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Tytuł :
Inhibition of Wnt signalling pathway by XAV939 enhances radiosensitivity in human cervical cancer HeLa cells.
Autorzy :
Zhang J; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Si J; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Gan L; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Guo M; School of Pharmacy, Lanzhou University, Lanzhou, China.
Yan J; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Chen Y; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Wang F; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Xie Y; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Wang Y; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Zhang H; Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 479-487.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/radiation effects
Radiation Tolerance*/drug effects
Radiation Tolerance*/radiation effects
Uterine Cervical Neoplasms*/metabolism
Uterine Cervical Neoplasms*/pathology
Uterine Cervical Neoplasms*/radiotherapy
Wnt Signaling Pathway*/drug effects
Wnt Signaling Pathway*/radiation effects
Heterocyclic Compounds, 3-Ring/*pharmacology
Apoptosis Regulatory Proteins/metabolism ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; G2 Phase Cell Cycle Checkpoints/radiation effects ; HeLa Cells ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; M Phase Cell Cycle Checkpoints/radiation effects ; Neoplasm Proteins/metabolism
Czasopismo naukowe
Tytuł :
Mcl-1 targeting strategies unlock the proapoptotic potential of TRAIL in melanoma cells.
Autorzy :
Sarif Z; Department of Dermatology, Venerology, and Allergology, Skin Cancer Center Charité, Charité-Universitätsmedizin Berlin (University Medical Center Charité), Berlin, Germany.
Tolksdorf B; Department of Applied Biochemistry, Institute of Biotechnology, Technical University of Berlin, Berlin, Germany.
Fechner H; Department of Applied Biochemistry, Institute of Biotechnology, Technical University of Berlin, Berlin, Germany.
Eberle J; Department of Dermatology, Venerology, and Allergology, Skin Cancer Center Charité, Charité-Universitätsmedizin Berlin (University Medical Center Charité), Berlin, Germany.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Nov; Vol. 59 (11), pp. 1256-1268. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Drug Resistance, Neoplasm*
Melanoma/*pathology
Myeloid Cell Leukemia Sequence 1 Protein/*antagonists & inhibitors
RNA, Small Interfering/*genetics
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/metabolism ; MicroRNAs/pharmacology ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Pyrimidines/pharmacology ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Thiophenes/pharmacology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
[Effect of small interfering RNA-mediated BIRC6 silencing on apoptosis and autophagy of renal cancer 786-O cells].
Autorzy :
Zhong K; Department of Urology, Meizhou People's Hospital, Meizhou 514031, China.
Chen D; Department of Urology, Sun Yat-sen Cancer Center, Guangzhou 510060, China.
Wu Z; Department of Urology, Sun Yat-sen Cancer Center, Guangzhou 510060, China.
Wang X; Department of Nephrology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
Pan B; Department of Urology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Chen N; Department of Urology, Meizhou People's Hospital, Meizhou 514031, China.
Zhong W; Department of Urology, Meizhou People's Hospital, Meizhou 514031, China.; Department of Urology, Sun Yat-sen Cancer Center, Guangzhou 510060, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2020 Nov 30; Vol. 40 (11), pp. 1651-1655.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Autophagy*
Kidney Neoplasms*/genetics
Cell Line, Tumor ; Cell Proliferation ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Combination of Scalp Acupuncture with Exercise Therapy Effectively Counteracts Ischemic Brain Injury in Rats.
Autorzy :
Li Z; Department of Rehabilitation, Pudong New Area People's Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201299, P. R. China.
Meng X; Department of Rehabilitation, Pudong New Area People's Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201299, P. R. China. Electronic address: .
Ren M; Department of Rehabilitation, Pudong New Area People's Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201299, P. R. China.
Shao M; Department of Rehabilitation, Pudong New Area People's Hospital affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201299, P. R. China.
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Nov; Vol. 29 (11), pp. 105286. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Acupuncture Points*
Acupuncture Therapy*
Apoptosis*
Exercise Therapy*
Scalp*
Brain/*pathology
Infarction, Middle Cerebral Artery/*prevention & control
Animals ; Apoptosis Regulatory Proteins/metabolism ; Behavior, Animal ; Brain/metabolism ; Brain/physiopathology ; Brain-Derived Neurotrophic Factor/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/psychology ; Inflammation Mediators/metabolism ; Male ; Necrosis ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; S100 Calcium Binding Protein beta Subunit/metabolism ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis.
