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Wyświetlanie 1-20 z 179
Tytuł:
The infusion of menthol into the esophagus evokes cold sensations in healthy subjects but induces heartburn in patients with gastroesophageal reflux disease (GERD).
Autorzy:
Banovcin P; Gastroenterology Clinic.
Duricek M; Gastroenterology Clinic.
Zatko T; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Martin, Slovakia.
Liptak P; Gastroenterology Clinic.
Hyrdel R; Gastroenterology Clinic.
Kollarik M; Department of Pathophysiology, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Martin, Slovakia.; Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
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Źródło:
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2019 Dec 30; Vol. 32 (11).
Typ publikacji:
Journal Article
MeSH Terms:
Gastroesophageal Reflux/*physiopathology
Heartburn/*chemically induced
Menthol/*pharmacology
Pain/*chemically induced
Thermosensing/*drug effects
Adult ; Afferent Pathways/physiopathology ; Aged ; Esophagus ; Female ; Gastroesophageal Reflux/complications ; Healthy Volunteers ; Humans ; Male ; Menthol/adverse effects ; Middle Aged ; Pain Measurement ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The social buffering of pain by affective touch: a laser-evoked potential study in romantic couples.
Autorzy:
von Mohr M; Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Krahé C; Department of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Beck B; Institute of Cognitive Neuroscience, University College London, London, UK.
Fotopoulou A; Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
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Źródło:
Social cognitive and affective neuroscience [Soc Cogn Affect Neurosci] 2018 Nov 08; Vol. 13 (11), pp. 1121-1130.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Affect*
Touch*
Pain/*psychology
Adult ; Afferent Pathways ; Anxiety/psychology ; Electroencephalography ; Female ; Humans ; Laser-Evoked Potentials ; Male ; Object Attachment ; Pain Measurement ; Social Support ; Spouses ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predominant synaptic potentiation and activation in the right central amygdala are independent of bilateral parabrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
Autorzy:
Miyazawa Y; 1 Department of Neuroscience, Jikei University School of Medicine, Tokyo, Japan.; 2 Center for Neuroscience of Pain, Jikei University School of Medicine, Tokyo, Japan.
Takahashi Y; 1 Department of Neuroscience, Jikei University School of Medicine, Tokyo, Japan.; 2 Center for Neuroscience of Pain, Jikei University School of Medicine, Tokyo, Japan.
Watabe AM; 2 Center for Neuroscience of Pain, Jikei University School of Medicine, Tokyo, Japan.; 3 Institute of Clinical Medicine and Research, Jikei University School of Medicine, Tokyo, Japan.
Kato F; 1 Department of Neuroscience, Jikei University School of Medicine, Tokyo, Japan.; 2 Center for Neuroscience of Pain, Jikei University School of Medicine, Tokyo, Japan.
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Źródło:
Molecular pain [Mol Pain] 2018 Jan-Dec; Vol. 14, pp. 1744806918807102. Date of Electronic Publication: 2018 Oct 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amygdala/*metabolism
Nociceptors/*metabolism
Pain/*drug therapy
Synapses/*metabolism
Afferent Pathways/physiology ; Animals ; Disease Models, Animal ; Excitatory Postsynaptic Potentials/physiology ; Inflammation/drug therapy ; Male ; Rats, Wistar ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Different processing of meningeal and cutaneous pain information in the spinal trigeminal nucleus caudalis.
Autorzy:
Melin C; 1 Clermont University, University of Auvergne, Clermont-Ferrand, France.; 2 Clermont-Ferrand University Hospital, Department of Odontology, Clermont-Ferrand, France.
Jacquot F; 1 Clermont University, University of Auvergne, Clermont-Ferrand, France.
Vitello N; 1 Clermont University, University of Auvergne, Clermont-Ferrand, France.
Dallel R; 1 Clermont University, University of Auvergne, Clermont-Ferrand, France.; 2 Clermont-Ferrand University Hospital, Department of Odontology, Clermont-Ferrand, France.
Artola A; 1 Clermont University, University of Auvergne, Clermont-Ferrand, France.
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2017 Oct; Vol. 37 (12), pp. 1189-1201. Date of Electronic Publication: 2016 Oct 05.
Typ publikacji:
Journal Article
MeSH Terms:
Pain*
Meninges/*cytology
Trigeminal Caudal Nucleus/*cytology
Afferent Pathways/cytology ; Animals ; Headache/physiopathology ; Male ; Neurons, Afferent/cytology ; Rats ; Rats, Sprague-Dawley ; Skin/innervation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Noxious mechanical heterotopic stimulation induces inhibition of the spinal dorsal horn neuronal network: analysis of spinal somatosensory-evoked potentials.
