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Tytuł :
Registration status of skin sensitisation data derived from the Local Lymph Node Assay (LLNA): BrdU-ELISA in REACH.
Autorzy :
Takeyoshi M; Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, Tokyo, Japan. .
Nara S; Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, Tokyo, Japan.
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Źródło :
Archives of toxicology [Arch Toxicol] 2021 May; Vol. 95 (5), pp. 1857-1858. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Local Lymph Node Assay*
Allergens ; Animals ; Bromodeoxyuridine ; Dermatitis, Allergic Contact ; Enzyme-Linked Immunosorbent Assay ; Humans ; Lymph Nodes ; Skin
Czasopismo naukowe
Tytuł :
Directed evolution of orthogonal RNA-RBP pairs through library-vs-library in vitro selection.
Autorzy :
Fukunaga K; Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904 0495, Japan.
Yokobayashi Y; Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904 0495, Japan.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2022 Jan 25; Vol. 50 (2), pp. 601-616.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Library*
Biological Assay/*methods
RNA/*metabolism
RNA-Binding Proteins/*metabolism
Aptamers, Nucleotide ; Biological Assay/standards ; Electrophoretic Mobility Shift Assay/methods ; High-Throughput Nucleotide Sequencing ; Models, Molecular ; RNA/chemistry ; RNA-Binding Proteins/chemistry ; Research Design ; SELEX Aptamer Technique ; Structure-Activity Relationship ; Surface Plasmon Resonance/methods
Czasopismo naukowe
Tytuł :
A tissue culture infectious dose-derived protocol for testing of SARS-CoV-2 neutralization of serum antibodies on adherent cells.
Autorzy :
Hasler F; Department of Dermatology, University of Zurich, 8091 Zurich, Switzerland.
Duda A; Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
Kündig TM; Department of Dermatology, University of Zurich, 8091 Zurich, Switzerland.; Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
Johansen P; Department of Dermatology, University of Zurich, 8091 Zurich, Switzerland.; Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
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Źródło :
STAR protocols [STAR Protoc] 2021 Dec 17; Vol. 2 (4), pp. 100824. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
COVID-19/*immunology
Neutralization Tests/*methods
SARS-CoV-2/*immunology
Viral Plaque Assay/*methods
Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/blood ; COVID-19/therapy ; Chlorocebus aethiops ; Enzyme-Linked Immunosorbent Assay ; Humans ; Vero Cells
Czasopismo naukowe
Tytuł :
Development and evaluation of a Mycobacterium bovis interferon-γ enzyme-linked immunospot (ELISpot) assay for detection of bovine tuberculosis.
Autorzy :
Li X; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225009, China.
Xia A; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.
Xu Z; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China.
Liu J; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China.
Fu S; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.
Cao Z; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.
Shen Y; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225009, China.
Xie Y; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China.
Meng C; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China.
Chen X; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China. Electronic address: .
Jiao X; Jiangsu Key Laboratory of Zoonosis and Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, Yangzhou 225009, China. Electronic address: .
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Źródło :
Journal of dairy science [J Dairy Sci] 2022 Jul; Vol. 105 (7), pp. 6021-6029. Date of Electronic Publication: 2022 May 13.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme-Linked Immunosorbent Assay*/methods
Enzyme-Linked Immunosorbent Assay*/veterinary
Tuberculosis, Bovine*/diagnosis
Tuberculosis, Bovine*/microbiology
Animals ; Antigens, Bacterial ; Bacterial Proteins ; Cattle ; Interferon-gamma ; Mycobacterium bovis ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Development and validation of a novel luciferase reporter gene assay to detect pyrogen.
Autorzy :
Wang C; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China.
Wang M; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China.
Liu L; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China; School of Pharmacy, Fudan University, Shanghai, 201203, PR China.
Li G; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China.
Wu Y; State Key Laboratory of Antibody Medicine and Targeted Therapy, Shanghai Zhangjiang Biotechnology Co. Ltd, 201203, PR China.
Wang Z; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China.
Duan X; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China.
Shao H; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China.
Chen G; NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal Antibodies, Shanghai Institute for Food and Drug Control, Shanghai, 201203, PR China. Electronic address: .
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Źródło :
Biologicals : journal of the International Association of Biological Standardization [Biologicals] 2022 Jun; Vol. 77, pp. 16-23. Date of Electronic Publication: 2022 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Pyrogens*
Genes, Reporter ; Luciferases/genetics ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Frequency histograms of three high-sensitivity cardiac troponin assays in a reference population.
