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Wyszukujesz frazę ""Abdel-Aziz AK"" wg kryterium: Autor


Wyświetlanie 1-20 z 20
Tytuł :
Dendritic cell vaccine immunotherapy; the beginning of the end of cancer and COVID-19. A hypothesis.
Autorzy :
Saadeldin MK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy. Electronic address: .
Abdel-Aziz AK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Abdellatif A; Biology Department, School of Science and Engineering, American University in Cairo, New Cairo 11835, Egypt. Electronic address: .
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 Jan; Vol. 146, pp. 110365. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Models, Immunological*
COVID-19/*therapy
Dendritic Cells/*immunology
Immunotherapy/*methods
Neoplasms/*therapy
COVID-19/immunology ; COVID-19 Vaccines/therapeutic use ; Cancer Vaccines/therapeutic use ; Clinical Trials as Topic ; Combined Modality Therapy ; Drug Development ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Neoplasms/immunology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Novel molecular mechanisms underlying the ameliorative effect of N-acetyl-L-cysteine against ϒ-radiation-induced premature ovarian failure in rats.
Autorzy :
Mantawy EM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Said RS; Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt. Electronic address: .
Kassem DH; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Badr AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Dec 15; Vol. 206, pp. 111190. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcysteine/*pharmacology
Gamma Rays/*adverse effects
Ovary/*drug effects
Primary Ovarian Insufficiency/*prevention & control
Radiation-Protective Agents/*pharmacology
Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/metabolism ; Disease Models, Animal ; Female ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/radiation effects ; NADPH Oxidase 4/metabolism ; Ovary/metabolism ; Ovary/radiation effects ; Ovary/ultrastructure ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Primary Ovarian Insufficiency/etiology ; Primary Ovarian Insufficiency/metabolism ; Primary Ovarian Insufficiency/pathology ; Rats ; Rats, Sprague-Dawley ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition.
Autorzy :
Abdel-Aziz AK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Pallavicini I; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Ceccacci E; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Meroni G; Experimental Therapeutics IFOM-FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
Saadeldin MK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.; Faculty of Biotechnology, October University for Modern Sciences and Arts, 6 October City, Cairo, Egypt.
Varasi M; Experimental Therapeutics IFOM-FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
Minucci S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy .; Department of Biosciences, University of Milan, Milan, Italy.
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Źródło :
Haematologica [Haematologica] 2020 Aug; Vol. 105 (8), pp. 2105-2117. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Humans ; Mechanistic Target of Rapamycin Complex 1 ; Signal Transduction ; Sirolimus
Czasopismo naukowe
Tytuł :
Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside.
Autorzy :
Abdel-Aziz AK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: AmalAbdel-Aziz@pharma.asu.edu.eg.
Saadeldin MK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy; Faculty of Biotechnology, October University for Modern Sciences and Arts, 6th October City, Cairo, Egypt.
D'Amico P; Division of Early Drug Development for Innovative Therapies, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Orecchioni S; Laboratory of Hematology-Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Bertolini F; Laboratory of Hematology-Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Curigliano G; Division of Early Drug Development for Innovative Therapies, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milano, Milan, Italy. Electronic address: .
Minucci S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Biosciences, University of Milan, Milan, Italy. Electronic address: .
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2019 Nov; Vol. 122, pp. 22-41. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Evaluation, Preclinical*
Antineoplastic Agents/*therapeutic use
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cell Cycle Checkpoints/*immunology
Immunologic Factors/*therapeutic use
Immunotherapy/*methods
Triple Negative Breast Neoplasms/*drug therapy
Antibodies, Monoclonal, Humanized/therapeutic use ; CTLA-4 Antigen/immunology ; Carcinoma, Non-Small-Cell Lung/immunology ; Humans ; Programmed Cell Death 1 Receptor/immunology ; Triple Negative Breast Neoplasms/immunology
Czasopismo naukowe
Tytuł :
Comparing apples with oranges: Studying LSD1 inhibitors in cellular assays.
Autorzy :
Abdel-Aziz AK; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Minucci S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Biosciences, University of Milan, Milan, Italy. Electronic address: .
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Źródło :
Pharmacological research [Pharmacol Res] 2019 Aug; Vol. 146, pp. 104345. Date of Electronic Publication: 2019 Jul 08.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Enzyme Inhibitors/*therapeutic use
Histone Demethylases/*antagonists & inhibitors
Animals ; Drug Approval/methods ; Humans
Raport
Tytuł :
Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain.
