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Wyszukujesz frazę ""Acetylmuramyl-Alanyl-Isoglutamine"" wg kryterium: Temat


Tytuł:
Muramyl Dipeptide Administration Delays Alzheimer's Disease Physiopathology via NOD2 Receptors.
Autorzy:
Piec PA; Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul., Québec, QC G1V 4G2, Canada.
Pons V; Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul., Québec, QC G1V 4G2, Canada.
Préfontaine P; Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul., Québec, QC G1V 4G2, Canada.
Rivest S; Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boul., Québec, QC G1V 4G2, Canada.
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Źródło:
Cells [Cells] 2022 Jul 19; Vol. 11 (14). Date of Electronic Publication: 2022 Jul 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine*
Alzheimer Disease*/metabolism
Animals ; Female ; Male ; Membrane Glycoproteins/metabolism ; Mice ; Microglia/metabolism ; Monocytes/metabolism ; Plaque, Amyloid/metabolism ; Receptors, Immunologic/metabolism
Czasopismo naukowe
Tytuł:
Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3-triazole.
Autorzy:
Peroković VP; Department of Chemistry, Faculty of Science, University Zagreb, Horvatovac 102, HR-10000 Zagreb, Croatia.
Car Ž; Department of Chemistry, Faculty of Science, University Zagreb, Horvatovac 102, HR-10000 Zagreb, Croatia.
Draženović J; Department of Chemistry, Faculty of Science, University Zagreb, Horvatovac 102, HR-10000 Zagreb, Croatia.
Stojković R; Division of Molecular Medicine and Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Milković L; Division of Molecular Medicine and Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Antica M; Division of Molecular Medicine and Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Škalamera Đ; Department of Chemistry, Faculty of Science, University Zagreb, Horvatovac 102, HR-10000 Zagreb, Croatia.
Tomić S; Department of Chemistry, Faculty of Science, University Zagreb, Horvatovac 102, HR-10000 Zagreb, Croatia.
Ribić R; Department of Nursing, University Center Varaždin, University North, Jurja Križanića 31b, HR-42000 Varaždin, Croatia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 21; Vol. 26 (21). Date of Electronic Publication: 2021 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Chemistry Techniques, Synthetic*
Drug Design*
Acetylmuramyl-Alanyl-Isoglutamine/*chemistry
Acetylmuramyl-Alanyl-Isoglutamine/*pharmacology
Triazoles/*chemistry
Acetylmuramyl-Alanyl-Isoglutamine/chemical synthesis ; Animals ; Antibody Formation/drug effects ; Dose-Response Relationship, Drug ; Immunologic Factors/chemical synthesis ; Immunologic Factors/chemistry ; Immunologic Factors/pharmacology ; Mice ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Als3-Th-cell-epitopes plus the novel combined adjuvants of CpG, MDP, and FIA synergistically enhanced the immune response of recombinant TRAP derived from Staphylococcus aureus in mice.
Autorzy:
Ma J; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
Liu W; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
Wang B; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
Yu S; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
Yu L; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
Song B; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
Yu Y; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
Zhu Z; College of Animal Science and Veterinary Medicine, Bayi Agricultural University, Daqing, Heilongjiang, China.
Cui Y; College of Life Science and Technology, Bayi Agricultural University, Daqing, Heilongjiang, China.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2021 Sep; Vol. 9 (3), pp. 971-983. Date of Electronic Publication: 2021 May 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine*
Staphylococcus aureus*
Animals ; Epitopes ; Immunity ; Mice ; RNA, Bacterial
Czasopismo naukowe
Tytuł:
Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.
Autorzy:
Schwarzer M; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
Gautam UK; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.
Makki K; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.; CarMeN Laboratory, INSERM, INRAE, Université Claude Bernard Lyon 1, 69310 Pierre-Bénite, France.
Lambert A; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
Brabec T; Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Joly A; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
Šrůtková D; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.
Poinsot P; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.; CarMeN Laboratory, INSERM, INRAE, Université Claude Bernard Lyon 1, 69310 Pierre-Bénite, France.; Univ Lyon, Hospices Civil de Lyon, Gastro-enterology and Pediatric Nutrition, Hôpital Femme Mere Enfant, F-69500 Bron, France.
Novotná T; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.
Geoffroy S; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
Courtin P; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350 Jouy-en-Josas, France.
Hermanová PP; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.
