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Wyszukujesz frazę ""Adaptor Proteins, Signal Transducing"" wg kryterium: Temat


Tytuł :
Endometrial extracellular matrix rigidity and IFNτ ensure the establishment of early pregnancy through activation of YAP.
Autorzy :
Zhang T; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Guo S; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Zhou H; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Wu Z; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Liu J; College of Animal Science, Tarim University, Alar, China.
Qiu C; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Deng G; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Feb; Vol. 54 (2), pp. e12976. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Cell Cycle Proteins/*metabolism
Endometrium/*metabolism
Extracellular Matrix/*metabolism
Interferon Type I/*metabolism
Pregnancy Proteins/*metabolism
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Antagomirs/metabolism ; Cattle ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Endometrium/cytology ; Epithelial Cell Adhesion Molecule/metabolism ; Female ; Gene Expression/drug effects ; Interferon Type I/pharmacology ; Male ; Mice ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle Proteins/metabolism ; Pregnancy ; Pregnancy Proteins/pharmacology ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Signal Transduction ; Uterus/metabolism ; Uterus/pathology
Czasopismo naukowe
Tytuł :
Shh-Yap signaling controls hepatic ductular reactions in CCl 4 -induced liver injury.
Autorzy :
Jin L; School of Life Science, Shaoxing University, Shaoxing, Zhejiang, China.
Huang H; College of Life and Environmental Science, Hangzhou Normal University, Hangzhou, China.
Ni J; School of Life Science, Shaoxing University, Shaoxing, Zhejiang, China.
Shen J; Department of pathology, affiliated hospital of Shaoxing University, Shaoxing, Zhejiang, China.
Liu Z; Department of pathology, affiliated hospital of Shaoxing University, Shaoxing, Zhejiang, China.
Li L; School of Life Science, Shaoxing University, Shaoxing, Zhejiang, China.
Fu S; School of Life Science, Shaoxing University, Shaoxing, Zhejiang, China.
Yan J; School of Life Science, Shaoxing University, Shaoxing, Zhejiang, China.
Hu B; School of Life Science, Shaoxing University, Shaoxing, Zhejiang, China.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Feb; Vol. 36 (2), pp. 194-203. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Cell Cycle Proteins/*metabolism
Chemical and Drug Induced Liver Injury, Chronic/*metabolism
Hedgehog Proteins/*metabolism
Hepatic Duct, Common/*metabolism
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Carbon Tetrachloride/toxicity ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Chemical and Drug Induced Liver Injury, Chronic/etiology ; Chemical and Drug Induced Liver Injury, Chronic/pathology ; Hedgehog Proteins/antagonists & inhibitors ; Hedgehog Proteins/genetics ; Hepatic Duct, Common/pathology ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Male ; Mice ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8.
Autorzy :
Gong Q; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Robinson K; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore.
Xu C; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Huynh PT; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technology University, 11 Mandalay Road, 308232, Singapore, Singapore.
Chong KHC; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Tan EYJ; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Zhang J; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Boo ZZ; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Teo DET; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore.
Lay K; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore.
Zhang Y; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore.
Lim JSY; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore.
Goh WI; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore.
Wright G; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore.
Zhong FL; Skin Research Institute (SRIS), Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore. .; Lee Kong Chian School of Medicine, Nanyang Technology University, 11 Mandalay Road, 308232, Singapore, Singapore. .; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore. .
Reversade B; Institute of Molecular and Cell Biology, Agency of Science Technology and Research (A*STAR), 61 Biopolis Dr, 138673, Singapore, Singapore. .; Genome Institute of Singapore, Agency of Science Technology and Research (A*STAR), 8A Biomedical Grove, #06-06 Immunos, 138648, Singapore, Singapore. .; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Dr, 117597, Singapore, Singapore. .; The Medical Genetics Department, School of Medicine (KUSoM), Koç University, 34010, Istanbul, Turkey. .
Wu B; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore. .; NTU Institute of Structural Biology, Nanyang Technological University, Singapore, 636921, Singapore. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 188. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Apoptosis Regulatory Proteins/*metabolism
CARD Signaling Adaptor Proteins/*metabolism
Inflammasomes/*chemistry
Inflammasomes/*metabolism
Neoplasm Proteins/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/genetics ; CARD Signaling Adaptor Proteins/genetics ; Caspase 1/metabolism ; Cryoelectron Microscopy ; HEK293 Cells ; Humans ; Inflammasomes/genetics ; Inflammation ; Molecular Docking Simulation ; Mutation ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
Autorzy :
Robert Hollingsworth L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA.
