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Wyświetlanie 1-17 z 17
Tytuł :
Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats.
Autorzy :
Molina DP; Departments of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1010, USA.
Ariwodola OJ
Weiner JL
Brunso-Bechtold JK
Adams MM
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Źródło :
Age (Dordrecht, Netherlands) [Age (Dordr)] 2013 Oct; Vol. 35 (5), pp. 1575-87. Date of Electronic Publication: 2012 Aug 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*metabolism
Growth Hormone/*pharmacology
Hippocampus/*metabolism
Insulin-Like Growth Factor I/*pharmacology
Aging/drug effects ; Animals ; Cognition Disorders/drug therapy ; Cognition Disorders/metabolism ; Cognition Disorders/physiopathology ; Disease Models, Animal ; Hippocampus/drug effects ; Male ; Rats ; Rats, Inbred BN ; Rats, Inbred F344 ; Synaptic Transmission/drug effects
Czasopismo naukowe
Tytuł :
Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I.
Autorzy :
Adams MM; Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1010, USA.
Elizabeth Forbes M
Constance Linville M
Riddle DR
Sonntag WE
Brunso-Bechtold JK
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Źródło :
Growth factors (Chur, Switzerland) [Growth Factors] 2009 Jun; Vol. 27 (3), pp. 181-8.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Dwarfism/*metabolism
Hippocampus/*metabolism
Insulin-Like Growth Factor I/*metabolism
Animals ; Caloric Restriction ; Hippocampus/blood supply ; Male ; Rats
Czasopismo naukowe
Tytuł :
Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability.
Autorzy :
Adams MM; Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. />Shi L
Linville MC
Forbes ME
Long AB
Bennett C
Newton IG
Carter CS
Sonntag WE
Riddle DR
Brunso-Bechtold JK
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Źródło :
Experimental neurology [Exp Neurol] 2008 May; Vol. 211 (1), pp. 141-9. Date of Electronic Publication: 2008 Feb 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caloric Restriction*
Aging/*physiology
Hippocampus/*physiology
Learning/*physiology
Receptors, Glutamate/*metabolism
Space Perception/*physiology
Age Factors ; Analysis of Variance ; Animals ; Behavior, Animal ; Gene Expression Regulation ; Male ; Maze Learning ; Rats ; Receptors, Glutamate/classification ; Swimming
Czasopismo naukowe
Tytuł :
Estrogen and aging affect synaptic distribution of phosphorylated LIM kinase (pLIMK) in CA1 region of female rat hippocampus.
Autorzy :
Yildirim M; Department of Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Janssen WG
Tabori NE
Adams MM
Yuen GS
Akama KT
McEwen BS
Milner TA
Morrison JH
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Źródło :
Neuroscience [Neuroscience] 2008 Mar 18; Vol. 152 (2), pp. 360-70. Date of Electronic Publication: 2008 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aging/*physiology
Estradiol/*pharmacology
Estrogens/*pharmacology
Hippocampus/*cytology
Lim Kinases/*metabolism
Synapses/*drug effects
Age Factors ; Animals ; Estrogen Receptor alpha/metabolism ; Female ; Hippocampus/drug effects ; Microscopy, Immunoelectron/methods ; Ovariectomy ; Phosphorylation ; Rats ; Rats, Sprague-Dawley ; Synapses/enzymology ; Synapses/ultrastructure
Czasopismo naukowe
Tytuł :
Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis.
