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Wyszukujesz frazę ""ATP Binding Cassette Transporter, Subfamily G, Member 2"" wg kryterium: Temat


Tytuł :
Ginkgo biloba leaf extract suppresses intestinal human breast cancer resistance protein expression in mice: Correlation with gut microbiota.
Autorzy :
Kim JK; Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Choi MS; Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Kim JY; Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Yu JS; Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Seo JI; Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.
Yoo HH; Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea. Electronic address: .
Kim DH; Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Aug; Vol. 140, pp. 111712. Date of Electronic Publication: 2021 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Herb-Drug Interactions*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Gastrointestinal Microbiome/*drug effects
Neoplasm Proteins/*metabolism
Plant Extracts/*pharmacology
Sulfasalazine/*pharmacokinetics
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Animals ; Caco-2 Cells ; Feces/chemistry ; Feces/microbiology ; Humans ; Male ; Metabolome ; Mice, Inbred C57BL ; Neoplasm Proteins/genetics ; Sulfasalazine/blood
Czasopismo naukowe
Tytuł :
Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.
Autorzy :
Kowal J; Institute of Molecular Biology and Biophysics, ETH Zurich, Switzerland. Electronic address: .
Ni D; Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, Switzerland.
Jackson SM; Institute of Molecular Biology and Biophysics, ETH Zurich, Switzerland.
Manolaridis I; Institute of Molecular Biology and Biophysics, ETH Zurich, Switzerland.
Stahlberg H; Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, Switzerland. Electronic address: .
Locher KP; Institute of Molecular Biology and Biophysics, ETH Zurich, Switzerland. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Jun 25; Vol. 433 (13), pp. 166980. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*chemistry
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Pharmaceutical Preparations/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily G, Member 2/ultrastructure ; Binding Sites ; Biological Transport ; Humans ; Models, Molecular ; Pharmaceutical Preparations/chemistry ; Structure-Activity Relationship ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Autorzy :
Yu Q; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland.
Ni D; Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, Basel, Switzerland.; Laboratory of Biological Electron Microscopy, Institute of Physics, SB, EPFL, Lausanne, Switzerland.
Kowal J; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland.
Manolaridis I; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland.
Jackson SM; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland.
Stahlberg H; Center for Cellular Imaging and NanoAnalytics (C-CINA), Biozentrum, University of Basel, Basel, Switzerland.; Laboratory of Biological Electron Microscopy, Institute of Physics, SB, EPFL, and Dep. Fund. Microbiol., Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Locher KP; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, Zürich, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 19; Vol. 12 (1), pp. 4376. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Pharmaceutical Preparations*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Neoplasm Proteins/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/chemistry ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Adenosine Triphosphatases/metabolism ; Biological Transport ; Cryoelectron Microscopy ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm/drug effects ; Humans ; Membrane Proteins ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Protein Domains
Czasopismo naukowe
Tytuł :
Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP).
Autorzy :
Engdahl E; Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
van Schijndel MDM; Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
Voulgaris D; Division of Micro and Nanosystems, Department of Intelligent Systems, KTH Royal Institute of Technology, 11428 Stockholm, Sweden.; AIMES, Department of Neuroscience, Karolinska Institute, 17177 Solna, Sweden.
Di Criscio M; Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
Ramsbottom KA; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.; Computational Biology Facility, Technology Directorate, University of Liverpool, Liverpool L69 3BX, UK.
Rigden DJ; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.; Computational Biology Facility, Technology Directorate, University of Liverpool, Liverpool L69 3BX, UK.
Herland A; Division of Micro and Nanosystems, Department of Intelligent Systems, KTH Royal Institute of Technology, 11428 Stockholm, Sweden.; AIMES, Department of Neuroscience, Karolinska Institute, 17177 Solna, Sweden.
Rüegg J; Environmental Toxicology, Department of Organismal Biology, Uppsala University, 75236 Uppsala, Sweden.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 24; Vol. 22 (11). Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Benzhydryl Compounds/*pharmacology
Blood-Brain Barrier/*metabolism
Endothelial Cells/*drug effects
Neoplasm Proteins/*metabolism
Phenols/*pharmacology
ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily G, Member 2/chemistry ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Benzhydryl Compounds/chemistry ; Benzhydryl Compounds/toxicity ; Benzimidazoles/metabolism ; Cell Culture Techniques ; Cells, Cultured ; Diketopiperazines/chemistry ; Diketopiperazines/pharmacology ; Gene Expression ; Heterocyclic Compounds, 4 or More Rings/chemistry ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; In Vitro Techniques ; Induced Pluripotent Stem Cells/metabolism ; Molecular Docking Simulation ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Phenols/chemistry ; Phenols/toxicity ; Protein Binding ; Sulfones/chemistry ; Sulfones/pharmacology ; Sulfones/toxicity
Czasopismo naukowe
Tytuł :
The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update.