Autorzy :
Holzerland J; Junior Research Group Arenavirus Biology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald-Isle of Riems, Germany.
Fénéant L; Junior Research Group Arenavirus Biology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald-Isle of Riems, Germany.
Banadyga L; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Hölper JE; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald-Isle of Riems, Germany.
Knittler MR; Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald-Isle of Riems, Germany.
Groseth A; Junior Research Group Arenavirus Biology, Friedrich-Loeffler-Institut, Federal Research Institute of Animal Health, Greifswald-Isle of Riems, Germany.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Oct 12; Vol. 16 (10), pp. e1008948. Date of Electronic Publication: 2020 Oct 12 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Virus Replication*
Apoptosis Regulatory Proteins/*metabolism
Arenaviridae Infections/*pathology
Arenaviruses, New World/*physiology
Proto-Oncogene Proteins/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
bcl-Associated Death Protein/*metabolism
Apoptosis Regulatory Proteins/genetics ; Arenaviridae Infections/genetics ; Arenaviridae Infections/metabolism ; Arenaviridae Infections/virology ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Protein Domains ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; bcl-Associated Death Protein/genetics
Czasopismo naukowe
Tytuł :
Effects of p38 MAPK signaling pathway on cognitive function and recovery of neuronal function after hypoxic-ischemic brain injury in newborn rats.
Autorzy :
Zhu Z; Departments of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Ge M; Departments of Hand Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Li C; Departments of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Yu L; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Gu Y; Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. Electronic address: .
Hu Y; Departments of Rehabilitation Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. Electronic address: .
Cao Z; Department of Intensive Care Unit, Nantong Third People's Hospital, Nantong, Jiangsu Province, China. Electronic address: .
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Źródło :
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2020 Aug; Vol. 78, pp. 365-370. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Recovery of Function*
Cognition/*drug effects
Hypoxia-Ischemia, Brain/*physiopathology
Neurons/*physiology
p38 Mitogen-Activated Protein Kinases/*pharmacology
Animals ; Animals, Newborn ; Apoptosis Regulatory Proteins/drug effects ; Hippocampus/metabolism ; Learning/drug effects ; Male ; Memory/drug effects ; Neurons/drug effects ; Rats ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Increased Ephrin-B2 expression in pericytes contributes to retinal vascular death in rodents.
Autorzy :
Coucha M; Department of Pharmaceutical Sciences, School of Pharmacy, South University, Savannah, GA, USA.
Barrett AC; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA.
Bailey J; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA.
Abdelghani M; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA.
Abdelsaid M; Department of Biomedical Sciences, School of Medicine, Mercer University, Savannah, GA, USA. Electronic address: .
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Źródło :
Vascular pharmacology [Vascul Pharmacol] 2020 Aug; Vol. 131, pp. 106761. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Diabetic Retinopathy/*metabolism
Ephrin-B2/*metabolism
Pericytes/*metabolism
Retinal Neovascularization/*metabolism
Retinal Vessels/*metabolism
Animals ; Apoptosis Regulatory Proteins/metabolism ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/complications ; Diabetic Retinopathy/etiology ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/pathology ; Ephrin-B2/deficiency ; Ephrin-B2/genetics ; Humans ; Inflammation Mediators/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Pericytes/pathology ; Rats, Wistar ; Retinal Neovascularization/etiology ; Retinal Neovascularization/genetics ; Retinal Neovascularization/pathology ; Retinal Vessels/pathology ; Signal Transduction ; Streptozocin
Czasopismo naukowe
Tytuł :
miR-22 protect PC12 from ischemia/reperfusion-induced injury by targeting p53 upregulated modulator of apoptosis (PUMA).
Autorzy :
Jiao H; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
Chen R; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
Jiang Z; External Abdominal Section, Linyi Cancer Hospital, Linyi, Shandong, China.
