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Wyszukujesz frazę ""APOBEC-3G Deaminase"" wg kryterium: Temat


Tytuł :
Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.
Autorzy :
Salamango DJ; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA .; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
McCann JL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Demir Ö; Department of Chemistry and Biochemistry, University of San Diego, La Jolla, California, USA.
Becker JT; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Wang J; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Department of Virology and Infectious Disease, Rockefeller University, New York, New York, USA.
Lingappa JR; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
Temiz NA; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Brown WL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Amaro RE; Department of Chemistry and Biochemistry, University of San Diego, La Jolla, California, USA.
Harris RS; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA .; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, USA.
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*chemistry
HIV-1/*genetics
Protein Phosphatase 2/*chemistry
vif Gene Products, Human Immunodeficiency Virus/*chemistry
APOBEC-3G Deaminase/genetics ; APOBEC-3G Deaminase/metabolism ; Amino Acid Sequence ; Amino Acid Substitution ; Binding Sites ; Gene Expression ; Gene Expression Regulation ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HEK293 Cells ; HIV Infections/virology ; HIV-1/isolation & purification ; HIV-1/metabolism ; HeLa Cells ; Host-Pathogen Interactions/genetics ; Humans ; Kinetics ; Models, Molecular ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; Protein Structure, Secondary ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Signal Transduction ; Substrate Specificity ; vif Gene Products, Human Immunodeficiency Virus/genetics ; vif Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans.
Autorzy :
Nakano Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Yamamoto K; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ueda MT; Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Soper A; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Konno Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Kimura I; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Uriu K; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Kumata R; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Faculty of Science, Kyoto University, Kyoto, Japan.
Aso H; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Misawa N; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Nagaoka S; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Shimizu S; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Mitsumune K; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Kosugi Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Juarez-Fernandez G; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ito J; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Nakagawa S; Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan.
Ikeda T; Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, United States of America.; Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Koyanagi Y; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Harris RS; Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, United States of America.
Sato K; Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.; Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.; Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; CREST, Japan Science and Technology Agency, Saitama, Japan.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 10; Vol. 16 (9), pp. e1008812. Date of Electronic Publication: 2020 Sep 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Evolution, Molecular*
Host-Pathogen Interactions*
Virus Replication*
APOBEC-3G Deaminase/*metabolism
Gene Products, vif/*metabolism
Simian Acquired Immunodeficiency Syndrome/*transmission
Simian Immunodeficiency Virus/*isolation & purification
APOBEC-3G Deaminase/chemistry ; APOBEC-3G Deaminase/genetics ; Amino Acid Sequence ; Animals ; Gene Products, vif/chemistry ; Gene Products, vif/genetics ; Gorilla gorilla ; Humans ; Pan troglodytes ; Phylogeny ; Protein Conformation ; Sequence Homology ; Simian Acquired Immunodeficiency Syndrome/virology
Czasopismo naukowe
Tytuł :
Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
Autorzy :
Yang H; Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California, Los Angeles, CA, 90089, USA.
Ito F; Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California, Los Angeles, CA, 90089, USA.
Wolfe AD; Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California, Los Angeles, CA, 90089, USA.; Genetic, Molecular and Cellular Biology Program, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90033, USA.
Li S; Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California, Los Angeles, CA, 90089, USA.; Center of Excellence in NanoBiophysics, University of Southern California, Los Angeles, CA, 90089, USA.
Mohammadzadeh N; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.
Love RP; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.
Yan M; Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California, Los Angeles, CA, 90089, USA.; School of Pharmacy, Jining Medical University, 276800, Rizhao, Shandong, China.
Zirkle B; Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California, Los Angeles, CA, 90089, USA.; Genetic, Molecular and Cellular Biology Program, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Gaba A; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.
Chelico L; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.