Autorzy :
Eckenstaler R; Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.
Benndorf RA; Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 22; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Susceptibility*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*genetics
Gout/*etiology
Hyperuricemia/*etiology
Neoplasm Proteins/*genetics
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Age of Onset ; Alleles ; Animals ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetic Variation ; Genotype ; Gout/diagnosis ; Gout/metabolism ; Gout/therapy ; Humans ; Hyperuricemia/diagnosis ; Hyperuricemia/metabolism ; Hyperuricemia/therapy ; Neoplasm Proteins/metabolism ; Phenotype ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
Prospective Drug Candidates as Human Multidrug Transporter ABCG2 Inhibitors: an In Silico Drug Discovery Study.
Autorzy :
Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt. .
Badr EAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Abdelrahman AHM; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Almansour NM; Department of Biology, College of Science, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia.
Shawky AM; Science and Technology Unit (STU), Umm Al-Qura University, Makkah, Saudi Arabia.
Mekhemer GAH; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Alrumaihi F; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Moustafa MF; Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.; Department of Botany & Microbiology, Faculty of Science, South Valley University, Qena, Egypt.
Atia MAM; Molecular Genetics and Genome Mapping Laboratory, Genome Mapping Department, Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center (ARC), Giza, Egypt. .
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Źródło :
Cell biochemistry and biophysics [Cell Biochem Biophys] 2021 Jun; Vol. 79 (2), pp. 189-200. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Benzimidazoles/*chemistry
Bridged Bicyclo Compounds, Heterocyclic/*chemistry
Fluorenes/*chemistry
Neoplasm Proteins/*antagonists & inhibitors
Pyrrolidines/*chemistry
Sulfonamides/*chemistry
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Benzimidazoles/metabolism ; Binding Sites ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Bridged Bicyclo Compounds, Heterocyclic/metabolism ; Databases, Chemical ; Drug Discovery ; Drug Resistance, Neoplasm ; Female ; Fluorenes/metabolism ; Humans ; Hydrogen Bonding ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Neoplasm Proteins/metabolism ; Protein Binding ; Pyrrolidines/metabolism ; Sulfonamides/metabolism ; Thermodynamics
Czasopismo naukowe
Tytuł :
Analysis of the interaction between tryptophan-related compounds and ATP-binding cassette transporter G2 (ABCG2) using targeted metabolomics.
Autorzy :
Garcia-Lino AM; Department of Biomedical Sciences-Physiology, Faculty of Veterinary Medicine, Animal Health Institute (INDEGSAL), University of Leon, Campus de Vegazana, 24071 Leon, Spain.
Gomez-Gomez A; Integrative Pharmacology and Systems Neuroscience Group, IMIM-Hospital del Mar Medical Research Institute, 88 Doctor Aiguader, 08003 Barcelona, Spain.
Garcia-Mateos D; Department of Biomedical Sciences-Physiology, Faculty of Veterinary Medicine, Animal Health Institute (INDEGSAL), University of Leon, Campus de Vegazana, 24071 Leon, Spain.
de la Fuente A; Department of Biomedical Sciences-Physiology, Faculty of Veterinary Medicine, Animal Health Institute (INDEGSAL), University of Leon, Campus de Vegazana, 24071 Leon, Spain.
Alvarez AI; Department of Biomedical Sciences-Physiology, Faculty of Veterinary Medicine, Animal Health Institute (INDEGSAL), University of Leon, Campus de Vegazana, 24071 Leon, Spain.
Pozo OJ; Integrative Pharmacology and Systems Neuroscience Group, IMIM-Hospital del Mar Medical Research Institute, 88 Doctor Aiguader, 08003 Barcelona, Spain.
