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    Wyświetlanie 1-16 z 16
    Tytuł:
    Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity
    Autorzy:
    Kassab RM
    Al-Hussain SA
    Elleboudy NS
    Albohy A
    Zaki MEA
    Abouzid KAM
    Muhammad ZA
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    Temat:
    5-bromoisatin
    thiosemicarbazone
    hydrazonoyl chlorides
    thiazoles
    tyrosyl-trna synthetases (tyrrs) inhibitors
    antimicrobial
    molecular docking
    mrsa
    antibiofilm
    Therapeutics. Pharmacology
    RM1-950
    Źródło:
    Drug Design, Development and Therapy, Vol Volume 16, Pp 2817-2832 (2022)
    Opis pliku:
    electronic resource
    Relacje:
    https://www.dovepress.com/tackling-microbial-resistance-with-isatin-decorated-thiazole-derivativ-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881
    Dostęp URL:
    https://doaj.org/article/d1f6dc596e464683ac8b3a5e0ce753b3  Link otwiera się w nowym oknie
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3β inhibitors.
    Autorzy:
    Saleh JS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, P.O. Box 11829, Badr City, Cairo, Egypt. .
    Abd El Hadi SR; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, P.O. Box 11829, Badr City, Cairo, Egypt. .
    Ibrahim HS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, P.O. Box 11829, Badr City, Cairo, Egypt.
    Elrazaz EZ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, P.O. Box 11566, Abbassia, Cairo, Egypt.
    Abouzid KAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, P.O. Box 11566, Abbassia, Cairo, Egypt. khaled.abouzid@pharma.asu.edu.eg.
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    Źródło:
    BMC chemistry [BMC Chem] 2023 Sep 27; Vol. 17 (1), pp. 127. Date of Electronic Publication: 2023 Sep 27.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Novel 6-Aminoquinazolinone Derivatives as Potential Cross GT1-4 HCV NS5B Inhibitors.
    Autorzy:
    Nasr T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, MTI University, Cairo 12055, Egypt.
    Aboshanab AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt.
    Mpekoulis G; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
    Drakopoulos A; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden.
    Vassilaki N; Molecular Virology Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.
    Zoidis G; Department of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
    Abouzid KAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt.
    Zaghary W; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt.
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    Źródło:
    Viruses [Viruses] 2022 Dec 12; Vol. 14 (12). Date of Electronic Publication: 2022 Dec 12.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiviral Agents*/pharmacology
    Enzyme Inhibitors*/pharmacology
    Hepacivirus*/drug effects
    Humans ; Hepatitis C, Chronic ; Quinazolinones/pharmacology ; Structure-Activity Relationship ; Viral Nonstructural Proteins ; Virus Replication
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells.
    Autorzy:
    Abdelhafiz AHA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
    Serya RAT; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
    Lasheen DS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
    Wang N; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
    Sobeh M; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.; AgroBioSciences Research, Mohammed VI Polytechnic University, Ben-Guerir, Morocco.
    Wink M; Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
    Abouzid KAM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2710-2724.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents*/chemistry
    Antineoplastic Agents*/pharmacology
    Neoplasms*
    ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B/pharmacology ; Adenosine Triphosphate ; Benzimidazoles/pharmacology ; Caco-2 Cells ; Cell Line, Tumor ; Cytotoxins/pharmacology ; Doxorubicin/pharmacology ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Humans ; Ligands ; Verapamil/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Design, synthesis, and biological evaluation of new thieno[2,3- d ] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study.
    Autorzy:
    Elmenier FM; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Cairo, Egypt.
    Lasheen DS; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Cairo, Egypt.
    Abouzid KAM; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Cairo, Egypt.; Faculty of Pharmacy, Department of Organic and Medicinal Chemistry, University of Sadat City, Menoufia, Egypt.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 315-332.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Design*
    Antineoplastic Agents/*pharmacology
    Phosphatidylinositol 3-Kinases/*metabolism
    Phosphoinositide-3 Kinase Inhibitors/*pharmacology
    Pyrimidines/*pharmacology
    Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Phosphoinositide-3 Kinase Inhibitors/chemical synthesis ; Phosphoinositide-3 Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs.
    Autorzy:
    Rana N; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.; Department of Oncology, University of Alberta-Cross Cancer Institute, Edmonton, AB T6G IZ2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, 2-132 Li Ka Shing, Edmonton, AB T6G 2E1, Canada.
    Aziz MA; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo P.O. Box 11566, Egypt.
    Oraby AK; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Misr University of Science & Technology, Al-Motamayez District, 6th of October City P.O. Box 77, Egypt.
    Wuest M; Department of Oncology, University of Alberta-Cross Cancer Institute, Edmonton, AB T6G IZ2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, 2-132 Li Ka Shing, Edmonton, AB T6G 2E1, Canada.
    Dufour J; Department of Oncology, University of Alberta-Cross Cancer Institute, Edmonton, AB T6G IZ2, Canada.
    Abouzid KAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo P.O. Box 11566, Egypt.; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City P.O. Box 32897, Egypt.
    Wuest F; Department of Oncology, University of Alberta-Cross Cancer Institute, Edmonton, AB T6G IZ2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, 2-132 Li Ka Shing, Edmonton, AB T6G 2E1, Canada.
    West FG; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, 2-132 Li Ka Shing, Edmonton, AB T6G 2E1, Canada.
