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Tytuł:
The future of engineered immune cell therapies.
Autorzy:
Irvine DJ; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Cambridge, MA, USA.
Maus MV; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Cellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston MA, USA.
Mooney DJ; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
Wong WW; Department of Biomedical Engineering and Biological Design Center, Boston University, Boston, MA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Nov 25; Vol. 378 (6622), pp. 853-858. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cell Engineering*
Hematologic Neoplasms*/therapy
T-Lymphocytes*/immunology
T-Lymphocytes*/transplantation
Adoptive Transfer*/methods
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis.
Autorzy:
Dong L; Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang, 453003, PR China.; Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Gao J; Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang, 453003, PR China.
Yu L; Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang, 453003, PR China.
Liu S; Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang, 453003, PR China.
Zhao Y; Department of Immunology, Xinjiang Medical University, Urumqi, PR China.
Zhang W; Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang, 453003, PR China.
Liang Y; Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang, 453003, PR China.; Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, PR China.
Wang H; Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang Medical University, Henan Province, Xinxiang, 453003, PR China. .; Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, PR China. .; Department of Immunology, Xinjiang Medical University, Urumqi, PR China. .
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Źródło:
BMC immunology [BMC Immunol] 2024 Jan 10; Vol. 25 (1), pp. 4. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, High-Fat*/adverse effects
Lipogenesis*
Male ; Animals ; Mice ; Th2 Cells ; Obesity/therapy ; Adoptive Transfer
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells.
Autorzy:
Holtappels R; Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Becker S; Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany.
Hamdan S; Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Freitag K; Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Podlech J; Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Lemmermann NA; Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany.
Reddehase MJ; Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Nov 16; Vol. 19 (11), pp. e1011643. Date of Electronic Publication: 2023 Nov 16 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Cytomegalovirus Infections*
Humans ; Mice ; Animals ; CD8-Positive T-Lymphocytes ; Cytomegalovirus ; Immunotherapy ; Adoptive Transfer ; Antiviral Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy.
Autorzy:
Herrera L; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Martin-Inaraja M; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Santos S; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Inglés-Ferrándiz M; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Azkarate A; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Perez-Vaquero MA; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Vesga MA; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
Vicario JL; Histocompatibility, Centro de Transfusión de Madrid, Madrid, Spain.
Soria B; Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Alicante, Spain.; Instituto de Investigación Sanitaria Hospital General y Universitario de Alicante (ISABIAL), Alicante, Spain.
Solano C; Hospital Clínico Universitario de Valencia/Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain.; School of Medicine, University of Valencia, Spain.
De Paz R; Hematology Department, University Hospital La Paz, Madrid, Spain.
Marcos A; Hematology Department, University Hospital La Paz, Madrid, Spain.
Ferreras C; Hospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.
Perez-Martinez A; Hospital La Paz Institute for Health Research, IdiPAZ, University Hospital La Paz, Madrid, Spain.; Pediatric Hemato-Oncology Department, University Hospital La Paz, Madrid, Spain.; Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Eguizabal C; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
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Źródło:
Immunology [Immunology] 2022 Feb; Vol. 165 (2), pp. 234-249. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adoptive Transfer*
Blood Donors*
Convalescence*
Immunologic Memory*
COVID-19/*immunology
Killer Cells, Natural/*immunology
SARS-CoV-2/*immunology
Adult ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Migration, Distribution, and Safety Evaluation of Specific Phenotypic and Functional Mouse Spleen-Derived Invariant Natural Killer T2 Cells after Adoptive Infusion.
Autorzy:
Chen D; College of Basic Medicine, Hebei University, Baoding, 071000 Hebei Province, China.; Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Baoding, 071000, Hebei Province, China.
Xu W; College of Basic Medicine, Hebei University, Baoding, 071000 Hebei Province, China.; Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Baoding, 071000, Hebei Province, China.
Teng J; College of Basic Medicine, Hebei University, Baoding, 071000 Hebei Province, China.; Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Baoding, 071000, Hebei Province, China.
Liu H; College of Basic Medicine, Hebei University, Baoding, 071000 Hebei Province, China.; Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Baoding, 071000, Hebei Province, China.