Matos RC; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
Landry JJM; Genomics Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Gérard C; CarMeN Laboratory, INSERM, INRAE, Université Claude Bernard Lyon 1, 69310 Pierre-Bénite, France.
Bulteau AL; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
Hudcovic T; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.
Kozáková H; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.
Filipp D; Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Chapot-Chartier MP; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350 Jouy-en-Josas, France.
Šinkora M; Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, 54922 Novy Hradek, Czech Republic.
Peretti N; CarMeN Laboratory, INSERM, INRAE, Université Claude Bernard Lyon 1, 69310 Pierre-Bénite, France.; Univ Lyon, Hospices Civil de Lyon, Gastro-enterology and Pediatric Nutrition, Hôpital Femme Mere Enfant, F-69500 Bron, France.
Boneca IG; Institut Pasteur, Université Paris Cité, CNRS UMR6047, INSERM U1306, Biology and Genetics of the Bacterial Cell Wall Unit, F-75015 Paris, France.
Chamaillard M; University of Lille, Inserm, U1003, F-59000 Lille, France.
Vidal H; CarMeN Laboratory, INSERM, INRAE, Université Claude Bernard Lyon 1, 69310 Pierre-Bénite, France.
De Vadder F; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
Leulier F; Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL Lyon-1, F-69007 Lyon, France.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Feb 24; Vol. 379 (6634), pp. 826-833. Date of Electronic Publication: 2023 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Gastrointestinal Microbiome*/physiology
Intestines*/microbiology
Intestines*/physiology
Lactobacillaceae*/physiology
Malnutrition*/physiopathology
Malnutrition*/therapy
Nod2 Signaling Adaptor Protein*/metabolism
Growth*/drug effects
Growth*/physiology
Animals ; Mice ; Cell Wall/chemistry ; Epithelial Cells/microbiology ; Epithelial Cells/physiology ; Germ-Free Life ; Growth Disorders/physiopathology ; Growth Disorders/therapy ; Insulin/metabolism ; Insulin-Like Growth Factor I/metabolism ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/physiology ; Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Acetylmuramyl-Alanyl-Isoglutamine/therapeutic use
Czasopismo naukowe
Tytuł:
A Protective Role of NOD2 on Oxazolone-induced Intestinal Inflammation Through IL-1β-mediated Signalling Pathway.
Autorzy:
Secher T; INEM, Orléans University, CNRS UMR 7355, F-45071, Orléans, France.; CEPR, Tours University, INSERM U1100, F-37000, Tours, France.
Couturier A; INEM, Orléans University, CNRS UMR 7355, F-45071, Orléans, France.
Huot L; Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019-UMR 9017, F-59000, Lille, France.
Bouscayrol H; Service d'oncologie-radiothérapie, CHR d'Orléans-La Source, Orléans, France.
Grandjean T; Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019-UMR 9017, F-59000, Lille, France.
Boulard O; Laboratory of Cell Physiology, Inserm U1003, University of Lille, Lille, France.
Hot D; CEPR, Tours University, INSERM U1100, F-37000, Tours, France.; University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41-UAR 2014-PLBS, F-59000 Lille, France.
Ryffel B; INEM, Orléans University, CNRS UMR 7355, F-45071, Orléans, France.
Chamaillard M; Laboratory of Cell Physiology, Inserm U1003, University of Lille, Lille, France.
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Źródło:
Journal of Crohn's & colitis [J Crohns Colitis] 2023 Jan 27; Vol. 17 (1), pp. 111-122.
Typ publikacji:
Journal Article
MeSH Terms:
Oxazolone*/adverse effects
Colitis*/metabolism
Mice ; Animals ; Acetylmuramyl-Alanyl-Isoglutamine/adverse effects ; Acetylmuramyl-Alanyl-Isoglutamine/metabolism ; Inflammation ; Signal Transduction ; Nod2 Signaling Adaptor Protein/genetics ; Nod2 Signaling Adaptor Protein/metabolism
Czasopismo naukowe
Tytuł:
Further Insights on Structural Modifications of Muramyl Dipeptides to Study the Human NOD2 Stimulating Activity.
Autorzy:
Cheng WC; Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.; Department of Chemistry, National Cheng-Kung University, No.1, University Road, Tainan, 701, Taiwan.; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Road, Chiayi, 600, Taiwan.; Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No.100, Shin-Chuan 1st Road, Kaohsiung, 807, Taiwan.
