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Starter badań:

Tytuł :
Identification of hot spot residues on serine-arginine protein kinase-1 by molecular dynamics simulation studies.
Autorzy :
Chandra A; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
Goyal N; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
Qamar I; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
Singh N; School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Mar; Vol. 39 (5), pp. 1579-1587. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine Kinase*
Protein-Serine-Threonine Kinases*/metabolism
Arginine ; Molecular Dynamics Simulation ; Nuclear Proteins/metabolism ; Phosphorylation ; Protein Kinases ; RNA-Binding Proteins ; Serine ; Serine-Arginine Splicing Factors/genetics
Czasopismo naukowe
Tytuł :
Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues.
Autorzy :
Hamey JJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
Rakow S; Institute for Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Germany.
Bouchard C; Institute for Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Germany.
Senst JM; Department of Pharmaceutical Chemistry, Philipps-University Marburg, Germany.
Kolb P; Department of Pharmaceutical Chemistry, Philipps-University Marburg, Germany.
Bauer UM; Institute for Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Germany.
Wilkins MR; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
Hart-Smith G; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.; Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
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Źródło :
The FEBS journal [FEBS J] 2021 Oct; Vol. 288 (19), pp. 5668-5691. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Motifs/*genetics
Amino Acid Substitution/*genetics
Nuclear Proteins/*genetics
Peptides/*genetics
Protein-Arginine N-Methyltransferases/*genetics
Arginine/genetics ; Histones/genetics ; Humans ; Methylation ; Protein Processing, Post-Translational ; Substrate Specificity/genetics
Czasopismo naukowe
Tytuł :
PAD4 inhibitor promotes DNA damage and radiosensitivity of nasopharyngeal carcinoma cells.
Autorzy :
Chen H; Department of Radiation Oncology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Wei L; Department of Endoscopy, Guangxi Medical University Affiliated Tumor Hospital, Nanning, China.
Luo M; Department of Oncology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wang X; Department of Oncology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhan Y; Department of Oncology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Mao Y; Department of Oncology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Huang C; Department of Oncology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li J; Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lu H; Department of Radiation Oncology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Nov; Vol. 36 (11), pp. 2291-2301. Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Nasopharyngeal Carcinoma*/drug therapy
Nasopharyngeal Carcinoma*/radiotherapy
Nasopharyngeal Neoplasms*/drug therapy
Nasopharyngeal Neoplasms*/radiotherapy
Radiation Tolerance*
2-Naphthylamine/*analogs & derivatives
Arginine/*analogs & derivatives
Protein-Arginine Deiminase Type 4/*antagonists & inhibitors
2-Naphthylamine/pharmacology ; Apoptosis ; Arginine/pharmacology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Protein-Arginine Deiminases
Czasopismo naukowe
Tytuł :
Factors Associated with Promoted Proliferation of Osteosarcoma by Peptidylarginine Deiminase 4.
Autorzy :
Guo J; Department of Oncology, Maternal and Child Health Care Hospital of Zibo, Zibo 255029, China.
Yin L; Human Resources Department, Zibo Central Hospital, Zibo 255036, China.
Zhang X; Department of Laboratory Medicine, Zibo Central Hospital, Zibo 255036, China.
Su P; Department of Laboratory Medicine, Zibo Central Hospital, Zibo 255036, China.
Zhai Q; Center of Translational Medicine, Zibo Central Hospital, Zibo 255036, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 May 15; Vol. 2021, pp. 5596014. Date of Electronic Publication: 2021 May 15 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*metabolism
Cell Proliferation/*drug effects
Osteosarcoma/*metabolism
Protein-Arginine Deiminase Type 4/*metabolism
Protein-Arginine Deiminase Type 4/*pharmacology
Adolescent ; Adult ; Aged ; Animals ; Bone Neoplasms/pathology ; Carcinogenesis ; Cell Line, Tumor ; Cholecystokinin ; Female ; Humans ; Male ; Mice ; Mice, Nude ; Middle Aged ; Osteosarcoma/pathology ; Peptide Fragments ; Protein-Arginine Deiminase Type 4/genetics ; Protein-Arginine Deiminases ; Signal Transduction ; Xenograft Model Antitumor Assays ; Young Adult ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Arginine methylation of METTL14 promotes RNA N -methyladenosine modification and endoderm differentiation of mouse embryonic stem cells.