Wang Y; College of Basic Medicine, Hebei University, Baoding, 071000 Hebei Province, China.; Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Baoding, 071000, Hebei Province, China.
Wang Y; Affiliated Hospital of Hebei University, Baoding, 071000 Hebei Province, China.
Cheng S; Affiliated Hospital of Hebei University, Baoding, 071000 Hebei Province, China.; Hebei Province Basic Research Key Laboratory of General Surgery for Digital Medicine, Baoding, 071000 Hebei Province, China.
Meng M; College of Basic Medicine, Hebei University, Baoding, 071000 Hebei Province, China.; Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Baoding, 071000, Hebei Province, China.
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Źródło:
Mediators of inflammation [Mediators Inflamm] 2021 Dec 08; Vol. 2021, pp. 5170123. Date of Electronic Publication: 2021 Dec 08 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Adoptive Transfer*
Natural Killer T-Cells/*immunology
Spleen/*immunology
Animals ; Cell Movement ; Galactosylceramides/pharmacology ; Immunophenotyping ; Male ; Mice ; Mice, Inbred DBA ; Natural Killer T-Cells/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A phase I/II clinical trial on the efficacy and safety of NKT cells combined with gefitinib for advanced EGFR-mutated non-small-cell lung cancer.
Autorzy:
Yu W; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.
Ye F; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yuan X; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Ma Y; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.
Mao C; Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Li X; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Li J; Department of Respiratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Dai C; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Qian F; Department of Respiratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Li J; Department of Epidemiology and Biostatistics, School of Medicine, Jiangsu University, Zhenjiang, China.
Fan X; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Zhou Y; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Wang D; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Guo Z; National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China.
An H; Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong, China.
Zhang M; School of Medicine, Tsinghua University, Beijing, China. .
Chen D; Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China. .
Xia S; Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China. .
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Źródło:
BMC cancer [BMC Cancer] 2021 Jul 31; Vol. 21 (1), pp. 877. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji:
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms:
Adoptive Transfer*/adverse effects
Adoptive Transfer*/methods
Mutation*
Carcinoma, Non-Small-Cell Lung/*therapy
Gefitinib/*therapeutic use
Lung Neoplasms/*therapy
Natural Killer T-Cells/*immunology
B7-H1 Antigen/antagonists & inhibitors ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/etiology ; Combined Modality Therapy ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Gefitinib/administration & dosage ; Gefitinib/adverse effects ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/etiology ; Molecular Targeted Therapy ; Natural Killer T-Cells/metabolism ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
OVA-Experienced CD4 T Cell Transfer and Chicken Protein Challenge Affect the Immune Response to OVA in a Murine Model.
Autorzy:
Fuc E; Department of Food Immunology and Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, J. Tuwima 10 Str., 10-748 Olsztyn, Poland.
Złotkowska D; Department of Food Immunology and Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, J. Tuwima 10 Str., 10-748 Olsztyn, Poland.
Wasilewska E; Department of Food Immunology and Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, J. Tuwima 10 Str., 10-748 Olsztyn, Poland.
Wróblewska B; Department of Food Immunology and Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, J. Tuwima 10 Str., 10-748 Olsztyn, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 18; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 18.
Typ publikacji:
Journal Article
MeSH Terms:
Adoptive Transfer*
Poultry Products*
Allergens/*immunology
CD4-Positive T-Lymphocytes/*immunology
Immunoglobulins/*immunology
Ovalbumin/*immunology
Animals ; Avian Proteins/immunology ; Cells, Cultured ; Chickens ; Female ; Food Hypersensitivity/immunology ; Interferon-gamma/immunology ; Lymphocyte Subsets/immunology ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Restored Macrophage Function Ameliorates Disease Pathophysiology in a Mouse Model for IL10 Receptor-deficient Very Early Onset Inflammatory Bowel Disease.
Autorzy:
Ackermann M; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Hematology of Congenital Diseases, Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.
Mucci A; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, MA, USA.
McCabe A; Division of Hematology/Oncology, Boston Children's Hospital, MA, USA.
Frei S; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, USA.
Wright K; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Snapper SB; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, USA.; Harvard Medical School, Boston, MA, USA.
Lachmann N; Translational Hematology of Congenital Diseases, Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, Hannover, Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.