You TY; Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.
Teo ZZ; Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.; School of Pharmacy, National Taiwan University, No. 17, Xuzhou Road, Taipei, 106, Taiwan.
Sayyad AA; Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.
Maharana J; Institute of Biological Chemistry Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.; Taiwan International Graduate Program (TIGP), Chemical biology and molecular Biophysics (CBMB), Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, No. 101, Sec. 2, Guangfu Rd., Hsinchu, 300, Taiwan.
Guo CW; Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.
Liang PH; School of Pharmacy, National Taiwan University, No. 17, Xuzhou Road, Taipei, 106, Taiwan.
Lin CS; Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.
Meng FC; Genomics Research Center, Academia Sinica, No. 128, Academia Road Sec. 2, Nangang District, Taipei, 115, Taiwan.
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Źródło:
Chemistry, an Asian journal [Chem Asian J] 2020 Nov 16; Vol. 15 (22), pp. 3836-3844. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*pharmacology
Nod2 Signaling Adaptor Protein/*metabolism
Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives ; Acetylmuramyl-Alanyl-Isoglutamine/chemistry ; Cell Line ; Humans ; Models, Molecular ; Molecular Conformation
Czasopismo naukowe
Tytuł:
Synthesis and Immunological Evaluation of Mannosylated Desmuramyl Dipeptides Modified by Lipophilic Triazole Substituents.
Autorzy:
Petrović Peroković V; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.
Car Ž; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.
Bušljeta M; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.
Mihelec D; Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.
Paurević M; Department of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8/A, 31000 Osijek, Croatia.
Ivanković S; Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia.
Stojković R; Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia.
Ribić R; University Center Varaždin, University North, Jurja Križanića 31b, 42000 Varaždin, Croatia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 03; Vol. 23 (15). Date of Electronic Publication: 2022 Aug 03.
Typ publikacji:
Journal Article
MeSH Terms:
Dipeptides*/pharmacology
Triazoles*/pharmacology
Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Adjuvants, Immunologic/pharmacology ; Animals ; Mice ; Ovalbumin
Czasopismo naukowe
Tytuł:
Squalane-based emulsion vaccine delivery system: composition with murabutide activate Th1 response.
Autorzy:
Kantipakala R; a Vaccine Immunology Laboratory, NPC Division , CSIR - Indian Institute of Chemical Technology , Hyderabad , India.
Bonam SR; a Vaccine Immunology Laboratory, NPC Division , CSIR - Indian Institute of Chemical Technology , Hyderabad , India.; b Academy of Scientific and Innovative Research CSIR - Indian Institute of Chemical Technology , Hyderabad , India.
Vemireddy S; a Vaccine Immunology Laboratory, NPC Division , CSIR - Indian Institute of Chemical Technology , Hyderabad , India.; b Academy of Scientific and Innovative Research CSIR - Indian Institute of Chemical Technology , Hyderabad , India.
Miryala S; a Vaccine Immunology Laboratory, NPC Division , CSIR - Indian Institute of Chemical Technology , Hyderabad , India.; b Academy of Scientific and Innovative Research CSIR - Indian Institute of Chemical Technology , Hyderabad , India.
Halmuthur M SK; a Vaccine Immunology Laboratory, NPC Division , CSIR - Indian Institute of Chemical Technology , Hyderabad , India.; b Academy of Scientific and Innovative Research CSIR - Indian Institute of Chemical Technology , Hyderabad , India.
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Źródło:
Pharmaceutical development and technology [Pharm Dev Technol] 2019 Mar; Vol. 24 (3), pp. 269-275. Date of Electronic Publication: 2018 Jul 04.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*analogs & derivatives
Adjuvants, Immunologic/*administration & dosage
Squalene/*analogs & derivatives
Vaccines/*administration & dosage
Acetylmuramyl-Alanyl-Isoglutamine/administration & dosage ; Acetylmuramyl-Alanyl-Isoglutamine/immunology ; Animals ; Antigens/immunology ; Cytokines/immunology ; Drug Delivery Systems ; Emulsions ; Fluorescein-5-isothiocyanate/chemistry ; Hexoses/chemistry ; Mice ; Mice, Inbred BALB C ; Ovalbumin/administration & dosage ; Ovalbumin/immunology ; Particle Size ; Poloxamer/chemistry ; RAW 264.7 Cells ; Squalene/chemistry ; Surface-Active Agents/chemistry ; Th1 Cells/immunology ; Th2 Cells/immunology
Czasopismo naukowe
Tytuł:
Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial).