Zhang L; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
Wang H; Department of Anesthesia, Linyi Cancer Hospital, Linyi, Shandong, China.
Pokaż więcej
Źródło :
Bioengineered [Bioengineered] 2020 Dec; Vol. 11 (1), pp. 209-218.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis Regulatory Proteins/*metabolism
MicroRNAs/*metabolism
Myocardial Reperfusion Injury/*metabolism
Reperfusion Injury/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Blotting, Western ; In Situ Nick-End Labeling ; MicroRNAs/genetics ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/pathology ; PC12 Cells ; Rats ; Reperfusion Injury/genetics ; Reperfusion Injury/pathology ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
[Antitumor Activity of TRAIL-Mu3 Protein in vitro and in vivo and the Mechanisms].
Autorzy :
Yang T; Cancer Research Institute, Chengdu University of Traditional Chinese Medicine, Chengdu 610037, China.
Zhu AJ; Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang JS; Department of Gynaecology and Obstetrics, North Sichuan Medical College, Nanchong 637100, China.
Jin Z; School of Basic Medical Science, Chengdu University of Traditional Chinese Medicine, Chengdu 610037, China.
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Źródło :
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2020 May; Vol. 51 (3), pp. 304-311.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
TNF-Related Apoptosis-Inducing Ligand*/genetics
Animals ; Apoptosis ; Cell Line, Tumor ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases.
Autorzy :
Hazafa A; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan. Electronic address: .
Batool A; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Ahmad S; Centre of Biotechnology & Microbiology, University of Peshawar, Pakistan.
Amjad M; Centre of Agricultural Biochemistry and Biotechnology (CABB), University of Agriculture, Faisalabad 38000, Pakistan.
Chaudhry SN; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Asad J; Department of Biochemistry, University of Health Sciences Lahore, Pakistan.
Ghuman HF; Centre of Agricultural Biochemistry and Biotechnology (CABB), University of Agriculture, Faisalabad 38000, Pakistan.
Khan HM; School of Biological Sciences, University of the Punjab, Lahore, Pakistan.
Naeem M; College of Life Science, Hebei Normal University, Shijiazhuang, China.
Ghani U; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118679. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis/*physiology
Cytoprotection/*physiology
Intracellular Signaling Peptides and Proteins/*metabolism
Intracellular Signaling Peptides and Proteins/*therapeutic use
Mitochondria/*metabolism
Amino Acid Sequence ; Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Apoptosis Regulatory Proteins/therapeutic use ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Mitochondria/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism
Czasopismo naukowe
Tytuł :
Anti‑survival and pro‑apoptotic effects of meridianin C derivatives on MV4‑11 human acute myeloid leukemia cells.
Autorzy :
Cho H; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Yadav AK; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Do Y; Department of Hematology and Oncology, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Heo M; Department of Hematology and Oncology, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Bishop-Bailey D; Comparative Biomedical Sciences, Royal Veterinary College, London NW 10TU, United Kingdom.
Lee J; Department of Chemistry, College of Life Science, Keimyung University, Daegu 42601, Republic of Korea.
Jang BC; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
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Źródło :
International journal of oncology [Int J Oncol] 2020 Jan; Vol. 56 (1), pp. 368-378. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Apoptosis Regulatory Proteins/*metabolism
Indoles/*chemistry
Indoles/*pharmacology
Leukemia, Myeloid, Acute/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-pim-1/*antagonists & inhibitors
Pyrimidines/*chemistry
Pyrimidines/*pharmacology
Apoptosis Regulatory Proteins/genetics ; Caspase 9/genetics ; Caspase 9/metabolism ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Phosphorylation ; Protein Kinase Inhibitors/chemistry ; Tumor Cells, Cultured ; X-Linked Inhibitor of Apoptosis Protein/genetics ; X-Linked Inhibitor of Apoptosis Protein/metabolism
Czasopismo naukowe
Tytuł :
Sevoflurane increases intracellular calcium to induce mitochondrial injury and neuroapoptosis.
Autorzy :
Zhu X; Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Yao Y; Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China; Department of Anesthesiology, Hunan Children's Hospital, Changsha, 410007, China.
