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Ви шукаєте ""APOPTOSIS"" за критеріями: Temat

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Tytuł:
TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling.
Autorzy:
Guerrache A; Université de Bourgogne, 21000 Dijon, France.; INSERM Research Center U1231, «Equipe DesCarTes», 21000 Dijon, France.
Micheau O; Université de Bourgogne, 21000 Dijon, France.; INSERM Research Center U1231, «Equipe DesCarTes», 21000 Dijon, France.; Laboratoire d'Excellence LipSTIC, 21000 Dijon, France.
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Źródło:
Cells [Cells] 2024 Mar 16; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
TNF-Related Apoptosis-Inducing Ligand*/metabolism
Neoplasms*/metabolism
Humans ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Apoptosis/physiology ; Signal Transduction
Czasopismo naukowe
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Tytuł:
Fluacrypyrim Protects Hematopoietic Stem and Progenitor Cells against Irradiation via Apoptosis Prevention.
Autorzy:
Zhang X; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Qiao Z; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Guan B; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215000, China.
Wang F; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.; School of Life Science, Anhui Medical University, Hefei 230032, China.
Shen X; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Shu H; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.; School of Life Science, Anhui Medical University, Hefei 230032, China.
Shan Y; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Cong Y; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xing S; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yu Z; Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 09; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis Regulatory Proteins*/metabolism
Hematopoietic Stem Cells*
Pyrimidines*
Mice ; Animals ; Acrylates/pharmacology ; Apoptosis ; Whole-Body Irradiation ; Mice, Inbred C57BL
Czasopismo naukowe
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Tytuł:
Reconciling ASPP-p53 binding mode discrepancies through an ensemble binding framework that bridges crystallography and NMR data.
Autorzy:
Liu T; Research Center for Pharmacoinformatics, College of Pharmacy, Harbin Medical University, Harbin, China.
Huang S; Research Center for Pharmacoinformatics, College of Pharmacy, Harbin Medical University, Harbin, China.
Zhang Q; Research Center for Pharmacoinformatics, College of Pharmacy, Harbin Medical University, Harbin, China.
Xia Y; Research Center for Pharmacoinformatics, College of Pharmacy, Harbin Medical University, Harbin, China.
Zhang M; Research Center for Pharmacoinformatics, College of Pharmacy, Harbin Medical University, Harbin, China.
Sun B; Research Center for Pharmacoinformatics, College of Pharmacy, Harbin Medical University, Harbin, China.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2024 Feb 07; Vol. 20 (2), pp. e1011519. Date of Electronic Publication: 2024 Feb 07 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis Regulatory Proteins*/chemistry
Tumor Suppressor Protein p53*/chemistry
Crystallography ; Protein Binding ; Apoptosis
Czasopismo naukowe
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Tytuł:
Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate.
Autorzy:
Abbas H; Université Oran 1, Ahmed Ben Bella, Oran 31000, Algeria.
Derkaoui DK; Université Oran 1, Ahmed Ben Bella, Oran 31000, Algeria.
Jeammet L; Jalon Therapeutics, 75010 Paris, France.
Adicéam E; Jalon Therapeutics, 75010 Paris, France.
Tiollier J; Jalon Therapeutics, 75010 Paris, France.
Sicard H; Jalon Therapeutics, 75010 Paris, France.
Braun T; Laboratoire de Transfert des Leucémies, EA3518, Institut de Recherche Saint Louis, Hôpital Saint Louis, Université de Paris, 75010 Paris, France.; AP-HP, Service d'Hématologie Clinique, Hôpital Avicenne, Université Paris XIII, 93000 Bobigny, France.; OPALE Carnot Institute, The Organization for Partnerships in Leukemia, Hôpital Saint-Louis, 75010 Paris, France.
Poyet JL; INSERM UMRS976, Institut de Recherche Saint Louis, Hôpital Saint Louis, 75010 Paris, France.; Université Paris Cité, 75015 Paris, France.
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Źródło:
Biomolecules [Biomolecules] 2024 Jan 22; Vol. 14 (1). Date of Electronic Publication: 2024 Jan 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Apoptosis Regulatory Proteins*/metabolism
Neoplasms*/genetics
Humans ; Nuclear Proteins/metabolism ; Apoptosis ; Cell Differentiation
Czasopismo naukowe
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Tytuł:
Apoptosis is mediated by FeHV-1 through the intrinsic pathway and interacts with the autophagic process.
Autorzy:
Ferrara G; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy. .
Longobardi C; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy.
Sgadari MF; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy.
Restucci B; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy.
Iovane G; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy.
Ciarcia R; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy.
Pagnini U; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy.
Montagnaro S; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Federico Delpino n.1, Naples, 80137, Italy.