David L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Li Y; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Griswold AR; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Ruan J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Immunology, University of Connecticut Health Center, Farmington, CT, USA.
Sharif H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Fontana P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Orth-He EL; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Fu TM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Biological Chemistry and Pharmacology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Bachovchin DA; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. .; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA. .; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 189. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Ankyrins/*metabolism
Apoptosis Regulatory Proteins/*metabolism
CARD Signaling Adaptor Proteins/*metabolism
Inflammasomes/*metabolism
Neoplasm Proteins/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Ankyrins/chemistry ; Apoptosis ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/genetics ; CARD Signaling Adaptor Proteins/chemistry ; CARD Signaling Adaptor Proteins/genetics ; Caspase 1/metabolism ; Caspase Activation and Recruitment Domain ; Cryoelectron Microscopy ; Death Domain Receptor Signaling Adaptor Proteins/chemistry ; Death Domain Receptor Signaling Adaptor Proteins/metabolism ; HEK293 Cells ; Humans ; Inflammasomes/chemistry ; Inflammasomes/ultrastructure ; Models, Molecular ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Protein Interaction Domains and Motifs ; Signal Transduction
Czasopismo naukowe
Tytuł :
Berberine Represses β -Catenin Translation Involving 4E-BPs in Hepatocellular Carcinoma Cells.
Autorzy :
Vishnoi K; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.).
Ke R; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.).
Saini KS; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.).
Viswakarma N; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.).
Nair RS; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.).
Das S; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.).
Chen Z; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.).
Rana A; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.) .
Rana B; Department of Surgery, Division of Surgical Oncology (K.V., R.K., K.S.S., N.V., R.S.N., S.D., A.R., B.R.), University of Illinois Hospital and Health Sciences System Cancer Center (S.D., A.R., B.R.), and Division of Epidemiology and Biostatistics, School of Public Health (Z.C.), University of Illinois at Chicago, Chicago, Illinois; Biostatistics Shared Resource Core, University of Illinois Cancer Institute, Chicago, Illinois (Z.C.); and Jesse Brown VA Medical Center, Chicago, Illinois (A.R., B.R.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2021 Jan; Vol. 99 (1), pp. 1-16. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Berberine/*pharmacology
Carcinoma, Hepatocellular/*metabolism
Cell Cycle Proteins/*metabolism
Eukaryotic Initiation Factors/*metabolism
Liver Neoplasms/*metabolism
beta Catenin/*metabolism
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/genetics ; Carcinoma, Hepatocellular/genetics ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Eukaryotic Initiation Factors/antagonists & inhibitors ; Eukaryotic Initiation Factors/genetics ; HEK293 Cells ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Protein Biosynthesis/drug effects ; Protein Biosynthesis/physiology ; beta Catenin/antagonists & inhibitors ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer.
Autorzy :
Jang M; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
An J; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Oh SW; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Lim JY; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim J; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Choi JK; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .
Cheong JH; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. .
Kim P; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .; Institute for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .
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Źródło :
Nature biomedical engineering [Nat Biomed Eng] 2021 Jan; Vol. 5 (1), pp. 114-123. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
DNA Methylation*/genetics
DNA Methylation*/physiology
Extracellular Matrix*/chemistry
Extracellular Matrix*/genetics
Extracellular Matrix*/metabolism
Stomach Neoplasms*/genetics
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/physiopathology
Transcription Factors*/genetics
Transcription Factors*/metabolism
Cell Line, Tumor ; Epigenesis, Genetic/genetics ; Epigenesis, Genetic/physiology ; Humans ; Mechanotransduction, Cellular/genetics ; Mechanotransduction, Cellular/physiology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/physiology
Czasopismo naukowe
Tytuł :
Plasma SGIP1 methylation in diagnosis and prognosis prediction in hepatocellular carcinoma.
Autorzy :
Xie GF; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.
Xu YX; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.
Xu F; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.
Sun LY; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.
Ye ZL; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.
Ma JJ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.
Wang HY; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Shao JY; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China.
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Źródło :
Neoplasma [Neoplasma] 2021 Jan; Vol. 68 (1), pp. 62-70. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing*/blood
Adaptor Proteins, Signal Transducing*/genetics
Carcinoma, Hepatocellular*/blood
Carcinoma, Hepatocellular*/diagnosis
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/blood
Liver Neoplasms*/diagnosis
Liver Neoplasms*/genetics
Biomarkers, Tumor/genetics ; DNA Methylation ; Humans ; Prognosis ; Promoter Regions, Genetic ; alpha-Fetoproteins/metabolism
Czasopismo naukowe
Tytuł :
Human NLRP1 is a sensor for double-stranded RNA.
