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Wyszukujesz frazę ""ANTITUBERCULAR agents"" wg kryterium: Temat


Tytuł :
A hydrogel-based implantable multidrug antitubercular formulation outperforms oral delivery.
Autorzy :
Pal S; Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad-121001, Haryana, India. .
Soni V
Kumar S
Jha SK
Medatwal N
Rana K
Yadav P
Mehta D
Jain D
Sharma P
Kar R
Srivastava A
Patil VS
Dasgupta U
Nandicoori VK
Bajaj A
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Źródło :
Nanoscale [Nanoscale] 2021 Aug 21; Vol. 13 (31), pp. 13225-13230. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents*/pharmacology
Antitubercular Agents*/therapeutic use
Hydrogels*
Animals ; Ethambutol ; Isoniazid ; Mice ; Pyrazinamide
Czasopismo naukowe
Tytuł :
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis : Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging.
Autorzy :
van der Westhuyzen R; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Mabhula A; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Njaria PM; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Müller R; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Ngumbu Muhunga D; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Taylor D; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Lawrence N; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Njoroge M; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Brunschwig C; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Moosa A; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Singh V; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Rao SPS; Novartis Institute for Tropical Diseases (NITD), 10 Biopolis Road, Chromos #05-01, Singapore 138670, Singapore.
Manjunatha UH; Novartis Institute for Tropical Diseases (NITD), 10 Biopolis Road, Chromos #05-01, Singapore 138670, Singapore.
Smith PW; Novartis Institute for Tropical Diseases (NITD), 10 Biopolis Road, Chromos #05-01, Singapore 138670, Singapore.
Warner DF; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Department of Pathology, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Street LJ; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
Chibale K; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 9444-9457. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antitubercular Agents/*pharmacology
Carbamates/*pharmacology
Heterocyclic Compounds/*pharmacology
Mycobacterium tuberculosis/*drug effects
Oximes/*pharmacology
Antitubercular Agents/chemistry ; Antitubercular Agents/metabolism ; Carbamates/chemistry ; Carbamates/metabolism ; Dose-Response Relationship, Drug ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/metabolism ; Microbial Sensitivity Tests ; Molecular Structure ; Mycobacterium tuberculosis/metabolism ; Oximes/chemistry ; Oximes/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019.
Autorzy :
Bhering M; Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa Acadêmico de Tuberculose, Rio de Janeiro, RJ, Brasil.; Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública Sergio Arouca, Rio de Janeiro, RJ, Brasil.
Kritski A; Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa Acadêmico de Tuberculose, Rio de Janeiro, RJ, Brasil.
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Źródło :
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2021 Aug 20; Vol. 54, pp. e00862021. Date of Electronic Publication: 2021 Aug 20 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents*/therapeutic use
Tuberculosis, Multidrug-Resistant*/drug therapy
Tuberculosis, Multidrug-Resistant*/epidemiology
Brazil/epidemiology ; Humans ; Research Design ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Early and Midterm Outcomes of Endovascular Repair of Tuberculous Infected Native (Mycotic) Aortic Aneurysms.
Autorzy :
He H; Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Li Q; Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Wang J; Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Li X; Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Li J; Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China.
Shu C; Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha, China; Department of Vascular Surgery, Fuwai Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. Electronic address: .
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Źródło :
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2021 Aug; Vol. 62 (2), pp. 314-315. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji :
Letter
MeSH Terms :
Endovascular Procedures*/methods
Antitubercular Agents/*administration & dosage
Aortic Aneurysm/*etiology
Aortic Aneurysm/*surgery
Tuberculosis/*complications
Aged ; Antitubercular Agents/therapeutic use ; Blood Vessel Prosthesis ; Drug-Eluting Stents ; Female ; Humans ; Isoniazid/administration & dosage ; Male ; Middle Aged ; Postoperative Complications/etiology ; Retrospective Studies ; Rifampin/administration & dosage ; Survival Rate ; Treatment Outcome ; Tuberculosis/drug therapy
Opinia redakcyjna
Tytuł :
Engineering of konjac glucomannan into respirable microparticles for delivery of antitubercular drugs.
