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Tytuł:
Whole-brain dopamine transporter binding pattern predicts survival in multiple system atrophy.
Autorzy:
Kang YK; Department of Nuclear Medicine, Seoul National University Hospital, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Shin JH; Department of Neurology, Seoul National University Hospital, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Choi H; Department of Nuclear Medicine, Seoul National University Hospital, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea. .; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. .
Kim HJ; Department of Neurology, Seoul National University Hospital, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea. .; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea. .
Cheon GJ; Department of Nuclear Medicine, Seoul National University Hospital, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.; Institute on Aging, Seoul National University, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.; Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jeon B; Department of Neurology, Seoul National University Hospital, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.; Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2024 Apr 02; Vol. 13 (1), pp. 18. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Letter
MeSH Terms:
Dopamine Plasma Membrane Transport Proteins*/metabolism
Multiple System Atrophy*/diagnostic imaging
Multiple System Atrophy*/metabolism
Humans ; Brain/metabolism ; Positron-Emission Tomography
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson's disease and multiple system atrophy.
Autorzy:
Laferrière F; Univ. Bordeaux, CNRS, IMN, UMR 5293, 33000, Bordeaux, France. .
Sabatier L; Univ. Bordeaux, CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
Claverol S; Bordeaux Proteome, Univ. Bordeaux, Bordeaux, France.
De Giorgi F; Univ. Bordeaux, CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
Ichas F; Univ. Bordeaux, CNRS, IMN, UMR 5293, 33000, Bordeaux, France.; DiSTeBA, Univ. Salento, Anatomia Umana, Lecce, Italy.
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2024 Mar 25; Vol. 13 (1), pp. 15. Date of Electronic Publication: 2024 Mar 25.
Typ publikacji:
Letter
MeSH Terms:
alpha-Synuclein*/chemistry
alpha-Synuclein*/immunology
alpha-Synuclein*/metabolism
Multiple System Atrophy*/diagnosis
Multiple System Atrophy*/genetics
Parkinson Disease*/diagnosis
Humans ; Bias ; Brain/metabolism
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Longitudinal evolution of sleep disturbances in early multiple system atrophy: a 2-year prospective cohort study.
Autorzy:
Zhang L; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.; Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Hou Y; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Li C; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Wei Q; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Ou R; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Liu K; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Lin J; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Yang T; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Xiao Y; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Jiang Q; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Zhao B; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Shang H; Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. .
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Źródło:
BMC medicine [BMC Med] 2023 Nov 22; Vol. 21 (1), pp. 454. Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple System Atrophy*/complications
Multiple System Atrophy*/epidemiology
Multiple System Atrophy*/diagnosis
Parkinson Disease*/complications
Parkinson Disease*/epidemiology
Parkinson Disease*/diagnosis
REM Sleep Behavior Disorder*/complications
REM Sleep Behavior Disorder*/diagnosis
Disorders of Excessive Somnolence*
Sleep Wake Disorders*/epidemiology
Humans ; Prospective Studies ; Sleep
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy.
Autorzy:
Corbin-Stein NJ; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.
Childers GM; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.
Webster JM; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.
Zane A; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.
Yang YT; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.
Mudium N; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.
Gupta R; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA.
Manfredsson FP; Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, USA.
Kordower JH; ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Harms AS; Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 1719 6th Ave South, Birmingham, AL, 35294, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Jan 18; Vol. 12 (1), pp. 11. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Demyelinating Diseases*/pathology
Multiple System Atrophy*/pathology
Synucleinopathies*/pathology
Animals ; Humans ; Mice ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Disease Models, Animal ; Interferon-gamma/metabolism ; Neuroinflammatory Diseases ; Oligodendroglia/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The role of α-synuclein prion strains in Parkinson's disease and multiple system atrophy.
Autorzy:
Khedmatgozar CR; Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America.
Holec SAM; Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America.