Autorzy:
Barnes DJ; Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, Oxford, OX1 3RE, UK.
Dutton P; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK.
Bruland Ø; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Department of Oncology-Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Gelderblom H; Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands.
Faleti A; Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
Bühnemann C; Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, Oxford, OX1 3RE, UK.
van Maldegem A; Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, Oxford, OX1 3RE, UK.; Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands.
Johnson H; Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
Poulton L; Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
Love S; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK.
Tiemeier G; Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, Oxford, OX1 3RE, UK.; Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands.
van Beelen E; Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands.
Herbschleb K; Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
Haddon C; Department of Oncology Early Phase trials unit and Oncology Clinical Trials Office (OCTO), University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
Billingham L; Cancer Research Clinical Trials Unit (Cancer Sciences), Institute of Cancer and Genomic Sciences, Robert Aitken Building, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Bradley K; Department of Radiology, Churchill Hospital, Oxford University Hospitals Foundation Trust, Oxford, OX3 7LJ, UK.
Ferrari S; Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy.
Palmerini E; Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy.
Picci P; Istituti Ortopedici Rizzoli, Via C. Pupilli 1, 40136, Bologna, Italy.
Dirksen U; Pediatrics III, West German Cancer Centre Network Essen-Muenster, University Hospital Essen, Hufelanstr 55, Essen, 45147, Germany.
Strauss SJ; Department of Oncology, UCLH NHS Foundation Trust, 250 Euston Road, London, NW1 2PG, UK.
Hogendoorn PCW; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK.; Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands.
Buddingh E; Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands.
Blay JY; Universitè Lyon 1 Claude Bernard, Lyon, France.
Cleton-Jansen AM; Leiden University Medical Center, P.O. Box 9600, Postzone K1-P, 2300RC, Leiden, The Netherlands.
Hassan AB; Oxford Molecular Pathology Institute, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, and Oxford University Hospital NHS Trust, Oxford, OX1 3RE, UK. .; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences and Centre for Statistics in Medicine (CSM), University of Oxford, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Jun 08; Vol. 22 (1), pp. 629. Date of Electronic Publication: 2022 Jun 08.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms:
Bone Neoplasms*/pathology
Osteosarcoma*/pathology
Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives ; Bayes Theorem ; Biomarkers ; Humans ; Liposomes ; Neoplasm Recurrence, Local/drug therapy ; Phosphatidylethanolamines
Czasopismo naukowe
Tytuł:
Increased inflammatory responsiveness of peripheral blood mononuclear cells (PBMCs) to in vitro NOD2 ligand stimulation in patients with ankylosing spondylitis.
Autorzy:
Vanaki N; a Department of Biochemistry, Faculty of Medicine , Tehran University of Medical Sciences , Tehran , Iran.; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
Golmohammadi T; a Department of Biochemistry, Faculty of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
Jamshidi A; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
Akhtari M; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.; c Department of Cell and Molecular Biology , School of Biology, College of Science, University of Tehran , Tehran , Iran.
Vojdanian M; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
Mostafaei S; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
Poursani S; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
Ahmadzadeh N; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
Mahmoudi M; b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.
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Źródło:
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2018 Oct; Vol. 40 (5), pp. 393-400. Date of Electronic Publication: 2018 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*pharmacology
Leukocytes, Mononuclear/*immunology
Nod2 Signaling Adaptor Protein/*metabolism
Spondylitis, Ankylosing/*immunology
Acetylmuramyl-Alanyl-Isoglutamine/immunology ; Adult ; Cell Culture Techniques ; Cell Survival/drug effects ; Cell Survival/immunology ; Cells, Cultured ; Gene Expression/drug effects ; Gene Expression/immunology ; Humans ; Immunity, Innate/drug effects ; Immunity, Innate/genetics ; Interleukin-17/genetics ; Interleukin-17/immunology ; Interleukin-23 Subunit p19/genetics ; Interleukin-23 Subunit p19/immunology ; Leukocytes, Mononuclear/drug effects ; Male ; Nod2 Signaling Adaptor Protein/genetics ; Spondylitis, Ankylosing/blood
Czasopismo naukowe
Tytuł:
Valosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses.