Chen XS; Molecular and Computational Biology, Departments of Biological Sciences, Chemistry, University of Southern California, Los Angeles, CA, 90089, USA. .; Genetic, Molecular and Cellular Biology Program, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. .; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90033, USA. .; Center of Excellence in NanoBiophysics, University of Southern California, Los Angeles, CA, 90089, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 31; Vol. 11 (1), pp. 632. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*chemistry
HIV Infections/*enzymology
HIV-1/*physiology
APOBEC-3G Deaminase/genetics ; APOBEC-3G Deaminase/metabolism ; Animals ; Dimerization ; HIV Infections/virology ; HIV-1/genetics ; Host-Pathogen Interactions ; Humans ; Macaca mulatta ; Protein Domains ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Virus Assembly ; Virus Replication
Czasopismo naukowe
Tytuł :
An Alu Element Insertion in Intron 1 Results in Aberrant Alternative Splicing of APOBEC3G Pre-mRNA in Northern Pig-Tailed Macaques ( Macaca leonina ) That May Reduce APOBEC3G-Mediated Hypermutation Pressure on HIV-1.
Autorzy :
Zhang XL; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.
Luo MT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Song JH; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.; Institute of Health Sciences, Anhui University, Hefei, Anhui, China.
Pang W; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China .; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
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Źródło :
Journal of virology [J Virol] 2020 Jan 31; Vol. 94 (4). Date of Electronic Publication: 2020 Jan 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*genetics
Alu Elements/*genetics
HIV-1/*genetics
APOBEC-3G Deaminase/metabolism ; Alternative Splicing/genetics ; Animals ; Cytidine Deaminase/metabolism ; DNA, Viral/genetics ; Disease Models, Animal ; HIV Infections/virology ; HIV Seropositivity/genetics ; HIV-1/pathogenicity ; Humans ; Introns/genetics ; Leukocytes, Mononuclear/virology ; Macaca/genetics ; Macaca fascicularis ; Macaca mulatta ; Mutation/genetics ; RNA Precursors/metabolism ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA.
Autorzy :
Morse M; Department of Physics, Northeastern University, Boston, United States.
Naufer MN; Department of Physics, Northeastern University, Boston, United States.
Feng Y; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada.
Chelico L; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada.
Rouzina I; Department of Chemistry and Biochemistry, Ohio State University, Columbus, United States.
Williams MC; Department of Physics, Northeastern University, Boston, United States.
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Źródło :
ELife [Elife] 2019 Dec 18; Vol. 8. Date of Electronic Publication: 2019 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*metabolism
DNA, Single-Stranded/*metabolism
Immunologic Factors/*metabolism
APOBEC-3G Deaminase/chemistry ; Immunologic Factors/chemistry ; Protein Binding ; Protein Conformation ; Protein Domains
Czasopismo naukowe
Tytuł :
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
Autorzy :
Solomon WC; Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.
Myint W; Basic Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Hou S; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Kanai T; Basic Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.; Department of Chemistry, Banasthali University, Banasthali-304022, Rajasthan, India.
Tripathi R; Department of Bioscience and Biotechnology, Banasthali University, Banasthali-304022, Rajasthan, India.
Kurt Yilmaz N; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Schiffer CA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Matsuo H; Basic Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2019 Aug 22; Vol. 47 (14), pp. 7676-7689.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Molecular Dynamics Simulation*
APOBEC-3G Deaminase/*metabolism
DNA/*metabolism
DNA, Single-Stranded/*metabolism
Magnetic Resonance Spectroscopy/*methods
RNA/*metabolism
APOBEC-3G Deaminase/chemistry ; APOBEC-3G Deaminase/genetics ; Biocatalysis ; Cytidine/chemistry ; Cytidine/metabolism ; DNA/chemistry ; DNA/genetics ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/genetics ; Deamination ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Protein Binding ; RNA/chemistry ; RNA/genetics ; RNA, Viral/chemistry ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Substrate Specificity ; Virion/genetics ; Virion/metabolism
Czasopismo naukowe
Tytuł :
Different antiviral activities of natural APOBEC3C, APOBEC3G, and APOBEC3H variants against hepatitis B virus.
Autorzy :
Kanagaraj A; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Sakamoto N; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Que L; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Li Y; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Mohiuddin M; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Koura M; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Wakae K; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Kurachi M; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Muramatsu M; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. Electronic address: .