Autorzy :
El-Agamy SE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Esmat A; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Azab SS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. .
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Źródło :
Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2019 Jul; Vol. 84 (1), pp. 1-14. Date of Electronic Publication: 2019 Apr 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibiotics, Antineoplastic/*adverse effects
Cognition Disorders/*chemically induced
Doxorubicin/*adverse effects
Animals ; Antibiotics, Antineoplastic/administration & dosage ; Brain/physiopathology ; Cognition/drug effects ; Cognition Disorders/physiopathology ; Doxorubicin/administration & dosage ; Humans ; Neoplasms/drug therapy ; Quality of Life
Czasopismo naukowe
Tytuł :
Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure: Emphasis on TGF-β/MAPKs signaling pathway.
Autorzy :
Mantawy EM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Said RS; Drug Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt. Electronic address: .
Abdel-Aziz AK; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Jan; Vol. 109, pp. 293-303. Date of Electronic Publication: 2018 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Flavonoids/*therapeutic use
MAP Kinase Signaling System/*drug effects
Primary Ovarian Insufficiency/*drug therapy
Radiation Injuries, Experimental/*drug therapy
Transforming Growth Factor beta/*antagonists & inhibitors
Animals ; Apoptosis/physiology ; Cytoprotection/drug effects ; Cytoprotection/physiology ; Female ; Flavonoids/pharmacology ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; MAP Kinase Signaling System/physiology ; Primary Ovarian Insufficiency/metabolism ; Primary Ovarian Insufficiency/pathology ; Radiation Injuries, Experimental/metabolism ; Radiation Injuries, Experimental/pathology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Transforming Growth Factor beta/metabolism ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study.
Autorzy :
Saadeldin MK; Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.; Department of Biochemistry, National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt.; Faculty of Biotechnology, October University for Modern Sciences and Arts, 6th October City, Cairo, Egypt.
Elshaer SS; Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Emara IA; Department of Biochemistry, National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt.
Maged M; Faculty of Biotechnology, October University for Modern Sciences and Arts, 6th October City, Cairo, Egypt.
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
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Źródło :
PloS one [PLoS One] 2018 Nov 07; Vol. 13 (11), pp. e0206761. Date of Electronic Publication: 2018 Nov 07 (Print Publication: 2018).
Typ publikacji :
Journal Article
MeSH Terms :
Atherosclerosis/*blood
Bone Morphogenetic Proteins/*blood
Diabetes Mellitus, Type 2/*blood
Fibronectins/*blood
Adaptor Proteins, Signal Transducing ; Adult ; Atherosclerosis/complications ; Biomarkers/blood ; Case-Control Studies ; Cohort Studies ; Diabetes Mellitus, Type 2/complications ; Egypt ; Female ; Genetic Markers ; Humans ; Middle Aged ; Obesity/blood ; Obesity/complications ; Prognosis ; ROC Curve
Czasopismo naukowe
Tytuł :
Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis.
Autorzy :
Abdel-Maged AE; National Organization for Research and Control of Biologicals (NORCB), Cairo, Egypt.
Gad AM; Department of Pharmacology, National Organization for Drug Control and Research (NODCAR), Cairo, Egypt.
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Aboulwafa MM; Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Azab SS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2018 Oct 01; Vol. 356, pp. 65-75. Date of Electronic Publication: 2018 Jul 17.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Angiogenesis Inhibitors/*therapeutic use
Antibodies, Monoclonal, Humanized/*therapeutic use
Antirheumatic Agents/*therapeutic use
Arthritis, Experimental/*drug therapy
Ranibizumab/*therapeutic use
Receptors, Interleukin-6/*antagonists & inhibitors
Vascular Endothelial Growth Factor A/*antagonists & inhibitors
Angiogenesis Inhibitors/pharmacology ; Animals ; Antibodies, Monoclonal, Humanized/pharmacology ; Antirheumatic Agents/pharmacology ; Apoptosis/drug effects ; Arthritis, Experimental/pathology ; Bone and Bones/pathology ; Cartilage/pathology ; Inflammation/pathology ; Inflammation/prevention & control ; Liver/enzymology ; Liver/pathology ; Male ; Methotrexate/pharmacology ; Ranibizumab/pharmacology ; Rats ; Spleen/pathology
Czasopismo naukowe
Tytuł :
Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors.
Autorzy :
Milik SN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, 11566, Egypt. Electronic address: .
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, 11566, Egypt; Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy.
Lasheen DS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Serya RAT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Minucci S; Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy; Department of Biosciences, University of Milan, Milan, 20100, Italy.