Autorzy:
Meléndez-Gallardo J; Centro de Biofísica y Bioquímica del Instituto Venezolano de Investigaciones Científicas, IVIC, Caracas, Venezuela.; Centro de Biofísica y Neurociencia, CBN, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela.
Eblen-Zajjur A; Centro de Biofísica y Neurociencia, CBN, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. .
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Źródło:
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2016 Sep; Vol. 37 (9), pp. 1491-7. Date of Electronic Publication: 2016 May 20.
Typ publikacji:
Journal Article
MeSH Terms:
Afferent Pathways/*physiology
Evoked Potentials, Somatosensory/*physiology
Neural Inhibition/*physiology
Pain/*physiopathology
Posterior Horn Cells/*physiology
Animals ; Electric Stimulation ; Functional Laterality ; Laminectomy ; Mice ; Pain/etiology ; Physical Stimulation/adverse effects ; Rats ; Rats, Sprague-Dawley ; Statistics, Nonparametric ; Sural Nerve/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Assessment of the potential role of muscle spindle mechanoreceptor afferents in chronic muscle pain in the rat masseter muscle.
Autorzy:
Lund JP; Groupe de Recherche sur le Système Nerveux Central du Fonds de Recherche en Santé du Québec, Department of Physiology, Université de Montréal, Montréal, Québec, Canada.
Sadeghi S
Athanassiadis T
Caram Salas N
Auclair F
Thivierge B
Arsenault I
Rompré P
Westberg KG
Kolta A
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Źródło:
PloS one [PLoS One] 2010 Jun 15; Vol. 5 (6), pp. e11131. Date of Electronic Publication: 2010 Jun 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Afferent Pathways*
Masseter Muscle/*physiopathology
Mechanoreceptors/*physiology
Pain/*physiopathology
Animals ; Behavior, Animal ; Chronic Disease ; Glutamic Acid/metabolism ; Male ; Masseter Muscle/metabolism ; Membrane Potentials ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and alpha2-adrenergic receptors.
Autorzy:
Wen YR; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Wang CC
Yeh GC
Hsu SF
Huang YJ
Li YL
Sun WZ
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Źródło:
Journal of biomedical science [J Biomed Sci] 2010 Mar 19; Vol. 17 (1), pp. 19. Date of Electronic Publication: 2010 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Afferent Pathways/*physiopathology
Analgesia/*methods
Neural Inhibition/*physiology
Pain/*physiopathology
Adrenergic alpha-Antagonists/pharmacology ; Afferent Pathways/drug effects ; Analysis of Variance ; Animals ; Area Under Curve ; Conditioning, Psychological/physiology ; Electric Stimulation ; Formaldehyde/administration & dosage ; Immunohistochemistry ; Male ; Naloxone/pharmacology ; Narcotic Antagonists ; Neural Inhibition/drug effects ; Rats ; Rats, Sprague-Dawley ; Yohimbine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Nonselective innervation of lamina I projection neurons by cocaine- and amphetamine-regulated transcript peptide (CART)-immunoreactive fibres in the rat spinal dorsal horn.
Autorzy:
Kozsurek M; Department of Anatomy, Histology and Embryology, János Szentágothai Laboratory, Semmelweis University, Tuzoltó u. 58, 1094-Budapest, Hungary.
Lukácsi E
Fekete C
Puskár Z
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2009 Jun; Vol. 29 (12), pp. 2375-87. Date of Electronic Publication: 2009 May 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Afferent Pathways/*metabolism
Nerve Tissue Proteins/*metabolism
Nociceptors/*metabolism
Pain/*metabolism
Posterior Horn Cells/*metabolism
Spinal Nerve Roots/*metabolism
Afferent Pathways/ultrastructure ; Animals ; Calcitonin Gene-Related Peptide/metabolism ; Dendrites/metabolism ; Dendrites/ultrastructure ; Galanin/metabolism ; Immunohistochemistry ; Male ; Microscopy, Electron, Transmission ; Nociceptors/ultrastructure ; Pain/physiopathology ; Posterior Horn Cells/ultrastructure ; Presynaptic Terminals/metabolism ; Presynaptic Terminals/ultrastructure ; Rats ; Rats, Wistar ; Spinal Nerve Roots/ultrastructure ; Substance P/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Excitatory and inhibitory purinergic control of neck muscle nociception in anaesthetized mice.