Autorzy :
Bauernfried S; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Scherr MJ; Max-Planck Institute of Biochemistry, Martinsried, Germany.
Pichlmair A; Institute of Virology, Technical University of Munich, School of Medicine, Munich, Germany.; German Center for Infection Research (DZIF), Munich, Germany.
Duderstadt KE; Max-Planck Institute of Biochemistry, Martinsried, Germany.; Physics Department, Technical University of Munich, Garching, Germany.
Hornung V; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany. .; Max-Planck Institute of Biochemistry, Martinsried, Germany.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 29; Vol. 371 (6528). Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Adaptor Proteins, Signal Transducing/*metabolism
Apoptosis Regulatory Proteins/*metabolism
Host-Pathogen Interactions/*immunology
Inflammasomes/*immunology
RNA, Double-Stranded/*metabolism
RNA, Viral/*metabolism
Adaptor Proteins, Signal Transducing/chemistry ; Adenosine Triphosphatases/chemistry ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; Alphavirus Infections/immunology ; Animals ; Apoptosis Regulatory Proteins/chemistry ; HEK293 Cells ; Humans ; Hydrolysis ; Inflammasomes/metabolism ; Keratinocytes/immunology ; Keratinocytes/metabolism ; Keratinocytes/virology ; Mice ; Mice, Transgenic ; Protein Domains ; Semliki forest virus/immunology ; Semliki forest virus/physiology ; Virus Replication
Czasopismo naukowe
Tytuł :
Nasopharyngeal papillary adenocarcinoma harboring a fusion of ROS1 with GOPC: A case report.
Autorzy :
Wang J; Department of Pathology, the First Affiliated Hospital of Zunyi Medical University, Guizhou, PR China.
Luo S
Li Y
Zheng H
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Jan 22; Vol. 100 (3), pp. e24377.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Adenocarcinoma, Papillary/*genetics
Golgi Matrix Proteins/*genetics
Protein-Tyrosine Kinases/*genetics
Proto-Oncogene Proteins/*genetics
Adaptor Proteins, Signal Transducing/analysis ; China ; Endoscopy/methods ; Female ; Golgi Matrix Proteins/analysis ; Humans ; Nasal Obstruction/etiology ; Protein-Tyrosine Kinases/analysis ; Proto-Oncogene Proteins/analysis ; Young Adult
Czasopismo naukowe
Tytuł :
Pseudogene PA2G4P4 promotes oncogene PA2G4 expression and nuclear translocation to affect glioblastoma cell viability and apoptosis.
Autorzy :
Hou X; Department of Neurosurgery, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Tang W; Department of Neurosurgery, Shanxian Central Hospital, Heze 274300, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118793. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*biosynthesis
Apoptosis/*physiology
Cell Survival/*physiology
Glioblastoma/*metabolism
Oncogenes/*physiology
Pseudogenes/*physiology
RNA-Binding Proteins/*biosynthesis
Adaptor Proteins, Signal Transducing/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; RNA-Binding Proteins/genetics ; Translocation, Genetic/physiology
Czasopismo naukowe
Tytuł :
The oncogenic role of HBXIP.
Autorzy :
Xiu M; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China; Second Clinical Medical College, Nanchang University, China.
Zeng X; Imaging Department, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Shan R; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Wen W; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Li J; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Wan R; Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 111045. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Oncogenes*
Signal Transduction*
Adaptor Proteins, Signal Transducing/*metabolism
Cell Transformation, Neoplastic/*metabolism
Neoplasms/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Antineoplastic Agents/therapeutic use ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Drug Resistance, Neoplasm ; Energy Metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Cisplatin-induced hair cell loss in zebrafish neuromasts is accompanied by protein nitration and Lmo4 degradation.
Autorzy :
Shahab M; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.
Rosati R; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA.
Meyers D; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.
Sheilds J; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA.
Crofts E; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA.
Baker TR; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.