Abouzid KAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, 11566, Egypt. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2018 Jul 15; Vol. 155, pp. 316-336. Date of Electronic Publication: 2018 Jun 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
ErbB Receptors/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Receptor, ErbB-2/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/metabolism ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Receptor, ErbB-2/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries.
Autorzy :
El-Agamy SE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Wahdan S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Esmat A; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Azab SS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2018 Jul; Vol. 55 (7), pp. 5727-5740. Date of Electronic Publication: 2017 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Oxidative Stress*/drug effects
Cognitive Dysfunction/*chemically induced
Cognitive Dysfunction/*drug therapy
Doxorubicin/*adverse effects
Inflammation/*pathology
Acetylcholinesterase/metabolism ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants ; Behavior, Animal ; Biomarkers/metabolism ; Cognitive Dysfunction/pathology ; Cognitive Dysfunction/physiopathology ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Hippocampus/drug effects ; Hippocampus/enzymology ; Hippocampus/pathology ; Hippocampus/physiopathology ; Male ; Models, Biological ; Motor Activity/drug effects ; Nerve Degeneration/pathology ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Rats ; Xanthophylls/pharmacology ; Xanthophylls/therapeutic use
Czasopismo naukowe
Tytuł :
Corrigendum: From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.
Autorzy :
Abdel-Aziz AK; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Shouman S; Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Minucci S; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.; Department of Biosciences, University of Milan, Milan, Italy.
Elgendy M; Max F. Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria.
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Źródło :
Frontiers in pharmacology [Front Pharmacol] 2018 Feb 12; Vol. 9, pp. 101. Date of Electronic Publication: 2018 Feb 12 (Print Publication: 2018).
Typ publikacji :
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł :
From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.
Autorzy :
Abdel-Aziz AK; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Abdel-Naim AB; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Shouman S; Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Minucci S; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.; Department of Biosciences, University of Milan, Milan, Italy.
Elgendy M; Max F. Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria.
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Źródło :
Frontiers in pharmacology [Front Pharmacol] 2017 Oct 10; Vol. 8, pp. 718. Date of Electronic Publication: 2017 Oct 10 (Print Publication: 2017).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
The tyrosine kinase inhibitor, sunitinib malate, induces cognitive impairment in vivo via dysregulating VEGFR signaling, apoptotic and autophagic machineries.
Autorzy :
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: AmalAbdel-Aziz@pharma.asu.edu.eg.
Mantawy EM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Said RS; National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
Helwa R; Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
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Źródło :
Experimental neurology [Exp Neurol] 2016 Sep; Vol. 283 (Pt A), pp. 129-41. Date of Electronic Publication: 2016 Jun 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Cognition Disorders/*chemically induced
Indoles/*pharmacology
Pyrroles/*pharmacology
Signal Transduction/*drug effects
Vascular Endothelial Growth Factor Receptor-2/*metabolism
Analysis of Variance ; Animals ; Avoidance Learning/drug effects ; Body Temperature/drug effects ; Body Weight/drug effects ; Cognition Disorders/physiopathology ; Disease Models, Animal ; Female ; Locomotion/drug effects ; Maze Learning/drug effects ; Mice ; Nerve Degeneration/chemically induced ; Prepulse Inhibition/drug effects ; RNA, Messenger/metabolism ; Sunitinib
Czasopismo naukowe
Tytuł :
Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents.
Autorzy :
Aziz MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Serya RA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Lasheen DS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.; Center for Drug Discovery and Development Research, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Abdel-Aziz AK; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Esmat A; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.; Center for Drug Discovery and Development Research, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Mansour AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Singab AN; Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.; Center for Drug Discovery and Development Research, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Abouzid KA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.; Center for Drug Discovery and Development Research, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
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Źródło :
Scientific reports [Sci Rep] 2016 Apr 15; Vol. 6, pp. 24460. Date of Electronic Publication: 2016 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Furans*/chemistry
Pyrimidines*/chemistry
Antineoplastic Agents/*pharmacology
Ornithine/*analogs & derivatives
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology ; Antineoplastic Agents/chemistry ; Drug Design ; Humans ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Targeted Therapy ; Ornithine/chemistry ; Protein Binding ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Vascular Endothelial Growth Factor Receptor-2/chemistry
Czasopismo naukowe
Tytuł :
Rational design, synthesis and molecular modeling studies of novel anti-oncological alkaloids against melanoma.