Kitamura K; Department of Molecular Genetics, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 Oct 08; Vol. 518 (1), pp. 26-31. Date of Electronic Publication: 2019 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Variation*
APOBEC-3G Deaminase/*genetics
Aminohydrolases/*genetics
Antiviral Agents/*metabolism
Cytidine Deaminase/*genetics
Hepatitis B virus/*physiology
APOBEC-3G Deaminase/metabolism ; Aminohydrolases/metabolism ; Cell Line, Tumor ; Cytidine Deaminase/metabolism ; DNA, Viral/genetics ; Gene Expression Regulation ; Humans ; Somatic Hypermutation, Immunoglobulin/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association.
Autorzy :
Fukuda H; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Li S; Systems Immunology Laboratory, WPI Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan.; Department of Genome Informatics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Sardo L; Department of Biological Sciences, McNeil Science and Technology Center, University of the Sciences, Philadelphia, PA, United States.
Smith JL; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Yamashita K; Systems Immunology Laboratory, WPI Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Sarca AD; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shirakawa K; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Standley DM; Systems Immunology Laboratory, WPI Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan.; Department of Genome Informatics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Takaori-Kondo A; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Izumi T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2019 May 21; Vol. 9, pp. 129. Date of Electronic Publication: 2019 May 21 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*chemistry
APOBEC-3G Deaminase/*metabolism
HIV-1/*immunology
RNA, Viral/*metabolism
APOBEC-3G Deaminase/genetics ; DNA Mutational Analysis ; HIV Infections/immunology ; HIV Infections/virology ; Molecular Docking Simulation ; Protein Binding
Czasopismo naukowe
Tytuł :
HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1.
Autorzy :
Ikeda T; 2 Institute for Molecular Virology, Minneapolis, MN 55455, USA.; 3 Center for Genome Engineering, Minneapolis, MN 55455, USA.; 5 Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA.; 1 Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN 55455, USA.; 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Molan AM; 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; 2 Institute for Molecular Virology, Minneapolis, MN 55455, USA.; 3 Center for Genome Engineering, Minneapolis, MN 55455, USA.; 1 Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN 55455, USA.
Jarvis MC; 3 Center for Genome Engineering, Minneapolis, MN 55455, USA.; 1 Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN 55455, USA.; 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; 2 Institute for Molecular Virology, Minneapolis, MN 55455, USA.
Carpenter MA; 3 Center for Genome Engineering, Minneapolis, MN 55455, USA.; 1 Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN 55455, USA.; 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; 2 Institute for Molecular Virology, Minneapolis, MN 55455, USA.; 5 Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Salamango DJ; 1 Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN 55455, USA.; 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; 2 Institute for Molecular Virology, Minneapolis, MN 55455, USA.; 3 Center for Genome Engineering, Minneapolis, MN 55455, USA.
Brown WL; 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; 3 Center for Genome Engineering, Minneapolis, MN 55455, USA.; 2 Institute for Molecular Virology, Minneapolis, MN 55455, USA.; 1 Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN 55455, USA.
Harris RS; 3 Center for Genome Engineering, Minneapolis, MN 55455, USA.; 1 Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN 55455, USA.; 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.; 2 Institute for Molecular Virology, Minneapolis, MN 55455, USA.; 5 Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło :
The Journal of general virology [J Gen Virol] 2019 Jul; Vol. 100 (7), pp. 1140-1152. Date of Electronic Publication: 2019 May 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
APOBEC-3G Deaminase/*metabolism
HIV Infections/*enzymology
HIV-1/*physiology
APOBEC-3G Deaminase/genetics ; HIV Infections/genetics ; HIV Infections/virology ; HIV-1/genetics ; Host-Pathogen Interactions ; Humans ; Mutation ; Myeloid Cells ; THP-1 Cells ; Virus Replication ; vif Gene Products, Human Immunodeficiency Virus/genetics ; vif Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA.
Autorzy :
Yan X; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai, 200032, China.; University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China.
Lan W; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai, 200032, China.
