drug ; Doxorubicin/chemistry ; Drug Screening Assays, Antitumor ; Hydroxides/chemistry ; Indocyanine Green/chemistry ; Indocyanine Green/pharmacology ; Lasers ; Melanoma/metabolism ; Melanoma/pathology ; Mice ; Molecular Structure ; Particle Size ; Reactive Oxygen Species/metabolism ; Serum Albumin, Bovine/chemistry ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Surface Properties
Czasopismo naukowe
Tytuł :
Dual Roles of Metal-Organic Frameworks as Nanocarriers for miRNA Delivery and Adjuvants for Chemodynamic Therapy.
Autorzy :
Zhao H; Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.
Li T; Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.
Yao C; Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.
Gu Z; School of Chemical Engineering and Australian Centre for NanoMedicine, University of New South Wales, Sydney, New South Wales 2052, Australia.
Liu C; Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.
Li J; Department of Bioengineering, Northeastern University, Boston, Massachusetts 02115, United States.
Yang D; Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Feb 10; Vol. 13 (5), pp. 6034-6042. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Adjuvants, Pharmaceutic/*pharmacology
Antibiotics, Antineoplastic/*pharmacology
Doxorubicin/*pharmacology
Metal-Organic Frameworks/*chemistry
MicroRNAs/*pharmacology
Nanoparticles/*chemistry
Adjuvants, Pharmaceutic/chemistry ; Animals ; Antibiotics, Antineoplastic/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Doxorubicin/chemistry ; Drug Carriers/chemistry ; Drug Screening Assays, Antitumor ; Humans ; Mammary Neoplasms, Experimental/diagnostic imaging ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mice ; MicroRNAs/chemistry ; Particle Size ; Reactive Oxygen Species/metabolism ; Surface Properties ; Zeolites/chemistry ; Zeolites/pharmacology
Czasopismo naukowe
Tytuł :
A Clinical-Epidemiological and Geospatial Study of Tuberculosis in a Neglected Area in the Amazonian Region Highlights the Urgent Need for Control Measures.
Autorzy :
Mesquita CR; Programa de Pós-Graduação em Biologia Parasitária na Amazônia, Universidade do Estado do Pará e Instituto Evandro Chagas, Tv. Perebebui, 2623, Belem 66087-662, Brazil.; Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde, Instituto Evandro Chagas, BR 316, km 7, Ananindeua 67000-000, Brazil.; Seção de Bacteriologia e Micologia, Instituto Evandro Chagas, BR 316, km 7, Ananindeua 67000-000, Brazil.
Conceição EC; Programa de Pós-Graduação em Pesquisa Clínica em Doenças Infecciosas do Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Av. Brasil, 4365, Rio de Janeiro 21040-900, Brazil.
Monteiro LHMT; Secretaria de Saúde do Estado do Pará-SESPA, Av. João Paulo II, 602, Belem 66087-048, Brazil.
da Silva OM; Secretaria de Saúde do Estado do Pará-SESPA, Av. João Paulo II, 602, Belem 66087-048, Brazil.
Lima LNGC; Programa de Pós-Graduação em Biologia Parasitária na Amazônia, Universidade do Estado do Pará e Instituto Evandro Chagas, Tv. Perebebui, 2623, Belem 66087-662, Brazil.; Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde, Instituto Evandro Chagas, BR 316, km 7, Ananindeua 67000-000, Brazil.; Seção de Bacteriologia e Micologia, Instituto Evandro Chagas, BR 316, km 7, Ananindeua 67000-000, Brazil.
de Oliveira RAC; Programa de Pós-Graduação em Saúde, Ambiente e Sociedade, Universidade Federal do Pará, Rua Augusto Corrêa, Belem 66075-110, Brazil.
de Brito AC; Coordenação Geral de Vigilância das Doenças de Transmissão Respiratória de Condições Crônicas, Av. Brasil, 4365, Rio de Janeiro 21040-900, Brazil.
Guimarães RJPSE; Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde, Instituto Evandro Chagas, BR 316, km 7, Ananindeua 67000-000, Brazil.
Lima KVB; Programa de Pós-Graduação em Biologia Parasitária na Amazônia, Universidade do Estado do Pará e Instituto Evandro Chagas, Tv. Perebebui, 2623, Belem 66087-662, Brazil.; Seção de Bacteriologia e Micologia, Instituto Evandro Chagas, BR 316, km 7, Ananindeua 67000-000, Brazil.
