Temat: "Adaptor Proteins, Signal Transducing" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study.
Autorzy:: Mo H; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang S; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen AM; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .; Pokaż więcej
Źródło:: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Oct 20; Vol. 626, pp. 229-235. Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Carrier Proteins*/metabolism
Osteoarthritis*/metabolism
Animals ; Cells, Cultured ; Chondrocytes/metabolism ; Interleukin-1beta/metabolism ; Mice ; NF-kappa B/metabolism ; Signal Transduction

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Skocz do pozycji: 2.

Tytuł:: YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation.
Autorzy:: Damkham N; Graduate Program in Immunology, Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand.
Lorthongpanich C; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand. .
Klaihmon P; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand.
Lueangamornnara U; Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kheolamai P; Division of Cell Biology, Department of Pre-Clinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Trakarnsanga K; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Issaragrisil S; Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand. .; Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. .; Bangkok Hematology Center, Wattanosoth Hospital, BDMS Center of Excellence for Cancer, Bangkok, Thailand. .; Pokaż więcej
Źródło:: Stem cell research & therapy [Stem Cell Res Ther] 2022 Sep 08; Vol. 13 (1), pp. 467. Date of Electronic Publication: 2022 Sep 08.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Trans-Activators*/genetics
Trans-Activators*/metabolism
Transcriptional Coactivator with PDZ-Binding Motif Proteins/*metabolism
YAP-Signaling Proteins/*metabolism
Animals ; Erythrocytes ; Erythropoiesis/genetics ; Humans ; Mammals/metabolism ; Methylcellulose ; Phosphoproteins/metabolism ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism

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Skocz do pozycji: 3.

Tytuł:: Interference of PTK6/GAB1 signaling inhibits cell proliferation, invasion, and migration of cervical cancer cells.
Autorzy:: Li J; Department of Gynecology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China.
Yang N; Department of Gynecology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China.
Tian X; Department of Gynecology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China.
Ouyang L; Department of Gynecology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China.
Jiang M; Department of Gynecology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China.
Zhang S; Department of Gynecology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2022 Sep; Vol. 26 (3). Date of Electronic Publication: 2022 Jul 27.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Protein-Tyrosine Kinases*/genetics
Protein-Tyrosine Kinases*/metabolism
Uterine Cervical Neoplasms*/genetics
Apoptosis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation ; Female ; Humans ; Signal Transduction

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Skocz do pozycji: 4.

Tytuł:: PFN1 Prevents Psoriasis Pathogenesis through IκBζ Regulation.
Autorzy:: Mok BR; Department of Biomedical Science, School of Medicine, CHA University, Seongnam, Korea.
Kim AR; Department of Biomedical Science, School of Medicine, CHA University, Seongnam, Korea.
Baek SH; Department of Biomedical Science, School of Medicine, CHA University, Seongnam, Korea.
Ahn JH; Department of Dermatology, Bundang Medical Center, School of Medicine, CHA University, Seongnam, Korea.
Seok SH; Department of Dermatology, Bundang Medical Center, School of Medicine, CHA University, Seongnam, Korea.
Shin JU; Department of Dermatology, Bundang Medical Center, School of Medicine, CHA University, Seongnam, Korea.
Kim DH; Department of Dermatology, Bundang Medical Center, School of Medicine, CHA University, Seongnam, Korea. Electronic address: .; Pokaż więcej
Źródło:: The Journal of investigative dermatology [J Invest Dermatol] 2022 Sep; Vol. 142 (9), pp. 2455-2463.e9. Date of Electronic Publication: 2022 Feb 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Profilins*/genetics
Profilins*/metabolism
Psoriasis*/pathology
Humans ; Interleukin-17/pharmacology ; Keratinocytes/metabolism ; Skin/pathology ; Tumor Necrosis Factor-alpha/pharmacology

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Skocz do pozycji: 5.

Tytuł:: Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2.
Autorzy:: Haure-Mirande JV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Audrain M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .
Gandy S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; Department of Psychiatry and the NIA-Designated Mount Sinai Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. .; James J Peters VA Medical Center, New York, Bronx NY, 10468, USA. .; Pokaż więcej
Źródło:: Molecular neurodegeneration [Mol Neurodegener] 2022 Aug 24; Vol. 17 (1), pp. 55. Date of Electronic Publication: 2022 Aug 24.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Alzheimer Disease*/metabolism
Amyloidosis*/metabolism
Membrane Proteins*/metabolism
Receptors, Immunologic*/genetics
Receptors, Immunologic*/metabolism
Tauopathies*/metabolism
Animals ; Brain/metabolism ; Disease Models, Animal ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Microglia/metabolism

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Skocz do pozycji: 6.