Autorzy :
Cho H; Department of Laboratory Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim H; Department of Laboratory Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee J; Department of Laboratory Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim SY; Department of Laboratory Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee HK; Department of Laboratory Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kwon HJ; Department of Laboratory Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim Y; Department of Laboratory Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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Źródło :
Journal of clinical laboratory analysis [J Clin Lab Anal] 2022 Jun; Vol. 36 (6), pp. e24432. Date of Electronic Publication: 2022 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Troponin I*/blood
Troponin T*/blood
Biomarkers/blood ; Female ; Humans ; Male ; Reference Values ; Republic of Korea
Czasopismo naukowe
Tytuł :
Affimer sandwich probes for stable and robust lateral flow assaying.
Autorzy :
Goyal G; Interdisciplinary Graduate School, Nanyang Technological University, Singapore, 639798, Singapore.; Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore, 637553, Singapore.; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Sharma A; Interdisciplinary Graduate School, Nanyang Technological University, Singapore, 639798, Singapore.; Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore, 637553, Singapore.; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Tok AIY; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Palaniappan A; Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore, 637553, Singapore. .; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore. .
Liedberg B; Interdisciplinary Graduate School, Nanyang Technological University, Singapore, 639798, Singapore. .; Center for Biomimetic Sensor Science, Nanyang Technological University, Singapore, 637553, Singapore. .; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore. .
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Źródło :
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2022 Jun; Vol. 414 (14), pp. 4245-4254. Date of Electronic Publication: 2022 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Interleukin-8*
Antibodies ; Biomarkers ; Humans ; Immunoassay/methods ; Peptides
Czasopismo naukowe
Tytuł :
Biomarker Assay Validation by Mass Spectrometry.
Autorzy :
Fernández-Metzler C; PharmaCadence Analytical Services, LLC, 1440 Industry Road, Hatfield, PA, 19940, USA. .
Ackermann B; Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Garofolo F; BRI - a Frontage Company, 8898 Heather St, Vancouver, British Columbia, V6P 3S8, Canada.
Arnold ME; Labcorp Drug Development, 221 Tulip Tree Drive, Westampton, NJ, 08060-5511, USA.
DeSilva B; Bristol-Myers Squibb Co., Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Gu H; Bristol-Myers Squibb Co., Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
Laterza O; Merck and Co Inc., 90 E Scott Ave, Rahway, NJ, 07065, USA.
Mao Y; Boehringer-Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT, 06877, USA.
Rose M; Gossamer Bio Inc., 3013 Science Park Road, Suite 200, San Diego, CA, 92121, USA.
Vazvaei-Smith F; Merck and Co Inc., 770 Sumneytown Pike, West Point, PA, 19486, USA.
Steenwyk R; Pfizer-Retired, 8739 N Homestead Circle, Irons, MI, 49644, USA.
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Źródło :
The AAPS journal [AAPS J] 2022 May 09; Vol. 24 (3), pp. 66. Date of Electronic Publication: 2022 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Biomarkers/analysis ; Chromatography, Liquid/methods ; Mass Spectrometry/methods ; Reference Standards
Czasopismo naukowe
Tytuł :
Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity.
Autorzy :
Robison TW; Division of Pharmacology-Toxicology for Immunology & Inflammation, Office of Immunology and Inflammation, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20903, United States. Electronic address: .
Heflich RH; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, United States.
Manjanatha MG; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, United States.
Elespuru R; Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20903, United States.
Atrakchi A; Division of Pharmacology and Toxicology for Neuroscience, Office of Neuroscience, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20903, United States.
Mei N; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, United States.
Ding W; Division of Clinical Review, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20903, United States.
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Źródło :
Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2021 Aug-Sep; Vol. 868-869, pp. 503386. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay/*methods
Drugs, Investigational/*chemistry
Drugs, Investigational/*metabolism
Mutation/*drug effects
Animals ; Animals, Genetically Modified/genetics ; Carcinogens/toxicity ; Comet Assay/methods ; Follow-Up Studies ; Micronucleus Tests/methods ; Mutagenicity Tests/methods ; Mutagens/toxicity ; Rodentia
Czasopismo naukowe
Tytuł :
Lateral flow assays for hormone detection.
Autorzy :
Khelifa L; Department of Chemical Engineering, Imperial College London, South Kensington, London, SW7 2BU, UK. .
Hu Y; Department of Chemical Engineering, Imperial College London, South Kensington, London, SW7 2BU, UK. .
Jiang N; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China. .