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Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2021 Feb 02; Vol. 18 (3). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibiotics, Antitubercular*/therapeutic use
Mycobacterium tuberculosis*
Tuberculosis*/drug therapy
Tuberculosis*/epidemiology
Tuberculosis*/prevention & control
Brazil/epidemiology ; Humans ; Neoplasm Recurrence, Local ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Comparison of Drug-Eluting Embolics versus Conventional Transarterial Chemoembolization for the Treatment of Patients with Unresectable Hepatocellular Carcinoma: A Cost-Effectiveness Analysis.
Autorzy :
Wu X; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
Chapiro J; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
Malhotra A; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT.
Kothary N; Department of Radiology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305. Electronic address: .
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Źródło :
Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2021 Jan; Vol. 32 (1), pp. 2-12.e1. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Drug Costs*
Antibiotics, Antineoplastic/*administration & dosage
Antibiotics, Antineoplastic/*economics
Carcinoma, Hepatocellular/*drug therapy
Chemoembolization, Therapeutic/*economics
Doxorubicin/*administration & dosage
Doxorubicin/*economics
Drug Carriers/*economics
Liver Neoplasms/*drug therapy
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibiotics, Antineoplastic/adverse effects ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/mortality ; Clinical Decision-Making ; Cost Savings ; Cost-Benefit Analysis ; Decision Support Techniques ; Decision Trees ; Disease Progression ; Doxorubicin/adverse effects ; Female ; Humans ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Models, Economic ; Quality of Life ; Quality-Adjusted Life Years ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Diagnosis of cutaneous tuberculosis (lymph node scrofuloderma) using the Xpert MTB/RIF® method.
Autorzy :
Costa LL; Dermatology Clinic, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Veasey JV; Dermatology Clinic, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil. Electronic address: .
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Źródło :
Anais brasileiros de dermatologia [An Bras Dermatol] 2021 Jan-Feb; Vol. 96 (1), pp. 82-84. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Case Reports
MeSH Terms :
Antibiotics, Antitubercular*/pharmacology
Antibiotics, Antitubercular*/therapeutic use
Mycobacterium tuberculosis*/genetics
Tuberculosis, Cutaneous*/diagnosis
Tuberculosis, Cutaneous*/drug therapy
Drug Resistance, Bacterial ; Humans ; Lymph Nodes ; Rifampin/therapeutic use ; Sensitivity and Specificity
Raport
Tytuł :
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Autorzy :
Lilic M; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Chen J; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Boyaci H; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Braffman N; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Hubin EA; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Herrmann J; Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarland University, 66123 Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.; Partner Site Hannover-Braunschweig, German Center for Infection Research, 38124 Braunschweig, Germany.
Müller R; Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarland University, 66123 Saarbrücken, Germany.; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.; Partner Site Hannover-Braunschweig, German Center for Infection Research, 38124 Braunschweig, Germany.
Mooney R; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Landick R; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706.
Darst SA; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Campbell EA; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 01; Vol. 117 (48), pp. 30423-30432. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Promoter Regions, Genetic*
Aminoglycosides/*pharmacology
Antibiotics, Antitubercular/*pharmacology
DNA-Directed RNA Polymerases/*metabolism
Drug Resistance, Bacterial/*drug effects
Mycobacterium tuberculosis/*drug effects
Mycobacterium tuberculosis/*physiology
Aminoglycosides/chemistry ; Antibiotics, Antitubercular/chemistry ; Binding Sites ; Humans ; Models, Molecular ; Molecular Conformation ; Protein Binding ; Rifampin/pharmacology ; Structure-Activity Relationship ; Tuberculosis/drug therapy ; Tuberculosis/microbiology
Czasopismo naukowe
Tytuł :
Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin.
Autorzy :
Wang C; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Qi P; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Lu Y; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Liu L; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Zhang Y; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Sheng Q; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Wang T; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Zhang M; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Wang R; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
Song S; Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 344-357.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Antibiotics, Antineoplastic/*administration & dosage
Doxorubicin/*administration & dosage
Polymers/*chemistry
Animals ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/pharmacology ; Boronic Acids/chemistry ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Carriers/chemistry ; Drug Liberation ; Female ; Humans ; Hydrogen-Ion Concentration ; Mice ; Micelles ; Neoplasms/drug therapy ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Phenylboronic ester-modified anionic micelles for ROS-stimuli response in HeLa cell.