Merino G; Department of Biomedical Sciences-Physiology, Faculty of Veterinary Medicine, Animal Health Institute (INDEGSAL), University of Leon, Campus de Vegazana, 24071 Leon, Spain. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 15; Vol. 344, pp. 128665. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolomics*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Tryptophan/*chemistry
Tryptophan/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Animals ; Cattle ; Female ; Humans ; Mice ; Milk/metabolism ; Polymorphism, Genetic ; Protein Binding
Czasopismo naukowe
Tytuł :
Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2 .
Autorzy :
Huang Y; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yu SH; State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Zhen WX; Department of biophysics and Kidney Disease Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Cheng T; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Wang D; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Lin JB; Women's Hospital, and Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Wu YH; College of Pharmaceutical Sciences, Zhejiang University.
Wang YF; Zhejiang University-University of Edinburgh united Institute.
Chen Y; State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Shu LP; Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, National & Guizhou Joint Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Guizhou Medical University, Guiyang, Guizhou, China, 550004.
Wang Y; College of Pharmaceutical Sciences, Zhejiang University.
Sun XJ; State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Hematology, Rui-Jin Hospital affiliated to Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Zhou Y; Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Pediatric Hematology/Oncology at Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.
Yang F; Department of biophysics and Kidney Disease Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Hsu CH; Women's Hospital, and Institute of Genetics, and Department of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Xu PF; Women's Hospital, and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
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Źródło :
Theranostics [Theranostics] 2021 May 08; Vol. 11 (14), pp. 6891-6904. Date of Electronic Publication: 2021 May 08 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Abietanes/*pharmacology
Antineoplastic Agents, Phytogenic/*pharmacology
Enhancer of Zeste Homolog 2 Protein/*antagonists & inhibitors
Hematopoiesis/*drug effects
Leukemia/*drug therapy
Leukemia/*metabolism
Matrix Metalloproteinase 9/*metabolism
Neoplasm Proteins/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Animals ; Animals, Genetically Modified ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Chromatin Immunoprecipitation ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Hematopoiesis/genetics ; Histones/metabolism ; Humans ; Leukemia/enzymology ; Leukemia/genetics ; Matrix Metalloproteinase 9/genetics ; Neoplasm Proteins/genetics ; Polycomb Repressive Complex 2/metabolism ; Protein Binding ; RNA-Seq ; Salvia miltiorrhiza/chemistry ; Surface Plasmon Resonance ; Transcriptome/genetics ; Xenograft Model Antitumor Assays ; Zebrafish
Czasopismo naukowe
Tytuł :
ABCG2 Is Overexpressed on Red Blood Cells in Ph-Negative Myeloproliferative Neoplasms and Potentiates Ruxolitinib-Induced Apoptosis.
Autorzy :
Buks R; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.
Brusson M; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.
Cochet S; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.
Galochkina T; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.
Cassinat B; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.; IRSL, U1131, INSERM, Université de Paris, F-75010 Paris, France.; Hôpital Saint-Louis, Laboratoire de Biologie Cellulaire, AP-HP, F-75010 Paris, France.
Nemazanyy I; Platform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS 3633, F-75015 Paris, France.
Peyrard T; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.; Centre National de Référence Pour les Groupes Sanguins, F-75011 Paris, France.
Kiladjian JJ; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.; IRSL, U1131, INSERM, Université de Paris, F-75010 Paris, France.; Centre d'Investigations Cliniques, Hôpital Saint-Louis, Université de Paris, F-75010 Paris, France.
de Brevern AG; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.
Azouzi S; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.
El Nemer W; BIGR, UMR_S1134, Inserm, Université de Paris, F-75015 Paris, France.; Institut National de la Transfusion Sanguine, F-75015 Paris, France.; Laboratoire d'Excellence GR-Ex, F-75015 Paris, France.; UMR 7268, 27 Boulevard Jean Moulin, F-13005 Marseille, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 29; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Erythrocytes/*metabolism
Neoplasm Proteins/*metabolism
Polycythemia Vera/*drug therapy
Pyrazoles/*pharmacology
ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily G, Member 2/chemistry ; Apoptosis/drug effects ; Binding Sites ; Cell Differentiation/drug effects ; Cell Line ; Computer Simulation ; Diketopiperazines/pharmacology ; Erythrocytes/drug effects ; Erythroid Cells/drug effects ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Hydroxyurea/metabolism ; Hydroxyurea/pharmacology ; Interferon-alpha/pharmacology ; K562 Cells ; Myeloproliferative Disorders/blood ; Myeloproliferative Disorders/drug therapy ; Myeloproliferative Disorders/pathology ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/chemistry ; Phosphatidylserines/metabolism ; Polycythemia Vera/blood ; Polycythemia Vera/pathology ; Pyrazoles/chemistry ; Pyrazoles/metabolism ; Pyrazoles/pharmacokinetics
Czasopismo naukowe
Tytuł :
The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations.