Autorzy :
Guerreiro F; Centre for Marine Sciences (CCMar), Faculty of Sciences and Technology, Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal; Centre for Biomedical Research (CBMR), Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal.
Swedrowska M; King's College London, Institute of Pharmaceutical Science, London SE1 9NH, UK. Electronic address: .
Patel R; King's College London, Institute of Pharmaceutical Science, London SE1 9NH, UK. Electronic address: .
Flórez-Fernández N; Centre for Marine Sciences (CCMar), Faculty of Sciences and Technology, Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal; Centre for Biomedical Research (CBMR), Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal; Department of Chemical Engineering, University of Vigo, Faculty of Sciences, As Lagoas, Ourense 32004, Spain. Electronic address: .
Torres MD; Department of Chemical Engineering, University of Vigo, Faculty of Sciences, As Lagoas, Ourense 32004, Spain. Electronic address: .
Rosa da Costa AM; Algarve Chemistry Research Centre (CIQA), Faculty of Sciences and Technology, Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal. Electronic address: .
Forbes B; King's College London, Institute of Pharmaceutical Science, London SE1 9NH, UK. Electronic address: .
Grenha A; Centre for Marine Sciences (CCMar), Faculty of Sciences and Technology, Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal; Centre for Biomedical Research (CBMR), Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Jul 15; Vol. 604, pp. 120731. Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents*
Drug Carriers*
Administration, Inhalation ; Mannans
Czasopismo naukowe
Tytuł :
Substance use disorders and adherence to antituberculosis medications in Southwest Ethiopia: a prospective cohort study.
Autorzy :
Soboka M; Department of Psychiatry, Medical Faculty, Jimma University, Jimma, Ethiopia .; Center for International Health, Ludwig Maxmilians University, Munich, Germany.
Tesfaye M; Center for International Health, Ludwig Maxmilians University, Munich, Germany.; Department of Psychiatry, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Adorjan K; Center for International Health, Ludwig Maxmilians University, Munich, Germany.; Department of Psychiatry and Psychotherapy, LMU Munich, Munich, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Krahl W; Center for International Health, Ludwig Maxmilians University, Munich, Germany.; Department of Forensic Psychiatry, Isar Amper Klinikum, Munich, Germany.
Tesfaye E; Department of Psychiatry, Medical Faculty, Jimma University, Jimma, Ethiopia.
Yitayih Y; Department of Psychiatry, Medical Faculty, Jimma University, Jimma, Ethiopia.
Strobl R; Institute for Medical Information Processing, Biometry and Epidemiology,Ludwig Maximilians University Muenchen, Munich, Germany.; German Center for Vertigo and Balance Disorders, University Hospital LMU Muenchen, Munich, Germany.
Grill E; Center for International Health, Ludwig Maxmilians University, Munich, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology,Ludwig Maximilians University Muenchen, Munich, Germany.; German Center for Vertigo and Balance Disorders, University Hospital LMU Muenchen, Munich, Germany.
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Źródło :
BMJ open [BMJ Open] 2021 Jul 05; Vol. 11 (7), pp. e043050. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antitubercular Agents*/therapeutic use
Substance-Related Disorders*/epidemiology
Catha ; Cross-Sectional Studies ; Ethiopia/epidemiology ; Humans ; Medication Adherence ; Prospective Studies
Czasopismo naukowe
Tytuł :
Treatment Outcomes of Childhood Tuberculosis in Three Districts of Balochistan, Pakistan: Findings from a Retrospective Cohort Study.
Autorzy :
Abdullah A; Department of Pharmacy Practice, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.
Ahmad N; Department of Pharmacy Practice, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.
Atif M; Department of Pharmacy, The Islamia University, Bahawalpur, Pakistan.
Khan S; Department of Pulmonology, Bolan Medical College, Quetta, Pakistan.
Wahid A; Department of Pharmacy Practice, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.
Ahmad I; Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan.
Khan A; Department of Pharmacy Practice, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.
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Źródło :
Journal of tropical pediatrics [J Trop Pediatr] 2021 Jul 02; Vol. 67 (3).
