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Tytuł:
Use of Remdesivir in children with COVID-19: report of an Italian multicenter study.
Autorzy:
Romani L; Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. .
Roversi M; PhD Course 'Immunology, Molecular Medicine and Applied Biotechnology', University of Rome Tor Vergata, Rome, Italy.
Bernardi S; Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Venturini E; Infectious Diseases Unit, Meyer Children's University Hospital, Florence, Italy.
Garazzino S; Pediatric Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Donà D; Division of Pediatric Infectious Diseases, Department for Woman and Child Health, University of Padua, Padua, Italy.
Krzysztofiak A; Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Montagnani C; Infectious Diseases Unit, Meyer Children's University Hospital, Florence, Italy.
Funiciello E; Pediatric Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Calò Carducci FI; Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Marabotto C; Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Castagnola E; Hematology and Oncology, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Salvini F; Pediatrics Division, Azienda Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Lancella L; Infectious Diseases Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Lo Vecchio A; Department of Translational Medical Sciences, Federico II University, Naples, Italy.
Galli L; Infectious Diseases Unit, Meyer Children's University Hospital, Florence, Italy.
Castelli Gattinara G; Institute of Child Health, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
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Corporate Authors:
Italian Society of Pediatric Infectious Diseases (SITIP)
Źródło:
Italian journal of pediatrics [Ital J Pediatr] 2024 Feb 27; Vol. 50 (1), pp. 32. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Multicenter Study; Journal Article
MeSH Terms:
Adenosine Monophosphate*/analogs & derivatives
Alanine*/analogs & derivatives
COVID-19*
Child ; Humans ; Antiviral Agents/therapeutic use ; COVID-19 Drug Treatment ; Italy/epidemiology ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus .
Autorzy:
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Woolsey C; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Chu VC; Gilead Sciences, Inc., Foster City, CA, USA.
Babusis D; Gilead Sciences, Inc., Foster City, CA, USA.
Bannister R; Gilead Sciences, Inc., Foster City, CA, USA.
Vermillion MS; Gilead Sciences, Inc., Foster City, CA, USA.
Geleziunas R; Gilead Sciences, Inc., Foster City, CA, USA.
Barrett KT; Gilead Sciences, Inc., Foster City, CA, USA.
Bunyan E; Gilead Sciences, Inc., Foster City, CA, USA.
Nguyen AQ; Gilead Sciences, Inc., Foster City, CA, USA.
Cihlar T; Gilead Sciences, Inc., Foster City, CA, USA.
Porter DP; Gilead Sciences, Inc., Foster City, CA, USA.
Prasad AN; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Deer DJ; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Borisevich V; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Agans KN; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Martinez J; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Harrison MB; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Dobias NS; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Fenton KA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Bilello JP; Gilead Sciences, Inc., Foster City, CA, USA.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar 15; Vol. 383 (6688), pp. eadk6176. Date of Electronic Publication: 2024 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Ebolavirus*/drug effects
Hemorrhagic Fever, Ebola*/drug therapy
Hemorrhagic Fever, Ebola*/prevention & control
Nucleosides*/administration & dosage
Nucleosides*/pharmacology
Alanine*/administration & dosage
Alanine*/analogs & derivatives
Alanine*/pharmacology
Prodrugs*/administration & dosage
Prodrugs*/pharmacology
Antiviral Agents*/administration & dosage
Antiviral Agents*/pharmacology
Animals ; Administration, Oral ; Macaca fascicularis ; Adenosine Monophosphate/administration & dosage ; Adenosine Monophosphate/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Effect of Bacterial AHL on the Cyclic Adenosine Monophosphate Content in Plants According to High-Performance Liquid Chromatography.
Autorzy:
Zhao X; School of Biological Science and Engineering, Hebei University of Economics and Business, Shijiazhuang 050061, China.; Biology Institute, Hebei Academy of Sciences, Shijiazhuang 050051, China.
Li W; Biology Institute, Hebei Academy of Sciences, Shijiazhuang 050051, China.
Li X; Biology Institute, Hebei Academy of Sciences, Shijiazhuang 050051, China.
Jia Z; Biology Institute, Hebei Academy of Sciences, Shijiazhuang 050051, China.; Hebei Technology Innovation Center of Microbiological Control on Main Crop Disease, Shijiazhuang 050051, China.