Wang C; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai, 200032, China.
Cao C; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Road, Shanghai, 200032, China.; University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing, 100049, China.
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Źródło :
Chemistry, an Asian journal [Chem Asian J] 2019 Jul 01; Vol. 14 (13), pp. 2235-2241. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
APOBEC-3G Deaminase/*metabolism
Cytidine/*metabolism
DNA/*metabolism
APOBEC-3G Deaminase/chemistry ; Base Sequence ; Catalytic Domain ; Cytidine/chemistry ; DNA/chemistry ; Deamination ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation ; Proton Magnetic Resonance Spectroscopy
Czasopismo naukowe
Tytuł :
APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity.
Autorzy :
Wang H; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China.
Zhong M; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China.
Li Y; CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li K; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China.
Wu S; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China.
Guo T; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China.
Cen S; CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jiang J; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China. Electronic address: .
Li Z; CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: .
Li Y; Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China. Electronic address: .
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Źródło :
Antiviral research [Antiviral Res] 2019 May; Vol. 165, pp. 23-33. Date of Electronic Publication: 2019 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*metabolism
Anisoles/*metabolism
Antiviral Agents/*metabolism
Benzamides/*metabolism
Enterovirus/*drug effects
APOBEC-3G Deaminase/genetics ; Animals ; Anisoles/pharmacology ; Antiviral Agents/pharmacology ; Benzamides/pharmacology ; Chlorocebus aethiops ; Enterovirus/genetics ; Enterovirus/growth & development ; HeLa Cells ; Humans ; Vero Cells ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells.
Autorzy :
Yoshino S; Division of Molecular Pathology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Matsui Y; Biomedical and Health Informatics Unit, Department of Integrated Health Science, Nagoya University Graduate School of Medicine, Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Fukui Y; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Seki M; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan.
Yamaguchi K; Division of Clinical Genome Research, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Kanamori A; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Saitoh Y; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.; Center for Medical Education, Teikyo University of Science, Senjusakuragi, Adachi-ku, Tokyo, Japan.
Shimamura T; Division of Systems Biology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Nagoya, Japan.
Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan.
Furukawa Y; Division of Clinical Genome Research, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Kaneko S; Department of System Biology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Takaramachi, Kanazawa, Ishikawa, Japan.
Seiki M; Division of Cancer Cell Research, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Murakami Y; Division of Molecular Pathology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Inoue JI; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Sakamoto T; Department of System Biology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Takaramachi, Kanazawa, Ishikawa, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 09; Vol. 10 (1), pp. 9275. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Exosome Multienzyme Ribonuclease Complex/*metabolism
RNA-Binding Proteins/*metabolism
Stress, Physiological/*physiology
APOBEC-3G Deaminase/genetics ; APOBEC-3G Deaminase/metabolism ; Animals ; Binding Sites ; Cell Line, Tumor ; Cytoplasmic Structures/metabolism ; DNA Damage ; Endoplasmic Reticulum Stress ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosomes/genetics ; Exosomes/metabolism ; Female ; Humans ; Mice, Inbred BALB C ; Oxidative Stress ; RNA-Binding Proteins/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Role of APOBEC3 proteins in proteasome inhibitor-mediated reactivation of latent HIV-1 viruses.
Autorzy :
Timilsina U; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, Delhi.
Ghimire D; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, Delhi.
Sharma S; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, Delhi.
Gaur R; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi-110021, Delhi.
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Źródło :
The Journal of general virology [J Gen Virol] 2019 Mar; Vol. 100 (3), pp. 523-532. Date of Electronic Publication: 2019 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*metabolism
Anti-HIV Agents/*pharmacology
Cytidine Deaminase/*metabolism
HIV Infections/*enzymology
HIV-1/*physiology
Proteasome Inhibitors/*pharmacology
Virus Latency/*drug effects
APOBEC-3G Deaminase/genetics ; Cytidine Deaminase/genetics ; HIV Infections/genetics ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; Virion/drug effects ; Virion/genetics ; Virion/physiology ; Virus Activation/drug effects ; Virus Assembly/drug effects
Czasopismo naukowe
Tytuł :
Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues.