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents*/therapeutic use
Tuberculosis*/drug therapy
Tuberculosis*/epidemiology
Adolescent ; Child ; Child, Preschool ; Humans ; Pakistan/epidemiology ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Costs of multidrug-resistant TB treatment in Finland and Estonia affected by the 2019 WHO guidelines.
Autorzy :
Feuth T; Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital, Turku.
Patovirta RL; Department of Respiratory Medicine, Kuopio University Hospital, Kuopio.
Grierson S; Finnish Lung Health Association (FILHA), Helsinki, Finland.
Danilovits M; Lung Clinic of Tartu University Hospital, Tartu, Estonia.
Viiklepp P; National Institute for Health Development, Tallinn, Estonia.
Aaltonen HK; Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku.
Vauhkonen M; Finnish Lung Health Association (FILHA), Helsinki, Finland.
Pehme L; Lung Clinic of Tartu University Hospital, Tartu, Estonia.
Vasankari T; Finnish Lung Health Association (FILHA), Helsinki, Finland.
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Źródło :
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2021 Jul 01; Vol. 25 (7), pp. 554-559.
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents*/therapeutic use
Tuberculosis, Multidrug-Resistant*/drug therapy
Tuberculosis, Multidrug-Resistant*/epidemiology
Estonia/epidemiology ; Finland/epidemiology ; Humans ; World Health Organization
Czasopismo naukowe
Tytuł :
The impact of contact evaluation and TB preventive therapy on TB incidence.
Autorzy :
Chaisson RE; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cavalcante SC; Municipal Health Secretariat of Rio de Janeiro, Rio de Janeiro, RJ, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Correspondence to: Richard E Chaisson, Center for Tuberculosis Research, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231, USA. , Email: .
Golub J; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Durovni B; Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil, Correspondence to: Richard E Chaisson, Center for Tuberculosis Research, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231, USA. , Email: .
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Źródło :
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2021 Jul 01; Vol. 25 (7), pp. 599a-599.
Typ publikacji :
Letter; Comment
MeSH Terms :
Antitubercular Agents*/therapeutic use
Isoniazid*
Antibiotic Prophylaxis ; Humans ; Incidence
Opinia redakcyjna
Tytuł :
A cohort study analyzing the impact of socioeconomic and spatial characteristics alongside treatment regimens on the environmental-health outcomes of the MDR-TB treatment in Pakistan.
Autorzy :
Arif A; School of Economics, Quaid-i-Azam University, Islamabad, Pakistan. .
Ahmad E; School of Economics, Quaid-i-Azam University, Islamabad, Pakistan.
Khan FN; School of Economics, Quaid-i-Azam University, Islamabad, Pakistan.
Fatima R; National Tuberculosis Control Program, Ministry of Health, Pakistan, EPI building, F block, PM Health Complex, Chak Shahzad, Islamabad, Pakistan.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Jul; Vol. 28 (26), pp. 34953-34967. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents*
Tuberculosis, Multidrug-Resistant*/drug therapy
Tuberculosis, Multidrug-Resistant*/epidemiology
Cohort Studies ; Humans ; Male ; Outcome Assessment, Health Care ; Pakistan ; Socioeconomic Factors
Czasopismo naukowe
Tytuł :
Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis.
Autorzy :
Li P; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Wang B; Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing, 101149, PR China.
Fu L; Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing, 101149, PR China.
Guo K; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Ma C; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Wang B; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Lin Z; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Li G; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China. Electronic address: .
Huang H; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China. Electronic address: .
Lu Y; Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing, 101149, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113603. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*pharmacology
Antitubercular Agents/*pharmacology
Benzopyrans/*pharmacology
Esters/*pharmacology
Mycobacterium tuberculosis/*drug effects
Amides/chemistry ; Amides/metabolism ; Antitubercular Agents/chemistry ; Antitubercular Agents/metabolism ; Benzopyrans/chemistry ; Benzopyrans/metabolism ; Dose-Response Relationship, Drug ; Esters/chemistry ; Esters/metabolism ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The Mur Enzymes Chink in the Armour of Mycobacterium tuberculosis cell wall.
