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Tytuł:
Protein lysine acetylation does not contribute to the high rates of fatty acid oxidation seen in the post-ischemic heart.
Autorzy:
Ketema EB; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Ahsan M; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Zhang L; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Karwi QG; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Lopaschuk GD; Cardiovascular Research Centre, Department of Pediatrics, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 12; Vol. 14 (1), pp. 1193. Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:
Journal Article
MeSH Terms:
Myocardium*/metabolism
Lysine*/metabolism
Rats ; Animals ; Rats, Sprague-Dawley ; Acetylation ; Fatty Acids/metabolism ; Heart/physiology ; Ischemia/metabolism ; Glycolysis/physiology ; Glucose/metabolism ; Oxidation-Reduction ; Palmitates/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.
Autorzy:
Krošel M; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Gabathuler M; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Moser L; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Maciukiewicz M; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of BioMedical Research, University of Bern, Murtenstrasse 28, 3008, Bern, Switzerland.; Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, Bern, Switzerland.
Züllig T; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Seifritz T; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Tomšič M; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Distler O; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Ospelt C; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Klein K; Department of BioMedical Research, University of Bern, Murtenstrasse 28, 3008, Bern, Switzerland. .; Department of Rheumatology and Immunology, Inselspital, Bern University Hospital, Bern, Switzerland. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 10; Vol. 13 (1), pp. 17112. Date of Electronic Publication: 2023 Oct 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CREB-Binding Protein*/metabolism
p300-CBP Transcription Factors*/genetics
p300-CBP Transcription Factors*/metabolism
Humans ; Acetylation ; Fibroblasts/metabolism ; Hypoxia ; Proteasome Endopeptidase Complex/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigenetic profiles of elevated cell free circulating H3.1 nucleosomes as potential biomarkers for non-Hodgkin lymphoma.
Autorzy:
Van den Ackerveken P; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium.
Lobbens A; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium.
Pamart D; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium.
Kotronoulas A; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium.
Rommelaere G; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium.
Eccleston M; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium.
Herzog M; Belgian Volition SRL, 22 Rue Phocas Lejeune, Parc Scientifique Crealys, 5032, Isnes, Belgium. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 28; Vol. 13 (1), pp. 16335. Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Lymphoma, Non-Hodgkin*/diagnosis
Lymphoma, Non-Hodgkin*/genetics
Neoplasms*
Humans ; Nucleosomes ; Histones/metabolism ; Lysine/metabolism ; Protein Processing, Post-Translational ; Biomarkers/metabolism ; Epigenesis, Genetic ; Acetylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer.
Autorzy:
Wang Y; DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.
Liu Y; DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.
Wang C; DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, 510150, Guangdong, China.
Kang R; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Tang D; Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA. .
Liu J; DAMP Laboratory, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China. .; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, 510150, Guangdong, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 11; Vol. 13 (1), pp. 15004. Date of Electronic Publication: 2023 Sep 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Pancreatic Ductal*/genetics
E1A-Associated p300 Protein*
Endoplasmic Reticulum Chaperone BiP*
Ferroptosis*
Pancreatic Neoplasms*/genetics
Humans ; Acetylation ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correlation of N-acetyltransferase 2 genotype and acetylation status with plasma isoniazid concentration and its metabolic ratio in ethiopian tuberculosis patients.
Autorzy:
Sileshi T; Department of Pharmacy, Ambo University, Ambo, Ethiopia. .; Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia. .
Telele NF; Department of Laboratory Medicines, Karolinska Institutet, Stockholm, Sweden.
Burkley V; Department of Laboratory Medicines, Karolinska Institutet, Stockholm, Sweden.
Makonnen E; Department of Pharmacology and Clinical Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.; Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, Addis Ababa, Ethiopia.
Aklillu E; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 15; Vol. 13 (1), pp. 11438. Date of Electronic Publication: 2023 Jul 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Tuberculosis*/drug therapy
Tuberculosis*/genetics
Arylamine N-Acetyltransferase*/genetics
Arylamine N-Acetyltransferase*/metabolism
Male ; Female ; Humans ; Isoniazid/adverse effects ; Chromatography, Liquid ; Acetylation ; Tandem Mass Spectrometry ; Antitubercular Agents/adverse effects ; Genotype ; Acetyltransferases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
N-terminal acetylation can stabilize proteins independent of their ubiquitination.
Autorzy:
van de Kooij B; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. .; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. .; Department of Medical Oncology, University Medical Center Groningen, Groningen, the Netherlands. .
de Vries E; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, the Netherlands.