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    Źródło:
    Pharmaceutics [Pharmaceutics] 2022 Apr 10; Vol. 14 (4). Date of Electronic Publication: 2022 Apr 10.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine-hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer.
    Autorzy:
    Abdel-Atty MM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
    Farag NA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
    Serya RAT; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
    Abouzid KAM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.; Organic and Medicinal Chemistry Department, Faculty of Pharmacy, University of Sadat City, Sadat City, Egypt.
    Mowafy S; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.; Department of Chemistry, University of Washington, Seattle, WA, USA.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1290-1312.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Histone Deacetylase Inhibitors/*chemical synthesis
    Histone Deacetylase Inhibitors/*pharmacology
    Hydroxamic Acids/*chemistry
    Pyrimidines/*chemistry
    Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; Histone Deacetylase Inhibitors/pharmacokinetics ; Humans ; In Vitro Techniques ; Molecular Docking Simulation ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design, synthesis and biological evaluation of a new thieno[2,3- d ]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breast cancer cell lines.
    Autorzy:
    Sharaky M; Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, Egypt.
    Kamel M; Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, Egypt.
    Aziz MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.
    Omran M; Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, Egypt.
    Rageh MM; Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
    Abouzid KAM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt.
    Shouman SA; Department of Cancer Biology, Pharmacology Unit, National Cancer Institute, Cairo University, Cairo, Egypt.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1641-1656.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Design*
    Antineoplastic Agents/*pharmacology
    Breast Neoplasms/*drug therapy
    Drug Resistance, Neoplasm/*drug effects
    Pyrimidines/*pharmacology
    Urea/*pharmacology
    Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship ; Tamoxifen/pharmacology ; Urea/analogs & derivatives ; Urea/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities.
    Autorzy:
    Jaballah MY; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Abbassia, Cairo, Egypt.
    Serya RAT; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Abbassia, Cairo, Egypt.
    Saad N; Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Pharmaceutical Chemistry Department, Future University in Egypt, Cairo, Egypt.
    Khojah SM; Faculty of Science, Biochemistry Department, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
    Ahmed M; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
    Barakat K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, AB, Canada.
    Abouzid KAM; Faculty of Pharmacy, Pharmaceutical Chemistry Department, Ain Shams University, Abbassia, Cairo, Egypt.; Faculty of Pharmacy, Department of Organic and Medicinal Chemistry, University of Sadat City, Menoufia, Egypt.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 1573-1589.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Discovery*
    Antineoplastic Agents/*pharmacology
    Protein Kinase Inhibitors/*pharmacology
    Pyridazines/*pharmacology
    Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
    Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Density Functional Theory ; Drug Screening Assays, Antitumor ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyridazines/chemical synthesis ; Pyridazines/chemistry ; Vascular Endothelial Growth Factor Receptor-2/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition.
    Autorzy:
    Elmeligie S; a Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy , Cairo University , Cairo , Egypt.
    Aboul-Magd AM; b Pharmaceutical Chemistry Department, Faculty of Pharmacy , Nahda University , Beni Suef , Egypt.
    Lasheen DS; c Pharmaceutical Chemistry Department, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt.
    Ibrahim TM; d Pharmaceutical Chemistry Department, Faculty of Pharmacy , Kafrelsheikh University , Kafr El-Sheikh , Egypt.
    Abdelghany TM; e Pharmacology and Toxicology Department, Faculty of Pharmacy , Al-Azhar University , Cairo , Egypt.
    Khojah SM; f Biochemistry Department, Faculty of science , King Abdulaziz University , Jedda , Kingdom of Saudi Arabia.
    Abouzid KAM; c Pharmaceutical Chemistry Department, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt.; g Department of Organic and Medicinal Chemistry, Faculty of Pharmacy , University of Sadat City , Sadat City , Egypt.
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    Źródło:
    Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 1347-1367.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Design*
    Antineoplastic Agents/*pharmacology
    Phthalazines/*pharmacology
    Protein Kinase Inhibitors/*pharmacology
    Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
    Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Phthalazines/chemical synthesis ; Phthalazines/chemistry ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers.
    Autorzy:
    El Newahie AMS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, October University for Modern Science and Arts (MSA), Cairo 12611, Egypt. .
    Nissan YM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. .; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Science and Arts (MSA), Cairo 12611, Egypt. .
    Ismail NSM; Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo 12311, Egypt. .
    Abou El Ella DA; Pharmaceutical Chemistry Department, Faculty of Pharmacy Ain Shams University, Abbassia, Cairo 11566, Egypt. .; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni Suef 62513, Egypt. .
    Khojah SM; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia. .
    Abouzid KAM; Pharmaceutical Chemistry Department, Faculty of Pharmacy Ain Shams University, Abbassia, Cairo 11566, Egypt. Khaled.abouzid@pharma.asu.edu.eg.; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia 32897, Egypt. Khaled.abouzid@pharma.asu.edu.eg.
    Pokaż więcej
    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Mar 25; Vol. 24 (6). Date of Electronic Publication: 2019 Mar 25.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Chemistry Techniques, Synthetic*
    Drug Design*
    Antineoplastic Agents/*chemistry
    Antineoplastic Agents/*pharmacology
    Apoptosis/*drug effects
    Quinoxalines/*chemistry
    Quinoxalines/*pharmacology
    Antineoplastic Agents/chemical synthesis ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Quinoxalines/chemical synthesis ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-16 z 16

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