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Tytuł :
Plasma levels of nitric oxide metabolites are markedly reduced in normotensive men with electrocardiographically determined left ventricular hypertrophy.
Autorzy :
Kamezaki F; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.). .
Tsutsui M; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Takahashi M; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Sonoda S; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Kubo T; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Fujino Y; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Adachi T; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Abe H; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Takeuchi M; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Mayumi T; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
Otsuji Y; From the Department of Emergency Medicine (F.K., T.M.), Second Department of Internal Medicine (M. Takahashi, S.S., H.A., M. Takeuchi, Y.O.), and Department of Public Health (T.K., Y.F.), School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M. Tsutsui); and Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan (T.A.).
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2014 Sep; Vol. 64 (3), pp. 516-22. Date of Electronic Publication: 2014 Jun 09.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electrocardiography*
Blood Pressure/*physiology
Hypertrophy, Left Ventricular/*blood
Nitric Oxide/*blood
Adult ; Biomarkers/blood ; Dinoprost/analogs & derivatives ; Dinoprost/blood ; Humans ; Hypertrophy, Left Ventricular/physiopathology ; Japan ; Lipid Peroxidation/physiology ; Male ; Middle Aged ; Nitrates/blood ; Nitrites/blood ; Oxidative Stress/physiology ; Prevalence ; Risk Factors ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Newly synthesized 'hidabeni' chalcone derivatives potently suppress LPS-induced NO production via inhibition of STAT1, but not NF-κB, JNK, and p38, pathways in microglia.
Autorzy :
Hara H; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University.
Ikeda R
Ninomiya M
Kamiya T
Koketsu M
Adachi T
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (6), pp. 1042-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chalcone*/analogs & derivatives
Chalcone*/chemical synthesis
Chalcone*/pharmacology
MAP Kinase Signaling System/*drug effects
Microglia/*drug effects
NF-kappa B/*metabolism
Nitric Oxide/*antagonists & inhibitors
STAT1 Transcription Factor/*antagonists & inhibitors
Animals ; Cell Culture Techniques ; Cell Line ; Lipopolysaccharides/pharmacology ; Microglia/enzymology ; Microglia/metabolism ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type II/genetics ; Rats
Czasopismo naukowe
Tytuł :
Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in the silkworm Bombyx mori.
Autorzy :
Ishii K; Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
Adachi T
Hamamoto H
Oonishi T
Kamimura M
Imamura K
Sekimizu K
Pokaż więcej
Źródło :
Developmental and comparative immunology [Dev Comp Immunol] 2013 Mar; Vol. 39 (3), pp. 147-53. Date of Electronic Publication: 2012 Nov 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bombyx/*immunology
Cytokines/*immunology
Insect Proteins/*metabolism
Neuropeptides/*immunology
Nitric Oxide/*metabolism
Nitric Oxide Synthase/*metabolism
Staphylococcus aureus/*immunology
Animals ; Apoptosis/drug effects ; Bombyx/microbiology ; Cells, Cultured ; Cytokines/chemical synthesis ; Immunity, Innate/drug effects ; Insect Proteins/genetics ; Muscle Contraction/drug effects ; NG-Nitroarginine Methyl Ester/pharmacology ; Neuropeptides/administration & dosage ; Neuropeptides/chemical synthesis ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/genetics ; Paralysis/etiology ; Paralysis/prevention & control ; Signal Transduction/drug effects ; Up-Regulation/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia.
Autorzy :
Hara H; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan. />Nakamura Y
Ninomiya M
Mochizuki R
Kamiya T
Aizenman E
Koketsu M
Adachi T
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2011 Sep 15; Vol. 19 (18), pp. 5559-68. Date of Electronic Publication: 2011 Jul 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brassica rapa/*chemistry
Chalcone/*pharmacology
Glycosides/*pharmacology
Lipopolysaccharides/*pharmacology
Microglia/*drug effects
Nitric Oxide/*biosynthesis
Animals ; Cells, Cultured ; Chalcone/chemistry ; Chalcone/isolation & purification ; Dose-Response Relationship, Drug ; Glycosides/chemistry ; Glycosides/isolation & purification ; Microglia/cytology ; Microglia/metabolism ; Molecular Structure ; Rats ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
High glucose oxidizes SERCA cysteine-674 and prevents inhibition by nitric oxide of smooth muscle cell migration.