Williams DA; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Brendel C; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
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Źródło:
Journal of Crohn's & colitis [J Crohns Colitis] 2021 Sep 25; Vol. 15 (9), pp. 1588-1595.
Typ publikacji:
Journal Article
MeSH Terms:
Adoptive Transfer*
Inflammatory Bowel Diseases/*physiopathology
Inflammatory Bowel Diseases/*therapy
Interleukin-10 Receptor beta Subunit/*physiology
Macrophages/*transplantation
Animals ; Disease Models, Animal ; Inflammatory Bowel Diseases/etiology ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
NK Cells in Cancer: Mechanisms of Dysfunction and Therapeutic Potential.
Autorzy:
Portale F; Tumor Microenviroment Unit, IRCCS Humanitas Research Hospital, 20089 Milan, Italy.
Di Mitri D; Tumor Microenviroment Unit, IRCCS Humanitas Research Hospital, 20089 Milan, Italy.; Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 30; Vol. 24 (11). Date of Electronic Publication: 2023 May 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/therapy
Neoplasms*/pathology
Humans ; Killer Cells, Natural/pathology ; Immunotherapy, Adoptive/methods ; Immunotherapy/methods ; Adoptive Transfer ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Translating Treg Therapy for Inflammatory Bowel Disease in Humanized Mice.
Autorzy:
Negi S; Biomedical Parasitology and Nano-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India.; BERPDC Department, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India.
Saini S; Biomedical Parasitology and Nano-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India.
Tandel N; Institute of Science, Nirma University, Ahmedabad, Gujarat 382481, India.
Sahu K; Biomedical Parasitology and Nano-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India.
Mishra RPN; BERPDC Department, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India.
Tyagi RK; Biomedical Parasitology and Nano-Immunology Lab, Division of Cell Biology and Immunology, CSIR-Institute of Microbial Technology (IMTECH), Chandigarh 160036, India.
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Źródło:
Cells [Cells] 2021 Jul 21; Vol. 10 (8). Date of Electronic Publication: 2021 Jul 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Adoptive Transfer*
Colitis, Ulcerative/*therapy
Crohn Disease/*therapy
T-Lymphocytes, Regulatory/*transplantation
Animals ; Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/metabolism ; Crohn Disease/genetics ; Crohn Disease/immunology ; Crohn Disease/metabolism ; Disease Models, Animal ; Hematopoietic Stem Cell Transplantation ; Humans ; Mice, Transgenic ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Transplantation, Heterologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Adoptive transfer of placental ischemia-stimulated natural killer cells causes a preeclampsia-like phenotype in pregnant rats.
Autorzy:
Travis OK; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Baik C; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Tardo GA; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Amaral L; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Jackson C; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Greer M; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Giachelli C; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Ibrahim T; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Herrock OT; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Williams JM; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
Cornelius DC; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
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Źródło:
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2021 Jun; Vol. 85 (6), pp. e13386. Date of Electronic Publication: 2020 Dec 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Adoptive Transfer*
Killer Cells, Natural/*transplantation
Pre-Eclampsia/*therapy
Animals ; Cyclic GMP/blood ; Cyclic GMP/metabolism ; Cytokines/blood ; Cytokines/metabolism ; Female ; Fetal Growth Retardation/prevention & control ; Ischemia/blood ; Ischemia/metabolism ; Ischemia/therapy ; Nitrates/blood ; Nitric Oxide Synthase Type III/metabolism ; Nitrites/blood ; Oxidative Stress ; Phenotype ; Placenta/blood supply ; Placenta/metabolism ; Pre-Eclampsia/blood ; Pre-Eclampsia/metabolism ; Pregnancy ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-1/blood ; Vascular Endothelial Growth Factor Receptor-1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tyrosine Kinase 2 Signalling Drives Pathogenic T cells in Colitis.
Autorzy:
De Vries LCS; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Ghiboub M; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
van Hamersveld PHP; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Welting O; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Verseijden C; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Bell MJ; Epigenetics RU, Oncology Therapy Area, Medicines Research Centre, GlaxoSmithKline, Stevenage, UK.
