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Tytuł :
New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19.
Autorzy :
Aleissa MM; Department of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Silverman EA; Division of Infectious Diseases, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Paredes Acosta LM; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Nutt CT; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Richterman A; Division of Infectious Diseases, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Marty FM; Division of Infectious Diseases, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA .; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Dec 16; Vol. 65 (1). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*administration & dosage
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/pharmacokinetics ; Adenosine Monophosphate/pharmacology ; Alanine/administration & dosage ; Alanine/chemistry ; Alanine/pharmacokinetics ; Alanine/pharmacology ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Breast Feeding ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Female ; Humans ; Immunocompromised Host ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Pregnancy ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Repurposing Nucleoside Analogs for Human Coronaviruses.
Autorzy :
Zandi K; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Amblard F; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Musall K; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Downs-Bowen J; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Kleinbard R; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Oo A; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Cao D; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Liang B; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Russell OO; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
McBrayer T; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Bassit L; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Kim B; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA .; Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Dec 16; Vol. 65 (1). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
Drug Repositioning/*methods
Nucleosides/*pharmacology
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/toxicity ; Cell Line ; Chlorocebus aethiops ; Coronavirus OC43, Human/drug effects ; Drug Evaluation, Preclinical ; Humans ; Nucleosides/chemistry ; Nucleosides/toxicity ; Propanolamines/pharmacology ; Sofosbuvir/pharmacology ; Vero Cells
Czasopismo naukowe
Tytuł :
Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses.
Autorzy :
Artese A; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy; Net4Science Academic Spin-Off, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Svicher V; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Costa G; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy; Net4Science Academic Spin-Off, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Salpini R; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Di Maio VC; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Alkhatib M; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Ambrosio FA; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Santoro MM; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Assaraf YG; The Fred Wyszkowski Cancer Research Lab, Faculty of Biology, Technion, Israel Institute of Technology, Haifa, Israel.
Alcaro S; Dipartimento di Scienze della Salute, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy; Net4Science Academic Spin-Off, Università 'Magna Græcia' di Catanzaro, Campus 'S. Venuta', Catanzaro, Italy.
Ceccherini-Silberstein F; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy. Electronic address: .
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Źródło :
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2020 Dec; Vol. 53, pp. 100721. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*administration & dosage
Coronavirus Infections/*drug therapy
Drug Delivery Systems/*methods
SARS-CoV-2/*drug effects
Amino Acid Sequence ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; COVID-19/drug therapy ; COVID-19/metabolism ; Coronavirus Infections/metabolism ; Drug Delivery Systems/trends ; Humans ; Protease Inhibitors/administration & dosage ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/chemistry ; Reverse Transcriptase Inhibitors/metabolism ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
Nano-based approaches in the development of antiviral agents and vaccines.
Autorzy :
Li Y; College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, 430023 Wuhan, China.
Xiao Y; School of Pharmacy, Hubei University of Chinese medicine, Wuhan 430065, China.
Chen Y; School of Pharmacy, Tongji Medical College. Huazhong University of Science & Technology, Wuhan 430030, China.
Huang K; School of Pharmacy, Tongji Medical College. Huazhong University of Science & Technology, Wuhan 430030, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118761. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Nanotechnology*/methods
Antiviral Agents/*therapeutic use
Viral Vaccines/*therapeutic use
Antiviral Agents/administration & dosage ; Humans ; Nanocapsules ; Viral Vaccines/administration & dosage ; Virus Diseases/drug therapy ; Virus Diseases/prevention & control
Czasopismo naukowe
Tytuł :
Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19.
Autorzy :
Li D; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
Hu J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China. .
Li D; Department of Modern Economy and Trade, Hunan Vocational College of Engineering, Changsha, 410151, People's Republic of China.
Yang W; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China. .
Yin SF; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
Qiu R; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China. .