Guo M; Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Li J; Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Yang P; Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Xu H; Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. Electronic address: .
Lin D; Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jan 01; Vol. 336, pp. 11-20. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Anesthetics, Inhalation/*toxicity
Apoptosis/*drug effects
Calcium/*metabolism
Calcium Signaling/*drug effects
Hippocampus/*drug effects
Mitochondria/*drug effects
Neurons/*drug effects
Sevoflurane/*toxicity
Animals ; Animals, Newborn ; Apoptosis Regulatory Proteins/metabolism ; Calcium Channels, L-Type/drug effects ; Calcium Channels, L-Type/metabolism ; Cells, Cultured ; Hippocampus/metabolism ; Hippocampus/pathology ; Mitochondria/metabolism ; Mitochondria/pathology ; Neurons/metabolism ; Neurons/pathology ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family.
Autorzy :
Eslami F; Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Mahdavi M; Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran. Electronic address: .
Babaei E; Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Hussen BM; Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Mostafavi H; Department of Organic Chemistry & Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
Shahbazi A; Department of Organic Chemistry & Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
Hidayat HJ; Department of Biology, College of Education, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Dec 15; Vol. 409, pp. 115331. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Caspase 3/*metabolism
Ciprofloxacin/*pharmacology
Down-Regulation/*drug effects
Proto-Oncogene Proteins c-bcl-2/*metabolism
Survivin/*metabolism
Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Inhibitor of Apoptosis Proteins/metabolism ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism
Czasopismo naukowe
Tytuł :
The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression.
Autorzy :
Ito-Kureha T; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Miyao T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Nishijima S; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Suzuki T; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Koizumi SI; Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Villar-Briones A; Instrumental Analysis Section, Research Support Division, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Takahashi A; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Akiyama N; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Morita M; Department of Molecular Medicine and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.
Naguro I; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Ishikawa H; Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.
Ichijo H; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Akiyama T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .
Yamamoto T; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan. .; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 02; Vol. 11 (1), pp. 6169. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Exoribonucleases/*genetics
Repressor Proteins/*genetics
Thymocytes/*immunology
Thymus Gland/*immunology
Animals ; Apoptosis/immunology ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/immunology ; Cell Differentiation ; Cell Lineage/genetics ; Cell Lineage/immunology ; Exoribonucleases/immunology ; Gene Expression Regulation, Developmental ; Mice ; Poly A/genetics ; Poly A/immunology ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; Repressor Proteins/immunology ; Signal Transduction ; Thymocytes/cytology ; Thymus Gland/cytology ; Thymus Gland/growth & development ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/immunology ; ras GTPase-Activating Proteins/genetics ; ras GTPase-Activating Proteins/immunology
Czasopismo naukowe
Tytuł :
Plumbagin protects the myocardial damage by modulating the cardiac biomarkers, antioxidants, and apoptosis signaling in the doxorubicin-induced cardiotoxicity in rats.
Autorzy :
Li Z; Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, China.
Chinnathambi A; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Ali Alharbi S; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Yin F; Department of Cardiology, Xidian Group Hospital, Xi'an, Shaanxi Province, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Dec; Vol. 35 (12), pp. 1374-1385. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Myocardium*/metabolism
Myocardium*/pathology
Antioxidants/*metabolism
Apoptosis/*drug effects
Doxorubicin/*toxicity
Heart/*drug effects
Naphthoquinones/*pharmacology
Animals ; Apoptosis Regulatory Proteins/metabolism ; Biomarkers/blood ; Cardiotoxicity ; Cytokines/metabolism ; Lipid Peroxidation/drug effects ; Male ; Phosphatidylinositol 3-Kinases/metabolism ; Rats ; Rats, Wistar ; Signal Transduction
Czasopismo naukowe
Tytuł :
Nitric Oxide Inhibits NF-κB-mediated Survival Signaling: Possible Role in Overcoming TRAIL Resistance.
Autorzy :
Bauer JA; Nitric Oxide Services, LLC, St. John Paul II Center for Science Innovation, North Canton, OH, U.S.A.
Lupica JA; Department of Math & Sciences, Walsh University, North Canton, OH, U.S.A.
Didonato JA; Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, U.S.A.