Autorzy :
Kvach MV; Institute of Fundamental Sciences , Massey University , Private Bag 11 222, Palmerston North 4442 , New Zealand.
Barzak FM; Institute of Fundamental Sciences , Massey University , Private Bag 11 222, Palmerston North 4442 , New Zealand.
Harjes S; Institute of Fundamental Sciences , Massey University , Private Bag 11 222, Palmerston North 4442 , New Zealand.
Schares HAM
Jameson GB; Institute of Fundamental Sciences , Massey University , Private Bag 11 222, Palmerston North 4442 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1142 , New Zealand.
Ayoub AM
Moorthy R
Aihara H
Harris RS; Howard Hughes Medical Institute , University of Minnesota , Minneapolis , Minnesota 55455 , United States.
Filichev VV; Institute of Fundamental Sciences , Massey University , Private Bag 11 222, Palmerston North 4442 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1142 , New Zealand.
Harki DA
Harjes E; Institute of Fundamental Sciences , Massey University , Private Bag 11 222, Palmerston North 4442 , New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1142 , New Zealand.
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Źródło :
Biochemistry [Biochemistry] 2019 Feb 05; Vol. 58 (5), pp. 391-400. Date of Electronic Publication: 2018 Nov 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*antagonists & inhibitors
Cytidine/*analogs & derivatives
Cytidine Deaminase/*antagonists & inhibitors
DNA, Single-Stranded/*pharmacology
Enzyme Inhibitors/*pharmacology
Proteins/*antagonists & inhibitors
APOBEC-3G Deaminase/metabolism ; Cytidine/chemistry ; Cytidine/pharmacology ; Cytidine Deaminase/metabolism ; DNA, Single-Stranded/chemistry ; Enzyme Inhibitors/chemistry ; Humans ; Minor Histocompatibility Antigens/metabolism ; Proteins/metabolism
Czasopismo naukowe
Tytuł :
The Enzymatic Activity of APOBE3G Multimers.
Autorzy :
Pan Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, 68198-6025, USA.
Zagorski K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, 68198-6025, USA.
Shlyakhtenko LS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, 68198-6025, USA. .
Lyubchenko YL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, 68198-6025, USA. .
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Źródło :
Scientific reports [Sci Rep] 2018 Dec 18; Vol. 8 (1), pp. 17953. Date of Electronic Publication: 2018 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Multimerization*
APOBEC-3G Deaminase/*chemistry
APOBEC-3G Deaminase/*metabolism
APOBEC-3G Deaminase/genetics ; Enzyme Activation ; Humans ; Microscopy, Atomic Force/methods ; Protein Binding
Czasopismo naukowe
Tytuł :
RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids.
Autorzy :
Feng Y; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Wong L; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Morse M; Department of Physics, Northeastern University, Boston, MA 02115, USA.
Rouzina I; Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH 43210, USA.
Williams MC; Department of Physics, Northeastern University, Boston, MA 02115, USA.
Chelico L; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2018 Dec 07; Vol. 430 (24), pp. 4891-4907. Date of Electronic Publication: 2018 Nov 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
APOBEC-3G Deaminase/*chemistry
APOBEC-3G Deaminase/*metabolism
HIV-1/*physiology
RNA/*metabolism
APOBEC-3G Deaminase/genetics ; DNA, Single-Stranded/metabolism ; Enzyme Stability ; Fluorescence Polarization ; HIV-1/genetics ; Humans ; Microscopy, Atomic Force ; Models, Molecular ; Protein Multimerization ; Protein Structure, Secondary ; RNA, Viral/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3G.
Autorzy :
Li Z; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Ning S; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Su X; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Liu X; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Wang H; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Liu Y; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Zheng W; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Zheng B; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
Yu XF; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.; Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Ministry of Education), Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, PR China.