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Źródło :
Topics in current chemistry (Cham) [Top Curr Chem (Cham)] 2021 Jan 11; Vol. 379 (1), pp. 4. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Small Molecule Libraries*
Antiviral Agents/*chemical synthesis
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Antimalarials/therapeutic use ; Antiviral Agents/therapeutic use ; Clinical Trials as Topic ; Drug Repositioning ; Humans ; Janus Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
QSAR Modeling of SARS-CoV M Inhibitors Identifies Sufugolix, Cenicriviroc, Proglumetacin, and other Drugs as Candidates for Repurposing against SARS-CoV-2.
Autorzy :
Alves VM; Office of Data Science, National Toxicology Program, NIEHS, Morrisville, NC, 27560, USA.
Bobrowski T; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Melo-Filho CC; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Korn D; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Computer Science, University of North Carolina, Chapel Hill, NC, 27599, USA.
Auerbach S; Toxinformatics Group, National Toxicology Program, NIEHS, Morrisville, NC, 27560, USA.
Schmitt C; Office of Data Science, National Toxicology Program, NIEHS, Morrisville, NC, 27560, USA.
Muratov EN; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Pharmaceutical Sciences, Federal University of Paraiba, Joao Pessoa, PB, Brazil.
Tropsha A; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
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Źródło :
Molecular informatics [Mol Inform] 2021 Jan; Vol. 40 (1), pp. e2000113. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents*/chemistry
Antiviral Agents*/therapeutic use
COVID-19*/drug therapy
COVID-19*/enzymology
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
Drug Repositioning*
Molecular Docking Simulation*
Protease Inhibitors*/chemistry
Protease Inhibitors*/therapeutic use
Imidazoles/*chemistry
Indoleacetic Acids/*chemistry
SARS-CoV-2/*enzymology
Sulfoxides/*chemistry
Catalytic Domain ; Humans ; Imidazoles/therapeutic use ; Indoleacetic Acids/therapeutic use ; Quantitative Structure-Activity Relationship ; Sulfoxides/therapeutic use
Czasopismo naukowe
Tytuł :
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size.
Autorzy :
Zhao H; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China; Peking University International Hospital, Beijing, China.
Zhu Q; Department of Tuberculosis, Wuhan Pulmonary Hospital, Wuhan, 430030, China.
Zhang C; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
Li J; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
Wei M; Wuhan Jinyintan Hospital, No. 1 Yintan Road, Dongxihu District, Wuhan, 430040, China.
Qin Y; Emergency Department of Peking University International Hospital, Life-Science Park, Changping District, Beijing, 102206, China.
Chen G; Department of Tuberculosis, Wuhan Pulmonary Hospital, Wuhan, 430030, China.
Wang K; Wuhan Jinyintan Hospital, No. 1 Yintan Road, Dongxihu District, Wuhan, 430040, China.
Yu J; Ezhou Central Hospital, 9 Wenxing Road, Ezhou City, Hubei Province, 463000, China.
Wu Z; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China.
Chen X; Surgical Department, Wuhan Pulmonary Hospital, No. 28 Baofeng Road, Wuhan, 430030, China. Electronic address: .
Wang G; Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing, China; Peking University International Hospital, Beijing, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 110825. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Amides/*therapeutic use
Antibodies, Monoclonal, Humanized/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Pyrazines/*therapeutic use
SARS-CoV-2/*drug effects
Adult ; Aged ; Aged, 80 and over ; Amides/administration & dosage ; Amides/adverse effects ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; COVID-19/diagnostic imaging ; COVID-19/pathology ; COVID-19/therapy ; Drug Therapy, Combination ; Female ; Humans ; Interleukin-6/blood ; Kaplan-Meier Estimate ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Middle Aged ; Models, Immunological ; Pyrazines/administration & dosage ; Pyrazines/adverse effects ; Receptors, Interleukin-6/antagonists & inhibitors ; Respiration, Artificial/statistics & numerical data ; Sample Size ; Treatment Outcome
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Hydroxychloroquine can potentially interfere with immune function in COVID-19 patients: Mechanisms and insights.
Autorzy :
Devarajan A; UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA; Neurocardiology Research Center of Excellence, University of California, Los Angeles, CA, USA. Electronic address: .
Vaseghi M; UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA; Neurocardiology Research Center of Excellence, University of California, Los Angeles, CA, USA.