Autorzy :
Girgis AS; Pesticide Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt. .
Panda SS
Srour AM
Farag H
Ismail NS
Elgendy M
Abdel-Aziz AK
Katritzky AR
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2015 Jun 21; Vol. 13 (23), pp. 6619-33. Date of Electronic Publication: 2015 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Quantitative Structure-Activity Relationship*
Alkaloids/*chemistry
Alkaloids/*pharmacology
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Melanoma/*drug therapy
Alkaloids/chemical synthesis ; Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Chemistry Techniques, Synthetic ; Cycloaddition Reaction ; Drug Design ; Humans ; Inhibitory Concentration 50 ; Models, Molecular ; Spiro Compounds/chemical synthesis ; Spiro Compounds/pharmacology
Czasopismo naukowe
Tytuł :
Modulation of imatinib cytotoxicity by selenite in HCT116 colorectal cancer cells.
Autorzy :
Abdel-Aziz AK; Pharmacology & Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Azab SS
Youssef SS
El-Sayed AM
El-Demerdash E
Shouman S
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Źródło :
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2015 Jan; Vol. 116 (1), pp. 37-46. Date of Electronic Publication: 2014 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Benzamides/*pharmacology
Colorectal Neoplasms/*pathology
Piperazines/*pharmacology
Pyrimidines/*pharmacology
Selenious Acid/*pharmacology
Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Beclin-1 ; Caspase 3/genetics ; Caspase 3/metabolism ; Colorectal Neoplasms/metabolism ; DNA Fragmentation/drug effects ; Drug Synergism ; HCT116 Cells/drug effects ; Humans ; Imatinib Mesylate ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Nitrogen Oxides/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.
Autorzy :
Elgendy M; Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy.
Ciro M; 1] Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy [2] IFOM (Fondazione Istituto FIRC di Oncologia Molecolare) at the IFOM-European Institute of Oncology (IEO) Campus, Via Adamello 16, 20139 Milan, Italy.
Abdel-Aziz AK; Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy.
Belmonte G; Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy.
Dal Zuffo R; Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy.
Mercurio C; Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy.
Miracco C; Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy.
Lanfrancone L; Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy.
Foiani M; 1] IFOM (Fondazione Istituto FIRC di Oncologia Molecolare) at the IFOM-European Institute of Oncology (IEO) Campus, Via Adamello 16, 20139 Milan, Italy [2] Department of Biosciences, University of Milan, 20100 Milan, Italy.
Minucci S; 1] Department of Experimental Oncology, European Institute of Oncology, IEO, 20139 Milan, Italy [2] Department of Biosciences, University of Milan, 20100 Milan, Italy [3] Drug Development Program, European Institute of Oncology, IEO, 20139 Milan, Italy.
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Źródło :
Nature communications [Nat Commun] 2014 Dec 04; Vol. 5, pp. 5637. Date of Electronic Publication: 2014 Dec 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis*
Apoptosis Regulatory Proteins/*metabolism
Melanoma/*metabolism
Membrane Proteins/*metabolism
Myeloid Cell Leukemia Sequence 1 Protein/*metabolism
Skin Neoplasms/*metabolism
Animals ; Autophagy ; Beclin-1 ; HEK293 Cells ; Haploinsufficiency ; HeLa Cells ; Humans ; Melanoma/secondary ; Mice ; Neoplasm Transplantation ; Skin Neoplasms/pathology ; Tumor Cells, Cultured ; Ubiquitin Thiolesterase/metabolism
Czasopismo naukowe
Tytuł :
Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries.
Autorzy :
Abdel-Aziz AK; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Shouman S; Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
El-Demerdash E; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Elgendy M; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Abdel-Naim AB; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: .
Pokaż więcej
Źródło :
Chemico-biological interactions [Chem Biol Interact] 2014 Jun 25; Vol. 217, pp. 28-40. Date of Electronic Publication: 2014 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carcinoma, Ehrlich Tumor/*drug therapy
Chloroquine/*pharmacology
Indoles/*pharmacology
Pyrroles/*pharmacology
Animals ; Apoptosis/drug effects ; Blotting, Western ; Caco-2 Cells ; Carcinoma, Ehrlich Tumor/blood supply ; Carcinoma, Ehrlich Tumor/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Synergism ; Female ; HCT116 Cells ; HeLa Cells ; Hep G2 Cells ; Humans ; Immunohistochemistry ; MCF-7 Cells ; Mice ; Neovascularization, Pathologic/drug therapy ; Sunitinib
Czasopismo naukowe
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