Tytuł:: Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis.
Autorzy:: Zhang Y; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Liu W; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Yuan W; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Cai Z; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Ye G; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Zheng G; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Xu C; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Wang X; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Zeng C; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Mi R; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Feng P; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Chen F; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China.
Wu Y; Center for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China. .
Shen H; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China. .
Wang P; Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-Sen University, 3025# Shennan Road, Shenzhen, 518000, People's Republic of China. .; Pokaż więcej
Źródło:: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Aug 19; Vol. 79 (9), pp. 488. Date of Electronic Publication: 2022 Aug 19.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Mesenchymal Stem Cells*/metabolism
Muscle Proteins*/metabolism
Osteoporosis*/genetics
Osteoporosis*/metabolism
Adipogenesis/genetics ; Aged ; Animals ; Autophagy/physiology ; Calcium-Binding Proteins ; Cell Differentiation/physiology ; Cells, Cultured ; Humans ; Mice ; Osteogenesis/genetics

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Skocz do pozycji: 7.

Tytuł:: Role of ELMO1 in inflammation and cancer-clinical implications.
Autorzy:: Tocci S; Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Ibeawuchi SR; Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Das S; Department of Pathology, University of California San Diego, La Jolla, CA, USA. .
Sayed IM; Department of Pathology, University of California San Diego, La Jolla, CA, USA. .; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt. .; Pokaż więcej
Źródło:: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2022 Aug; Vol. 45 (4), pp. 505-525. Date of Electronic Publication: 2022 Jun 06.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Neoplasms*/genetics
Actins/metabolism ; Humans ; Inflammation ; Signal Transduction

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Skocz do pozycji: 8.

Tytuł:: The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase.
Autorzy:: Tarcan Z; Institute of Cancer and Genomic Sciences, Birmingham Centre for Genome Biology, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham United Kingdom.
Poovathumkadavil D; Institute of Cancer and Genomic Sciences, Birmingham Centre for Genome Biology, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham United Kingdom.
Skagia A; Institute of Cancer and Genomic Sciences, Birmingham Centre for Genome Biology, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham United Kingdom.
Gambus A; Institute of Cancer and Genomic Sciences, Birmingham Centre for Genome Biology, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham United Kingdom. Electronic address: .; Pokaż więcej
Źródło:: The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102234. Date of Electronic Publication: 2022 Jul 04.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Chromatin*/metabolism
DNA Replication*
S Phase*
Xenopus Proteins*/genetics
Xenopus Proteins*/metabolism
Animals ; DNA Helicases/genetics ; DNA Helicases/metabolism ; Minichromosome Maintenance Complex Component 7/metabolism ; Ubiquitination ; Xenopus laevis/metabolism

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Skocz do pozycji: 9.

Tytuł:: Molecular mechanism of CAIF inhibiting myocardial infarction by sponging miR‑488 and regulating AVEN expression.
Autorzy:: Li X; Intensive Care Unit, Guilin People's Hospital, Xiangshan 541002, P.R. China.
Chen R; Intensive Care Unit, Guilin People's Hospital, Xiangshan 541002, P.R. China.
Wang L; Intensive Care Unit, Guilin People's Hospital, Xiangshan 541002, P.R. China.
Lu Z; Department of Gastroenterology, Xing'an County People's Hospital, Xing'an, Guilin, Guangxi 541300, P.R. China.
Li Y; Intensive Care Unit, Guilin People's Hospital, Xiangshan 541002, P.R. China.
Tang D; Intensive Care Unit, Guilin People's Hospital, Xiangshan 541002, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2022 Aug; Vol. 26 (2). Date of Electronic Publication: 2022 Jul 07.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/biosynthesis
Adaptor Proteins, Signal Transducing*/genetics
Apoptosis Regulatory Proteins*/biosynthesis
Apoptosis Regulatory Proteins*/genetics
MicroRNAs*/genetics
MicroRNAs*/metabolism
Myocardial Infarction*/genetics
Myocardial Infarction*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Reperfusion Injury*/genetics
Reperfusion Injury*/metabolism
Animals ; Autophagy ; Hydrogen Peroxide/pharmacology ; Myocytes, Cardiac/metabolism ; Rats

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Skocz do pozycji: 10.