Autorzy:
Ghalandary M; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Li Y; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Fröhlich T; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Munich, Germany.
Magg T; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Liu Y; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Rohlfs M; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Hollizeck S; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Conca R; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Schwerd T; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Uhlig HH; Translational Gastroenterology Unit and Department of Pediatrics, and Biomedical Research Centre, University of Oxford, Oxford, UK.
Bufler P; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.; Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin, Germany.
Koletzko S; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.; Department of Pediatrics, School of Medicine Collegium, Medicum University of Warmia and Mazury, Olsztyn, Poland.
Muise AM; SickKids Inflammatory Bowel Disease Center, Research Institute, Hospital for Sick Children, Toronto, ON, M5G1X8, Canada.; Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, M5G1X8, Canada.; VEO-IBD Consortium, University Hospital, LMU Munich, 80337, Munich, Germany.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G1X8, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, M5G1A8, Canada.
Snapper SB; VEO-IBD Consortium, University Hospital, LMU Munich, 80337, Munich, Germany.; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA.; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Hauck F; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.
Klein C; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany.; VEO-IBD Consortium, University Hospital, LMU Munich, 80337, Munich, Germany.; Gene Center, LMU Munich, Munich, Germany.; Deutsche Zentrum für Infektionsforschung (DZIF), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Kotlarz D; Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, Ludwig-Maximilians-Universität (LMU) Munich, 80337, Munich, Germany. .; VEO-IBD Consortium, University Hospital, LMU Munich, 80337, Munich, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 10; Vol. 12 (1), pp. 3906. Date of Electronic Publication: 2022 Mar 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endoplasmic Reticulum Stress*
Interleukin-8*/metabolism
Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Humans ; Nod2 Signaling Adaptor Protein/genetics ; Nod2 Signaling Adaptor Protein/metabolism ; Valosin Containing Protein/genetics ; Valosin Containing Protein/metabolism
Czasopismo naukowe
Tytuł:
Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity.
Autorzy:
Kitaura H; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Ishida M; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Kimura K; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Sugisawa H; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Kishikawa A; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Shima K; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Ogawa S; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Qi J; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Shen WR; Division of Orthodontics and Dentofacial Orthopedics, Department of Translational Medicine, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
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Źródło:
Analytical cellular pathology (Amsterdam) [Anal Cell Pathol (Amst)] 2018 Feb 14; Vol. 2018, pp. 8047610. Date of Electronic Publication: 2018 Feb 14 (Print Publication: 2018).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*pharmacology
Lipopolysaccharides/*pharmacology
Osteoclasts/*metabolism
Acetylmuramyl-Alanyl-Isoglutamine/chemistry ; Animals ; Bone Remodeling/drug effects ; Humans ; Lipopolysaccharides/chemistry ; Models, Biological ; Osteoclasts/drug effects
Czasopismo naukowe
Tytuł:
Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development.
Autorzy:
Pasco ST; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, 48160 Derio, Spain.
Anguita J; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE-Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, 48160 Derio, Spain.
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Źródło:
Cells [Cells] 2020 Sep 16; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Adaptive Immunity/*drug effects
BCG Vaccine/*administration & dosage
COVID-19/*prevention & control
Epigenesis, Genetic/*drug effects
Myeloid Cells/*drug effects
SARS-CoV-2/*pathogenicity
Tuberculosis, Pulmonary/*prevention & control
Acetylmuramyl-Alanyl-Isoglutamine/immunology ; Acetylmuramyl-Alanyl-Isoglutamine/metabolism ; COVID-19/immunology ; COVID-19/virology ; Cross Protection ; Epigenesis, Genetic/immunology ; Histones/genetics ; Histones/immunology ; Humans ; Mycobacterium tuberculosis ; Myeloid Cells/immunology ; Myeloid Cells/pathology ; Nod2 Signaling Adaptor Protein/genetics ; Nod2 Signaling Adaptor Protein/immunology ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Pathogen-Associated Molecular Pattern Molecules/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/immunology ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/immunology ; Tuberculosis, Pulmonary/immunology ; Tuberculosis, Pulmonary/microbiology
Czasopismo naukowe
Tytuł:
Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity.
Autorzy:
Chen KT; Genomics Research Center, Academia Sinica No. 128, Academia Road Sec. 2, Nankang District, Taipei, 115 (Taiwan).; School of Pharmacy, National Taiwan University, No. 17, Xuzhou Road, Taipei 100 (Taiwan).
