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Tytuł :
Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons.
Autorzy :
Parviainen L; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London, SE5 9RX, UK.
Dihanich S; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London, SE5 9RX, UK.
Anderson GW; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London, SE5 9RX, UK.
Wong AM; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London, SE5 9RX, UK.
Brooks HR; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London, SE5 9RX, UK.
Abeti R; Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen's Square, London, WC1N, 3BG, UK.
Rezaie P; Department of Life, Health and Chemical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK.
Lalli G; Wolfson Centre for Age-Related Diseases, King's College London, London, SE1 1UL, UK.
Pope S; Genetics and Genomic Medicine UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.
Heales SJ; Genetics and Genomic Medicine UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.
Mitchison HM; Genetics and Genomic Medicine UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.
Williams BP; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London, SE5 9RX, UK.
Cooper JD; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London, SE5 9RX, UK. .; Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute and David Geffen School of Medicine UCLA, 1124 West Carson Street, Hanley Hardison Building, Torrance, CA, 90502, USA. .
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Źródło :
Acta neuropathologica communications [Acta Neuropathol Commun] 2017 Oct 17; Vol. 5 (1), pp. 74. Date of Electronic Publication: 2017 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*physiopathology
Neuroglia/*physiology
Neuronal Ceroid-Lipofuscinoses/*physiopathology
Neurons/*physiology
Adult ; Aminopeptidases/deficiency ; Aminopeptidases/genetics ; Animals ; Brain/pathology ; Cell Movement/physiology ; Cell Survival/physiology ; Cells, Cultured ; Child ; Coculture Techniques ; Cytoskeleton/metabolism ; Cytoskeleton/pathology ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/deficiency ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/genetics ; Female ; Glutathione/metabolism ; Humans ; Male ; Membrane Glycoproteins/deficiency ; Membrane Glycoproteins/genetics ; Mice, Inbred C57BL ; Mice, Transgenic ; Molecular Chaperones/genetics ; Neuroglia/pathology ; Neuronal Ceroid-Lipofuscinoses/pathology ; Neurons/pathology ; Serine Proteases/deficiency ; Serine Proteases/genetics ; Young Adult
Czasopismo naukowe
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