Autorzy :
Wang QY; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Xu YS; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Zhang NX; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Dong ZP; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Zhao BN; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Liu LC; Department of Rheumatology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Lu T; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
Wang Y; Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing, China.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 681-690.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*administration & dosage
Biocompatible Materials/*chemistry
Boronic Acids/*chemistry
Doxorubicin/*administration & dosage
Drug Carriers/*chemistry
Polyethylene Glycols/*chemistry
Reactive Oxygen Species/*metabolism
A549 Cells ; Animals ; Anions ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/pharmacokinetics ; Antibiotics, Antineoplastic/pharmacology ; Cell Survival/drug effects ; Doxorubicin/chemistry ; Doxorubicin/pharmacokinetics ; Doxorubicin/pharmacology ; Drug Liberation ; HeLa Cells ; Humans ; MCF-7 Cells ; Mice ; Micelles ; Molecular Structure ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Heparan sulfate targeting strategy for enhancing liposomal drug accumulation and facilitating deep distribution in tumors.
Autorzy :
Kuo PH; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Teng YH; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Cin AL; Operations Center for Industry Collaboration, National Tsing Hua University, Hsinchu, Taiwan.
Han W; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.; Graduate Program of Biotechnology in Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Huang PW; Mackay Memorial Hospital, Hsinchu, Taiwan.
Wang LH; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Chou YT; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Yang JL; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Tseng YL; Taiwan Liposome Company, Ltd, Taipei, Taiwan.
Kao M; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Chang MD; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.; Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
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Źródło :
Drug delivery [Drug Deliv] 2020 Dec; Vol. 27 (1), pp. 542-555.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*drug therapy
Antibiotics, Antineoplastic/*administration & dosage
Antibiotics, Antineoplastic/*pharmacokinetics
Doxorubicin/*analogs & derivatives
Heparitin Sulfate/*metabolism
Lung Neoplasms/*drug therapy
A549 Cells ; Adenocarcinoma of Lung/metabolism ; Animals ; Antibiotics, Antineoplastic/chemistry ; Cell Line, Tumor ; Doxorubicin/administration & dosage ; Doxorubicin/chemistry ; Doxorubicin/pharmacokinetics ; Drug Delivery Systems ; Female ; Glycosaminoglycans/metabolism ; Humans ; Liposomes/administration & dosage ; Liposomes/chemical synthesis ; Liposomes/chemistry ; Liposomes/pharmacokinetics ; Lung Neoplasms/metabolism ; Mice ; NIH 3T3 Cells ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics ; Tissue Distribution/drug effects ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Efficacy of BCG vaccine and Mitomycin C for the treatment of ocular squamous cell carcinoma in bovines.
Autorzy :
Podarala V; College of Veterinary Science, Tirupati, AP, India. Electronic address: .
Prasanna Lakshmi M; Sri Venkateswara Veterinary University|College of Veterinary Science, Tirupati, AP, India.
Venkata SKR; Sri Venkateswara Veterinary University|College of Veterinary Science, Tirupati, AP, India.
Devalam RP; Sri Venkateswara Veterinary University|College of Veterinary Science, Tirupati, AP, India.
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Źródło :
Research in veterinary science [Res Vet Sci] 2020 Dec; Vol. 133, pp. 48-52. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*therapeutic use
BCG Vaccine/*standards
Carcinoma, Squamous Cell/*veterinary
Cattle Diseases/*drug therapy
Eye Neoplasms/*veterinary
Mitomycin/*therapeutic use
Administration, Intravesical ; Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/standards ; BCG Vaccine/administration & dosage ; BCG Vaccine/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Cattle ; Combined Modality Therapy/veterinary ; Eye Neoplasms/drug therapy ; Female ; Humans ; Male ; Mitomycin/administration & dosage ; Mitomycin/standards ; Nucleic Acid Synthesis Inhibitors/administration & dosage ; Nucleic Acid Synthesis Inhibitors/standards ; Nucleic Acid Synthesis Inhibitors/therapeutic use ; Prospective Studies ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/veterinary
Czasopismo naukowe
Tytuł :
Safety and feasibility of early single-dose mitomycin C bladder instillation after robot-assisted radical nephroureterectomy.
Autorzy :
Gulamhusein A; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
Silva P; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
Cullen D; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
Tran M; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
Mumtaz F; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
Patki P; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
Barod R; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
Bex A; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, London, UK.
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Źródło :
BJU international [BJU Int] 2020 Dec; Vol. 126 (6), pp. 739-744. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic*/administration & dosage
Antibiotics, Antineoplastic*/adverse effects
Antibiotics, Antineoplastic*/therapeutic use
Mitomycin*/administration & dosage
Mitomycin*/adverse effects
Mitomycin*/therapeutic use
Nephroureterectomy*
Robotic Surgical Procedures*
Urologic Neoplasms*/drug therapy
Urologic Neoplasms*/surgery
Administration, Intravesical ; Aged ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Urinary Bladder/surgery
Czasopismo naukowe
Tytuł :
Environmentally Self-Adaptative Nanocarriers Suppress Glioma Proliferation and Stemness via Codelivery of shCD163 and Doxorubicin.