Autorzy :
Tong X; Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, X720, 650 Albany Street, Boston, MA 02118, USA. />Ying J
Pimentel DR
Trucillo M
Adachi T
Cohen RA
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Źródło :
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2008 Feb; Vol. 44 (2), pp. 361-9. Date of Electronic Publication: 2007 Nov 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Movement/*drug effects
Cysteine/*metabolism
Glucose/*pharmacology
Myocytes, Smooth Muscle/*cytology
Myocytes, Smooth Muscle/*enzymology
Nitric Oxide/*pharmacology
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*metabolism
Animals ; Biotinylation ; Calcineurin/metabolism ; Calcium/pharmacology ; Calmodulin/metabolism ; Cyclic N-Oxides/pharmacology ; Glutathione/metabolism ; Humans ; Iodoacetamide ; Mannose/pharmacology ; Myocytes, Smooth Muscle/drug effects ; Nitric Oxide Donors/pharmacology ; Nitric Oxide Synthase Type II/metabolism ; Oxidation-Reduction/drug effects ; Rats ; S-Nitroso-N-Acetylpenicillamine/pharmacology ; Spin Labels ; Sulfonic Acids/pharmacology ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Cysteine-674 of the sarco/endoplasmic reticulum calcium ATPase is required for the inhibition of cell migration by nitric oxide.
Autorzy :
Ying J; Vascular Biology Unit, Boston University School of Medicine, Boston, MA 02118, USA.
Tong X
Pimentel DR
Weisbrod RM
Trucillo MP
Adachi T
Cohen RA
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2007 Apr; Vol. 27 (4), pp. 783-90. Date of Electronic Publication: 2007 Jan 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Movement*/drug effects
Cell Movement*/physiology
Muscle, Smooth, Vascular/*cytology
Myocytes, Smooth Muscle/*physiology
Nitric Oxide/*pharmacology
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*genetics
Sarcoplasmic Reticulum Calcium-Transporting ATPases/*metabolism
Amino Acid Sequence ; Animals ; Aorta/cytology ; Calcium/metabolism ; Cells, Cultured ; Cyclic GMP/metabolism ; Cysteine ; Glutathione/metabolism ; Humans ; Mutation ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Oxidation-Reduction ; Rats ; Transfection
Czasopismo naukowe
Tytuł :
Nitric-oxide-induced vasodilatation: regulation by physiologic s-glutathiolation and pathologic oxidation of the sarcoplasmic endoplasmic reticulum calcium ATPase.
Autorzy :
Cohen RA; Vascular Biology Unit, Robert Dawson Evans Department of Medicine, Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA. />Adachi T
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Źródło :
Trends in cardiovascular medicine [Trends Cardiovasc Med] 2006 May; Vol. 16 (4), pp. 109-14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Calcium-Transporting ATPases/*metabolism
Endothelium-Dependent Relaxing Factors/*pharmacology
Glutathione/*metabolism
Muscle, Smooth, Vascular/*physiology
Nitric Oxide/*pharmacology
Oxidative Stress/*physiology
Vasodilation/*physiology
Animals ; Humans ; Muscle, Smooth, Vascular/drug effects ; Sarcoplasmic Reticulum Calcium-Transporting ATPases ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Carbon monoxide from heme oxygenase-2 Is a tonic regulator against NO-dependent vasodilatation in the adult rat cerebral microcirculation.
Autorzy :
Ishikawa M; Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan.
Kajimura M
Adachi T
Maruyama K
Makino N
Goda N
Yamaguchi T
Sekizuka E
Suematsu M
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Źródło :
Circulation research [Circ Res] 2005 Dec 09; Vol. 97 (12), pp. e104-14. Date of Electronic Publication: 2005 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebrovascular Circulation*
Vasodilation*
Carbon Monoxide/*physiology
Heme Oxygenase (Decyclizing)/*physiology
Nitric Oxide/*physiology
Animals ; Arterioles/physiology ; Brain/metabolism ; Cells, Cultured ; Cerebral Arteries/physiology ; Endothelial Cells/metabolism ; Heme Oxygenase (Decyclizing)/analysis ; Male ; Nitric Oxide Synthase/antagonists & inhibitors ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway.
Autorzy :
Takabuchi S; Department of Anesthesia, The Tazuke Kofukai Medical Research Institute Kitano Hospital, Osaka, Japan.