Huang DY; Department of Pharmacology, National Taiwan University, No. 1, Jen-Ai Road, Sec. 1, Taipei 100 (Taiwan).
Chiu CH; Genomics Research Center, Academia Sinica No. 128, Academia Road Sec. 2, Nankang District, Taipei, 115 (Taiwan).
Lin WW; Department of Pharmacology, National Taiwan University, No. 1, Jen-Ai Road, Sec. 1, Taipei 100 (Taiwan). .
Liang PH; School of Pharmacy, National Taiwan University, No. 17, Xuzhou Road, Taipei 100 (Taiwan). .
Cheng WC; Genomics Research Center, Academia Sinica No. 128, Academia Road Sec. 2, Nankang District, Taipei, 115 (Taiwan). .
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2015 Aug 17; Vol. 21 (34), pp. 11984-8. Date of Electronic Publication: 2015 Jul 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*chemical synthesis
Immunity, Innate/*drug effects
Acetylmuramyl-Alanyl-Isoglutamine/chemistry ; Humans ; Ligands ; Molecular Structure
Czasopismo naukowe
Tytuł:
Species-specific engagement of human nucleotide oligomerization domain 2 (NOD)2 and Toll-like receptor (TLR) signalling upon intracellular bacterial infection: role of Crohn's associated NOD2 gene variants.
Autorzy:
Salem M; Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
Seidelin JB
Eickhardt S
Alhede M
Rogler G
Nielsen OH
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2015 Mar; Vol. 179 (3), pp. 426-34.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*immunology
Crohn Disease/*immunology
Leukocytes, Mononuclear/*immunology
Listeria monocytogenes/*immunology
Listeriosis/*immunology
Mycobacterium Infections/*immunology
Mycobacterium avium subsp. paratuberculosis/*immunology
Mycobacterium smegmatis/*immunology
Nod2 Signaling Adaptor Protein/*genetics
Acetylation ; Acetylmuramyl-Alanyl-Isoglutamine/analogs & derivatives ; Acetylmuramyl-Alanyl-Isoglutamine/chemistry ; Cells, Cultured ; Crohn Disease/etiology ; Crohn Disease/microbiology ; Cytokines/metabolism ; DNA Mutational Analysis ; Genetic Predisposition to Disease ; Glycols/chemistry ; Humans ; Immunity, Innate/genetics ; Intracellular Space/microbiology ; Leukocytes, Mononuclear/microbiology ; Listeriosis/complications ; Listeriosis/microbiology ; Lymphocyte Activation/genetics ; Mutation/genetics ; Mycobacterium Infections/complications ; Mycobacterium Infections/microbiology ; Mycobacterium smegmatis/genetics ; Nod2 Signaling Adaptor Protein/metabolism ; Polymorphism, Single Nucleotide ; Signal Transduction ; Species Specificity ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł:
Up-regulation of MDP and tuftsin gene expression in Th1 and Th17 cells as an adjuvant for an oral Lactobacillus casei vaccine against anti-transmissible gastroenteritis virus.
Autorzy:
Jiang X; Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, Heilongjiang, People's Republic of China.
Yu M
Qiao X
Liu M
Tang L
Jiang Y
Cui W
Li Y
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2014 Oct; Vol. 98 (19), pp. 8301-12. Date of Electronic Publication: 2014 Jul 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*genetics
Gastroenteritis, Transmissible, of Swine/*immunology
Lacticaseibacillus casei/*genetics
Th1 Cells/*immunology
Th17 Cells/*immunology
Transmissible gastroenteritis virus/*immunology
Tuftsin/*genetics
Viral Vaccines/*immunology
Acetylmuramyl-Alanyl-Isoglutamine/administration & dosage ; Acetylmuramyl-Alanyl-Isoglutamine/immunology ; Administration, Oral ; Animals ; Female ; Gastroenteritis, Transmissible, of Swine/prevention & control ; Gastroenteritis, Transmissible, of Swine/virology ; Lacticaseibacillus casei/immunology ; Male ; Mice ; Spike Glycoprotein, Coronavirus/administration & dosage ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Swine ; Transmissible gastroenteritis virus/genetics ; Tuftsin/administration & dosage ; Tuftsin/immunology ; Up-Regulation ; Viral Vaccines/administration & dosage ; Viral Vaccines/genetics
Czasopismo naukowe
Tytuł:
The Role of the Bacterial Muramyl Dipeptide in the Regulation of GLP-1 and Glycemia.