Rioja I; Epigenetics RU, Oncology Therapy Area, Medicines Research Centre, GlaxoSmithKline, Stevenage, UK.
Prinjha RK; Epigenetics RU, Oncology Therapy Area, Medicines Research Centre, GlaxoSmithKline, Stevenage, UK.
Koelink PJ; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Strobl B; Institute of Animal Breeding and Genetics and Biomodels Austria, University of Veterinary Medicine, Vienna, Austria.
Müller M; Institute of Animal Breeding and Genetics and Biomodels Austria, University of Veterinary Medicine, Vienna, Austria.
D'Haens GR; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Wildenberg ME; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
De Jonge WJ; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Surgery, University of Bonn, Bonn, Germany.
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Źródło:
Journal of Crohn's & colitis [J Crohns Colitis] 2021 Apr 06; Vol. 15 (4), pp. 617-630.
Typ publikacji:
Journal Article
MeSH Terms:
Administration, Oral*
Adoptive Transfer*
Inflammatory Bowel Diseases/*enzymology
Inflammatory Bowel Diseases/*immunology
T-Lymphocytes/*drug effects
T-Lymphocytes/*immunology
TYK2 Kinase/*antagonists & inhibitors
Animals ; Cell Differentiation/immunology ; Cytokines/immunology ; Disease Models, Animal ; Female ; Flow Cytometry ; Homeodomain Proteins ; Humans ; Mice ; Signal Transduction ; Th1 Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Autorzy:
Kim HR; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju, 61005, Korea.; Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Korea.; Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 609, Rochester, NY, 14642, USA.
Park JS; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju, 61005, Korea.; Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Korea.
Park JH; KYNOGEN Co., Suwon, 16229, Korea.
Yasmin F; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju, 61005, Korea.; Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Korea.
Kim CH; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju, 61005, Korea.; Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Korea.
Oh SK; KYNOGEN Co., Suwon, 16229, Korea.
Chung IJ; Department of Hematology-Oncology, Immunotherapy Innovation Center, Chonnam National University Medical School, Hwasun, 58128, Korea.
Jun CD; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju, 61005, Korea. .; Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, Korea. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2021 Mar 17; Vol. 14 (1), pp. 43. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adoptive Transfer*
Dendritic Cells/*immunology
Melanoma, Experimental/*therapy
Microfilament Proteins/*immunology
Muscle Proteins/*immunology
Animals ; Cell Movement ; Cells, Cultured ; Dendritic Cells/cytology ; Female ; Immunity ; Melanoma, Experimental/genetics ; Melanoma, Experimental/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins/genetics ; Muscle Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Formation of a Unique Population of CD8+ T Lymphocytes after Adoptive Transfer of Syngeneic Splenocytes to Mice with Lymphopenia.
Autorzy:
Silaeva YY; Core Facility Center, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. .
Kalinina AA; Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Khromykh LM; Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Deykin AV; Core Facility Center, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Kazansky DB; Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
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Źródło:
Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2021 Mar; Vol. 497 (1), pp. 71-74. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Adoptive Transfer*
CD8-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*pathology
Lymphopenia/*immunology
Spleen/*immunology
Animals ; Biomarkers/metabolism ; Cell Count ; Gene Expression Regulation/immunology ; Mice ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cytotoxic effect of CLL‑1 CAR‑T cell immunotherapy with PD‑1 silencing on relapsed/refractory acute myeloid leukemia.
Autorzy:
Lin G; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Zhang Y; Department of Hematology, Huai'an Hospital Affiliated to Xuzhou Medical College, Huai'an Second People's Hospital, Huai'an, Jiangsu 223002, P.R. China.
Yu L; Institute of Biomedical Engineering and Technology, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200065, P.R. China.
Wu D; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2021 Mar; Vol. 23 (3). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Adoptive Transfer*
Gene Silencing*
Leukemia, Myeloid, Acute/*immunology
Leukemia, Myeloid, Acute/*therapy
Programmed Cell Death 1 Receptor/*deficiency
Receptors, Chimeric Antigen/*immunology
Humans ; K562 Cells ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Programmed Cell Death 1 Receptor/immunology ; Receptors, Chimeric Antigen/genetics ; THP-1 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dexamethasone and lactoferrin induced PMN-MDSCs relieved inflammatory adverse events of anti-cancer therapy without tumor promotion.