Zhang W; The First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun 130021, PR China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2018 Nov 30; Vol. 46 (21), pp. 11514-11527.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*metabolism
Enterovirus A, Human/*pathogenicity
Enterovirus A, Human/*physiology
Host-Pathogen Interactions/*physiology
5' Untranslated Regions ; APOBEC-3G Deaminase/genetics ; Binding, Competitive ; Cell Line ; HEK293 Cells ; Humans ; Jurkat Cells ; Poly C/metabolism ; Proteolysis ; RNA-Binding Proteins/metabolism ; Viral Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity.
Autorzy :
Pautasso S; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.
Galitska G; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.
Dell'Oste V; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.
Biolatti M; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.
Cagliani R; Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Italy.
Forni D; Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Italy.
De Andrea M; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.; Department of Translational Medicine, Novara Medical School, Novara, Italy.
Gariglio M; Department of Translational Medicine, Novara Medical School, Novara, Italy.
Sironi M; Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Italy.
Landolfo S; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy .
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Źródło :
Journal of virology [J Virol] 2018 Sep 12; Vol. 92 (19). Date of Electronic Publication: 2018 Sep 12 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Immune Evasion*
APOBEC-3G Deaminase/*genetics
Cytomegalovirus/*genetics
Interferon-beta/*genetics
APOBEC-3G Deaminase/immunology ; CRISPR-Cas Systems ; Cell Line ; Computational Biology ; Cytomegalovirus/immunology ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Fibroblasts/immunology ; Fibroblasts/virology ; Foreskin/cytology ; Gene Expression Regulation ; Gene Knockout Techniques ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells/immunology ; Human Umbilical Vein Endothelial Cells/virology ; Humans ; Immunity, Innate ; Interferon-beta/immunology ; Male ; Mutagenesis ; Open Reading Frames ; Primary Cell Culture ; Signal Transduction ; THP-1 Cells ; Virus Replication
Czasopismo naukowe
Tytuł :
Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque ( Macaca leonina ).
Autorzy :
Pang W; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Song JH; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Institute of Health Sciences, Anhui University, Hefei, China.
Lu Y; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Zhang XL; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Zheng HY; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Jiang J; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.; Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 Aug 28; Vol. 9, pp. 1965. Date of Electronic Publication: 2018 Aug 28 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*metabolism
Carrier Proteins/*metabolism
HIV Infections/*immunology
HIV-1/*physiology
Interferon Type I/*metabolism
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*physiology
APOBEC-3G Deaminase/genetics ; Animals ; Carrier Proteins/genetics ; Disease Models, Animal ; Female ; Gene Expression ; Genes, vif/genetics ; Humans ; Interferon Type I/genetics ; Macaca ; Male ; Mutation/genetics ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases ; Viremia ; Virus Replication
Czasopismo naukowe
Tytuł :
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
Autorzy :
Tiwarekar V; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Wohlfahrt J; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Fehrholz M; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Scholz CJ; Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
Kneitz S; Theodor-Boveri-Institut für Biowissenschaften, Lehrstuhl für Physiologische Chemie, Würzburg, Germany.
Schneider-Schaulies J; Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany .
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Źródło :
Journal of virology [J Virol] 2018 Aug 16; Vol. 92 (17). Date of Electronic Publication: 2018 Aug 16 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*genetics
Measles virus/*physiology
Mechanistic Target of Rapamycin Complex 1/*antagonists & inhibitors
Transcription Factors/*antagonists & inhibitors
Virus Replication/*genetics
APOBEC-3G Deaminase/metabolism ; Animals ; Antiviral Agents/pharmacology ; Cell Line ; Chlorocebus aethiops ; DNA Replication ; Host-Pathogen Interactions/genetics ; Humans ; Interleukin-2/pharmacology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/virology ; Lymphocytes/drug effects ; Lymphocytes/virology ; Measles virus/drug effects ; Mechanistic Target of Rapamycin Complex 1/drug effects ; Phytohemagglutinins/pharmacology ; RNA, Small Interfering ; Sirolimus/pharmacology ; Transcription Factors/deficiency ; Transcription Factors/drug effects ; Vero Cells ; Virus Replication/drug effects
Czasopismo naukowe

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