Autorzy :
Shi L; Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157-1010, USA. />Adams MM
Linville MC
Newton IG
Forbes ME
Long AB
Riddle DR
Brunso-Bechtold JK
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Źródło :
Experimental neurology [Exp Neurol] 2007 Jul; Vol. 206 (1), pp. 70-9. Date of Electronic Publication: 2007 Apr 04.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caloric Restriction*
Cognition Disorders/*prevention & control
Hippocampus/*metabolism
Homeostasis/*physiology
Memory Disorders/*prevention & control
Receptors, Glutamate/*metabolism
Aging/physiology ; Animals ; Cognition Disorders/metabolism ; Cognition Disorders/physiopathology ; Dendritic Spines/metabolism ; Dendritic Spines/ultrastructure ; Down-Regulation/physiology ; Hippocampus/physiopathology ; Hippocampus/ultrastructure ; Longevity/physiology ; Male ; Memory Disorders/metabolism ; Memory Disorders/physiopathology ; Microscopy, Electron, Transmission ; Protein Subunits/metabolism ; Rats ; Rats, Inbred F344 ; Receptors, AMPA/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/metabolism ; Synapses/ultrastructure ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus.
Autorzy :
Shi L; Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA. />Adams MM
Long A
Carter CC
Bennett C
Sonntag WE
Nicolle MM
Robbins M
D'Agostino R
Brunso-Bechtold JK
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Źródło :
Radiation research [Radiat Res] 2006 Dec; Vol. 166 (6), pp. 892-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain Injuries/*metabolism
Hippocampus/*physiology
Hippocampus/*radiation effects
Memory Disorders/*etiology
Memory Disorders/*metabolism
Radiation Injuries/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Brain Injuries/etiology ; Male ; Organ Specificity ; Protein Subunits/metabolism ; Radiation Dosage ; Radiation Injuries/etiology ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Tytuł :
Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus.
Autorzy :
Ramsey MM; Department of Physiology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1083, USA.
Adams MM
Ariwodola OJ
Sonntag WE
Weiner JL
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Źródło :
Journal of neurophysiology [J Neurophysiol] 2005 Jul; Vol. 94 (1), pp. 247-54.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Hippocampus/*cytology
Insulin-Like Growth Factor I/*pharmacology
Neurons/*drug effects
Synapses/*drug effects
Synaptic Transmission/*drug effects
Androstadienes/pharmacology ; Animals ; Animals, Newborn ; Dose-Response Relationship, Drug ; Drug Interactions ; Electric Stimulation/methods ; Enzyme Inhibitors/pharmacology ; Excitatory Amino Acid Agonists/pharmacology ; Excitatory Postsynaptic Potentials/drug effects ; Genistein/pharmacology ; Hippocampus/physiology ; In Vitro Techniques ; Male ; Neurons/physiology ; Patch-Clamp Techniques/methods ; Rats ; Rats, Sprague-Dawley ; Wortmannin ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Estrogen modulates synaptic N-methyl-D-aspartate receptor subunit distribution in the aged hippocampus.
Autorzy :
Adams MM; Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA.
Fink SE
Janssen WG
Shah RA
Morrison JH
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Źródło :
The Journal of comparative neurology [J Comp Neurol] 2004 Jun 28; Vol. 474 (3), pp. 419-26.
Typ publikacji :
Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Aging/*drug effects
Estrogens/*pharmacology
Hippocampus/*drug effects
Receptors, N-Methyl-D-Aspartate/*analysis
Synapses/*drug effects
Aging/physiology ; Animals ; Estrogens/physiology ; Female ; Hippocampus/chemistry ; Hippocampus/ultrastructure ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/ultrastructure ; Synapses/physiology ; Synapses/ultrastructure
Czasopismo naukowe
Tytuł :
Estrogen and the aging hippocampal synapse.
Autorzy :
Adams MM; Kastor Neurobiology of Aging Laboratory, Fishberg Research Center for Neurobiology, and Henry L. Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA.
Morrison JH
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Źródło :
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2003 Dec; Vol. 13 (12), pp. 1271-5.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
MeSH Terms :
Aging/*physiology
Estrogens/*metabolism
Hippocampus/*physiology
Neuronal Plasticity/*physiology
Receptors, Estrogen/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Synapses/*physiology
Adaptation, Physiological/physiology ; Animals ; Estrogen Receptor alpha ; Hippocampus/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats.