Tytuł:: KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure.
Autorzy:: Jang JH; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.; Department of Bioscience, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.
Lee JW; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Cho MJ; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Hwang B; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Kwon MG; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.; Department of Bioscience, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea.
Kim DH; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Lee NK; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Lee J; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Park YJ; Environmental Disease Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Yang YR; Aging Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Kim J; Aging Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Kim YH; Laboratory Animal Resource Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
An TH; Metabolic Regulation Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Oh KJ; Metabolic Regulation Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Bae KH; Metabolic Regulation Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea.
Park JG; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea. .; Department of Bioscience, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea. .
Min JK; Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon, Republic of Korea. .; Department of Bioscience, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Republic of Korea. .; Pokaż więcej
Źródło:: Experimental & molecular medicine [Exp Mol Med] 2022 Aug; Vol. 54 (8), pp. 1250-1261. Date of Electronic Publication: 2022 Aug 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Energy Metabolism*/genetics
Insulin Resistance*/genetics
Microfilament Proteins*/genetics
Microfilament Proteins*/metabolism
Non-alcoholic Fatty Liver Disease*/genetics
Non-alcoholic Fatty Liver Disease*/metabolism
Animals ; Diet, High-Fat/adverse effects ; Humans ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/genetics ; Obesity/metabolism

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Skocz do pozycji: 11.

Tytuł:: Single-cell sequencing reveals the antifibrotic effects of YAP/TAZ in systemic sclerosis.
Autorzy:: Wu D; Department of Paediatrics, First Affiliated Hospital of Nanchang University, Nanchang 330000, China.
Wang W; Department of Pathogenic Microbiology and Immunology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China.
Li X; Department of Internal Medicine, Medical College of Nanchang University, Nanchang 330000, China.
Yin B; Department of Internal Medicine, Medical College of Nanchang University, Nanchang 330000, China.
Ma Y; Department of Internal Medicine, First Affiliated Hospital of Nanchang University, Nanchang 330000, China. Electronic address: .; Pokaż więcej
Źródło:: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2022 Aug; Vol. 149, pp. 106257. Date of Electronic Publication: 2022 Jun 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Scleroderma, Systemic*/genetics
Scleroderma, Systemic*/pathology
Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Fibrosis ; Humans ; Inflammation ; Mice ; YAP-Signaling Proteins

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Skocz do pozycji: 12.

Tytuł:: FOXD3 and GAB2 as a pair of rivals antagonistically control hepatocellular carcinogenesis.
Autorzy:: Liu R; School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China.
Sun Y; School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China.
Chen S; School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China.
Hong Y; School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China.
Lu Z; School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China.; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen, China.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2022 Aug; Vol. 289 (15), pp. 4536-4548. Date of Electronic Publication: 2022 Feb 25.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Carcinoma, Hepatocellular*/pathology
Forkhead Transcription Factors*/genetics
Forkhead Transcription Factors*/metabolism
Liver Neoplasms*/pathology
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Mice

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Szczegóły

Skocz do pozycji: 13.

Tytuł:: Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model.
Autorzy:: Takwale AD; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Kim EY; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Jang Y; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Lee DH; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Kim S; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Choi Y; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Kim JH; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Lee DY; College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
Kim Y; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Lee SM; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Lee HK; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Nam HJ; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Lee JY; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea.
Cho JH; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Moon JH; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Lee GS; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28160, Republic of Korea.
Kim JH; Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Department of Bioscience, University of Science and Technology, Daejeon 34113, Republic of Korea.
Kim P; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
Park CH; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: .
Hwang JY; Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Republic of Korea; Medicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic chemistry [Bioorg Chem] 2022 Oct; Vol. 127, pp. 105923. Date of Electronic Publication: 2022 Jun 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adaptor Proteins, Signal Transducing*
Animals ; Disease Models, Animal ; Heterografts ; Humans ; Lenalidomide/chemistry ; Lenalidomide/pharmacology ; Mice ; Proteolysis ; Structure-Activity Relationship

Czasopismo naukowe

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Szczegóły

Skocz do pozycji: 14.