Autorzy :
Shinde Y; Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, District Dhule, 425405, Maharashtra, India.
Ahmad I; Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, District Dhule, 425405, Maharashtra, India.
Surana S; Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, District Dhule, 425405, Maharashtra, India.
Patel H; Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, District Dhule, 425405, Maharashtra, India. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113568. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antitubercular Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Mycobacterium tuberculosis/*enzymology
Peptide Synthases/*antagonists & inhibitors
Peptidoglycan/*pharmacology
Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Cell Wall/drug effects ; Cell Wall/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Molecular Structure ; Mycobacterium tuberculosis/cytology ; Peptide Synthases/metabolism ; Peptidoglycan/chemistry
Czasopismo naukowe
Tytuł :
Standard versus high dose of rifampicin in the treatment of pulmonary tuberculosis: a systematic review and meta-analysis.
Autorzy :
Onorato L; Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Naples, Italy.
Gentile V; Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Naples, Italy.
Russo A; Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Naples, Italy.
Di Caprio G; Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Naples, Italy.
Alessio L; Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Naples, Italy.
Chiodini P; Department of Mental Health and Public Medicine, Section of Statistics, University of Campania, Naples, Italy.
Coppola N; Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Naples, Italy. Electronic address: .
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Źródło :
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2021 Jun; Vol. 27 (6), pp. 830-837. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Antitubercular Agents/*administration & dosage
Antitubercular Agents/*therapeutic use
Rifampin/*administration & dosage
Rifampin/*therapeutic use
Tuberculosis, Pulmonary/*drug therapy
Antitubercular Agents/adverse effects ; Dose-Response Relationship, Drug ; Humans ; Rifampin/adverse effects
Czasopismo naukowe
Tytuł :
Monocarbonyl curcuminoids as antituberculosis agents with their moderate in-vitro metabolic stability on human liver microsomes.
Autorzy :
Gagandeep; Department of Chemistry, University of Delhi, New Delhi, India.
Singh M; Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, Faridabad, India.
Kidawi S; Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, Faridabad, India.
Das US; Department of Ocular Pharmacology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Velpandian T; Department of Ocular Pharmacology, Dr. R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Singh R; Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, Faridabad, India.
Rawat DS; Department of Chemistry, University of Delhi, New Delhi, India.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 Jun; Vol. 35 (6), pp. 1-10. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents*/pharmacokinetics
Antitubercular Agents*/pharmacology
Diarylheptanoids*/pharmacokinetics
Diarylheptanoids*/pharmacology
Microsomes, Liver/*metabolism
Mycobacterium tuberculosis/*growth & development
Humans ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Thiazole-Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation.
Autorzy :
Kasetti AB; Research Scholar, Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Pacific University, Udaipur 313003, India.; Dr. Samuel George Institute of Pharmaceutical Sciences, Markapuram, Andhra Pradesh 523316, India.
Singhvi I; Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Pacific University, Udaipur 313003, India.
Nagasuri R; A.M. Reddy Memorial College of Pharmacy, Narasaraopeta, Andhra Pradesh 523316, India.
Bhandare RR; Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, Ajman P.O. Box 346, United Arab Emirates.; Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Shaik AB; Department of Pharmaceutical Chemistry, Vignan Pharmacy College, Vadlamudi, Guntur, Andhra Pradesh 522213, India.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 11; Vol. 26 (10). Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Molecular Docking Simulation*
Antineoplastic Agents/*pharmacology
Antitubercular Agents/*pharmacology
Chalcones/*pharmacokinetics
Chalcones/*pharmacology
Thiazoles/*pharmacokinetics
Thiazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacokinetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Thiazoles/chemical synthesis ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Tuberculosis: An Overview of the Immunogenic Response, Disease Progression, and Medicinal Chemistry Efforts in the Last Decade toward the Development of Potential Drugs for Extensively Drug-Resistant Tuberculosis Strains.
Autorzy :
Sharma A; Department of Biophysics, Panjab University, Chandigarh 160014, India.; UIPS, Panjab University, Chandigarh 160014, India.