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Źródło:
Virology journal [Virol J] 2023 Dec 12; Vol. 20 (1), pp. 295. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Caspases*/metabolism
Cats ; Animals ; Caspase 3 ; Apoptosis Regulatory Proteins ; NF-kappa B/metabolism ; Autophagy
Czasopismo naukowe
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Tytuł:
Structural insights for selective disruption of Beclin 1 binding to Bcl-2.
Autorzy:
Pan YZ; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Liang Q; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
De Brabander JK; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Rizo J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. .; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. .; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Oct 24; Vol. 6 (1), pp. 1080. Date of Electronic Publication: 2023 Oct 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Apoptosis Regulatory Proteins*/genetics
Apoptosis Regulatory Proteins*/metabolism
Membrane Proteins*/metabolism
Apoptosis/physiology ; bcl-2-Associated X Protein/metabolism ; Beclin-1 ; Humans
Czasopismo naukowe
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Tytuł:
Downregulation of BIRC2 hinders the progression of rheumatoid arthritis through regulating TRADD.
Autorzy:
Rao Y; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Xu S; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Lu T; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Wang Y; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Liu M; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Zhang W; Department of Rheumatology and Immunology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Oct; Vol. 11 (10), pp. e978.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*/genetics
Arthritis, Rheumatoid*/genetics
Arthritis, Rheumatoid*/metabolism
Humans ; Down-Regulation ; Lipopolysaccharides/pharmacology ; Signal Transduction ; Inflammation ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism
Czasopismo naukowe
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Tytuł:
Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
Autorzy:
Takimoto-Sato M; Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Suzuki M; Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan. .
Kimura H; Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America.
Ge H; Department of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Matsumoto M; Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Makita H; Hokkaido Medical Research Institute of Respiratory Diseases, Sapporo, Japan.
Arai S; Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan.; The Institute for AIM Medicine, Tokyo, Japan.
Miyazaki T; The Institute for AIM Medicine, Tokyo, Japan.; LEAP, Japan Agency for Medical Research and Development, Tokyo, Japan.
Nishimura M; Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.; Hokkaido Medical Research Institute of Respiratory Diseases, Sapporo, Japan.
Konno S; Department of Respiratory Medicine, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
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Źródło:
Respiratory research [Respir Res] 2023 Aug 17; Vol. 24 (1), pp. 201. Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:
Journal Article
MeSH Terms:
Emphysema*
Pulmonary Disease, Chronic Obstructive*
Pulmonary Emphysema*/chemically induced
Apoptosis Regulatory Proteins*
Animals ; Mice ; Apoptosis ; Cohort Studies ; Immunoglobulin M ; Macrophages ; Matrix Metalloproteinase 12/genetics ; Humans
Czasopismo naukowe
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Tytuł:
The Hippo signaling pathway contributes to the 2,5-Hexadion-induced apoptosis of ovarian granulosa cells.
Autorzy:
Sun Y; Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.; Key Laboratory of Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Chen H; Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Chen S; Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Xu X; Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Zhang W; Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China. .
Li Y; Department of Preventive Medicine, Fujian Provincial Key Laboratory of Environmental Factors and Cancer, Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China. .
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Źródło:
Journal of ovarian research [J Ovarian Res] 2023 Aug 11; Vol. 16 (1), pp. 161. Date of Electronic Publication: 2023 Aug 11.
Typ publikacji:
Journal Article
MeSH Terms:
Hippo Signaling Pathway*
Apoptosis Regulatory Proteins*/genetics
Rats ; Animals ; Female ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Granulosa Cells/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Apoptosis/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
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Tytuł:
Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation.
Autorzy:
Song SR; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Seo SU; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Woo SM; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Yoon JY; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.
Yook S; College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea.
Kwon TK; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea.; Center for Forensic Pharmaceutical Science, Keimyung University, Daegu 42601, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 24; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 24.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
TNF-Related Apoptosis-Inducing Ligand*/metabolism
Humans ; Apoptosis Regulatory Proteins/metabolism ; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics ; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism ; Cell Line, Tumor ; Down-Regulation ; Ligands ; Peptide Hydrolases/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Animals
Czasopismo naukowe
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Tytuł:
The Effect of Xevinapant Combined with Ionizing Radiation on HNSCC and Normal Tissue Cells and the Impact of Xevinapant on Its Targeted Proteins cIAP1 and XIAP.
Autorzy:
Fleischmann J; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Hildebrand LS; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Kuhlmann L; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Fietkau R; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
Distel LV; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Comprehensive Cancer Center Erlangen-Europäische Metropolregion Nürnberg (CCC ER-EMN), 91054 Erlangen, Germany.