Autorzy :
Adams MM; Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Henry L. Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
Fink SE
Shah RA
Janssen WG
Hayashi S
Milner TA
McEwen BS
Morrison JH
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2002 May 01; Vol. 22 (9), pp. 3608-14.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Aging/*metabolism
Estrogens/*pharmacology
Hippocampus/*drug effects
Hippocampus/*metabolism
Receptors, Estrogen/*metabolism
Age Factors ; Animals ; Cell Compartmentation ; Cell Surface Extensions/metabolism ; Cell Surface Extensions/ultrastructure ; Estrogen Receptor alpha ; Female ; Hippocampus/ultrastructure ; Immunohistochemistry ; Microscopy, Immunoelectron ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/physiology ; Ovariectomy ; Presynaptic Terminals/drug effects ; Presynaptic Terminals/metabolism ; Presynaptic Terminals/ultrastructure ; Pyramidal Cells/metabolism ; Pyramidal Cells/ultrastructure ; Rats ; Rats, Sprague-Dawley ; Synaptic Vesicles/metabolism ; Synaptic Vesicles/ultrastructure
Czasopismo naukowe
Tytuł :
Length of postovariectomy interval and age, but not estrogen replacement, regulate N-methyl-D-aspartate receptor mRNA levels in the hippocampus of female rats.
Autorzy :
Adams MM; Kastor Neurobiology of Aging Laboratory, Mount Sinai School of Medicine, New York, New York 10029, USA.
Oung T
Morrison JH
Gore AC
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Źródło :
Experimental neurology [Exp Neurol] 2001 Aug; Vol. 170 (2), pp. 345-56.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Estrogen Replacement Therapy*
Gene Expression Regulation*/drug effects
Ovariectomy*
Transcription, Genetic*/drug effects
Aging/*physiology
Estradiol/*pharmacology
Hippocampus/*physiology
Receptors, N-Methyl-D-Aspartate/*genetics
Animals ; Drug Implants ; Estradiol/administration & dosage ; Female ; Hippocampus/growth & development ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Time Factors
Czasopismo naukowe
Tytuł :
Different modes of hippocampal plasticity in response to estrogen in young and aged female rats.
Autorzy :
Adams MM; Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Shah RA
Janssen WG
Morrison JH
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2001 Jul 03; Vol. 98 (14), pp. 8071-6. Date of Electronic Publication: 2001 Jun 26.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Aging/*physiology
Hippocampus/*physiology
Neuronal Plasticity/*physiology
Animals ; Estrogens/pharmacology ; Estrogens/physiology ; Female ; Hippocampus/cytology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
N-methyl-D-aspartate receptor mRNA levels change during reproductive senescence in the hippocampus of female rats.
Autorzy :
Adams MM; Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA.
Morrison JH
Gore AC
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Źródło :
Experimental neurology [Exp Neurol] 2001 Jul; Vol. 170 (1), pp. 171-9.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Aging/*metabolism
Hippocampus/*metabolism
RNA, Messenger/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Reproduction/*physiology
Animals ; Estrogens/blood ; Estrus ; Female ; Gene Frequency ; Ovary/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/genetics ; Reproduction/drug effects
Czasopismo naukowe
Tytuł :
Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats.
Autorzy :
Smith TD; Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
Adams MM
Gallagher M
Morrison JH
Rapp PR
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2000 Sep 01; Vol. 20 (17), pp. 6587-93.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Aging/*physiology
Hippocampus/*physiology
Maze Learning/*physiology
Neurons/*physiology
Synaptophysin/*metabolism
Animals ; Biomarkers ; Hippocampus/cytology ; Hippocampus/growth & development ; Immunohistochemistry ; Male ; Microscopy, Confocal ; Neurons/cytology ; Rats ; Rats, Long-Evans ; Space Perception/physiology ; Synaptophysin/analysis
Czasopismo naukowe
    Wyświetlanie 1-17 z 17

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