Jamesdaniel S; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA; Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115342. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing*/metabolism
LIM Domain Proteins*/metabolism
Antineoplastic Agents/*toxicity
Cisplatin/*toxicity
Hair Cells, Auditory/*drug effects
Oxidative Stress/*drug effects
Proteolysis/*drug effects
Animals ; Animals, Genetically Modified ; Female ; Hair Cells, Auditory/metabolism ; Hair Cells, Auditory/pathology ; Male ; Oxidative Stress/physiology ; Zebrafish
Czasopismo naukowe
Tytuł :
YAP mediates the interaction between the Hippo and PI3K/Akt pathways in mesangial cell proliferation in diabetic nephropathy.
Autorzy :
Qian X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
He L; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Hao M; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Li Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Li X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Liu Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jiang H; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xu L; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Li C; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Wu W; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Du L; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Yin X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Lu Q; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China. .
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Źródło :
Acta diabetologica [Acta Diabetol] 2021 Jan; Vol. 58 (1), pp. 47-62. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*physiology
Cell Cycle Proteins/*physiology
Diabetes Mellitus, Experimental/*metabolism
Diabetic Nephropathies/*metabolism
Mesangial Cells/*physiology
Protein-Serine-Threonine Kinases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Cycle Proteins/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cells, Cultured ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/pathology ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/pathology ; Dose-Response Relationship, Drug ; Glucose/pharmacology ; Male ; Mesangial Cells/drug effects ; Mesangial Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/drug effects ; Phosphorylation/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Methylation of the Sclerostin (SOST) Gene in Serum Free DNA: A New Bone Biomarker?
Autorzy :
Del Real A; Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, University of Cantabria, Santander, Spain.
Perez-Campo FM; Department of Molecular Biology, University of Cantabria-IDIVAL, Santander, Spain.
Perez-Nuñez MI; Department of Traumatology/Hospital U.M. Valdecilla, University of Cantabria, Santander, Spain.
Sañudo C; Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, University of Cantabria, Santander, Spain.
Santurtun A; Unit of Legal Medicine, Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain.
Garcia-Ibarbia C; Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, University of Cantabria, Santander, Spain.
Garcia-Unzueta MT; Service of Clinical Biochemistry, Hospital U.M. Valdecilla, University of Cantabria, IDIVAL, Santander, Spain.
Fraga MF; Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), Nanomaterials and Nanotechnology Research Center (CINN-CSIC), University of Oviedo, Asturias, Spain.
Fernandez AF; Institute of Oncology of Asturias (IUOPA), ISPA-HUCA. Fundación para la Investigación Biosanitaria de Asturias (FINBA), Asturias, Spain.
Valero MC; Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, University of Cantabria, Santander, Spain.
Laguna E; Department of Molecular Biology, University of Cantabria-IDIVAL, Santander, Spain.
Riancho JA; Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL, University of Cantabria, Santander, Spain.
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Źródło :
Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2021 Jan; Vol. 25 (1), pp. 42-47. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing*
Arthroplasty, Replacement, Hip*
DNA Methylation*
Promoter Regions, Genetic*
Cell-Free Nucleic Acids/*metabolism
Osteoporosis/*blood
Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Autorzy :
Mears HV; Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address: .
Sweeney TR; Division of Virology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 18; Vol. 295 (51), pp. 17781-17801.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Biosynthesis*
Adaptor Proteins, Signal Transducing/*metabolism
Coronavirus/*genetics
Coronavirus/*growth & development
RNA Cap-Binding Proteins/*metabolism
RNA Caps/*metabolism
RNA-Binding Proteins/*metabolism
Adaptor Proteins, Signal Transducing/deficiency ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Coronavirus/metabolism ; Disease Models, Animal ; HEK293 Cells ; Humans ; Mice ; Mice, Knockout ; Models, Molecular ; Mutation ; Protein Binding ; RAW 264.7 Cells ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy.
Autorzy :
Zeng H; Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Rd., Hefei, Anhui, China.
Qi X; Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Rd., Hefei, Anhui, China.
Xu X; Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Rd., Hefei, Anhui, China. .
Wu Y; Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Rd., Hefei, Anhui, China. .
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Źródło :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2020 Dec; Vol. 69 (12), pp. 1215-1234. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*genetics
Adaptor Proteins, Signal Transducing/*metabolism
Diabetic Neuropathies/*genetics
Diabetic Neuropathies/*metabolism
Glycolysis/*genetics
Macrophage Activation/*genetics
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Albuminuria/drug therapy ; Albuminuria/pathology ; Animals ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Gene Knockdown Techniques ; Hypoxia-Inducible Factor 1, alpha Subunit/drug effects ; Mesangial Cells/pathology ; Mice ; Mice, Inbred C57BL ; NF-kappa B/drug effects ; Nephritis, Interstitial/pathology ; Nitric Oxide Synthase Type II/drug effects ; RNA, Small Interfering/pharmacology
Czasopismo naukowe
Tytuł :
Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization.