Hirota K
Nishi K
Oda S
Oda T
Shingu K
Takabayashi A
Adachi T
Semenza GL
Fukuda K
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2004 Nov 05; Vol. 324 (1), pp. 417-23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Signal Transduction*
DNA-Binding Proteins/*metabolism
Nitric Oxide/*metabolism
Nitric Oxide Donors/*pharmacology
Nitroprusside/*pharmacology
Nuclear Proteins/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Transcription Factors/*metabolism
Animals ; Cell Line ; Cyclic N-Oxides/chemistry ; Cyclic N-Oxides/metabolism ; DNA-Binding Proteins/genetics ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/metabolism ; Guanylate Cyclase ; Humans ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit ; Imidazoles/chemistry ; Imidazoles/metabolism ; Isosorbide Dinitrate/metabolism ; Nitric Oxide Donors/metabolism ; Nitroglycerin/metabolism ; Nitroprusside/metabolism ; Nuclear Proteins/genetics ; Oxygen/metabolism ; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors ; Soluble Guanylyl Cyclase ; Transcription Factors/genetics ; Transcription, Genetic ; Vasodilator Agents/metabolism
Czasopismo naukowe
Tytuł :
S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide.
Autorzy :
Adachi T; Vascular and Myocardial Biology Units, Whitaker Cardiovascular Institute, Boston University Medical Center, X707, 650 Albany Street, Boston, Massachusetts 02118-2393, USA. />Weisbrod RM
Pimentel DR
Ying J
Sharov VS
Schöneich C
Cohen RA
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Źródło :
Nature medicine [Nat Med] 2004 Nov; Vol. 10 (11), pp. 1200-7. Date of Electronic Publication: 2004 Oct 17.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Arteriosclerosis/*metabolism
Calcium/*metabolism
Calcium-Transporting ATPases/*metabolism
Glutathione/*metabolism
Muscle, Smooth, Vascular/*metabolism
Nitric Oxide/*metabolism
Peroxynitrous Acid/*metabolism
Animals ; Calcium-Transporting ATPases/genetics ; Cells, Cultured ; Chromatography, High Pressure Liquid ; DNA Primers ; Humans ; Immunoprecipitation ; Mass Spectrometry ; Mice ; Mice, Transgenic ; Mutagenesis ; Mutation/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases
Czasopismo naukowe
Tytuł :
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling.
Autorzy :
Kasuno K; Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, IKEDA, Osaka, Japan 563-0053.
Takabuchi S
Fukuda K
Kizaka-Kondoh S
Yodoi J
Adachi T
Semenza GL
Hirota K
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2004 Jan 23; Vol. 279 (4), pp. 2550-8. Date of Electronic Publication: 2003 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription Factors*
DNA-Binding Proteins/*biosynthesis
Nitric Oxide/*metabolism
Nuclear Proteins/*biosynthesis
Phosphatidylinositol 3-Kinases/*metabolism
Cell Line ; Humans ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit ; MAP Kinase Signaling System/drug effects ; Nitric Oxide Donors/pharmacology ; Nitroso Compounds/pharmacology ; S-Nitrosoglutathione/pharmacology
Czasopismo naukowe
Tytuł :
Nitric oxide and its decomposed derivatives decrease the binding of extracellular-superoxide dismutase to the endothelial cell surface.
Autorzy :
Yamamoto M; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.
Hara H
Adachi T
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Źródło :
FEBS letters [FEBS Lett] 2001 Sep 14; Vol. 505 (2), pp. 296-300.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Membrane/*enzymology
Cell Membrane/*metabolism
Endothelium, Vascular/*cytology
Extracellular Matrix/*enzymology
Nitric Oxide/*metabolism
Superoxide Dismutase/*metabolism
Animals ; Cattle ; Cells, Cultured ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Heparin/metabolism ; Humans ; Inflammation/enzymology ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Nitric Oxide Donors/pharmacology ; Nitrites/metabolism ; Oxidative Stress ; Penicillamine/analogs & derivatives ; Penicillamine/pharmacology ; Protein Binding ; Proteoglycans/metabolism ; Pyridines/pharmacology ; Umbilical Veins/cytology
Czasopismo naukowe
Tytuł :
Reduced sarco/endoplasmic reticulum Ca(2+) uptake activity can account for the reduced response to NO, but not sodium nitroprusside, in hypercholesterolemic rabbit aorta.
Autorzy :
Adachi T; Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University Medical Center, Boston, MA, USA.