Autorzy:
Williams L; Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Alshehri A; Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Robichaud B; Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Cudmore A; Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
Gagnon J; Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 24; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 24.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylmuramyl-Alanyl-Isoglutamine/*pharmacology
Glucagon-Like Peptide 1/*metabolism
Hyperglycemia/*metabolism
Obesity/*metabolism
Animals ; Dietary Fats/adverse effects ; Dietary Fats/pharmacology ; Female ; Humans ; Hyperglycemia/chemically induced ; Hyperglycemia/pathology ; Male ; Mice ; Nod2 Signaling Adaptor Protein/metabolism ; Obesity/chemically induced ; Obesity/pathology
Czasopismo naukowe
Tytuł:
Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease.
Autorzy:
Fani Maleki A; Neuroscience Laboratory, CHU de Quebec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada.
Cisbani G; Neuroscience Laboratory, CHU de Quebec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada.
Plante MM; Neuroscience Laboratory, CHU de Quebec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada.
Préfontaine P; Neuroscience Laboratory, CHU de Quebec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada.
Laflamme N; Neuroscience Laboratory, CHU de Quebec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada.
Gosselin J; Laboratory of Innate Immunity, CHU of Quebec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada.
Rivest S; Neuroscience Laboratory, CHU de Quebec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2020 Jul 22; Vol. 17 (1), pp. 218. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/immunology
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Immunomodulation*
Acetylmuramyl-Alanyl-Isoglutamine/*pharmacology
Brain/*drug effects
Monocytes/*drug effects
Amyloid beta-Protein Precursor/genetics ; Animals ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neuronal Plasticity/drug effects ; Presenilin-1/genetics
Czasopismo naukowe
Tytuł:
BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations.
Autorzy:
Mourits VP; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.
Koeken VACM; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.
de Bree LCJ; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.; Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, 2300 Copenhagen, Denmark.; Odense Patient Data Explorative Network, University of Southern Denmark/Odense University Hospital, 5000 Odense, Denmark.
Moorlag SJCFM; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.
Chu WC; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Queenstown, Singapore 138673.
Xu X; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Queenstown, Singapore 138673.
Dijkstra H; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.
Lemmers H; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.
Joosten LAB; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Wang Y; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Queenstown, Singapore 138673.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Queenstown, Singapore 119228.
van Crevel R; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.
Netea MG; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6525 Nijmegen, Netherlands.; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany.
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Źródło:
Journal of immunology research [J Immunol Res] 2020 Jun 15; Vol. 2020, pp. 5812743. Date of Electronic Publication: 2020 Jun 15 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Immunity*
BCG Vaccine/*immunology
Host-Pathogen Interactions/*immunology
Acetylmuramyl-Alanyl-Isoglutamine/blood ; Adolescent ; Adult ; Aged ; Biomarkers ; Blood Cell Count ; Cytokines/metabolism ; Female ; Healthy Volunteers ; Humans ; Immunization ; Leukocytes, Mononuclear ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł:
Synthetic mycobacterial molecular patterns partially complete Freund's adjuvant.
Autorzy:
Dubé JY; Department of Microbiology and Immunology, McGill University, Montréal, Canada. .; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada. .; McGill International TB Centre, Montréal, Canada. .
McIntosh F; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada.; McGill International TB Centre, Montréal, Canada.
Zarruk JG; Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montréal, Canada.
David S; Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montréal, Canada.
Nigou J; Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, Toulouse, France.
Behr MA; Department of Microbiology and Immunology, McGill University, Montréal, Canada. .; Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, Canada. .; McGill International TB Centre, Montréal, Canada. .; Department of Medicine, McGill University Health Centre, Montréal, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2020 Apr 03; Vol. 10 (1), pp. 5874. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Freund's Adjuvant/*metabolism
Mycobacterium/*metabolism
Acetylmuramyl-Alanyl-Isoglutamine/metabolism ; Animals ; Dendritic Cells/metabolism ; Female ; Freund's Adjuvant/pharmacology ; Immunity, Cellular/drug effects ; Lectins, C-Type/metabolism ; Lymph Nodes/metabolism ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nod2 Signaling Adaptor Protein/metabolism ; Peptidoglycan/metabolism
Czasopismo naukowe

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