Autorzy:
Reitz M; Experimental Neurosurgery Section, Department of Neurosurgery, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Makowska A
Ellrich J
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Źródło:
Cephalalgia : an international journal of headache [Cephalalgia] 2009 Jan; Vol. 29 (1), pp. 58-67.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Afferent Pathways/*physiopathology
Neck Muscles/*physiopathology
Pain/*physiopathology
Receptors, Purinergic P2/*metabolism
Tension-Type Headache/*physiopathology
Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/pharmacology ; Afferent Pathways/drug effects ; Anesthesia, General ; Animals ; Electrophysiology ; Male ; Mice ; Mice, Inbred C57BL ; Neck Muscles/drug effects ; Neck Muscles/metabolism ; Nociceptors/metabolism ; Purines/metabolism ; Reflex/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin.
Autorzy:
Zhang X; Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555-1069, USA. />Wu J
Fang L
Willis WD
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Źródło:
Molecular pain [Mol Pain] 2006 Jul 17; Vol. 2, pp. 23. Date of Electronic Publication: 2006 Jul 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Afferent Pathways/*enzymology
Enzyme Inhibitors/*pharmacology
Nociceptors/*enzymology
Pain/*enzymology
Phosphoprotein Phosphatases/*antagonists & inhibitors
Posterior Horn Cells/*enzymology
Afferent Pathways/drug effects ; Afferent Pathways/physiopathology ; Alkenes/pharmacology ; Animals ; Capsaicin/pharmacology ; Disease Models, Animal ; Inflammation Mediators/pharmacology ; Male ; Nociceptors/drug effects ; Nociceptors/physiopathology ; Okadaic Acid/pharmacology ; Okadaic Acid/therapeutic use ; Pain/chemically induced ; Pain/physiopathology ; Pain Threshold/drug effects ; Phosphoprotein Phosphatases/metabolism ; Physical Stimulation ; Polyenes ; Posterior Horn Cells/drug effects ; Posterior Horn Cells/physiopathology ; Pyrones/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reaction Time/drug effects ; Synaptic Transmission/drug effects ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The development of nociceptive circuits.
Autorzy:
Fitzgerald M; Department of Anatomy and Developmental Biology, Wellcome Pain Consortium; University College London, Gower Street, London, WC1E 6BT, UK.
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Źródło:
Nature reviews. Neuroscience [Nat Rev Neurosci] 2005 Jul; Vol. 6 (7), pp. 507-20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Afferent Pathways/*physiopathology
Nerve Net/*physiopathology
Nociceptors/*physiology
Pain/*physiopathology
Afferent Pathways/growth & development ; Animals ; Animals, Newborn ; Developmental Biology ; Humans ; Infant ; Infant, Newborn ; Nerve Net/growth & development ; Neural Networks, Computer ; Neurons, Afferent/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Can we conquer pain?
Autorzy:
Scholz J; Neural Plasticity Research Group, Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.
Woolf CJ
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Źródło:
Nature neuroscience [Nat Neurosci] 2002 Nov; Vol. 5 Suppl, pp. 1062-7.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Afferent Pathways/*metabolism
Central Nervous System/*metabolism
Nociceptors/*metabolism
Pain/*metabolism
Afferent Pathways/drug effects ; Afferent Pathways/physiopathology ; Analgesics/pharmacology ; Animals ; Central Nervous System/drug effects ; Central Nervous System/physiopathology ; Drug Design ; Humans ; Nociceptors/drug effects ; Pain/drug therapy ; Pain/physiopathology ; Receptors, Cell Surface/drug effects ; Receptors, Cell Surface/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing.
Autorzy:
Battaglia AA; Centre for Neuroscience Research, King's College London, Guy's Campus, London SE1 1UL, UK.
Sehayek K
Grist J
McMahon SB
Gavazzi I
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Źródło:
Nature neuroscience [Nat Neurosci] 2003 Apr; Vol. 6 (4), pp. 339-40.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Afferent Pathways/*metabolism
Ephrin-B1/*metabolism
Pain/*metabolism
Posterior Horn Cells/*metabolism
Receptors, Eph Family/*metabolism
Spinal Nerve Roots/*metabolism
Synapses/*metabolism
Afferent Pathways/drug effects ; Animals ; Carrageenan/pharmacology ; Disease Models, Animal ; Ephrin-B2/genetics ; Ephrin-B2/metabolism ; Ephrin-B2/pharmacology ; Hyperalgesia/chemically induced ; Hyperalgesia/metabolism ; Hyperalgesia/physiopathology ; Injections, Spinal ; Pain/physiopathology ; Pain Measurement ; Phosphorylation ; Posterior Horn Cells/drug effects ; Proto-Oncogene Proteins c-fos/drug effects ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Reaction Time/drug effects ; Reaction Time/physiology ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism ; Recombinant Fusion Proteins/pharmacology ; Spinal Nerve Roots/drug effects ; Synapses/drug effects ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; src-Family Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat.