Yetisen AK; Department of Chemical Engineering, Imperial College London, South Kensington, London, SW7 2BU, UK. .
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Źródło :
Lab on a chip [Lab Chip] 2022 Jun 28; Vol. 22 (13), pp. 2451-2475. Date of Electronic Publication: 2022 Jun 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biological Assay*
Point-of-Care Systems*
Antibodies ; Hormones ; Humans
Czasopismo naukowe
Tytuł :
Label-free prediction of cell painting from brightfield images.
Autorzy :
Cross-Zamirski JO; Department for Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, CB3 0WA, UK. .; Discovery Sciences, R&D, AstraZeneca, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK. .; Downing College, Cambridge, CB2 1DQ, UK. .
Mouchet E; Discovery Sciences, R&D, AstraZeneca, Alderley Park, Cheshire, SK10 4TG, UK.
Williams G; Discovery Sciences, R&D, AstraZeneca, Alderley Park, Cheshire, SK10 4TG, UK.
Schönlieb CB; Department for Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, CB3 0WA, UK.
Turkki R; Discovery Sciences, R&D, AstraZeneca, Gothenburg, Pepparedsleden 1, 431 50, Mölndal, Sweden.
Wang Y; Discovery Sciences, R&D, AstraZeneca, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK.
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Źródło :
Scientific reports [Sci Rep] 2022 Jun 15; Vol. 12 (1), pp. 10001. Date of Electronic Publication: 2022 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Drug Discovery*
Image Processing, Computer-Assisted/methods
Czasopismo naukowe
Tytuł :
Assay, Purity, and Impurity Profile of Phosphorothioate Oligonucleotide Therapeutics by Ion Pair-HPLC-MS.
Autorzy :
Rentel C; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Gaus H; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Bradley K; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Luu N; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Kolkey K; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Mai B; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Madsen M; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Pearce M; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Bock B; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
Capaldi D; Analytical Development Quality Control, Ionis Pharmaceuticals, Carlsbad, California, USA.
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Źródło :
Nucleic acid therapeutics [Nucleic Acid Ther] 2022 Jun; Vol. 32 (3), pp. 206-220. Date of Electronic Publication: 2022 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*
Phosphorothioate Oligonucleotides*/therapeutic use
Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
One-step assembly of barcoded planar microparticles for efficient readout of multiplexed immunoassay.
Autorzy :
Bae S; Bio-MAX/N-Bio, Seoul National University, Seoul 08826, South Korea. .k.
Lee D; Education and Research Program for Future ICT Pioneers, Seoul National University, Seoul 08826, South Korea.; SOFT Foundry Institute, Seoul National University, Seoul 08826, South Korea.
Na H; Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, South Korea.; QuantaMatrix Inc., Medical Innovation Center, Seoul National University Hospital, Seoul, 03080, South Korea.
Jang J; QuantaMatrix Inc., Medical Innovation Center, Seoul National University Hospital, Seoul, 03080, South Korea.
Kwon S; Bio-MAX/N-Bio, Seoul National University, Seoul 08826, South Korea. .k.; Education and Research Program for Future ICT Pioneers, Seoul National University, Seoul 08826, South Korea.; Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, South Korea.; QuantaMatrix Inc., Medical Innovation Center, Seoul National University Hospital, Seoul, 03080, South Korea.
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Źródło :
Lab on a chip [Lab Chip] 2022 May 31; Vol. 22 (11), pp. 2090-2096. Date of Electronic Publication: 2022 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Immunoassay/methods ; Oligonucleotide Array Sequence Analysis
Czasopismo naukowe
Tytuł :
Laboratory Community Should Be More Proactive in Highlighting the Negative Impact of Analytical Non-Selectivity of Some Creatinine Assays.
Autorzy :
Panteghini M; Research Centre for Metrological Traceability in Laboratory Medicine (CIRME), Università degli Studi di Milano, Milan, Italy.
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Źródło :
Clinical chemistry [Clin Chem] 2022 May 18; Vol. 68 (5), pp. 723.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*
Laboratories*
Creatinine ; Glomerular Filtration Rate ; Humans
Czasopismo naukowe
Tytuł :
High-Throughput Assessment of the Abiotic Stability of Test Chemicals in In Vitro Bioassays.
Autorzy :
Huchthausen J; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.
Mälzer S; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.
Nicol B; Safety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedford MK44 1LQ, U.K.
Sparham C; Safety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedford MK44 1LQ, U.K.