Autorzy :
Liu X; School of Life Sciences, University of Science and Technology of China, Hefei, P.R. China.; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.; State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Wang H; Kingmed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China.
Zhao X; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Luo Q; Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou, P.R. China.
Wang Q; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Tan K; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Wang Z; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Jiang J; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Cui J; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Du E; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Xia L; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.
Du W; Sichuan MoDe Technology Co., Ltd, Chengdu, P. R. China.
Chen D; State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. .; Institute of Biomedical Research, Yunnan University, Kunming, P.R. China. .
Xia L; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China. .; State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, P.R. China. .
Xiao S; Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 18; Vol. 12 (1), pp. 3780. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine/*analogs & derivatives
Arginine/*metabolism
Endoderm/*cytology
Methyltransferases/*metabolism
Mouse Embryonic Stem Cells/*cytology
Adenosine/genetics ; Adenosine/metabolism ; Animals ; Cell Differentiation/genetics ; Gene Expression Regulation/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Methylation ; Methyltransferases/genetics ; Mice ; Protein Processing, Post-Translational/genetics ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; RNA Interference ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Autocitrullination of PAD4 does not alter its enzymatic activity: In vitro and in silico studies.
Autorzy :
Liu X; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD, Maastricht, the Netherlands.
Wichapong K; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD, Maastricht, the Netherlands.
Lamers S; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD, Maastricht, the Netherlands.
Reutelingsperger CPM; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD, Maastricht, the Netherlands.
Nicolaes GAF; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 MD, Maastricht, the Netherlands. Electronic address: .
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Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2021 May; Vol. 134, pp. 105938. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Rheumatoid/*metabolism
Citrulline/*metabolism
Protein-Arginine Deiminase Type 4/*metabolism
Arginine/metabolism ; Arthritis, Rheumatoid/enzymology ; Arthritis, Rheumatoid/pathology ; Citrullination ; Computer Simulation ; Enzyme Assays/methods ; Humans ; In Vitro Techniques ; Mass Spectrometry/methods ; Molecular Dynamics Simulation ; Protein-Arginine Deiminase Type 4/chemistry ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
Autorzy :
Zhu J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Li X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Cai X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Zha H; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Zhou Z; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Sun X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Rong F; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Tang J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Zhu C; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Liu X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Fan S; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Wang J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Liao Q; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Ouyang G; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China.
Xiao W; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, P.R. China; The Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan 430072, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan 430072, P.R. China; Hubei Hongshan Laboratory, Wuhan 430070, P.R. China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Aug 05; Vol. 81 (15), pp. 3171-3186.e8. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Arginine/*metabolism
Host-Pathogen Interactions/*physiology
Immunity, Innate/*physiology
Protein-Arginine N-Methyltransferases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Animals ; DEAD Box Protein 58/metabolism ; Fibroblasts/virology ; HEK293 Cells ; Herpes Simplex/immunology ; Herpes Simplex/metabolism ; Herpes Simplex/virology ; Humans ; Methylation ; Mice ; Mice, Knockout ; Polyunsaturated Alkamides ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/immunology ; Receptors, Immunologic/metabolism ; Respirovirus Infections/immunology ; Respirovirus Infections/metabolism ; Respirovirus Infections/virology ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Arginine methylation of APE1 promotes its mitochondrial translocation to protect cells from oxidative damage.
Autorzy :
Zhang Y; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China.
Zhang Q; Department of Infectious Disease, Nanjing Liuhe District People's Hospital, Yangzhou University, Nanjing, 211500, China.
Li L; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China.
Mu D; Department of Radiology, Affiliated Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, 210008, China.
Hua K; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China.
Ci S; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China.
Shen L; Department of Cancer Genetics and Epigenetics, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, 91010, USA.
Zheng L; Department of Cancer Genetics and Epigenetics, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, 91010, USA.
Shen B; Department of Cancer Genetics and Epigenetics, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, 91010, USA. Electronic address: .
Guo Z; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2020 Oct; Vol. 158, pp. 60-73. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arginine*
Endonucleases*
Animals ; DNA Damage ; DNA Repair ; DNA-(Apurinic or Apyrimidinic Site) Lyase/genetics ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism ; HEK293 Cells ; Humans ; Methylation ; Oxidative Stress ; Protein Processing, Post-Translational ; Protein-Arginine N-Methyltransferases/genetics ; Repressor Proteins
Czasopismo naukowe
Tytuł :
Double trouble: Bacillus depends on a functional Tat machinery to avoid severe oxidative stress and starvation upon entry into a NaCl-depleted environment.