Rooswinkel RW; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Janssen GMC; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.
Kok FK; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Leiden Academic Centre for Drug Research, Leiden, the Netherlands.
van Veelen PA; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.
Borst J; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. .; Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, the Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2023 Apr 01; Vol. 13 (1), pp. 5333. Date of Electronic Publication: 2023 Apr 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysine*/metabolism
Proteome*/metabolism
Animals ; Humans ; Acetylation ; Protein Processing, Post-Translational ; Ubiquitination ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Coenzyme A binding sites induce proximal acylation across protein families.
Autorzy:
Carrico C; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Cruz A; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Walter M; Buck Institute for Research on Aging, Novato, CA, 94945, USA.; Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, WA, USA.
Meyer J; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Wehrfritz C; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Shah S; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Wei L; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Schilling B; Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Verdin E; Buck Institute for Research on Aging, Novato, CA, 94945, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 28; Vol. 13 (1), pp. 5029. Date of Electronic Publication: 2023 Mar 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Lysine*/metabolism
Acyl Coenzyme A*/metabolism
Acylation ; Acetylation ; Protein Processing, Post-Translational ; Binding Sites
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synaptic branch stability is mediated by non-enzymatic functions of MEC-17/αTAT1 and ATAT-2.
Autorzy:
Teoh JS; Neuroscience Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Vasudevan A; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
Wang W; Development and Stem Cells Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Dhananjay S; Neuroscience Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Chandhok G; Neuroscience Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Pocock R; Development and Stem Cells Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Koushika SP; Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India.
Neumann B; Neuroscience Program, Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 17; Vol. 12 (1), pp. 14003. Date of Electronic Publication: 2022 Aug 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Acetylation ; Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Animals ; Caenorhabditis elegans/metabolism ; Microtubules/metabolism ; Tubulin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Acetylome analysis of acetylation providing new insight into sclerotial generation in medicinal fungus Polyporus umbellatus.
Autorzy:
Li B; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, 100193, China.
Liu L; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, 100193, China.
Shan T; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, 100193, China.
Xing Y; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, 100193, China. .
Guo S; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, 100193, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 May 10; Vol. 12 (1), pp. 7629. Date of Electronic Publication: 2022 May 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ascomycota*/metabolism
Polyporus*
Acetylation ; Reactive Oxygen Species/metabolism
SCR Organism:
Polyporus umbellatus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates.
Autorzy:
Zhang H; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Rd NE, C3008, Atlanta, GA, 30322, USA.
Dammer EB; Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, 4133 Rollins Research Building, Atlanta, GA, 30322, USA.
Duong DM; Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, 4133 Rollins Research Building, Atlanta, GA, 30322, USA.
Danelia D; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Rd NE, C3008, Atlanta, GA, 30322, USA.
Seyfried NT; Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, 4133 Rollins Research Building, Atlanta, GA, 30322, USA. .
Yu DS; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Rd NE, C3008, Atlanta, GA, 30322, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 09; Vol. 12 (1), pp. 3822. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Colorectal Neoplasms*/genetics
Proteomics*
Sirtuin 2*/genetics
Acetylation ; Humans ; Lysine/metabolism ; Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells.
Autorzy:
Park M; Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jang S; Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
Chung JH; Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kwon O; Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea.; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jo SJ; Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea. .; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. .; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2021 Dec 15; Vol. 11 (1), pp. 24056. Date of Electronic Publication: 2021 Dec 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dermis/*cytology
Dermis/*physiology
Hair Follicle/*drug effects
Hair Follicle/*physiology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Acetylation ; Animals ; Biomarkers ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Histones/metabolism ; Lymphoid Enhancer-Binding Factor 1/genetics ; Lymphoid Enhancer-Binding Factor 1/metabolism ; Mice ; Stem Cells/drug effects ; Stem Cells/metabolism ; Wnt Signaling Pathway
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tandem Mass Tag labelling quantitative acetylome analysis of differentially modified proteins during mycoparasitism of Clonostachys chloroleuca 67-1.
Autorzy:
Jiang N; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Lv B; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Wu H; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Li S; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Sun M; Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 17; Vol. 11 (1), pp. 22383. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Processing, Post-Translational*
Proteome*
Proteomics*/methods
Hypocreales/*metabolism
Acetylation ; Amino Acid Motifs ; Amino Acid Sequence ; Fungal Proteins/chemistry ; Fungal Proteins/metabolism ; Hypocreales/genetics ; Protein Interaction Mapping ; Protein Interaction Maps
SCR Organism:
Clonostachys chloroleuca
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
PER2 mediates CREB-dependent light induction of the clock gene Per1.