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, DE-72076 Tübingen, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2022 May 16; Vol. 35 (5), pp. 867-879. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Solid Phase Microextraction*
Hydrolysis ; Photolysis ; Serum Albumin, Bovine/chemistry ; Water/chemistry
Czasopismo naukowe
Tytuł :
Is Incurred Sample Reanalysis (ISR) Applicable in Biomarker Assays?
Autorzy :
Hays A; BioAgilytix Labs, 2300 Englert Drive, Durham, NC, 27713, USA. .
Amaravadi L; Boston Pharmaceuticals, Cambridge, MA, USA.
Fernandez-Metzler C; Pharmacadence Analytical Services, Hatfield, PA, USA.
King L; Pfizer Inc., Cambridge, MA, USA.
Mathews J; Ionis Pharmaceuticals, Carlsbad, CA, USA.
Ni Y; Passage Bio, Inc., Philadelphia, PA, USA.
Quadrini K; Passage Bio, Inc., Philadelphia, PA, USA.
Tinder C; Bristol Myers Squibb, Princeton, NJ, USA.
Vazvaei F; Merck & Co. Inc., Rahway, NJ, USA.
Zeng J; Bristol Myers Squibb, Princeton, NJ, USA.
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Źródło :
The AAPS journal [AAPS J] 2022 May 05; Vol. 24 (3), pp. 65. Date of Electronic Publication: 2022 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*
Biomarkers ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Studying and mitigating the effects of data drifts on ML model performance at the example of chemical toxicity data.
Autorzy :
Morger A; In Silico Toxicology and Structural Bioinformatics, Institute of Physiology, Charité Universitätsmedizin Berlin, Berlin, 10117, Germany.
Garcia de Lomana M; BASF SE, 67056, Ludwigshafen, Germany.; Division of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, University of Vienna, Vienna, 1090, Austria.
Norinder U; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, 751 24, Sweden.; Dept Computer and Systems Sciences, Stockholm University, Kista, 164 07, Sweden.; MTM Research Centre, School of Science and Technology, 701 82, Örebro, Sweden.
Svensson F; Alzheimer's Research UK UCL Drug Discovery Institute, London, WC1E 6BT, UK.
Kirchmair J; Division of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, University of Vienna, Vienna, 1090, Austria.
Mathea M; BASF SE, 67056, Ludwigshafen, Germany. .
Volkamer A; In Silico Toxicology and Structural Bioinformatics, Institute of Physiology, Charité Universitätsmedizin Berlin, Berlin, 10117, Germany. .
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Źródło :
Scientific reports [Sci Rep] 2022 May 04; Vol. 12 (1), pp. 7244. Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay*
Machine Learning*
Calibration ; Molecular Conformation
Czasopismo naukowe
Tytuł :
The never-ending quest for antibody assays standardization and appropriate measurement units.
Autorzy :
Plebani M; Department of Medicine-DIMED, University of Padova, Padova, Italy.
Galli C; Medical Affairs, Core Diagnostics, Abbott, Rome, Italy.
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Źródło :
Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2022 May 03; Vol. 60 (7), pp. 959-960. Date of Electronic Publication: 2022 May 03.
Typ publikacji :
Editorial
MeSH Terms :
Antibodies*
Biological Assay*
Humans ; Reference Standards
Opinia redakcyjna
Tytuł :
Methods for Evaluation of TNF-α Inhibition Effect.
Autorzy :
Hira K; Department of Pharmacy, BITS-Pilani Hyderabad Campus, Hyderabad, Telangana State, India.
Sajeli Begum A; Department of Pharmacy, BITS-Pilani Hyderabad Campus, Hyderabad, Telangana State, India. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2248, pp. 271-279.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay*/methods
Tumor Necrosis Factor-alpha/*metabolism
Animals ; Blotting, Western ; Cell Survival/drug effects ; Cells, Cultured ; Cytokines/genetics ; Cytokines/metabolism ; Enzyme-Linked Immunosorbent Assay ; Gene Expression ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; RAW 264.7 Cells ; Real-Time Polymerase Chain Reaction ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
Assay pH and critical reagent optimization in measuring concentrations of a monoclonal antibody and its target.
Autorzy :
Chen J; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Kendra K; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Shank S; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Rafique A; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Ehrlich G; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Lin KJ; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
DeStefano L; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Andisik MD; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Partridge MA; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Torri A; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Sumner G; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
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Źródło :
Bioanalysis [Bioanalysis] 2022 Apr; Vol. 14 (8), pp. 491-502. Date of Electronic Publication: 2022 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal*
Biological Assay*
Indicators and Reagents
Czasopismo naukowe

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