Autorzy :
Prajapati B; University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, the Netherlands.
Bernal-Cabas M; University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, the Netherlands.
López-Álvarez M; University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, the Netherlands.
Schaffer M; University Medicine Greifswald, Interfaculty Institute of Genetics and Functional Genomics, Department of Functional Genomics, Greifswald, Germany.
Bartel J; University of Greifswald, Institute of Microbiology, Department of Microbial Proteomics, Greifswald, Germany.
Rath H; University Medicine Greifswald, Interfaculty Institute of Genetics and Functional Genomics, Department of Functional Genomics, Greifswald, Germany.
Steil L; University Medicine Greifswald, Interfaculty Institute of Genetics and Functional Genomics, Department of Functional Genomics, Greifswald, Germany.
Becher D; University of Greifswald, Institute of Microbiology, Department of Microbial Proteomics, Greifswald, Germany.
Völker U; University Medicine Greifswald, Interfaculty Institute of Genetics and Functional Genomics, Department of Functional Genomics, Greifswald, Germany.
Mäder U; University Medicine Greifswald, Interfaculty Institute of Genetics and Functional Genomics, Department of Functional Genomics, Greifswald, Germany. Electronic address: .
van Dijl JM; University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, the Netherlands. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Feb; Vol. 1868 (2), pp. 118914. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacillus subtilis/*metabolism
Bacterial Proteins/*metabolism
Membrane Transport Proteins/*metabolism
Oxidative Stress/*genetics
Sodium Chloride/*metabolism
Twin-Arginine-Translocation System/*metabolism
Arginine/metabolism ; Bacillus subtilis/genetics ; Bacterial Proteins/genetics ; Cell Membrane/metabolism ; Membrane Transport Proteins/genetics ; Microbial Viability/genetics ; Mutant Proteins/metabolism ; Organisms, Genetically Modified ; Protein Transport/genetics ; Twin-Arginine-Translocation System/genetics
Czasopismo naukowe
Tytuł :
PRMT5 promotes colorectal cancer growth by interaction with MCM7.
Autorzy :
Li X; Department of Pathology & Pathophysiology, and Department of Colorectal Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wang X; Department of Pathology & Pathophysiology, and Department of Colorectal Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhao J; Department of Pathology & Pathophysiology, and Department of Colorectal Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wang J; Department of Colorectal Surgery and Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wu J; Department of Pathology & Pathophysiology, and Department of Colorectal Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Apr; Vol. 25 (7), pp. 3537-3547. Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinogenesis/*metabolism
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*metabolism
Minichromosome Maintenance Complex Component 7/*metabolism
Protein-Arginine N-Methyltransferases/*genetics
Protein-Arginine N-Methyltransferases/*metabolism
Animals ; Arginine/metabolism ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Knockdown Techniques ; HCT116 Cells ; HEK293 Cells ; HT29 Cells ; Humans ; Methylation ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Protein Binding ; Protein Interaction Domains and Motifs
Czasopismo naukowe
Tytuł :
Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.
Autorzy :
Li WJ; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
He YH; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Yang JJ; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Hu GS; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Lin YA; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Ran T; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Peng BL; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Xie BL; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Huang MF; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Gao X; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China.
Huang HH; Department of Pathology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China.
Zhu HH; Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Ye F; Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Fujian, China.
Liu W; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China. .; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China. .; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 29; Vol. 12 (1), pp. 1946. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*genetics
Colorectal Neoplasms/*genetics
Heterogeneous Nuclear Ribonucleoprotein A1/*genetics
Prostatic Neoplasms/*genetics
Protein-Arginine N-Methyltransferases/*genetics
Alternative Splicing ; Amino Acid Sequence ; Arginine/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Enzyme Inhibitors/pharmacology ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Heterogeneous Nuclear Ribonucleoprotein A1/antagonists & inhibitors ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Humans ; Male ; Methylation/drug effects ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Binding ; Protein Processing, Post-Translational ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Protein-Arginine N-Methyltransferases/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Spliceosomes/drug effects ; Spliceosomes/genetics ; Spliceosomes/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.
Autorzy :
Yin XK; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Wang YL; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Wang F; Department of Gastroenterology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China.