Autorzy:
Brenna A; Department of Biology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.; Laboratory of Cardiovascular and Aging Research, Department of Endocrinology, Metabolism, Cardiovascular System, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Ripperger JA; Department of Biology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Saro G; Department of Biology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Glauser DA; Department of Biology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Yang Z; Laboratory of Cardiovascular and Aging Research, Department of Endocrinology, Metabolism, Cardiovascular System, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Albrecht U; Department of Biology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 05; Vol. 11 (1), pp. 21766. Date of Electronic Publication: 2021 Nov 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclic AMP Response Element-Binding Protein/*metabolism
Gene Expression Regulation/*radiation effects
Period Circadian Proteins/*metabolism
Acetylation ; Animals ; Chromatin/metabolism ; Male ; Mice ; Proto-Oncogene Proteins c-fos/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metacyclogenesis defects and gene expression hallmarks of histone deacetylase 4-deficient Trypanosoma cruzi cells.
Autorzy:
Picchi-Constante GFA; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil.
Guerra-Slompo EP; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil.
Tahira AC; Laboratório de Parasitologia, Instituto Butantan, São Paulo, SP, 05503-900, Brazil.
Alcantara MV; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil.
Amaral MS; Laboratório de Parasitologia, Instituto Butantan, São Paulo, SP, 05503-900, Brazil.
Ferreira AS; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil.
Batista M; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil.
Batista CM; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil.
Goldenberg S; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil.
Verjovski-Almeida S; Laboratório de Parasitologia, Instituto Butantan, São Paulo, SP, 05503-900, Brazil.; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, 05508-900, Brazil.
Zanchin NIT; Instituto Carlos Chagas, Fiocruz Paraná, Curitiba, Paraná, 81350-010, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 04; Vol. 11 (1), pp. 21671. Date of Electronic Publication: 2021 Nov 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation/*genetics
Histone Deacetylases/*deficiency
Histone Deacetylases/*genetics
Trypanosoma cruzi/*genetics
Acetylation ; Animals ; Cell Culture Techniques ; Chagas Disease/genetics ; Chlorocebus aethiops ; Chromatin/metabolism ; Gene Expression/genetics ; Humans ; Life Cycle Stages/genetics ; Protein Processing, Post-Translational/genetics ; Protozoan Proteins/genetics ; Repressor Proteins/deficiency ; Repressor Proteins/genetics ; Trypanosoma cruzi/metabolism ; Vero Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The effect of fatty diacid acylation of human PYY 3-36 on Y 2 receptor potency and half-life in minipigs.
Autorzy:
Østergaard S; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark. .
Paulsson JF; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Kofoed J; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Zosel F; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Olsen J; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Jeppesen CB; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Spetzler J; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Ynddal L; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.; Gubra Aps, Hørsholm Kongevej 11B, 2970, Hørsholm, Denmark.
Schleiss LG; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Christoffersen BØ; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Raun K; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Sensfuss U; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.; STipe Therapeutics, Copenhagen, Denmark.
Nielsen FS; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
Jørgensen R; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.; CitoKi Pharma, Værløse, Denmark.
Wulff BS; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Research Park, 2760, Maaloev, Denmark.
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Źródło:
Scientific reports [Sci Rep] 2021 Oct 27; Vol. 11 (1), pp. 21179. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji:
Journal Article
MeSH Terms:
Oligopeptides/*pharmacokinetics
Peptide YY/*chemistry
Receptors, Neuropeptide Y/*metabolism
Acetylation ; Animals ; Anti-Obesity Agents/administration & dosage ; Anti-Obesity Agents/therapeutic use ; CHO Cells ; Cricetinae ; Cricetulus ; Drug Combinations ; Fatty Acids/chemistry ; Female ; HEK293 Cells ; Half-Life ; Humans ; Liraglutide/administration & dosage ; Liraglutide/therapeutic use ; Obesity/drug therapy ; Oligopeptides/administration & dosage ; Oligopeptides/chemistry ; Oligopeptides/therapeutic use ; Protein Binding ; Swine ; Swine, Miniature
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
H3K23/H3K36 hypoacetylation and HDAC1 up-regulation are associated with adverse consequences in obstructive sleep apnea patients.
Autorzy:
Chen YC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan.; Sleep Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Department of Medicine, Chang Gung University, Taoyuan, Taiwan.
Hsu PY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan.; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Chin CH; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan.; Sleep Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Hsiao CC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan. .; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taouyan, 33302, Taiwan. .