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Źródło :
Redox biology [Redox Biol] 2021 Jan; Vol. 38, pp. 101810. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Antiviral Agents*/adverse effects
Antiviral Agents*/therapeutic use
Autophagic Cell Death*/drug effects
Autophagic Cell Death*/immunology
COVID-19*/drug therapy
COVID-19*/epidemiology
COVID-19*/immunology
COVID-19*/pathology
Hydroxychloroquine*/adverse effects
Hydroxychloroquine*/therapeutic use
Pandemics*
Antigen Presentation/*drug effects
SARS-CoV-2/*immunology
Humans ; Oxidation-Reduction/drug effects
Czasopismo naukowe
Tytuł :
Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2.
Autorzy :
Shin YS; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Lee JY; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Noh S; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kwak Y; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Jeon S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Kwon S; Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea.
Jin YH; KM Application Center, Korea Institute of Oriental Medicine, Dong-gu, Daegu 41062, South Korea.
Jang MS; Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea.
Kim S; Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea.
Song JH; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Kim HR; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
Park CM; Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jan 01; Vol. 31, pp. 127667. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Antiviral Agents/*pharmacology
SARS-CoV-2/*drug effects
Sulfonamides/*pharmacology
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; COVID-19/drug therapy ; Cell Line ; Chlorocebus aethiops ; Cricetulus ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Mice ; Microbial Sensitivity Tests ; Molecular Structure ; Rats ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Fighting on two fronts: drug-drug interactions in people living with HIV infected with SARS-CoV-2.
Autorzy :
Bahap M; Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Ankara, Turkey .
Kara E; Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Ankara, Turkey.
Sain Guven G; Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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Źródło :
European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2021 Jan; Vol. 28 (1), pp. e3. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Letter
MeSH Terms :
Antiviral Agents/*therapeutic use
COVID-19/*complications
COVID-19/*drug therapy
HIV Infections/*complications
HIV Infections/*drug therapy
Antiretroviral Therapy, Highly Active ; Antiviral Agents/adverse effects ; Antiviral Agents/pharmacokinetics ; Cytochrome P-450 Enzyme System/metabolism ; Drug Interactions ; Humans
Opinia redakcyjna
Tytuł :
New insights into antiviral and cytotoxic potential of quercetin and its derivatives - A biochemical perspective.
Autorzy :
Gansukh E; Department of Bio-resources and Food Science, Konkuk University, Seoul 143701, South Korea; Department of Life Science and Biotechnology, Huree University, Ulaanbaatar, Mongolia.
Nile A; Department of Bio-resources and Food Science, Konkuk University, Seoul 143701, South Korea.
Kim DH; Department of Bio-resources and Food Science, Konkuk University, Seoul 143701, South Korea.
Oh JW; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Republic of Korea.
Nile SH; Department of Bio-resources and Food Science, Konkuk University, Seoul 143701, South Korea; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jan 01; Vol. 334, pp. 127508. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Influenza A virus/*drug effects
Quercetin/*analogs & derivatives
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Binding Sites ; Cell Survival/drug effects ; DNA-Directed RNA Polymerases/chemistry ; DNA-Directed RNA Polymerases/metabolism ; Dogs ; Humans ; Influenza A virus/enzymology ; Influenzavirus B/drug effects ; Madin Darby Canine Kidney Cells ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Quercetin/chemistry ; Quercetin/metabolism ; Quercetin/pharmacology ; Thermodynamics
Czasopismo naukowe
Tytuł :
Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches.
Autorzy :
Batalha PN; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil. Electronic address: .
Forezi LSM; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
Lima CGS; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
Pauli FP; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
Boechat FCS; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
de Souza MCBV; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
Cunha AC; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil.
Ferreira VF; Universidade Federal Fluminense, Faculdade de Farmácia, Departamento de Tecnologia Farmacêutica, CEP 24241-000 Niterói, RJ, Brazil. Electronic address: .
da Silva FC; Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Campus do Valonguinho, CEP 24020-150 Niterói, RJ, Brazil. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jan; Vol. 106, pp. 104488. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Repositioning*
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; COVID-19/epidemiology ; Cell Line, Tumor ; Clinical Trials as Topic ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans ; Pandemics ; SARS-CoV-2/drug effects
Czasopismo naukowe
Tytuł :
Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.