Feng WX; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Bai SM; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Zhao WW; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Feng LL; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Wei MB; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Qin CL; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Wang F; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Chen ZL; Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Yi HJ; Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Huang Y; Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Xie PY; Department of Radiology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China.
Kim T; Base for International Science and Technology Cooperation, Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen University Health Science Center, Shenzhen, 518055, PR China.; The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.
Wang YN; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Hou JW; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Li CW; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Liu Q; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 116044, PR China.; State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China.
Fan XJ; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China. .; Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China. .
Hung MC; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. .; Graduate Institute of Biomedical Sciences and Research Centers for Cancer Biology and Molecular Medicine, China Medical University, Taichung, 404, Taiwan. .; Department of Biotechnology, Asia University, Taichung, 413, Taiwan. .
Wan XB; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China. .; Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China. .; Department of Medical Engineering, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510655, PR China. .
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Źródło :
Oncogene [Oncogene] 2021 Feb; Vol. 40 (7), pp. 1375-1389. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*genetics
DNA-Binding Proteins/*genetics
Protein-Arginine N-Methyltransferases/*genetics
Proto-Oncogene Proteins p21(ras)/*genetics
RNA-Binding Proteins/*genetics
Repressor Proteins/*genetics
Animals ; Arginine ; Carcinogenesis/genetics ; Cell Movement/genetics ; Cell Proliferation/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Heterografts ; Humans ; Methylation ; Mice
Czasopismo naukowe
Tytuł :
L-arginine supplementation increases cardiac collagenogenesis in mice chronically infected with Berenice-78 Trypanosoma cruzi strain.
Autorzy :
Bianchini Narde M; Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Espírito Santo, Alto Universitário, CEP 29500-000, Alegre, Espírito Santo, Brazil.
Belli Cassa Domingues EL; Programa de Pós-graduação em Nutrição e Saúde, Universidade Federal do Espírito Santo, Av. Marechal Campos, 1468, Maruípe, CEP 29043-900, Vitória, Espírito Santo, Brazil.
Ribeiro Gonçalves K; Laboratório de Doenças Parasitárias, Escola de Medicina, Universidade Federal de Ouro Preto, Morro do Cruzeiro, CEP 35400-000, Ouro Preto, Minas Gerais, Brazil.
Lomar Viana M; Departamento de Farmácia e Nutrição, Universidade Federal do Espírito Santo, Alto Universitário, CEP 29500-000, Alegre, Espírito Santo, Brazil.
Santos Zanini M; Programa de Pós-graduação em Ciências Veterinárias, Universidade Federal do Espírito Santo, Alto Universitário, CEP 29500-000, Alegre, Espírito Santo, Brazil; Departamento de Medicina Veterinária, Alto Universitário, CEP 29500-000, Alegre, Espírito Santo, Brazil.
Geraldo de Lima W; Departamento de Ciências Biológicas, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto, Morro do Cruzeiro, CEP 35400-000, Ouro Preto, Minas Gerais, Brazil.
Bahia MT; Laboratório de Doenças Parasitárias, Escola de Medicina, Universidade Federal de Ouro Preto, Morro do Cruzeiro, CEP 35400-000, Ouro Preto, Minas Gerais, Brazil.
Matos Dos Santos F; Departamento de Farmácia e Nutrição, Universidade Federal do Espírito Santo, Alto Universitário, CEP 29500-000, Alegre, Espírito Santo, Brazil. Electronic address: .
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Źródło :
Parasitology international [Parasitol Int] 2021 Aug; Vol. 83, pp. 102345. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine/*metabolism
Chagas Cardiomyopathy/*pathology
Collagen/*physiology
Heart/*parasitology
Trypanocidal Agents/*pharmacology
Trypanosoma cruzi/*drug effects
Animal Feed/analysis ; Animals ; Arginine/administration & dosage ; Arginine/pharmacology ; Chagas Cardiomyopathy/drug therapy ; Chagas Cardiomyopathy/parasitology ; Diet ; Dietary Supplements/analysis ; Heart/drug effects ; Mice ; Trypanocidal Agents/administration & dosage ; Trypanocidal Agents/metabolism
Czasopismo naukowe
Tytuł :
Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage.