Liou CW; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Wang TY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan.
Lin YY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan.
Lee CP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan.
Lin HC; Sleep Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Lin MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan. .; Sleep Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. .; Department of Medicine, Chang Gung University, Taoyuan, Taiwan. .
Su MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta-Pei Rd, Niao-Sung District, Kaohsiung City, Taiwan. .; Sleep Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. .; Chang Gung University of Science and Technology, Chia-yi, Taiwan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Oct 19; Vol. 11 (1), pp. 20697. Date of Electronic Publication: 2021 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Histone Deacetylase 1/*genetics
Histones/*genetics
Sleep Apnea, Obstructive/*genetics
Up-Regulation/*genetics
Acetylation ; Adult ; C-Reactive Protein/genetics ; Case-Control Studies ; Cohort Studies ; Continuous Positive Airway Pressure/methods ; DNA Methylation/genetics ; Disorders of Excessive Somnolence/genetics ; Female ; Humans ; Hypoxia/genetics ; Jumonji Domain-Containing Histone Demethylases/genetics ; Leukocytes, Mononuclear/physiology ; Male ; Middle Aged ; NADPH Oxidase 1/genetics ; Polysomnography/methods ; Promoter Regions, Genetic/genetics ; Sleep Apnea Syndromes/genetics ; Snoring/genetics ; THP-1 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Global analysis of lysine acetylation in soybean leaves.
Autorzy:
Li G; College of Agronomy, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
Zheng B; College of Agronomy, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
Zhao W; College of Agronomy, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
Ren T; College of Agronomy, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
Zhang X; College of Agronomy, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
Ning T; College of Agronomy, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China. .
Liu P; College of Agronomy, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China. .
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Źródło:
Scientific reports [Sci Rep] 2021 Sep 09; Vol. 11 (1), pp. 17858. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysine/*metabolism
Plant Leaves/*metabolism
Protein Processing, Post-Translational/*physiology
Glycine max/*metabolism
Acetylation ; Fabaceae/metabolism ; Oryza/metabolism ; Proteome/metabolism ; Proteomics/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice.
Autorzy:
Seo MK; Paik Institute for Clinical Research, Inje University, Busan, 47392, Republic of Korea.
Lee JG; Paik Institute for Clinical Research, Inje University, Busan, 47392, Republic of Korea. .; Department of Psychiatry, College of Medicine, Haeundae Paik Hospital, Inje University, Busan, 48108, Republic of Korea. .
Park SW; Paik Institute for Clinical Research, Inje University, Busan, 47392, Republic of Korea. .; Department of Convergence Biomedical Science, College of Medicine, Inje University, Busan, 47392, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2021 Sep 01; Vol. 11 (1), pp. 10663. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adverse Childhood Experiences/*psychology
Annexin A2/*genetics
DNA Methylation/*genetics
S100 Proteins/*genetics
Stress, Psychological/*genetics
Acetylation ; Animals ; CpG Islands/genetics ; Epigenesis, Genetic/genetics ; Hippocampus/physiopathology ; Histones/genetics ; Humans ; Maternal Deprivation ; Mice ; Promoter Regions, Genetic/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau-microtubule interactions and inhibits aggregation.
Autorzy:
Xia Y; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Bell BM; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Giasson BI; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. .; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA. .; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 23; Vol. 11 (1), pp. 17069. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Multimerization*
Protein Processing, Post-Translational*
Microtubules/*metabolism
tau Proteins/*metabolism
Acetylation ; Amino Acid Motifs ; HEK293 Cells ; Humans ; Mutation ; Protein Binding ; tau Proteins/chemistry ; tau Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interplay between p300 and HDAC1 regulate acetylation and stability of Api5 to regulate cell proliferation.
Autorzy:
Sharma VK; Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, Maharashtra, 411008, India.
Lahiri M; Department of Biology, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, Maharashtra, 411008, India. .
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Źródło:
Scientific reports [Sci Rep] 2021 Aug 12; Vol. 11 (1), pp. 16427. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation*
Apoptosis Regulatory Proteins/*metabolism
Histone Deacetylase 1/*metabolism
Nuclear Proteins/*metabolism
p300-CBP Transcription Factors/*metabolism
Acetylation ; Adenylate Kinase/metabolism ; Cell Cycle ; Cell Nucleus/metabolism ; Computer Simulation ; Cytoplasm/metabolism ; Humans ; Protein Binding ; Protein Stability ; Proto-Oncogene Proteins c-akt/metabolism ; Subcellular Fractions/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 1503

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