Woerman AL; Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Jan 25; Vol. 20 (1), pp. e1011920. Date of Electronic Publication: 2024 Jan 25 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Parkinson Disease*
Multiple System Atrophy*
Prions*
Humans ; alpha-Synuclein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy.
Autorzy:
Schneider Y; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.
Gauer C; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.
Andert M; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.
Hoffmann A; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.; UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.; Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, ON, Canada.; Department of Immunology, The University of Toronto, Toronto, ON, Canada.
Riemenschneider MJ; Department of Neuropathology, Regensburg University Hospital, 93053, Regensburg, Germany.
Krebs W; Core Unit Bioinformatics, Data Integration and Analysis (CUBiDA), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen, Germany.
Chalmers N; Institute of Biochemistry, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Lötzsch C; Institute of Biochemistry, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Naumann UJ; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Xiang W; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.
Rothhammer V; Department of Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Beckervordersandforth R; Institute of Biochemistry, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Schlachetzki JCM; Department of Cellular and Molecular Medicine, University of California-San Diego, La Jolla, CA, 92093, USA.
Winkler J; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Jan 02; Vol. 12 (1), pp. 1. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Multiple System Atrophy*/pathology
Parkinsonian Disorders*/pathology
Humans ; Mice ; Animals ; Astrocytes/metabolism ; Corpus Striatum/metabolism ; Substantia Nigra/metabolism ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
α-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils.
Autorzy:
Dhakal S; Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Mondal M; Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Mirzazadeh A; Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Banerjee S; Department of Chemistry and Biochemistry, University of Alabama, Tuscaloosa, AL, 35401, USA.
Ghosh A; Department of Chemistry and Biochemistry, University of Alabama, Tuscaloosa, AL, 35401, USA.
Rangachari V; Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA. .; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA. .
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Źródło:
Communications biology [Commun Biol] 2023 Dec 05; Vol. 6 (1), pp. 1227. Date of Electronic Publication: 2023 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
Prions*
Multiple System Atrophy*
Humans ; alpha-Synuclein/metabolism ; RNA/genetics ; Amyloid ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.
Autorzy:
Taha HB; Department of Integrative Biology & Physiology, University of California Los Angeles, Los Angeles, California, USA.
Ati SS; Department of Integrative Biology & Physiology, University of California Los Angeles, Los Angeles, California, USA.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Dec; Vol. 29 (12), pp. 3741-3755. Date of Electronic Publication: 2023 Jul 07.
Typ publikacji:
Meta-Analysis; Systematic Review; Journal Article; Review
MeSH Terms:
Extracellular Vesicles*
Multiple System Atrophy*/diagnosis
Parkinson Disease*/diagnosis
Parkinsonian Disorders*/diagnosis
Humans ; alpha-Synuclein ; Biomarkers ; Central Nervous System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alzheimer's disease pathology concomitant with memory impairment in late-onset multiple system atrophy.
Autorzy:
Miki Y; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Bettencourt C; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Jaunmuktane Z; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Holton JL; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Warner TT; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology, London, UK.
Wakabayashi K; Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
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Źródło:
Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2023 Feb; Vol. 49 (1), pp. e12878.
Typ publikacji:
Letter
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/pathology
Multiple System Atrophy*/complications
Lewy Body Disease*/pathology
Humans ; tau Proteins ; Atrophy ; Magnetic Resonance Imaging
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis.
Autorzy:
Wang P; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.; National Human Brain Bank for Health and Disease, Zhejiang University, Hangzhou, 310002, China.
Lan G; Department of Pathology, Peking University Health Science Center, Beijing, 100191, China.
Xu B; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.
Yu Z; Department of Neurology, Center for Movement Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.; China National Clinical Research Center for Neurological Diseases, Beijing, 100070, China.
Tian C; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.
Lei X; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China.
Meissner WG; CNRS, IMN, UMR 5293, University of Bordeaux, 33000, Bordeaux, France.; CHU Bordeaux, Service de Neurologie des Maladies Neurodégénératives, IMNc, 33000, Bordeaux, France.; Department of Medicine, New Zealand Brain Research Institute, University of Otago, Christchurch, Christchurch, New Zealand.