Autorzy :
Liu J; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Zhang Y; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Chen T; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Chen H; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
He H; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Jin T; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Wang J; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Ke Y; The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Nov 25; Vol. 12 (47), pp. 52354-52369. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*chemistry
Doxorubicin/*chemistry
Nanoparticles/*chemistry
RNA, Small Interfering/*metabolism
Animals ; Antibiotics, Antineoplastic/pharmacology ; Antibiotics, Antineoplastic/therapeutic use ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/genetics ; Antigens, Differentiation, Myelomonocytic/metabolism ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Glioma/drug therapy ; Glioma/mortality ; Glioma/pathology ; Humans ; Liposomes/chemistry ; Mice ; Mice, Nude ; Nanoparticles/metabolism ; Oligopeptides/chemistry ; Polyethylene Glycols/chemistry ; RNA Interference ; RNA, Small Interfering/chemistry ; Receptors, Cell Surface/antagonists & inhibitors ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Survival Rate ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy.
Autorzy :
Liu Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Eckenrode JM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Zhang Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Zhang J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Hayden RC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Kyomuhangi A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Ponomareva LV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Cui Z; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Rohr J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Tsodikov OV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Van Lanen SG; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Shaaban KA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Leggas M; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
Thorson JS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.; Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 14067-14086. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibiotics, Antineoplastic/*pharmacokinetics
Antibiotics, Antineoplastic/*pharmacology
Bone Neoplasms/*drug therapy
Oximes/*chemistry
Plicamycin/*chemistry
Sarcoma, Ewing/*drug therapy
Animals ; Antibiotics, Antineoplastic/chemistry ; Apoptosis ; Bone Neoplasms/pathology ; Cell Proliferation ; Female ; Humans ; Mice ; Mice, SCID ; Sarcoma, Ewing/pathology ; Tissue Distribution ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Self-Distinguishing and Stimulus-Responsive Carrier-Free Theranostic Nanoagents for Imaging-Guided Chemo-Photothermal Therapy in Small-Cell Lung Cancer.
Autorzy :
Zhu Q; School of Pharmaceutical Science & College of Materials, Fujian Provincial Key Laboratory of Innovative Drug Target Research & Key Laboratory of Biomedical Engineering of Fujian Province, Xiamen University, Xiamen 361005, China.
Fan Z; School of Pharmaceutical Science & College of Materials, Fujian Provincial Key Laboratory of Innovative Drug Target Research & Key Laboratory of Biomedical Engineering of Fujian Province, Xiamen University, Xiamen 361005, China.
Zuo W; School of Pharmaceutical Science & College of Materials, Fujian Provincial Key Laboratory of Innovative Drug Target Research & Key Laboratory of Biomedical Engineering of Fujian Province, Xiamen University, Xiamen 361005, China.
Chen Y; School of Pharmaceutical Science & College of Materials, Fujian Provincial Key Laboratory of Innovative Drug Target Research & Key Laboratory of Biomedical Engineering of Fujian Province, Xiamen University, Xiamen 361005, China.
Hou Z; School of Pharmaceutical Science & College of Materials, Fujian Provincial Key Laboratory of Innovative Drug Target Research & Key Laboratory of Biomedical Engineering of Fujian Province, Xiamen University, Xiamen 361005, China.
Zhu X; School of Pharmaceutical Science & College of Materials, Fujian Provincial Key Laboratory of Innovative Drug Target Research & Key Laboratory of Biomedical Engineering of Fujian Province, Xiamen University, Xiamen 361005, China.
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Źródło :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Nov 18; Vol. 12 (46), pp. 51314-51328. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*chemistry
Doxorubicin/*chemistry
Indocyanine Green/*chemistry
Nanoparticles/*chemistry
Photosensitizing Agents/*chemistry
Animals ; Antibiotics, Antineoplastic/pharmacology ; Antibiotics, Antineoplastic/therapeutic use ; CD56 Antigen/metabolism ; Carcinoma, Small Cell/diagnostic imaging ; Carcinoma, Small Cell/drug therapy ; Carcinoma, Small Cell/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Glutathione/chemistry ; Glutathione/metabolism ; Humans ; Indocyanine Green/pharmacology ; Indocyanine Green/therapeutic use ; Infrared Rays ; Ligands ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Mice ; Microscopy, Confocal ; Nanoparticles/metabolism ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Photothermal Therapy ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Transplantation, Heterologous
Czasopismo naukowe

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