De Rosa M; Drug Discovery Unit, Ri.MED Foundation, Palermo 90133, Italy.
Singla N; Department of Biophysics, Panjab University, Chandigarh 160014, India.
Singh G; UIPS, Panjab University, Chandigarh 160014, India.
Barnwal RP; Department of Biophysics, Panjab University, Chandigarh 160014, India.
Pandey A; Department of Chemistry, Panjab University, Chandigarh 160014, India.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 4359-4395. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antitubercular Agents/*chemistry
Extensively Drug-Resistant Tuberculosis/*pathology
Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Ciprofloxacin/chemistry ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Disease Progression ; Drug Carriers/chemistry ; Drug Evaluation, Preclinical ; Drug Resistance, Bacterial/genetics ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Extensively Drug-Resistant Tuberculosis/immunology ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Streptomycin/chemistry ; Streptomycin/pharmacology ; Streptomycin/therapeutic use ; Structure-Activity Relationship ; Thiophenes/chemistry ; Thiophenes/pharmacology ; Thiophenes/therapeutic use ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
Rapid and Sensitive LC-MS/MS Method for Simultaneous Determination of Three First-Line Oral Antituberculosis Drug in Plasma.
Autorzy :
Han F; Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li W; Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jin Y; Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang F; Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yuan B; Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xu H; Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang 110016, China.
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Źródło :
Journal of chromatographic science [J Chromatogr Sci] 2021 Apr 21; Vol. 59 (5), pp. 432-438.
Typ publikacji :
Journal Article
MeSH Terms :
Antitubercular Agents/*blood
Chromatography, Liquid/*methods
Tandem Mass Spectrometry/*methods
Administration, Oral ; Animals ; Antitubercular Agents/administration & dosage ; Antitubercular Agents/pharmacokinetics ; Dogs ; Humans ; Linear Models ; Male ; Rats ; Reproducibility of Results ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Synthesis, Characterization and Biological Evaluation of New 3,5-Disubstituted-Pyrazoline Derivatives as Potential Anti- Mycobacterium tuberculosis H37Ra Compounds.
Autorzy :
Wong KT; School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang 11800, Malaysia.
Osman H; School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang 11800, Malaysia.
Parumasivam T; School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang 11800, Malaysia.
Supratman U; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Che Omar MT; Biological Section, School of Distance Education, Universiti Sains Malaysia, Penang 11800, Malaysia.
Azmi MN; School of Chemical Sciences, Universiti Sains Malaysia, Minden, Penang 11800, Malaysia.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 05; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article
MeSH Terms :
14-alpha Demethylase Inhibitors/*chemical synthesis
Antitubercular Agents/*chemical synthesis
Bacterial Proteins/*antagonists & inhibitors
Pyrazoles/*chemical synthesis
Semicarbazides/*chemical synthesis
Sterol 14-Demethylase/*chemistry
14-alpha Demethylase Inhibitors/pharmacology ; Antitubercular Agents/pharmacology ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Catalytic Domain ; Fluconazole/chemistry ; Fluconazole/pharmacology ; Isoniazid/chemistry ; Isoniazid/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/enzymology ; Mycobacterium tuberculosis/growth & development ; Protein Binding ; Protein Conformation ; Protein Interaction Domains and Motifs ; Pyrazoles/pharmacology ; Semicarbazides/pharmacology ; Sterol 14-Demethylase/metabolism ; Structural Homology, Protein ; Thermodynamics
Czasopismo naukowe
Tytuł :
Pharmacokinetics and Drug-Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping.
Autorzy :
Gausi K; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Wiesner L; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Norman J; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Wallis CL; BARC Laboratories South Africa, Johannesburg, South Africa.
Onyango-Makumbi C; Makerere University - Johns Hopkins University Research Collaboration, Kampala, Uganda.
Chipato T; Department of Obstetrics and Gynaecology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Haas DW; Departments of Medicine, Pharmacology, Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA.
Browning R; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Chakhtoura N; National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland, USA.