Feng T; Department of Neurology, Center for Movement Disorders, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. .; China National Clinical Research Center for Neurological Diseases, Beijing, 100070, China. .
Yang Y; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China. rebecca_.; Department of Pathology, Peking University Health Science Center, Beijing, 100191, China. rebecca_.
Zhang J; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310002, China. .; National Human Brain Bank for Health and Disease, Zhejiang University, Hangzhou, 310002, China. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2023 Aug 25; Vol. 12 (1), pp. 40. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/diagnosis
Multiple System Atrophy*
Extracellular Vesicles*
Humans ; alpha-Synuclein/genetics ; Astrocytes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity.
Autorzy:
Wojewska MJ; Department of Brain Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Otero-Jimenez M; Department of Brain Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Guijarro-Nuez J; Department of Brain Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Alegre-Abarrategui J; Department of Brain Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 25; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Synucleinopathies*
Dementia*
Parkinson Disease*/genetics
Multiple System Atrophy*/genetics
Humans ; alpha-Synuclein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A case report and literature review of possible multiple system atrophy-parkinsonian type with cholinergic deficiency.
Autorzy:
Wang M; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Wang Y; Department of Geriatric Medicine, The Qingdao Eighth People's Hospital, Qingdao, China.
Yang Y; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Luan M; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhong M; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xu L; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zheng X; Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Aug; Vol. 29 (8), pp. 2384-2387. Date of Electronic Publication: 2023 Apr 30.
Typ publikacji:
Review; Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple System Atrophy*/complications
Parkinsonian Disorders*
Supranuclear Palsy, Progressive*
Humans ; Cholinergic Agents
Recenzja
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease.
Autorzy:
Lau HHC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Martinez-Valbuena I; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
So RWL; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Mehra S; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
Silver NRG; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Mao A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
Stuart E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
Schmitt-Ulms C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.
Hyman BT; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.; Neuroscience Program, Harvard Medical School, Boston, MA, USA.
Ingelsson M; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.
Kovacs GG; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Watts JC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada. .; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 May 03; Vol. 11 (1), pp. 72. Date of Electronic Publication: 2023 May 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/genetics
Parkinson Disease*/pathology
Multiple System Atrophy*/genetics
Multiple System Atrophy*/pathology
Synucleinopathies*/genetics
Humans ; Mice ; Animals ; alpha-Synuclein/genetics ; alpha-Synuclein/chemistry ; Mutation/genetics ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
α-Synuclein Strains and Their Relevance to Parkinson's Disease, Multiple System Atrophy, and Dementia with Lewy Bodies.
Autorzy:
Graves NJ; EMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.
Gambin Y; EMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.
Sierecki E; EMBL Australia Node for Single Molecule Sciences and School of Biomedical Sciences, Faculty of Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 28; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Lewy Body Disease*/metabolism
Multiple System Atrophy*
Parkinson Disease*/metabolism
Synucleinopathies*
Humans ; alpha-Synuclein/metabolism ; Protein Aggregates
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Multidimensional biomarkers for multiple system atrophy: an update and future directions.
Autorzy:
Wan L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.; Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, China.; National International Collaborative Research Center for Medical Metabolomics, Central South University, Changsha, 410008, China.
Zhu S; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Chen Z; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, 410008, China.
Qiu R; School of Computer Science and Engineering, Central South University, Changsha, 410083, China.
Tang B; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China.; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, 410008, China.
Jiang H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China. .; Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. .; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, 410008, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. .; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, 410008, China. .; National International Collaborative Research Center for Medical Metabolomics, Central South University, Changsha, 410008, China. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2023 Jul 28; Vol. 12 (1), pp. 38. Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiple System Atrophy*/diagnostic imaging
Humans ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hot-Cross Bun Sign and REM Sleep Behavior Disorder Mimicking Multiple System Atrophy after Pontine Hemorrhage.