Autorzy :
Lee DYW; Bio-Organic and Natural Products Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478. Electronic address: .
Li QY; Bio-Organic and Natural Products Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478; Henan University of Chinese Medicine, Zhengzhou, China 450046.
Liu J; Bio-Organic and Natural Products Research Laboratory, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany 55128. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Jan; Vol. 80, pp. 153337. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Drugs, Chinese Herbal/*therapeutic use
Plants, Medicinal/*chemistry
Antiviral Agents/chemistry ; COVID-19/immunology ; China ; Clinical Trials as Topic ; Drugs, Chinese Herbal/chemistry ; Humans ; Medicine, Chinese Traditional ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action.
Autorzy :
Yousefi H; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.
Mashouri L; Department of Medical Sciences, University of Arkansas, Little Rock, AK, USA.
Okpechi SC; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.
Alahari N; Department of Biological Engineering, Louisiana State University, Baton Rouge, LA, USA.
Alahari SK; Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA; Stanley Scott Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114296. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Antioxidants/*therapeutic use
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Drug Repositioning/*methods
SARS-CoV-2/*drug effects
Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/pharmacology ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/pharmacology ; Alanine/therapeutic use ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Drug Repositioning/trends ; Humans ; Treatment Outcome ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models.
Autorzy :
Wang G; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Yang ML; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China.
Duan ZL; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Liu FL; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Jin L; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Long CB; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Zhang M; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Tang XP; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.; Sino-African Joint Research Center, Chinese Academy of Science, Wuhan, Hubei, 430074, China.
Xu L; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Li YC; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.
Kamau PM; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; Sino-African Joint Research Center, Chinese Academy of Science, Wuhan, Hubei, 430074, China.
Yang L; Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
Liu HQ; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China.
Xu JW; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China.
Chen JK; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, 510530, China.
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China. .; Kunming National High-level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology Chinese Academic of Sciences, Kunming, Yunnan, 650107, China. .
Peng XZ; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, Yunnan, 650031, China. .
Lai R; Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Kunming, Yunnan, 650107, China. .; Sino-African Joint Research Center, Chinese Academy of Science, Wuhan, Hubei, 430074, China. .; Kunming National High-level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology Chinese Academic of Sciences, Kunming, Yunnan, 650107, China. .; Institutes for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, 201203, China. .
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Źródło :
Cell research [Cell Res] 2021 Jan; Vol. 31 (1), pp. 17-24. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents*/pharmacokinetics
Antiviral Agents*/pharmacology
Angiotensin-Converting Enzyme 2/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Teicoplanin/*analogs & derivatives
Animals ; Caco-2 Cells ; Chlorocebus aethiops ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Protein Binding/drug effects ; Teicoplanin/pharmacokinetics ; Teicoplanin/pharmacology ; Vero Cells
Czasopismo naukowe
Tytuł :
Synthesis, molecular docking, and in silico ADME/Tox profiling studies of new 1-aryl-5-(3-azidopropyl)indol-4-ones: Potential inhibitors of SARS CoV-2 main protease.
Autorzy :
Domínguez-Villa FX; Facultad de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacán, DF, Mexico.
Durán-Iturbide NA; Facultad de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacán, DF, Mexico.
Ávila-Zárraga JG; Facultad de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacán, DF, Mexico. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Jan; Vol. 106, pp. 104497. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*metabolism
Azides/*metabolism
Coronavirus 3C Proteases/*antagonists & inhibitors
Cysteine Proteinase Inhibitors/*metabolism
Indoles/*metabolism
SARS-CoV-2/*chemistry
Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacokinetics ; Azides/chemical synthesis ; Azides/pharmacokinetics ; Catalytic Domain ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/pharmacokinetics ; Indoles/chemical synthesis ; Indoles/pharmacokinetics ; Internet ; Molecular Docking Simulation ; Protein Binding
Czasopismo naukowe
Tytuł :
FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2.