Song S; Biology Institute, Hebei Academy of Sciences, Shijiazhuang 050051, China.; Hebei Technology Innovation Center of Microbiological Control on Main Crop Disease, Shijiazhuang 050051, China.
Zhao Q; Biology Institute, Hebei Academy of Sciences, Shijiazhuang 050051, China.; Hebei Technology Innovation Center of Microbiological Control on Main Crop Disease, Shijiazhuang 050051, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Acyl-Butyrolactones*
Arabidopsis*
Chromatography, High Pressure Liquid ; Methanol ; Bacteria ; Plants ; Cyclic AMP ; Water ; Adenosine Monophosphate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Liquid plasma promotes angiogenesis through upregulation of endothelial nitric oxide synthase-induced extracellular matrix metabolism: potential applications of liquid plasma for vascular injuries.
Autorzy:
Kang SU; Department of Otolaryngology, Department of Molecular Science and Technology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-Gu, Suwon, 443-380, Republic of Korea.
Kim HJ; Department of Otolaryngology, Department of Molecular Science and Technology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-Gu, Suwon, 443-380, Republic of Korea.
Ma S; Medical Accelerator Research Team, Korea Institute of Radiological & Medical Sciences (KIRAMS), 75 Nowonro, Nowon-gu, Seoul, 01812, South Korea.
Oh DY; Department of Otolaryngology, Department of Molecular Science and Technology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-Gu, Suwon, 443-380, Republic of Korea.
Jang JY; Department of Otolaryngology, Department of Molecular Science and Technology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-Gu, Suwon, 443-380, Republic of Korea.
Seo C; Department of Otolaryngology, Department of Molecular Science and Technology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-Gu, Suwon, 443-380, Republic of Korea.
Lee YS; Department of Otolaryngology, Department of Molecular Science and Technology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-Gu, Suwon, 443-380, Republic of Korea.
Kim CH; Department of Otolaryngology, Department of Molecular Science and Technology, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-Gu, Suwon, 443-380, Republic of Korea. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 19; Vol. 22 (1), pp. 138. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Extracellular Matrix*/metabolism
Nitric Oxide Synthase Type III*/genetics
Nitric Oxide Synthase Type III*/metabolism
Vascular System Injuries*/metabolism
Vascular System Injuries*/therapy
Plasma*/metabolism
Humans ; Adenosine Monophosphate/metabolism ; Adenosine Monophosphate/pharmacology ; Angiogenesis ; Human Umbilical Vein Endothelial Cells/metabolism ; Neovascularization, Physiologic ; Nitric Oxide/metabolism ; Nitric Oxide/pharmacology ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase/pharmacology ; Phosphorylation ; Protein Kinases/metabolism ; Up-Regulation ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparable outcomes of outpatient remdesivir and sotrovimab among high-risk patients with mild to moderate COVID-19 during the omicron BA.1 surge.
Autorzy:
Chesdachai S; Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. .
Rivera CG; Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
Cole KC; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Teaford HR; Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
Gonzalez Suarez ML; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Larsen JJ; Department of Nursing, Mayo Clinic, Rochester, MN, USA.
Ganesh R; Department of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Tulledge-Scheitel S; Department of Community Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Razonable RR; Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 05; Vol. 14 (1), pp. 5430. Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Outpatients*
COVID-19*
Antibodies, Neutralizing*
Antibodies, Monoclonal, Humanized*
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19 Drug Treatment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway.
Autorzy:
Chi J; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.; Guangzhou Key Laboratory of Cardiac Rehabilitation, Guangzhou, China.
Wu N; Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Li P; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.
Hu J; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Cai H; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lin C; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.; School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Lai Y; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.; School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Yang H; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.
Huang J; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.
Li M; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China.
Xu L; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China. xxgnk_.; Department of Geriatric Cardiology, General Hospital of Southern Theater Command, Guangzhou, China. xxgnk_.; Branch of National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Guangzhou, China. xxgnk_.; Guangzhou Key Laboratory of Cardiac Rehabilitation, Guangzhou, China. xxgnk_.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 29; Vol. 14 (1), pp. 5010. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Connexin 43*/metabolism
AMP-Activated Protein Kinases*/metabolism
Rats ; Animals ; Rats, Sprague-Dawley ; Arrhythmias, Cardiac ; Protein Serine-Threonine Kinases/metabolism ; Phosphorylation ; Adenosine Monophosphate/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hypothermia increases adenosine monophosphate and xanthosine monophosphate levels in the mouse hippocampus, preventing their reduction by global cerebral ischemia.