Lindner DJ; Translational Hematology Oncology Research (THOR), Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH, U.S.A. .
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Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6751-6763. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
NF-kappa B/*metabolism
Nitric Oxide/*pharmacology
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Male ; Mice, Nude ; NF-KappaB Inhibitor alpha/metabolism ; Nitroso Compounds/pharmacology ; Vitamin B 12/analogs & derivatives ; Vitamin B 12/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Designed ferritin nanocages displaying trimeric TRAIL and tumor-targeting peptides confer superior anti-tumor efficacy.
Autorzy :
Yoo JD; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Bae SM; PrismCDX, Inc., 593-16, Dongtangiheung-ro, Hwaseong-si, Gyeonggi-do, 18469, Republic of Korea.
Seo J; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Jeon IS; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Vadevoo SMP; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Kim SY; Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 138-736, Republic of Korea.; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Kim IS; Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Lee B; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Kim S; Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 17; Vol. 10 (1), pp. 19997. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Ferritins/*chemistry
Nanostructures/*chemistry
Peptides/*chemistry
TNF-Related Apoptosis-Inducing Ligand/*chemistry
TNF-Related Apoptosis-Inducing Ligand/*metabolism
A549 Cells ; Animals ; Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Female ; Humans ; Interleukin-4 Receptor alpha Subunit/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Pancreatic Neoplasms/drug therapy ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays/methods
SCR Disease Name :
Pancreatic Carcinoma
Czasopismo naukowe
Tytuł :
Anti-apoptotic capacity of Mcl-1Δ127.
Autorzy :
Wang Y; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
Su W; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
Mai Z; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
Yu S; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
Wang X; Department of Pain Management, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. Electronic address: .
Chen T; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 11; Vol. 526 (4), pp. 1042-1048. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Myeloid Cell Leukemia Sequence 1 Protein/*metabolism
Apoptosis Regulatory Proteins/metabolism ; HeLa Cells ; Humans ; Protein Transport ; Proto-Oncogene Proteins/metabolism ; bcl-2 Homologous Antagonist-Killer Protein/metabolism
Czasopismo naukowe
Tytuł :
MiR-29a in mesenchymal stem cells inhibits FSTL1 secretion and promotes cardiac myocyte apoptosis in hypoxia-reoxygenation injury.
Autorzy :
Li KS; Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, PR China.
Jiang WP; Department of Cardiology, Shenzhen University General Hospital, Shenzhen 518000, Guangdong Province, PR China.
Li QC; Puyang Medical College, Shangyang Road and Wenyan Street, Puyang 457000, Henan Province, PR China.
Zhang HW; Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, PR China.
Bai Y; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, PR China.
Zhang X; Department of Geratology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310003, Zhejiang Province, PR China.
Li HY; Department of Cardiology, Shenzhen University General Hospital, Shenzhen 518000, Guangdong Province, PR China. Electronic address: .
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Źródło :
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology [Cardiovasc Pathol] 2020 May - Jun; Vol. 46, pp. 107180. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Follistatin-Related Proteins/*metabolism
Mesenchymal Stem Cells/*metabolism
MicroRNAs/*metabolism
Myocardial Reperfusion Injury/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Hypoxia ; Cell Line ; Follistatin-Related Proteins/genetics ; Janus Kinase 2/metabolism ; Mesenchymal Stem Cells/pathology ; MicroRNAs/genetics ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/pathology ; Rats ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability.
Autorzy :
Hope JM; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
Lopez-Cavestany M; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
Wang W; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
Reinhart-King CA; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA.
King MR; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37235, USA. .
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Nov 04; Vol. 10 (11), pp. 837. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Apoptosis*
Models, Biological*
Ion Channels/*metabolism
Mitochondrial Membranes/*metabolism
Neoplasms/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Ion Channels/antagonists & inhibitors ; Ion Channels/genetics ; Neoplasms/drug therapy ; Neoplasms/pathology ; PC-3 Cells ; Permeability ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Pyrazines/pharmacology ; Spider Venoms/pharmacology ; Thiadiazoles/pharmacology ; X-Linked Inhibitor of Apoptosis Protein/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe

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