Autorzy :
Mader MM; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Böger R; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Appel D; Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Schwedhelm E; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Haddad M; Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mohme M; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lamszus K; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Westphal M; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Czorlich P; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hannemann J; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2021 Aug; Vol. 41 (8), pp. 1964-1977. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine/*metabolism
Cerebral Hemorrhage/*pathology
Aged ; Arginine/analogs & derivatives ; Arginine/blood ; Arginine/cerebrospinal fluid ; Case-Control Studies ; Cerebral Hemorrhage/metabolism ; Chromatography, High Pressure Liquid ; Citrulline/blood ; Female ; Humans ; Male ; Middle Aged ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/metabolism ; Ornithine/blood ; Risk Factors ; Tandem Mass Spectrometry ; Up-Regulation
Czasopismo naukowe
Tytuł :
Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.
Autorzy :
Uysal-Onganer P; Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6 UW, UK.
D'Alessio S; Tissue Architecture and Regeneration Research Group, School of Life Sciences, University of Westminster, London W1W 6 UW, UK.
Mortoglou M; Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6 UW, UK.
Kraev I; Electron Microscopy Suite, Faculty of Science, Technology, Engineering and Mathematics, Open University, Milton Keynes MK7 6AA, UK.
Lange S; Tissue Architecture and Regeneration Research Group, School of Life Sciences, University of Westminster, London W1W 6 UW, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 30; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Pancreatic Ductal/*pathology
Extracellular Vesicles/*metabolism
Pancreatic Neoplasms/*pathology
Protein-Arginine Deiminase Type 2/*metabolism
Protein-Arginine Deiminase Type 3/*metabolism
Carcinoma, Pancreatic Ductal/drug therapy ; Cell Line, Tumor ; Extracellular Vesicles/drug effects ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Neoplasm Invasiveness/pathology ; Ornithine/analogs & derivatives ; Ornithine/pharmacology ; Ornithine/therapeutic use ; Pancreatic Neoplasms/drug therapy ; Protein-Arginine Deiminase Type 2/antagonists & inhibitors ; Protein-Arginine Deiminase Type 3/antagonists & inhibitors ; Protein-Arginine Deiminase Type 4/antagonists & inhibitors ; Protein-Arginine Deiminase Type 4/metabolism
Czasopismo naukowe
Tytuł :
Pharmacologic downregulation of protein arginine methyltransferase1 expression by adenosine dialdehyde increases cell senescence in breast cancer.
Autorzy :
Singh P; Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603 203, Chennai, Tamil Nadu, India.
Charles S; Department of Medical Research, Medical College Hospital and Research Center, SRM Institute of Science and Technology, Kattankulathur, 603 203, Chennai, Tamil Nadu, India; Department of Biotechnology, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603 203, Chennai, Tamil Nadu, India.
Madhavan T; Computational Biology Laboratory, Department of Genetic Engineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603 203, Chennai, Tamil Nadu, India.
Munusamy-Ramanujam G; Interdisciplinary Institute of Indian System of Medicine, College of Engineering and Technology,SRM Institute of Science and Technology, Kattankulathur, 603 203, Chennai, Tamil Nadu, India.
Saraswathi NT; Molecular Biophysics Lab, School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, 613 401, Tamil Nadu, India.
Arasu MV; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Al-Dhabi NA; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Arshad A; International Institute of Aquaculture and Aquatic Sciences (I-AQUAS), Universiti Putra Malaysia, 71050, Port Dickson, Negeri Sembilan, Malaysia; Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Arockiaraj J; SRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, 603 203, Chennai, Tamil Nadu, India. Electronic address: .
Mala K; Department of Medical Research, Medical College Hospital and Research Center, SRM Institute of Science and Technology, Kattankulathur, 603 203, Chennai, Tamil Nadu, India. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Jan 15; Vol. 891, pp. 173697. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Adenosine/*analogs & derivatives
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Breast Neoplasms/*drug therapy
Cell Proliferation/*drug effects
Cellular Senescence/*drug effects
Protein Processing, Post-Translational/*drug effects
Protein-Arginine N-Methyltransferases/*metabolism
Repressor Proteins/*metabolism
Tamoxifen/*pharmacology
Adenosine/metabolism ; Adenosine/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/metabolism ; Arginine/analogs & derivatives ; Arginine/metabolism ; Betaine-Homocysteine S-Methyltransferase/metabolism ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Cycle Checkpoints/drug effects ; Down-Regulation ; Drug Synergism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MCF-7 Cells ; Methylation ; Molecular Docking Simulation ; Oxidative Stress/drug effects ; Phosphatidylethanolamine N-Methyltransferase/metabolism ; Protein-Arginine N-Methyltransferases/genetics ; Repressor Proteins/genetics ; Signal Transduction ; Tamoxifen/metabolism
Czasopismo naukowe
Tytuł :
GC-MS and LC-MS/MS pilot studies on the guanidine (N -dimethylated arginine-vasopressin peptides and proteins in human red blood cells.