Autorzy :
Renz A; Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI).; Department of Computer Science, University of Tübingen, Tübingen 72076, Germany.
Widerspick L; Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI).
Dräger A; Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI).; Department of Computer Science, University of Tübingen, Tübingen 72076, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Germany.
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Źródło :
Bioinformatics (Oxford, England) [Bioinformatics] 2020 Dec 30; Vol. 36 (Suppl 2), pp. i813-i821.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
COVID-19*/drug therapy
Guanylate Kinases ; Humans ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Taming the Autophagy as a Strategy for Treating COVID-19.
Autorzy :
García-Pérez BE; Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, Mexico City 11340, Mexico.
González-Rojas JA; Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, Mexico City 11340, Mexico.
Salazar MI; Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, Mexico City 11340, Mexico.
Torres-Torres C; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Ingeniería Mecánica y Eléctrica, Unidad Zacatenco, Instituto Politécnico Nacional, Gustavo A. Madero, Mexico City 07738, Mexico.
Castrejón-Jiménez NS; Área Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias-Universidad Autónoma del Estado de Hidalgo, Av. Universidad km. 1. Exhacienda de Aquetzalpa A.P. 32, Tulancingo, Hidalgo 43600, Mexico.
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Źródło :
Cells [Cells] 2020 Dec 13; Vol. 9 (12). Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Anti-Inflammatory Agents*/pharmacology
Anti-Inflammatory Agents*/therapeutic use
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
Autophagy/*drug effects
COVID-19/*drug therapy
SARS-CoV-2/*drug effects
Humans
Czasopismo naukowe
Tytuł :
Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction.
Autorzy :
Sikander M; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Malik S; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Rodriguez A; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Yallapu MM; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Narula AS; Narula Research, LLC, 107 Boulder Bluff, Chapel Hill, NC 27516, USA.
Satapathy SK; Division of Hepatology, Department of Internal Medicine, Sandra Atlas Bass Center for Liver Diseases and Transplantation, Barbara and Zucker School of Medicine, Northwell Health, Manhasset, NY 11030, USA.
Dhevan V; Department of Surgery, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Chauhan SC; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Jaggi M; Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.; South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Dec 13; Vol. 25 (24). Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/adverse effects
Antiviral Agents*/therapeutic use
COVID-19*/drug therapy
COVID-19*/epidemiology
Chemical and Drug Induced Liver Injury*/diet therapy
Chemical and Drug Induced Liver Injury*/epidemiology
Dietary Supplements*
Pandemics*
SARS-CoV-2*
Humans
Czasopismo naukowe
Tytuł :
Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis.
Autorzy :
Piscoya A; Unidad de Revisiones Sistemáticas y Meta-análisis (URSIGET), Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima, Peru.; Hospital Guillermo Kaelin de La Fuente, Lima, Peru.
Ng-Sueng LF; Unidad de Revisiones Sistemáticas y Meta-análisis (URSIGET), Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima, Peru.; Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, United States of America.
Parra Del Riego A; Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru.
Cerna-Viacava R; Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru.
Pasupuleti V; MedErgy Health Group Inc. Yardley, Pennsylvania, United States of America.
Roman YM; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, Connecticut, United States of America.; Department of Research Administration, Hartford Hospital. Hartford, Connecticut, United States of America.
Thota P; Hemex Health Inc. Portland, Oregon, United States of America.
White CM; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, Connecticut, United States of America.; Department of Research Administration, Hartford Hospital. Hartford, Connecticut, United States of America.
Hernandez AV; Unidad de Revisiones Sistemáticas y Meta-análisis (URSIGET), Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima, Peru.; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, Connecticut, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 10; Vol. 15 (12), pp. e0243705. Date of Electronic Publication: 2020 Dec 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
SARS-CoV-2/*drug effects
Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/adverse effects ; Adenosine Monophosphate/therapeutic use ; Alanine/administration & dosage ; Alanine/adverse effects ; Alanine/therapeutic use ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome
Czasopismo naukowe

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