Autorzy:
Doshi M; Department of Human Physiology and Pathology, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. .
Natori Y; Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Ishii A; Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Saigusa D; Department of Biomedical and Analytical Sciences, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Watanabe S; Division of Nutritional Biochemistry, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Hosoyamada M; Department of Human Physiology and Pathology, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Hirashima-Akae Y; Akae Clinic, 310 Horioka, Imizu, Toyama, 933-0223, Japan.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 07; Vol. 14 (1), pp. 3187. Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Hypothermia*/metabolism
Brain Ischemia*/metabolism
Ribonucleotides*
Humans ; Xanthine/metabolism ; Cerebral Infarction/metabolism ; Hippocampus/metabolism ; Adenosine Monophosphate/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metformin Prevents Cocaine Sensitization: Involvement of Adenosine Monophosphate-Activated Protein Kinase Trafficking between Subcellular Compartments in the Corticostriatal Reward Circuit.
Autorzy:
Aruldas R; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Orenstein LB; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Spencer S; Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55455, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 28; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
Metformin*/pharmacology
Metformin*/metabolism
Cocaine*
Female ; Rats ; Animals ; Male ; Dopamine Uptake Inhibitors/pharmacology ; AMP-Activated Protein Kinases/metabolism ; Adenosine Monophosphate/metabolism ; Rats, Sprague-Dawley ; Nucleus Accumbens/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3.
Autorzy:
Höpfner, Dorothea (AUTHOR)
Cichy, Adam (AUTHOR)
Pogenberg, Vivian (AUTHOR)
Krisp, Christoph (AUTHOR)
Mezouar, Soraya (AUTHOR)
Bach, Nina C. (AUTHOR)
Grotheer, Jan (AUTHOR)
Zarza, Sandra Madariaga (AUTHOR)
Martinez, Eric (AUTHOR)
Bonazzi, Matteo (AUTHOR)
Feige, Matthias J. (AUTHOR)
Sieber, Stephan A. (AUTHOR)
Schlüter, Hartmut (AUTHOR)
Itzen, Aymelt (AUTHOR)
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Źródło:
Communications Biology. 11/6/2023, Vol. 6 Issue 1, p1-25. 25p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Risk factors for hyperglycemia in COVID-19 patients treated with remdesivir.
Autorzy:
Kim W; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.; Department of Pharmacy, Kangwon National University, Chuncheon, Korea.
Lee GW; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.; Department of Pharmacy, Bestian Hospital, Cheongju-si, Korea.
Rhee N; Medical Department, Bestian Hospital, Cheongju-si, Korea.
Min KH; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.
Kim JH; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.
Gil JY; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.
Kim SY; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.; National Institute of Food and Drug Safety Evaluation, Cheongju-si, Korea.
Han JM; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.
Lee KE; College of Pharmacy, Chungbuk National University, Cheongju-si, Korea.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2024 Jan; Vol. 17 (1), pp. e13684. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Hyperglycemia*
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Humans ; COVID-19 Drug Treatment ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants.
Autorzy:
Humeniuk R; Gilead Sciences, Inc., Foster City, California, USA.
Juneja K; Gilead Sciences, Inc., Foster City, California, USA.
Chen S; Gilead Sciences, Inc., Foster City, California, USA.
Ellis S; Gilead Sciences, Inc., Foster City, California, USA.
Anoshchenko O; Gilead Sciences, Inc., Foster City, California, USA.
Xiao D; Gilead Sciences, Inc., Foster City, California, USA.
Share A; Gilead Sciences, Inc., Foster City, California, USA.
Johnston M; ICON plc, Salt Lake City, Utah, USA.
Davies S; Gilead Sciences, Inc., Foster City, California, USA.
DeZure A; Gilead Sciences, Inc., Foster City, California, USA.
Llewellyn J; Gilead Sciences, Inc., Foster City, California, USA.
Osinusi A; Gilead Sciences, Inc., Foster City, California, USA.
Winter H; Gilead Sciences, Inc., Foster City, California, USA.