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Źródło:
Cells [Cells] 2023 Jun 17; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
Head and Neck Neoplasms*/drug therapy
Head and Neck Neoplasms*/radiotherapy
Radiation-Sensitizing Agents*/pharmacology
Squamous Cell Carcinoma of Head and Neck*/drug therapy
Squamous Cell Carcinoma of Head and Neck*/radiotherapy
Inhibitor of Apoptosis Proteins*/antagonists & inhibitors
Inhibitor of Apoptosis Proteins*/metabolism
Humans ; Radiation, Ionizing ; X-Linked Inhibitor of Apoptosis Protein/antagonists & inhibitors ; X-Linked Inhibitor of Apoptosis Protein/metabolism
Czasopismo naukowe
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Tytuł:
LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis.
Autorzy:
Quintero-Espinosa DA; Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.
Sanchez-Hernandez S; Genomic Medicine Department, Centre for Genomics and Oncological Research (GENYO), Pfizer-University of Granada-Andalusian Regional Government, Parque Tecnólogico Ciencias de la Salud, Av. de la Ilustración 114, 18016 Granada, Spain.
Velez-Pardo C; Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.
Martin F; Genomic Medicine Department, Centre for Genomics and Oncological Research (GENYO), Pfizer-University of Granada-Andalusian Regional Government, Parque Tecnólogico Ciencias de la Salud, Av. de la Ilustración 114, 18016 Granada, Spain.; Biochemistry and Molecular Biology 3 and Immunology Department, Faculty of Medicine, University of Granada, Avda. de la Investigacion 11, 18071 Granada, Spain.
Jimenez-Del-Rio M; Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 22; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Rotenone*/toxicity
Apoptosis Regulatory Proteins*/metabolism
Humans ; Caspase 3/metabolism ; HEK293 Cells ; Oxidative Stress ; Apoptosis/genetics ; Protein Kinases/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism
Czasopismo naukowe
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Tytuł:
Bcl-xL Is Spontaneously Inserted into Preassembled Nanodiscs and Stimulates Bax Insertion in a Cell-Free Protein Synthesis System.
Autorzy:
Rouchidane Eyitayo A; Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, CNRS, UMR 5095, 33077 Bordeaux, France.
Boudier-Lemosquet A; Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, CNRS, UMR 5095, 33077 Bordeaux, France.
Chaignepain S; Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, CNRS, UMR 5095, 33077 Bordeaux, France.; Centre de Génomique Fonctionnelle de Bordeaux, Université de Bordeaux, 33077 Bordeaux, France.
Priault M; Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, CNRS, UMR 5095, 33077 Bordeaux, France.
Manon S; Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, CNRS, UMR 5095, 33077 Bordeaux, France.
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Źródło:
Biomolecules [Biomolecules] 2023 May 23; Vol. 13 (6). Date of Electronic Publication: 2023 May 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Escherichia coli*/genetics
Escherichia coli*/metabolism
Apoptosis*
bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/genetics ; Apoptosis Regulatory Proteins
Czasopismo naukowe
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Tytuł:
BAG3: Nature's Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue.
Autorzy:
Brenner CM; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.
Choudhary M; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.
McCormick MG; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.; Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Cheung D; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.; Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Landesberg GP; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.; Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Wang JF; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.; Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Song J; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.; Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Martin TG; Department of Molecular, Cellular and Developmental Biology, Colorado University School of Medicine, Aurora, CO 80045, USA.
Cheung JY; Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Qu HQ; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 191104, USA.
Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 191104, USA.; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 191104, USA.; Division of Human Genetics and Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 191104, USA.; Department of Pediatrics, Division of Human Genetics and Division of Pulmonary Medicine, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 191104, USA.
Feldman AM; Department of Medicine, Division of Cardiology, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, MERB 752, Philadelphia, PA 19140, USA.; Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
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Źródło:
Cells [Cells] 2023 Mar 19; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Apoptosis Regulatory Proteins*/genetics
Apoptosis Regulatory Proteins*/metabolism
Animals ; Apoptosis ; Cytoplasm/metabolism ; Myocardium/metabolism
Czasopismo naukowe
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Tytuł:
Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.
Autorzy:
Dietz L; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Ellison CJ; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Riechmann C; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Cassidy CK; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Felfoldi FD; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
Pinto-Fernández A; Target Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, OX3 7FZ, UK.; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK.
Kessler BM; Target Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, OX3 7FZ, UK.; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK.
Elliott PR; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1112-1117. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Caspase 3*/metabolism
Caspase 7*/metabolism
Caspase 9*/metabolism
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Humans ; Cryoelectron Microscopy ; X-Linked Inhibitor of Apoptosis Protein/metabolism ; Catalytic Domain ; Protein Multimerization
Czasopismo naukowe
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Tytuł:
Altered expression of anti-apoptotic protein Api5 affects breast tumorigenesis.
Autorzy:
Kuttanamkuzhi A; Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, Maharashtra, 411008, India.
Panda D; Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, Maharashtra, 411008, India.