Autorzy:
Tambeli CH; Department of Oral and Maxillofacial Surgery, University of California, San Francisco 94143 CA, USA.
Parada CA
Levine JD
Gear RW
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2002 Oct; Vol. 16 (8), pp. 1547-53.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Afferent Pathways/*metabolism
Neural Inhibition/*physiology
Nociceptors/*metabolism
Pain/*metabolism
Posterior Horn Cells/*metabolism
Receptors, Glutamate/*metabolism
Synaptic Transmission/*physiology
Afferent Pathways/drug effects ; Animals ; Calcium Channel Blockers/pharmacology ; Calcium Channels/drug effects ; Calcium Channels/metabolism ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamic Acid/metabolism ; Male ; Neural Inhibition/drug effects ; Neural Pathways/drug effects ; Neural Pathways/metabolism ; Neurokinin-1 Receptor Antagonists ; Nociceptors/drug effects ; Nucleus Accumbens/metabolism ; Opioid Peptides/metabolism ; Pain/physiopathology ; Posterior Horn Cells/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/antagonists & inhibitors ; Receptors, AMPA/metabolism ; Receptors, Glutamate/drug effects ; Receptors, Metabotropic Glutamate/antagonists & inhibitors ; Receptors, Metabotropic Glutamate/metabolism ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/metabolism ; Receptors, Neurokinin-1/metabolism ; Synaptic Transmission/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli.
Autorzy:
Spike RC; Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Puskár Z
Sakamoto H
Stewart W
Watt C
Todd AJ
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2002 Apr; Vol. 15 (8), pp. 1306-16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Afferent Pathways/*metabolism
Nerve Fibers/*metabolism
Nociceptors/*metabolism
Pain/*metabolism
Posterior Horn Cells/*metabolism
Receptors, Opioid, mu/*metabolism
Substance P/*metabolism
Afferent Pathways/ultrastructure ; Animals ; Cell Communication/physiology ; Female ; Hot Temperature/adverse effects ; Hyperalgesia/metabolism ; Hyperalgesia/physiopathology ; Male ; Nerve Fibers/ultrastructure ; Nociceptors/ultrastructure ; Oligopeptides/metabolism ; Pain/physiopathology ; Posterior Horn Cells/ultrastructure ; Presynaptic Terminals/metabolism ; Presynaptic Terminals/ultrastructure ; Proto-Oncogene Proteins c-fos/metabolism ; Rats ; Rats, Wistar ; Receptors, Neurokinin-1/metabolism ; Receptors, Neurokinin-1/ultrastructure ; Receptors, Opioid, mu/ultrastructure ; Synaptic Transmission/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulating excitability of peripheral afferents: emerging ion channel targets.
Autorzy:
Waxman SG; 1] Center for Neuroscience & Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Veterans Affairs Medical Center, West Haven, Connecticut, USA.
Zamponi GW; Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
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Źródło:
Nature neuroscience [Nat Neurosci] 2014 Feb; Vol. 17 (2), pp. 153-63. Date of Electronic Publication: 2014 Jan 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
Afferent Pathways/*physiopathology
Ion Channels/*physiology
Pain/*pathology
Peripheral Nerves/*physiopathology
Animals ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Peripheral gating of pain signals by endogenous lipid mediators.
Autorzy:
Piomelli D; 1] Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California, USA. [2] Department of Pharmacology, University of California, Irvine, Irvine, California, USA. [3] Department of Biological Chemistry, University of California, Irvine, Irvine, California, USA. [4] Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Genoa, Italy.
Sasso O; Department of Pharmacology, University of California, Irvine, Irvine, California, USA.
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Źródło:
Nature neuroscience [Nat Neurosci] 2014 Feb; Vol. 17 (2), pp. 164-74. Date of Electronic Publication: 2014 Jan 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Lipid Metabolism*
Neurotransmitter Agents/*metabolism
Nociceptors/*physiology
Pain/*pathology
Peripheral Nerves/*physiopathology
Afferent Pathways/physiology ; Animals ; Humans ; Inflammation/complications ; Neurotransmitter Agents/therapeutic use ; Pain/etiology ; Pain/metabolism ; Peripheral Nerves/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 179

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