Girish S; Gilead Sciences, Inc., Foster City, California, USA.
Palaparthy R; Gilead Sciences, Inc., Foster City, California, USA.
Dresser M; Gilead Sciences, Inc., Foster City, California, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Nov; Vol. 16 (11), pp. 2276-2288. Date of Electronic Publication: 2023 Sep 25.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alanine*/adverse effects
Adult ; Humans ; Healthy Volunteers ; Adenosine Monophosphate/adverse effects ; Double-Blind Method ; Dose-Response Relationship, Drug
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cyclic adenosine monophosphate potentiates immune checkpoint blockade therapy in acute myeloid leukemia.
Autorzy:
Mao P; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Feng W; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Zhang Z; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Huang C; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Zhou S; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Zhao Z; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Mu Y; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Zhao AY; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Wang L; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Li F; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
Zhao AZ; Department of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Nov; Vol. 13 (11), pp. e1489.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Immune Checkpoint Inhibitors*/therapeutic use
Leukemia, Myeloid, Acute*/drug therapy
Humans ; Adenosine Monophosphate/therapeutic use
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity.
Autorzy:
Huang S; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Jia A; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Song W; Institute of Biochemistry, University of Cologne, 50674 Cologne, Germany.; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
Hessler G; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
Meng Y; School of Pharmaceutical Sciences, Zhengzhou University, 450001 Zhengzhou, China.
Sun Y; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Xu L; National Protein Science Facility, Tsinghua University, 100084 Beijing, China.
Laessle H; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
Jirschitzka J; Institute of Biochemistry, University of Cologne, 50674 Cologne, Germany.; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
Ma S; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Xiao Y; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Yu D; Institute of Biochemistry, University of Cologne, 50674 Cologne, Germany.; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
Hou J; School of Pharmaceutical Sciences, Zhengzhou University, 450001 Zhengzhou, China.
Liu R; School of Pharmaceutical Sciences, Zhengzhou University, 450001 Zhengzhou, China.
Sun H; Institute of Biochemistry, University of Cologne, 50674 Cologne, Germany.; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
Liu X; National Protein Science Facility, Tsinghua University, 100084 Beijing, China.
Han Z; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.
Chang J; School of Pharmaceutical Sciences, Zhengzhou University, 450001 Zhengzhou, China.; Henan Key Laboratory of Organic Functional Molecules and Drug Innovation, Henan Normal University, 453007 Xinxiang, China.
Parker JE; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
Chai J; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua University, 100084 Beijing, China.; Institute of Biochemistry, University of Cologne, 50674 Cologne, Germany.; Max-Planck Institute for Plant Breeding Research, Department of Plant-Microbe Interactions, 50829 Cologne, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jul 29; Vol. 377 (6605), pp. eabq3297. Date of Electronic Publication: 2022 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Adenosine Diphosphate*/metabolism
Adenosine Monophosphate*/metabolism
Arabidopsis*/enzymology
Arabidopsis*/immunology
Arabidopsis Proteins*/chemistry
Arabidopsis Proteins*/genetics
Arabidopsis Proteins*/metabolism
Carboxylic Ester Hydrolases*/chemistry
Carboxylic Ester Hydrolases*/genetics
Carboxylic Ester Hydrolases*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Plant Immunity*/genetics
Catalysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CD73 mediates the therapeutic effects of endometrial regenerative cells in concanavalin A-induced hepatitis by regulating CD4 T cells.
Autorzy:
Qin H; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Sun C; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Kong D; School of Medicine, Nankai University, Tianjin, 300071, China.
Zhu Y; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Shao B; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Ren S; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Wang H; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Zhang J; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Xu Y; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Wang H; Department of General Surgery, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China. .; Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2023 Sep 29; Vol. 14 (1), pp. 277. Date of Electronic Publication: 2023 Sep 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatitis*
Mice ; Animals ; Concanavalin A ; Th1 Cells ; Transaminases ; Adenosine Monophosphate ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infections.
Autorzy:
Hickman MR; Joint Project Manager for Chemical, Biological, Radiological, and Nuclear Medical (JPM CBRN Medical), Fort Detrick, Maryland, United States of America.
Saunders DL; U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Maryland, United States of America.
Bigger CA; Logistics Management International Inc, Tysons Corner, Virginia, United States of America.