Autorzy :
Nagy T; Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, 1094, Budapest, Hungary.
Tóth Á; Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, 1094, Budapest, Hungary.
Telbisz Á; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudosok krt. 2, 1117, Budapest, Hungary.
Sarkadi B; Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, 1094, Budapest, Hungary.; Institute of Enzymology, Research Centre for Natural Sciences, Magyar Tudosok krt. 2, 1117, Budapest, Hungary.
Tordai H; Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, 1094, Budapest, Hungary.
Tordai A; Department of Transfusion Medicine, Semmelweis University, Nagyvarad ter 4, 1089, Budapest, Hungary.
Hegedűs T; Department of Biophysics and Radiation Biology, Semmelweis University, Tuzolto u. 37-47, 1094, Budapest, Hungary. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (5), pp. 2329-2339. Date of Electronic Publication: 2020 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*chemistry
Cholesterol/*chemistry
Membrane Lipids/*chemistry
Neoplasm Proteins/*chemistry
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Binding Sites/genetics ; Biological Transport ; Cholesterol/metabolism ; Humans ; Irinotecan/chemistry ; Irinotecan/metabolism ; Membrane Lipids/metabolism ; Mutation ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Protein Binding ; Protein Domains
Czasopismo naukowe
Tytuł :
Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2.
Autorzy :
Guragossian N; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
Belhani B; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji Mokhtar - Annaba University, 23000, Annaba, Algeria.
Moreno A; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
Nunes MT; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
Gonzalez-Lobato L; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
Marminon C; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, 69373, France.
Berthier L; Laboratoire de Biologie Tissulaire et Ingénierie, CNRS-UCBL1 UMR 5305, IBCP, 69367, Lyon, France.
Rocio Andrade Pires AD; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France; Departamento de Bioquímica e Biologia Molecular, Universidade Federal Do Paraná, Curitiba, Brazil.
Özvegy-Laczka C; Lnstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 1117, Budapest, Hungary.
Sarkadi B; Lnstitute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 1117, Budapest, Hungary.
Terreux R; Laboratoire de Biologie Tissulaire et Ingénierie, CNRS-UCBL1 UMR 5305, IBCP, 69367, Lyon, France.
Bouaziz Z; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France.
Berredjem M; Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji Mokhtar - Annaba University, 23000, Annaba, Algeria.
Jose J; Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus - Westfälische Wilhelms-Universität Münster, D-48149, Münster, Germany.
Di Pietro A; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France.
Falson P; Drug Resistance & Membrane Proteins Group - Molecular Microbiology and Structural Biochemistry Laboratory, CNRS-UCBL1 UMR 5086, IBCP, 69367, Lyon, France. Electronic address: .
Le Borgne M; EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, 69373, Lyon, France; Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, 69373, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 05; Vol. 211, pp. 113017. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Indoles/*pharmacology
Neoplasm Proteins/*antagonists & inhibitors
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Female ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Molecular Dynamics Simulation ; Molecular Structure ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Overexpression of human ATP-binding cassette transporter ABCG2 contributes to reducing the cytotoxicity of GSK1070916 in cancer cells.
Autorzy :
Wu ZX; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
Mai Q; Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China.
Yang Y; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
Wang JQ; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
Ma H; Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China.
Zeng L; Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China.
Chen ZS; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA. Electronic address: .
Pan Y; Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Apr; Vol. 136, pp. 111223. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Antineoplastic Agents/*pharmacology
Aza Compounds/*pharmacology
Indoles/*pharmacology
Neoplasm Proteins/*metabolism
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Antineoplastic Agents/metabolism ; Aza Compounds/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic ; Humans ; Indoles/metabolism ; Neoplasm Proteins/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Kinase Inhibitors/metabolism ; Spheroids, Cellular ; Up-Regulation
Czasopismo naukowe
Tytuł :
C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors.