Tytuł:: Comparing the levels of CTLA-4-dependent biological defects in patients with LRBA deficiency and CTLA-4 insufficiency.
Autorzy:: Catak MC; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Akcam B; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Bilgic Eltan S; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Babayeva R; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Karakus IS; Marmara University, School of Medicine, Istanbul, Turkey.
Akgun G; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Baser D; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Bulutoglu A; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Bayram F; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Kasap N; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Kiykim A; Cerrahpasa Faculty of Medicine, Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Hancioglu G; Division of Pediatric Allergy and Immunology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Kokcu Karadag SI; Division of Pediatric Allergy and Immunology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Kendir Demirkol Y; Division of Pediatric Genetics, University of Health Sciences, Umraniye Education and Research Hospital, Istanbul, Turkey.
Ozen S; Division of Pediatric Allergy and Immunology, University of Health Sciences, Dr. Behcet Uz Children's Education and Research Hospital, Izmir, Turkey.
Cekic S; Faculty of Medicine, Pediatric Allergy and Immunology, Uludag University, Bursa, Turkey.
Ozcan D; Division of Pediatric Allergy-Immunology, Faculty of Medicine, Çukurova University, Adana, Turkey.
Edeer Karaca N; Faculty of Medicine, Pediatric Allergy and Immunology, Ege University, Izmir, Turkey.
Sasihuseyinoglu AS; Ministry of Health, Sanliurfa Training and Research Hospital, Urfa, Turkey.
Cansever M; Faculty of Medicine, Pediatric Immunology, Erciyes University, Kayseri, Turkey.
Ozek Yucel E; Istanbul Faculty of Medicine, Pediatric Allergy and Immunology, Istanbul University, Istanbul, Turkey.
Tamay Z; Istanbul Faculty of Medicine, Pediatric Allergy and Immunology, Istanbul University, Istanbul, Turkey.
Altintas DU; Division of Pediatric Allergy-Immunology, Faculty of Medicine, Çukurova University, Adana, Turkey.
Aydogmus C; Pediatric Allergy and Immunology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
Celmeli F; Ministry of Health, Antalya Training and Research Hospital, Antalya, Turkey.
Cokugras H; Cerrahpasa Faculty of Medicine, Pediatric Allergy and Immunology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Gulez N; Division of Pediatric Allergy and Immunology, University of Health Sciences, Dr. Behcet Uz Children's Education and Research Hospital, Izmir, Turkey.
Genel F; Division of Pediatric Allergy and Immunology, University of Health Sciences, Dr. Behcet Uz Children's Education and Research Hospital, Izmir, Turkey.
Metin A; Pediatric Immunology and Allergy, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Guner SN; Faculty of Medicine, Pediatric Allergy and Immunology, Necmettin Erbakan University, Konya, Turkey.
Kutukculer N; Faculty of Medicine, Pediatric Allergy and Immunology, Ege University, Izmir, Turkey.
Keles S; Faculty of Medicine, Pediatric Allergy and Immunology, Necmettin Erbakan University, Konya, Turkey.
Reisli I; Faculty of Medicine, Pediatric Allergy and Immunology, Necmettin Erbakan University, Konya, Turkey.
Kilic SS; Faculty of Medicine, Pediatric Allergy and Immunology, Uludag University, Bursa, Turkey.
Yildiran A; Division of Pediatric Allergy and Immunology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Karakoc-Aydiner E; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Lo B; Division of Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar.; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
Ozen A; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.
Baris S; Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine, Istanbul, Turkey.; Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey.; The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey.; Pokaż więcej
Źródło:: Allergy [Allergy] 2022 Oct; Vol. 77 (10), pp. 3108-3123. Date of Electronic Publication: 2022 May 12.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/metabolism
Lipopolysaccharides*
Abatacept/metabolism ; Abatacept/therapeutic use ; CTLA-4 Antigen/genetics ; CTLA-4 Antigen/metabolism ; Forkhead Transcription Factors/metabolism ; Humans

Czasopismo naukowe

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Szczegóły

Skocz do pozycji: 15.

Tytuł:: Ambra1 in cancer: implications for clinical oncology.
Autorzy:: Qin YQ; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China.
Liu SY; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China.
Lv ML; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China.
Sun WL; Department of Medical Oncology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning, 530007, Guangxi, People's Republic of China. .; Pokaż więcej
Źródło:: Apoptosis : an international journal on programmed cell death [Apoptosis] 2022 Oct; Vol. 27 (9-10), pp. 720-729. Date of Electronic Publication: 2022 Aug 22.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Adaptor Proteins, Signal Transducing*/metabolism
Apoptosis*/genetics
Autophagy/genetics ; Beclin-1/metabolism ; Carcinogenesis/genetics ; Humans ; Medical Oncology

Czasopismo naukowe

na półce

Szczegóły

Skocz do pozycji: 16.