Autorzy :
Bollenbach A; Institute of Toxicology and Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany.
Gambaryan S; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg 194223, Russia.
Mindukshev I; Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, St. Petersburg 194223, Russia.
Pich A; Institute of Toxicology and Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany.
Tsikas D; Institute of Toxicology and Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany. Electronic address: .
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Źródło :
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2020 Mar 15; Vol. 1141, pp. 122024. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine Vasopressin*/analysis
Arginine Vasopressin*/blood
Arginine Vasopressin*/chemistry
Chromatography, Liquid/*methods
Gas Chromatography-Mass Spectrometry/*methods
Guanidine/*chemistry
Tandem Mass Spectrometry/*methods
Arginine/analogs & derivatives ; Arginine/analysis ; Arginine/blood ; Arginine/chemistry ; Blood Proteins/analysis ; Blood Proteins/chemistry ; Humans ; Linear Models ; Male ; Peptides/analysis ; Peptides/blood ; Peptides/chemistry ; Pilot Projects ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł :
Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design.
Autorzy :
Funabashi K; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan.
Sawata M; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan.
Nagai A; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan; Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai Naka, Japan.
Akimoto M; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan; Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai Naka, Japan.
Mashimo R; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan; Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai Naka, Japan.
Takahara H; Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai Naka, Japan; College of Agriculture, Ibaraki University, Ami Inashiki, Japan.
Kizawa K; Kao Corporation, Biological Science Research Laboratory, Odawara, Japan.
Thompson PR; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA.
Ite K; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan; Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai Naka, Japan.
Kitanishi K; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan; Tokyo University of Science, Faculty of Science Division I, Tokyo, Japan.
Unno M; Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan; Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai Naka, Japan. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Sep 15; Vol. 708, pp. 108911. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Enzyme Inhibitors/*pharmacology
Protein-Arginine Deiminase Type 3/*chemistry
Protein-Arginine Deiminase Type 3/*metabolism
Crystallography, X-Ray ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein-Arginine Deiminase Type 3/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer.
Autorzy :
Lin J; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Liu H; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Fukumoto T; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Zundell J; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Yan Q; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Tang CA; Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center, Houston Methodist Research Institute, Houston, TX, USA.
Wu S; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Zhou W; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Guo D; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Karakashev S; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Hu CA; Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center, Houston Methodist Research Institute, Houston, TX, USA.
Sarma K; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Kossenkov AV; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Zhang R; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 07; Vol. 12 (1), pp. 5321. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Carcinoma, Ovarian Epithelial/*therapy
Endoribonucleases/*genetics
Ovarian Neoplasms/*therapy
Programmed Cell Death 1 Receptor/*genetics
Protein-Arginine N-Methyltransferases/*genetics
Protein-Serine-Threonine Kinases/*genetics
X-Box Binding Protein 1/*genetics
Animals ; Antibodies, Monoclonal/pharmacology ; Base Sequence ; Benzopyrans/pharmacology ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/immunology ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Endoplasmic Reticulum Stress/drug effects ; Endoribonucleases/antagonists & inhibitors ; Endoribonucleases/immunology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Hymecromone/analogs & derivatives ; Hymecromone/pharmacology ; Immune Checkpoint Inhibitors ; Mice ; Molecular Targeted Therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/immunology ; Ovarian Neoplasms/pathology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Protein Binding ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Protein-Arginine N-Methyltransferases/immunology ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/immunology ; Signal Transduction ; X-Box Binding Protein 1/antagonists & inhibitors ; X-Box Binding Protein 1/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A hydrazone-based spectroscopic off-on probe for sensing of basic arginine and lysine.
Autorzy :
Wang T; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Pang Q; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Tong Z; School of Public Health, Capital Medical University, Beijing 100069, China.
Xiang H; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
Xiao N; School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China. Electronic address: .
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2021 Sep 05; Vol. 258, pp. 119824. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Arginine*
Lysine*
Amino Acid Sequence ; Hydrazones ; Peptide Fragments ; Trypsin
Czasopismo naukowe

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