Kane CD; National Cancer Institute, Frederick, Maryland, United States of America.
Iversen PL; Oregon State University, Corvallis, Oregon, United States of America.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Mar 08; Vol. 16 (3), pp. e0010220. Date of Electronic Publication: 2022 Mar 08 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
Drug Development*
Medical Countermeasures*
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*pharmacology
Hemorrhagic Fevers, Viral/*drug therapy
RNA Virus Infections/*drug therapy
Adenosine Monophosphate/pharmacology ; Alanine/pharmacology ; Animals ; Humans ; Models, Animal ; Primates ; United States ; United States Food and Drug Administration/legislation & jurisprudence
Czasopismo naukowe
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Tytuł:
Comparative outcomes of combined corticosteroid and remdesivir therapy with corticosteroid monotherapy in ventilated COVID-19 patients.
Autorzy:
Mandadi S; Department of Infectious Diseases, Charleston Area Medical Center, Charleston, West Virginia, United States of America.
Pulluru H; Department of Hospital Medicine, Charleston Area Medical Center, Charleston, West Virginia, United States of America.
Annie F; Charleston Area Medical Center Health Education and Research Institute, Charleston, West Virginia, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Feb 23; Vol. 17 (2), pp. e0264301. Date of Electronic Publication: 2022 Feb 23 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19 Drug Treatment*
Adenosine Monophosphate/*analogs & derivatives
Adrenal Cortex Hormones/*therapeutic use
Alanine/*analogs & derivatives
Adenosine Monophosphate/therapeutic use ; Aged ; Alanine/therapeutic use ; COVID-19/complications ; COVID-19/mortality ; COVID-19/virology ; Cohort Studies ; Drug Therapy, Combination ; Female ; Hospital Mortality ; Humans ; Incidence ; Kaplan-Meier Estimate ; Length of Stay ; Male ; Middle Aged ; Proportional Hazards Models ; Pseudomonas Infections/diagnosis ; Pseudomonas Infections/epidemiology ; Pseudomonas Infections/etiology ; Respiration, Artificial ; SARS-CoV-2/isolation & purification ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/etiology ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Remdesivir in combination with dexamethasone for patients hospitalized with COVID-19: A retrospective multicenter study.
Autorzy:
Gressens SB; Département des Maladies Infectieuses, Hôpitaux Saint Louis-Lariboisière, Université de Paris, AP-HP, Paris, France.
Esnault V; Département des Maladies Infectieuses, Hôpitaux Saint Louis-Lariboisière, Université de Paris, AP-HP, Paris, France.
De Castro N; Département des Maladies Infectieuses, Hôpitaux Saint Louis-Lariboisière, Université de Paris, AP-HP, Paris, France.
Sellier P; Département des Maladies Infectieuses, Hôpitaux Saint Louis-Lariboisière, Université de Paris, AP-HP, Paris, France.
Sene D; Département de Médecine Interne, AP-HP Hôpital Lariboisière, Paris, France.
Chantelot L; Service de Pneumologie, AP-HP Hôpital Saint Louis, Paris, France.
Hervier B; UF de Médecine Interne, AP-HP Hôpital Saint Louis, Paris, France.
Delaugerre C; Laboratoire de Virologie, AP-HP Hôpital Saint Louis, Paris, France.
Chevret S; Service de Biostatistique et Information Médicale, AP-HP Hôpital Saint Louis, Paris, France.
Molina JM; Département des Maladies Infectieuses, Hôpitaux Saint Louis-Lariboisière, Université de Paris, AP-HP, Paris, France.
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Corporate Authors:
Saint-Louis CORE group
Źródło:
PloS one [PLoS One] 2022 Feb 17; Vol. 17 (2), pp. e0262564. Date of Electronic Publication: 2022 Feb 17 (Print Publication: 2022).
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
COVID-19 Drug Treatment*
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Anti-Inflammatory Agents/*therapeutic use
Antiviral Agents/*therapeutic use
Dexamethasone/*therapeutic use
SARS-CoV-2/*drug effects
Adenosine Monophosphate/therapeutic use ; Aged ; Alanine/therapeutic use ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/virology ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; France/epidemiology ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; SARS-CoV-2/isolation & purification ; Survival Rate
Czasopismo naukowe
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Wyświetlanie 1-20 z 10372

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