Tytuł:: Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers.
Autorzy:: Howard A; Department of Life Sciences, University of Bath, Bath, UK.
Bojko J; Department of Life Sciences, University of Bath, Bath, UK.
Flynn B; Department of Life Sciences, University of Bath, Bath, UK.
Bowen S; Department of Life Sciences, University of Bath, Bath, UK.
Jungwirth U; Department of Life Sciences, University of Bath, Bath, UK.; Centre for Therapeutic Innovation, University of Bath, Bath, UK.
Walko G; Department of Life Sciences, University of Bath, Bath, UK.; Centre for Therapeutic Innovation, University of Bath, Bath, UK.; Pokaż więcej
Źródło:: Experimental dermatology [Exp Dermatol] 2022 Oct; Vol. 31 (10), pp. 1477-1499. Date of Electronic Publication: 2022 Aug 12.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Adaptor Proteins, Signal Transducing*/metabolism
Skin Neoplasms*/metabolism
Cell Transformation, Neoplastic ; Humans ; Trans-Activators ; Transcription Factors/metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; YAP-Signaling Proteins

Czasopismo naukowe

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Szczegóły

Skocz do pozycji: 17.

Tytuł:: XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis.
Autorzy:: Nishimura Y; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Iwashita M; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. .
Hayashi M; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Shinjo T; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Watanabe Y; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Zeze T; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yamashita A; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Fukuda T; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Sanui T; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Sano T; Department of Cell Biology and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Asano T; Department of Medical Chemistry, Division of Molecular Medical Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Nishimura F; Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; Pokaż więcej
Źródło:: Acta diabetologica [Acta Diabetol] 2022 Oct; Vol. 59 (10), pp. 1275-1286. Date of Electronic Publication: 2022 Jul 13.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/genetics
Apoptosis Regulatory Proteins*/genetics
Diabetes Mellitus, Type 2*/genetics
Diabetes Mellitus, Type 2*/metabolism
Insulin-Secreting Cells*/metabolism
Islets of Langerhans*/metabolism
Animals ; Apoptosis/genetics ; Diet, High-Fat/adverse effects ; Insulin/metabolism ; Insulin Secretion ; Mice ; Mice, Inbred C57BL

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na półce

Szczegóły

Skocz do pozycji: 18.

Tytuł:: Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis.
Autorzy:: Li T; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Cheng Q; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Wang S; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Ma C; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.; Pokaż więcej
Źródło:: ELife [Elife] 2022 Sep 29; Vol. 11. Date of Electronic Publication: 2022 Sep 29.
Typ publikacji:: Journal Article
MeSH Terms:: Adaptor Proteins, Signal Transducing*/metabolism
Exocytosis*/physiology
Membrane Fusion*
Nerve Tissue Proteins*/metabolism
Synaptosomal-Associated Protein 25*/metabolism
Vesicular Transport Proteins*/metabolism
Animals ; Rats ; SNARE Proteins/metabolism ; Secretory Vesicles/metabolism ; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins/metabolism ; rab3 GTP-Binding Proteins/metabolism

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na półce

Szczegóły

Skocz do pozycji: 19.

Tytuł:: Serum Sclerostin and Its Association with Bone Turnover Marker in Metabolic Bone Diseases.
Autorzy:: Chen L; Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Gao G; Medical Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Shen L; Clinical Research Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Yue H; Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Zhang G; Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tsai, Hong Kong.
Zhang Z; Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.; Pokaż więcej
Źródło:: Disease markers [Dis Markers] 2022 Sep 10; Vol. 2022, pp. 7902046. Date of Electronic Publication: 2022 Sep 10 (Print Publication: 2022).
Typ publikacji:: Journal Article
MeSH Terms:: Bone Diseases, Metabolic*
beta Catenin*
Adaptor Proteins, Signal Transducing/*blood
Adaptor Proteins, Signal Transducing/metabolism ; Adolescent ; Adult ; Bone Morphogenetic Proteins ; Bone Remodeling ; Child ; Child, Preschool ; Collagen/metabolism ; Collagen Type I ; Female ; Genetic Markers ; Humans ; Male ; Middle Aged ; Young Adult

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na półce

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Skocz do pozycji: 20.

Tytuł:: In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.
Autorzy:: Mirzadeh A; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.
Kobakhidze G; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.
Vuillemot R; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.; IMPMC - UMR 7590, CNRS, Sorbonne Université, Muséum National d'Histoire Naturelle, Paris, France.
Jonic S; IMPMC - UMR 7590, CNRS, Sorbonne Université, Muséum National d'Histoire Naturelle, Paris, France.
Rouiller I; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia. .; Pokaż więcej
Źródło:: BMC molecular and cell biology [BMC Mol Cell Biol] 2022 Sep 10; Vol. 23 (1), pp. 39. Date of Electronic Publication: 2022 Sep 10.
Typ publikacji:: Journal Article
MeSH Terms:: Adenosine Triphosphatases*/metabolism
Molecular Dynamics Simulation*
Adaptor Proteins, Signal Transducing/*chemistry
Valosin Containing Protein/*chemistry
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Humans ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Rats ; Valosin Containing Protein/metabolism

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