Autorzy:
Li X; Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, PR China. .
Chen J; Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, PR China.
Chen YJ; Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, PR China.
Qiao YD; Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, PR China.
Zhao LY; Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, PR China.
Jiang N; Department of Transplantation, the Second Affiliated Hospital of Southern University of Science and Technology and the Third People's Hospital of Shenzhen, 29th Bulan Road, Shenzhen, 510623, PR China.
Wu XY; Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, PR China. .
Xing YF; Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, 63 Duobao Road, Guangzhou, 510150, PR China. .
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Źródło:
Communications biology [Commun Biol] 2021 Feb 26; Vol. 4 (1), pp. 252. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adoptive Transfer*
Acute Kidney Injury/*therapy
Anti-Inflammatory Agents/*pharmacology
Dexamethasone/*pharmacology
Lactoferrin/*pharmacology
Lung Diseases, Interstitial/*therapy
Myeloid-Derived Suppressor Cells/*drug effects
Myeloid-Derived Suppressor Cells/*transplantation
Pneumonia/*therapy
Acute Kidney Injury/chemically induced ; Acute Kidney Injury/immunology ; Acute Kidney Injury/metabolism ; Animals ; Bleomycin ; Cell Line, Tumor ; Cisplatin ; Disease Models, Animal ; Drug Therapy, Combination ; Female ; Humans ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/immunology ; Lung Diseases, Interstitial/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Ovalbumin ; Phenotype ; Pneumonia/chemically induced ; Pneumonia/immunology ; Pneumonia/metabolism ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulatory T-cell therapy approaches.
Autorzy:
McCallion O; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Bilici M; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Hester J; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Issa F; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
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Źródło:
Clinical and experimental immunology [Clin Exp Immunol] 2023 Mar 16; Vol. 211 (2), pp. 96-107.
Typ publikacji:
Review; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
T-Lymphocytes, Regulatory*
Humans ; Adoptive Transfer
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Adoptive cell transfer therapy for melanoma.
Autorzy:
Inozume T; Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan.
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Źródło:
Experimental dermatology [Exp Dermatol] 2023 Mar; Vol. 32 (3), pp. 250-255. Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Melanoma*/therapy
Humans ; Lymphocytes, Tumor-Infiltrating ; Adoptive Transfer ; Immunotherapy, Adoptive/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A CpG-Oligodeoxynucleotide Suppresses Th2/Th17 Inflammation by Inhibiting IL-33/ST2 Signaling in Mice from a Model of Adoptive Dendritic Cell Transfer of Smoke-Induced Asthma.
Autorzy:
Yang X; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.; Department of Pulmonary and Critical Care Medicine, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518000, China.
Su B; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Liu J; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Zheng L; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Tao P; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Lin Y; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Zou X; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Yang H; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Wu W; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Meng P; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Zhang T; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
Li H; Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Institute of Respiratory Diseases of Sun Yat-sen University, Guangzhou 510630, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 04; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 04.
Typ publikacji:
Journal Article
MeSH Terms:
Asthma*/metabolism
Interleukin-33*/metabolism
Animals ; Humans ; Mice ; Adoptive Transfer ; Allergens ; Cytokines/metabolism ; Dendritic Cells ; Inflammation ; Mice, Inbred BALB C ; Oligodeoxyribonucleotides/pharmacology ; Th2 Cells ; Thymic Stromal Lymphopoietin ; Th17 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gene Modified CAR-T Cellular Therapy for Hematologic Malignancies.
Autorzy:
Lin WY; Department of Internal Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Wang HH; Department of Pediatrics, Division of Pediatric Immunology and Nephrology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Department of Pediatrics, Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.; Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Chen YW; Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Lin CF; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.; Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Fan HC; Department of Pediatrics, Tungs' Taichung Metroharbor Hospital, Wuchi, Taichung 435403, Taiwan.; Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Wuchi, Taichung 435403, Taiwan.; Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan.; Department of Rehabilitation, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan.
Lee YY; School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.; Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Division of Pediatric Neurosurgery, Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 17; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 17.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Adoptive Transfer*
Hematologic Neoplasms/*therapy
Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 3627

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