Malaviya R; Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, Maharashtra, 411008, India.
Gaidhani G; Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, Maharashtra, 411008, India.; The School of Chemistry and Molecular Biology, St. Lucia Campus, The University of Queensland, Brisbane, QLD, 4072, Australia.
Lahiri M; Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, Maharashtra, 411008, India. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Apr 25; Vol. 23 (1), pp. 374. Date of Electronic Publication: 2023 Apr 25.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis Regulatory Proteins*/metabolism
Neoplasms*
Humans ; Fibroblast Growth Factor 2 ; Apoptosis ; Cell Transformation, Neoplastic ; Carcinogenesis ; Cell Proliferation ; Cell Line, Tumor ; Nuclear Proteins/genetics
Czasopismo naukowe
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Tytuł:
Apoptin causes apoptosis in HepG-2 cells via Ca imbalance and activation of the mitochondrial apoptotic pathway.
Autorzy:
Yu X; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Wang T; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Li Y; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Li Y; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Bai B; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Fang J; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Han J; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Li S; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Xiu Z; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Liu Z; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Yang X; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Li Y; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Zhu G; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
Jin N; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China.
Shang C; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Li X; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Zhu Y; Academicians Workstation of Jilin Province, Changchun University of Chinese Medicine, Changchun, China.
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Źródło:
Cancer medicine [Cancer Med] 2023 Apr; Vol. 12 (7), pp. 8306-8318. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Mitochondria*
Mice ; Animals ; Mice, Nude ; Endoplasmic Reticulum Stress ; Apoptosis Regulatory Proteins/metabolism ; Calcium/metabolism
Czasopismo naukowe
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Tytuł:
Pharmacological Targeting of Bcl-2 Induces Caspase 3-Mediated Cleavage of HDAC6 and Regulates the Autophagy Process in Colorectal Cancer.
Autorzy:
Yang D; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.; College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing 400715, China.
He L; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Ma S; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Li S; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Zhang Y; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Hu C; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Huang J; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.; College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing 400715, China.
Xu Z; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Tang D; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Chen Z; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 03; Vol. 24 (7). Date of Electronic Publication: 2023 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis Regulatory Proteins*/metabolism
Colorectal Neoplasms*/drug therapy
Humans ; Apoptosis/physiology ; Autophagy/physiology ; Beclin-1/genetics ; Caspase 3/metabolism ; Histone Deacetylase 6 ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
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Tytuł:
Characterization of BV6-Induced Sensitization to the NK Cell Killing of Pediatric Rhabdomyosarcoma Spheroids.
Autorzy:
Särchen V; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany.
Reindl LM; Department for Children and Adolescents Medicine, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt, Germany.; Experimental Immunology, Goethe-University, 60590 Frankfurt, Germany.
Wiedemann S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany.
Shanmugalingam S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany.
Bukur T; TRON gGmbH-Translational Oncology, The University Medical Center, The Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Becker J; TRON gGmbH-Translational Oncology, The University Medical Center, The Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Suchan M; TRON gGmbH-Translational Oncology, The University Medical Center, The Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Ullrich E; Department for Children and Adolescents Medicine, University Hospital Frankfurt, Goethe-University, 60590 Frankfurt, Germany.; Experimental Immunology, Goethe-University, 60590 Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Mainz/Frankfurt, 69120 Heidelberg, Germany.; University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe-University Frankfurt, 60590 Frankfurt, Germany.; Frankfurt Cancer Institute, Goethe-University, 60590 Frankfurt, Germany.
Vogler M; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, 60528 Frankfurt, Germany.; German Cancer Consortium (DKTK), Partner Site Mainz/Frankfurt, 69120 Heidelberg, Germany.
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Źródło:
Cells [Cells] 2023 Mar 15; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*/physiology
Rhabdomyosarcoma*
Child ; Humans ; NF-kappa B/metabolism ; Apoptosis Regulatory Proteins ; Cell Death ; Killer Cells, Natural/metabolism
Czasopismo naukowe
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Tytuł:
Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca Elevation via PDCD6 and FKBP8.
Autorzy:
Drescher DG; Laboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.; Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Drescher MJ; Laboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Selvakumar D; Laboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Annam NP; Laboratory of Bio-otology, Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 28; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium*/metabolism
Dysferlin*/metabolism
Muscle, Skeletal*/injuries
Muscle, Skeletal*/physiology
Calcium-Binding Proteins*/metabolism
Apoptosis Regulatory Proteins*/metabolism
Tacrolimus Binding Proteins*/metabolism
Regeneration*
Annexin A1/metabolism ; Calpain/metabolism ; Caveolin 3/metabolism ; Sarcolemma/metabolism ; Surface Plasmon Resonance ; Apoptosis ; Signal Transduction ; Animals ; Rats
Czasopismo naukowe
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