Autorzy :
Dalskov L; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Narita R; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Andersen LL; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Jensen N; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Assil S; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Kristensen KH; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Mikkelsen JG; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Fujita T; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Mogensen TH; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital Skejby, 8200 Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
Paludan SR; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Hartmann R; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 18; Vol. 48 (20), pp. 11421-11433.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Interferon Regulatory Factor-3/*metabolism
Interferon Regulatory Factor-7/*metabolism
Signal Transduction/*genetics
Adaptor Proteins, Signal Transducing/chemistry ; Adaptor Proteins, Signal Transducing/genetics ; Dimerization ; Genes, Reporter ; HEK293 Cells ; Humans ; Immunity, Innate ; Interferon Regulatory Factor-3/chemistry ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-7/genetics ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phosphorylation ; Protein Binding/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells.
Autorzy :
Wang B; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China.; Department of Medicine, The University of Hong Kong, Hong Kong, China.
Lin H; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Li X; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Lu W; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China.
Kim JB; Department of Biological Sciences, Institute of Molecular Biology and Genetics, Center for Adipose Tissue Remodeling, Seoul National University, Seoul 08826, South Korea.
Xu A; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China; .; Department of Medicine, The University of Hong Kong, Hong Kong, China.; Department of Pharmacology & Pharmacy, The University of Hong Kong, Hong Kong, China.
Cheng KKY; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28307-28315. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*metabolism
Adaptor Proteins, Signal Transducing/*metabolism
Adaptor Proteins, Signal Transducing/*pharmacology
Glucose/*metabolism
Insulin Secretion/*drug effects
Insulin-Secreting Cells/*metabolism
Actin Cytoskeleton/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Female ; GTPase-Activating Proteins/metabolism ; Gene Knockdown Techniques ; Glucose Intolerance ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Knockout ; Neuropeptides/genetics ; Neuropeptides/metabolism ; SNARE Proteins/metabolism ; Transcriptome ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe
Tytuł :
KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression.
Autorzy :
Zhou XA; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Zhou J; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Zhao L; Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, 100044 Beijing, China.
Yu G; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Zhan J; Department of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Shi C; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Yuan R; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Wang Y; Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Chen C; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Zhang W; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Xu D; Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, 100871 Beijing, China.
Ye Y; Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, 100044 Beijing, China.
Wang W; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China.
Shen Z; Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, 100044 Beijing, China; .
Wang W; Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China; .
Wang J; Department of Radiation Medicine, Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, 100191 Beijing, China; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28239-28250. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Homeostasis*
Adaptor Proteins, Signal Transducing/*metabolism
Programmed Cell Death 1 Receptor/*metabolism
T-Lymphocytes/*immunology
Adaptor Proteins, Signal Transducing/drug effects ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Fluorouracil ; HEK293 Cells ; Humans ; Immune Checkpoint Proteins ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proteolysis ; Signal Transduction ; Transcriptome ; Tumor Microenvironment/immunology ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency.
Autorzy :
Diofano F; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Ulm, Germany.
Weinmann K; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Ulm, Germany.; Department of Internal Medicine II, University of Ulm, Ulm, Germany.
Schneider I; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Ulm, Germany.
Thiessen KD; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Ulm, Germany.
Rottbauer W; Department of Internal Medicine II, University of Ulm, Ulm, Germany.
Just S; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, Ulm, Germany.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Nov 02; Vol. 16 (11), pp. e1009088. Date of Electronic Publication: 2020 Nov 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*deficiency
Adaptor Proteins, Signal Transducing/*genetics
Apoptosis Regulatory Proteins/*deficiency
Apoptosis Regulatory Proteins/*genetics
Cardiomyopathies/*genetics
Heart Failure/*genetics
Heart Failure/*metabolism
Zebrafish Proteins/*deficiency
Zebrafish Proteins/*genetics
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Disease Models, Animal ; Heart Failure/pathology ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Muscle Fibers, Skeletal/metabolism ; Muscular Diseases/genetics ; Muscular Diseases/metabolism ; Muscular Diseases/pathology ; Mutation ; Myocardium/metabolism ; Myopathies, Structural, Congenital/metabolism ; Phenotype ; Proteomics ; Zebrafish ; Zebrafish Proteins/metabolism
SCR Disease Name :
Myofibrillar Myopathy
Czasopismo naukowe

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