Autorzy :
Namasivayam V; Department of Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Silbermann K; Department of Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Wiese M; Department of Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Pahnke J; Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, Norway.; LIED, University of Lübeck, Ratzenburger Allee 160, 23538 Lübeck, Germany.; Department of Pharmacology, Faculty of Medicine, University of Latvia, Jelgavas iela 1, 1004 Riga, Latvia.; Department of Bioorganic Chemistry, Leibniz-Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.
Stefan SM; Department of Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.; Department of Neuro-/Pathology, University of Oslo and Oslo University Hospital, Sognsvannsveien 20, 0372 Oslo, Norway.; Cancer Drug Resistance and Stem Cell Program, University of Sydney, Kolling Building, 10 Westbourne Street, Sydney, New South Wales 2065, Australia.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 3350-3366. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*antagonists & inhibitors
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Drug Discovery/*methods
Multidrug Resistance-Associated Proteins/*antagonists & inhibitors
Small Molecule Libraries/*chemistry
Small Molecule Libraries/*pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Dogs ; Drug Design ; Humans ; Madin Darby Canine Kidney Cells ; Models, Molecular ; Multidrug Resistance-Associated Proteins/metabolism ; Pattern Recognition, Automated/methods
Czasopismo naukowe
Tytuł :
The influence of calculated physicochemical properties of compounds on their ADMET profiles.
Autorzy :
Ma S; Medicinal Chemistry, Biotherapeutic and Medicinal Science Department, Biogen, 225 Binney Street, Cambridge, MA 02142, United States.
McGann M; OpenEye Scientific, Santa Fe, NM 87507, United States.
Enyedy IJ; Medicinal Chemistry, Biotherapeutic and Medicinal Science Department, Biogen, 225 Binney Street, Cambridge, MA 02142, United States. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Mar 15; Vol. 36, pp. 127825. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Blood Proteins/*metabolism
Ether-A-Go-Go Potassium Channels/*antagonists & inhibitors
Neoplasm Proteins/*metabolism
Pharmaceutical Preparations/*chemistry
ATP Binding Cassette Transporter, Subfamily B, Member 1/chemistry ; ATP Binding Cassette Transporter, Subfamily G, Member 2/chemistry ; Animals ; Blood Proteins/chemistry ; Chemistry, Physical ; Dose-Response Relationship, Drug ; Ether-A-Go-Go Potassium Channels/genetics ; Ether-A-Go-Go Potassium Channels/metabolism ; Humans ; Mice ; Microsomes/chemistry ; Microsomes/metabolism ; Molecular Structure ; Molecular Weight ; Neoplasm Proteins/chemistry ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Medically Important Alterations in Transport Function and Trafficking of ABCG2.
Autorzy :
Homolya L; Research Centre for Natural Sciences, Institute of Enzymology, H-1117 Budapest, Hungary.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 10; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mutation*
Polymorphism, Single Nucleotide*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*genetics
Genetic Predisposition to Disease/*genetics
Gout/*genetics
Hyperuricemia/*genetics
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Gout/metabolism ; Humans ; Hyperuricemia/metabolism ; Models, Genetic ; Protein Transport/genetics
Czasopismo naukowe
Tytuł :
Identification of Two Dysfunctional Variants in the ABCG2 Urate Transporter Associated with Pediatric-Onset of Familial Hyperuricemia and Early-Onset Gout.
Autorzy :
Toyoda Y; Department of Pharmacy, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Pavelcová K; Institute of Rheumatology, 128 00 Prague, Czech Republic.; Department of Rheumatology, First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
Bohatá J; Institute of Rheumatology, 128 00 Prague, Czech Republic.; Department of Rheumatology, First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
Ješina P; Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, 121 00 Prague, Czech Republic.
Kubota Y; Department of Pharmacy, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Suzuki H; Department of Pharmacy, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Takada T; Department of Pharmacy, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Stiburkova B; Institute of Rheumatology, 128 00 Prague, Czech Republic.; Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, 121 00 Prague, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 16; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Single Nucleotide*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*genetics
Gout/*complications
Gout/*genetics
Hyperuricemia/*complications
Hyperuricemia/*genetics
Neoplasm Proteins/*genetics
Organic Anion Transporters/*genetics
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Adult ; Child ; Czech Republic ; Female ; Genetic Predisposition to Disease ; HEK293 Cells ; Humans ; Hyperuricemia/blood ; Male ; Mutation ; Neoplasm Proteins/metabolism ; Organic Anion Transporters/metabolism ; Pedigree ; Phenotype ; Transfection ; Uric Acid/blood
Czasopismo naukowe
Tytuł :
Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.