Autorzy:
Kim MS; Department of Neurology, Dongtan Sacred Heart Hospital Hallym University College of Medicine, Hwaseong, Republic of Korea.
Kang SY; Department of Neurology, Dongtan Sacred Heart Hospital Hallym University College of Medicine, Hwaseong, Republic of Korea.
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Źródło:
Neurology India [Neurol India] 2023 Jul-Aug; Vol. 71 (4), pp. 833-834.
Typ publikacji:
Letter
MeSH Terms:
REM Sleep Behavior Disorder*/diagnosis
REM Sleep Behavior Disorder*/etiology
Multiple System Atrophy*/complications
Multiple System Atrophy*/diagnosis
Nervous System Malformations*
Humans ; Pons/diagnostic imaging ; Cerebral Hemorrhage
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dopamine transporter SPECT imaging in Parkinson's disease and atypical Parkinsonism: a study of 137 patients.
Autorzy:
Constantinides VC; First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 72-74 Vas. Sophias Ave., 11528, Athens, Greece. .
Souvatzoglou M; Nuclear Medicine Division, First Radiology Department, National and Kapodistrian University of Athens, Aretaieion Hospital, Athens, Greece.
Paraskevas GP; Second Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Attikon Hospital, Athens, Greece.
Chalioti M; Nuclear Medicine Division, First Radiology Department, National and Kapodistrian University of Athens, Aretaieion Hospital, Athens, Greece.
Stefanis L; First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 72-74 Vas. Sophias Ave., 11528, Athens, Greece.
Kapaki E; First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, Eginition Hospital, 72-74 Vas. Sophias Ave., 11528, Athens, Greece.
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Źródło:
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 May; Vol. 44 (5), pp. 1613-1623. Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Parkinson Disease*/diagnosis
Parkinsonian Disorders*/diagnosis
Supranuclear Palsy, Progressive*/diagnosis
Multiple System Atrophy*/diagnostic imaging
Humans ; Dopamine Plasma Membrane Transport Proteins ; Tomography, Emission-Computed, Single-Photon/methods ; Diagnosis, Differential
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Automatic stridor detection using small training set via patch-wise few-shot learning for diagnosis of multiple system atrophy.
Autorzy:
Ahn JH; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Lee JH; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.; Medical AI Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea.
Lim CY; Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.; Medical AI Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea.
Joo EY; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Youn J; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Chung MJ; Medical AI Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea.; Department of Data Convergence and Future Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Cho JW; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. .; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. .
Kim K; Medical AI Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea. .; Department of Data Convergence and Future Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 05; Vol. 13 (1), pp. 10899. Date of Electronic Publication: 2023 Jul 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Artificial Intelligence*
Multiple System Atrophy*/diagnosis
Humans ; Respiratory Sounds/diagnosis ; Prognosis ; Polysomnography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration.
Autorzy:
Fodder K; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
de Silva R; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
Warner TT; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.
Bettencourt C; Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. .; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Jun 29; Vol. 11 (1), pp. 106. Date of Electronic Publication: 2023 Jun 29.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Parkinson Disease*
Multiple System Atrophy*
Humans ; DNA Methylation ; Oligodendroglia ; Myelin Sheath ; Epigenesis, Genetic ; Plaque, Amyloid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain.
Autorzy:
Kim A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5T 0S8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Martinez-Valbuena I; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5T 0S8, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON M5T 0S8, Canada.
Li J; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5T 0S8, Canada.
Lang AE; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5T 0S8, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON M5T 0S8, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON M5T 2S6, Canada.
Kovacs GG; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5T 0S8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON M5T 0S8, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON M5T 2S6, Canada.; Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada.
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Źródło:
Biomolecules [Biomolecules] 2023 Jun 02; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lewy Body Disease*
Multiple System Atrophy*
Synucleinopathies*
Humans ; alpha-Synuclein/metabolism ; Paraffin ; Paraffin Embedding/methods ; Formaldehyde ; Brain/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 9826

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