Matsui R
Weisbrod RM
Najibi S
Cohen RA
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Źródło :
Circulation [Circulation] 2001 Aug 28; Vol. 104 (9), pp. 1040-5.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Aorta, Thoracic/*drug effects
Calcium-Transporting ATPases/*metabolism
Hypercholesterolemia/*physiopathology
Nitric Oxide/*pharmacology
Nitroprusside/*pharmacology
Acetylcholine/pharmacology ; Animals ; Aorta, Thoracic/metabolism ; Aorta, Thoracic/physiopathology ; Calcium/pharmacokinetics ; Cells, Cultured ; Dose-Response Relationship, Drug ; Endothelium, Vascular/physiology ; Ethylenediamines/pharmacology ; Free Radical Scavengers/pharmacology ; Hypercholesterolemia/metabolism ; In Vitro Techniques ; Indoles/pharmacology ; Male ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Organometallic Compounds/pharmacology ; Oxadiazoles/pharmacology ; Quinoxalines/pharmacology ; Rabbits ; Sarcoplasmic Reticulum/drug effects ; Sarcoplasmic Reticulum/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases ; Superoxide Dismutase/pharmacology ; Thapsigargin/pharmacology ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells.
Autorzy :
Hara H; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan. />Mitani N
Adachi T
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Źródło :
Free radical research [Free Radic Res] 2000 Sep; Vol. 33 (3), pp. 279-85.
Typ publikacji :
Journal Article
MeSH Terms :
Caco-2 Cells/*enzymology
Calcitriol/*pharmacology
Cytochrome P-450 Enzyme System/*genetics
Gene Expression/*drug effects
Mixed Function Oxygenases/*genetics
Nitric Oxide/*pharmacology
RNA, Messenger/*biosynthesis
Cytochrome P-450 CYP3A ; Drug Stability ; Enzyme Inhibitors/pharmacology ; Guanylate Cyclase/antagonists & inhibitors ; Humans ; Oxadiazoles/pharmacology ; Quinoxalines/pharmacology
Czasopismo naukowe
Tytuł :
Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia.
Autorzy :
Adachi T; Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston Medical Center, Boston, Massachusetts, MA 02118, USA.
Cohen RA
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2000 Mar; Vol. 129 (5), pp. 1014-20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Aorta, Thoracic/*metabolism
Glutathione/*metabolism
Hypercholesterolemia/*metabolism
Muscle, Smooth, Vascular/*metabolism
Nitric Oxide/*pharmacology
Acetylcholine/pharmacology ; Animals ; Aorta, Thoracic/drug effects ; Carmustine/pharmacology ; Diamide/pharmacology ; Diet, Atherogenic ; Isometric Contraction/drug effects ; Male ; Muscle Relaxation/drug effects ; NADP/metabolism ; Nitroprusside/pharmacology ; Oxidants/pharmacology ; Rabbits ; Sulfhydryl Reagents/pharmacology ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Plasma levels of extracellular superoxide dismutase in an Australian population: genetic contribution to normal variation and correlations with plasma nitric oxide and apolipoprotein A-I levels.
Autorzy :
Mahaney MC; Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. />Czerwinski SA
Adachi T
Wilcken DE
Wang XL
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2000 Mar; Vol. 20 (3), pp. 683-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Genetic Variation*
Apolipoprotein A-I/*blood
Nitric Oxide/*blood
Superoxide Dismutase/*blood
Superoxide Dismutase/*genetics
Adult ; Australia ; Family Health ; Female ; Humans ; Male ; Middle Aged ; Point Mutation ; Reference Values ; Sex Factors
Czasopismo naukowe
Tytuł :
Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.
Autorzy :
Adachi T; Department of Internal Medicine, Keio University, Tokyo, Japan.
Hori S
Miyazaki K
Nakagawa M
Inoue S
Ohnishi Y
Nakazawa H
Aikawa N
Ogawa S
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Źródło :
Shock (Augusta, Ga.) [Shock] 1998 Mar; Vol. 9 (3), pp. 204-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Myocardial Ischemia/*metabolism
NG-Nitroarginine Methyl Ester/*pharmacology
Nitric Oxide/*metabolism
Shock, Hemorrhagic/*complications
Adenosine Triphosphate/metabolism ; Animals ; Aorta/physiology ; Catecholamines/blood ; Disease Models, Animal ; Dogs ; Enzyme Inhibitors/pharmacology ; Fluorescence ; Freezing ; Hemodynamics ; Lactic Acid/metabolism ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/pathology ; NAD/metabolism ; Oxygen/metabolism ; Shock, Hemorrhagic/drug therapy ; Shock, Hemorrhagic/metabolism
Czasopismo naukowe

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