Autorzy :
Silbermann K; Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, Rheinische Friedrich-Wilhelms-University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Li J; Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, Rheinische Friedrich-Wilhelms-University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Namasivayam V; Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, Rheinische Friedrich-Wilhelms-University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Stefan SM; Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, Rheinische Friedrich-Wilhelms-University of Bonn, An der Immenburg 4, 53121, Bonn, Germany. Electronic address: .
Wiese M; Pharmaceutical and Cellbiological Chemistry, Pharmaceutical Institute, Rheinische Friedrich-Wilhelms-University of Bonn, An der Immenburg 4, 53121, Bonn, Germany. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 113045. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Pyrimidines/*pharmacology
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Binding Sites/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Neoplasm Proteins/metabolism ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Water-soluble inhibitors of ABCG2 (BCRP) - A fragment-based and computational approach.
Autorzy :
Antoni F; Institute of Pharmacy, University of Regensburg, D-93040, Regensburg, Germany. Electronic address: .
Wifling D; Institute of Pharmacy, University of Regensburg, D-93040, Regensburg, Germany.
Bernhardt G; Institute of Pharmacy, University of Regensburg, D-93040, Regensburg, Germany.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 15; Vol. 210, pp. 112958. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Small Molecule Libraries/*chemistry
Small Molecule Libraries/*pharmacology
ATP Binding Cassette Transporter, Subfamily G, Member 2/chemistry ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Drug Discovery ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/metabolism ; Solubility ; Water/chemistry
Czasopismo naukowe
Tytuł :
The BCRP inhibitor febuxostat enhances the effect of nilotinib by regulation of intracellular concentration.
Autorzy :
Ito F; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan.
Miura M; Department of Pharmacy, Akita University Hospital, Akita, Japan.
Fujioka Y; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan.
Abumiya M; Department of Pharmacy, Akita University Hospital, Akita, Japan.
Kobayashi T; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan.
Takahashi S; Clinical Research Promotion and Support Center, Akita University Hospital, Akita, Japan.
Yoshioka T; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan.
Kameoka Y; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan.; Clinical Research Promotion and Support Center, Akita University Hospital, Akita, Japan.
Takahashi N; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan. .
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Źródło :
International journal of hematology [Int J Hematol] 2021 Jan; Vol. 113 (1), pp. 100-105. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*genetics
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Febuxostat/*pharmacology
Gene Expression/*drug effects
Neoplasm Proteins/*genetics
Neoplasm Proteins/*metabolism
Pyrimidines/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/antagonists & inhibitors ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Therapy, Combination ; Febuxostat/therapeutic use ; Humans ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Molecular Targeted Therapy ; Neoplasm Proteins/antagonists & inhibitors ; Protein Kinase Inhibitors/pharmacology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pyrimidines/therapeutic use
Czasopismo naukowe
Tytuł :
Molecular Docking Studies Reveal Rhein from rhubarb ( Rheum rhabarbarum ) as a Putative Inhibitor of ATP-binding Cassette Super-family G member 2.
Autorzy :
Khan MS; Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Mehmood B; Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Yousafi Q; Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Bibi S; Yunnan Herbal Laboratory, Institute of Herb Biotic Resources, School of Life Sciences, Yunnan University, Kunming, China.
Fazal S; Department of Biosciences, Faculty of Health and Life Sciences, Capital University of Sciences and Technology, Islamabad, Pakistan.
Saleem S; Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Sajid MW; Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Ihsan A; Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Azhar M; Department of Biosciences, Faculty of Sciences, COMSATS University Islamabad, Sahiwal, Pakistan.
Kamal MA; King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia.
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Źródło :
Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2021; Vol. 17 (3), pp. 273-288.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
ATP Binding Cassette Transporter, Subfamily G, Member 2/*metabolism
Anthraquinones/*metabolism
Anthraquinones/*pharmacology
Rheum/*chemistry
ATP Binding Cassette Transporter, Subfamily G, Member 2/chemistry ; Databases, Pharmaceutical ; Drug Design ; Protein Conformation ; Thermodynamics
Czasopismo naukowe

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