Montepiedra G; Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Aaron L; Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
McCarthy K; FHI 360, Durham, North Carolina, USA.
Bradford S; FHI 360, Durham, North Carolina, USA.
Vhembo T; Department of Obstetrics and Gynaecology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Stranix-Chibanda L; Department of Obstetrics and Gynaecology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Masheto GR; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Violari A; The Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Mmbaga BT; Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Aurpibul L; Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
Bhosale R; Byramjee Jeejeebhoy Government Medical College, Pune, India.
Nevrekhar N; Byramjee Jeejeebhoy Government College-Johns Hopkins Clinical Research Site, Pune, India.
Rouzier V; Weill Cornell Center for Global Health New York, New York, New York, USA.; Centres GHESKIO, Port-au-Prince, Haiti.
Kabugho E; MU-JHU Research Collaboration, Kampala, Uganda.
Mutambanengwe M; University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe.
Chanaiwa V; University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe.
Nyati M; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Mhembere T; University of Zimbabwe College of Health Sciences Clinical Trials Research Centre, Harare, Zimbabwe.
Tongprasert F; Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Hesseling A; Department of Paediatrics and Child Health, The Desmond Tutu TB Center, Stellenbosch University, Tygerberg, South Africa.
Shin K; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Zimmer B; University of California, Los Angeles, California, USA.
Costello D; Frontier Science Foundation, Amherst, New York, USA.
Jean-Philippe P; Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Sterling TR; Vanderbilt Tuberculosis Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Theron G; Department of Obstetrics and Gynaecology, Stellenbosch University, Cape Town, South Africa.
Weinberg A; University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA.
Gupta A; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Denti P; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
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Corporate Authors :
IMPAACT P1078 (TB APPRISE) Study Group Team; Research Group: IMPAACT P1078 Study Group Team, Durham, North Carolina, USA.
Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Apr; Vol. 109 (4), pp. 1034-1044. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Alkynes/*pharmacokinetics
Anti-HIV Agents/*pharmacokinetics
Antitubercular Agents/*pharmacology
Benzoxazines/*pharmacokinetics
Cyclopropanes/*pharmacokinetics
HIV Infections/*drug therapy
Isoniazid/*pharmacology
Adolescent ; Adult ; Antitubercular Agents/administration & dosage ; Antitubercular Agents/pharmacokinetics ; Arylamine N-Acetyltransferase/genetics ; Body Weight ; Cytochrome P-450 CYP2B6/genetics ; Double-Blind Method ; Drug Interactions ; Equivalence Trials as Topic ; Female ; Genotype ; Humans ; Isoniazid/pharmacokinetics ; Metabolic Clearance Rate ; Middle Aged ; Pregnancy ; Prospective Studies ; Reverse Transcriptase Inhibitors/pharmacokinetics ; Tuberculosis/prevention & control ; Young Adult
Czasopismo naukowe
Tytuł :
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide.
Autorzy :
Santucci P; Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, London, UK.
Greenwood DJ; Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, London, UK.; Institute of Molecular Systems Biology, ETH, Zurich, Switzerland.
Fearns A; Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, London, UK.
Chen K; School of Molecular Sciences, University of Western Australia, Perth, AU, Australia.
Jiang H; School of Molecular Sciences, University of Western Australia, Perth, AU, Australia. .; Department of Chemistry, The University of Hong Kong, Hong Kong, China. .
Gutierrez MG; Host-Pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, London, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 21; Vol. 12 (1), pp. 3816. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antitubercular Agents/*pharmacology
Cytosol/*microbiology
Mycobacterium tuberculosis/*drug effects
Pyrazinamide/*pharmacology
Antitubercular Agents/pharmacokinetics ; Diarylquinolines/pharmacokinetics ; Diarylquinolines/pharmacology ; Drug Synergism ; Humans ; Hydrogen-Ion Concentration ; Macrophages/microbiology ; Microscopy, Electron ; Mutation ; Mycobacterium tuberculosis/growth & development ; Mycobacterium tuberculosis/metabolism ; Pyrazinamide/pharmacokinetics ; Type VII Secretion Systems/genetics
Czasopismo naukowe

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