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Wyszukujesz frazę ""Age of Onset"" wg kryterium: Temat


Tytuł :
Higher prevalence but later age at onset of asthma in cross-country skiers compared with general population.
Autorzy :
Mäki-Heikkilä R; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Karjalainen J; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Allergy Centre, Tampere University Hospital, Tampere, Finland.
Parkkari J; Tampere Research Center of Sports Medicine, UKK Institute, Tampere, Finland.; Tampere University Hospital, Tampere, Finland.
Huhtala H; Faculty of Social Sciences, Tampere University, Tampere, Finland.
Valtonen M; KIHU - Research Institute for Olympic Sports, Jyväskylä, Finland.
Lehtimäki L; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Allergy Centre, Tampere University Hospital, Tampere, Finland.
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Źródło :
Scandinavian journal of medicine & science in sports [Scand J Med Sci Sports] 2021 Dec; Vol. 31 (12), pp. 2259-2266. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article
MeSH Terms :
Age of Onset*
Asthma/*epidemiology
Skiing/*physiology
Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Asthma/drug therapy ; Bronchodilator Agents/therapeutic use ; Cold Temperature ; Competitive Behavior ; Cross-Sectional Studies ; Drug Therapy, Combination ; Female ; Finland/epidemiology ; Humans ; Male ; Physical Conditioning, Human/physiology ; Prevalence ; Young Adult
Czasopismo naukowe
Tytuł :
Human iPSC-derived neurons reveal early developmental alteration of neurite outgrowth in the late-occurring neurodegenerative Wolfram syndrome.
Autorzy :
Pourtoy-Brasselet S; CECS/AFM, I-STEM, Corbeil-Essonnes 91100, France.
Sciauvaud A; INSERM UMR 861, I-STEM, AFM, Corbeil-Essonnes 91100, France; Université Paris-Saclay, INSERM, Univ Evry, Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques, Corbeil-Essonnes 91100, France.
Boza-Moran MG; INSERM UMR 861, I-STEM, AFM, Corbeil-Essonnes 91100, France; Université Paris-Saclay, INSERM, Univ Evry, Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques, Corbeil-Essonnes 91100, France.
Cailleret M; INSERM UMR 861, I-STEM, AFM, Corbeil-Essonnes 91100, France; Université Paris-Saclay, INSERM, Univ Evry, Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques, Corbeil-Essonnes 91100, France.
Jarrige M; INSERM UMR 861, I-STEM, AFM, Corbeil-Essonnes 91100, France; Université Paris-Saclay, INSERM, Univ Evry, Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques, Corbeil-Essonnes 91100, France; CECS/AFM, I-STEM, Corbeil-Essonnes 91100, France.
Polvèche H; CECS/AFM, I-STEM, Corbeil-Essonnes 91100, France.
Polentes J; CECS/AFM, I-STEM, Corbeil-Essonnes 91100, France.
Chevet E; INSERM U1242, Université Rennes 1, Rennes 35000, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes 35000, France.
Martinat C; INSERM UMR 861, I-STEM, AFM, Corbeil-Essonnes 91100, France; Université Paris-Saclay, INSERM, Univ Evry, Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques, Corbeil-Essonnes 91100, France.
Peschanski M; INSERM UMR 861, I-STEM, AFM, Corbeil-Essonnes 91100, France; Université Paris-Saclay, INSERM, Univ Evry, Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques, Corbeil-Essonnes 91100, France; CECS/AFM, I-STEM, Corbeil-Essonnes 91100, France.
Aubry L; INSERM UMR 861, I-STEM, AFM, Corbeil-Essonnes 91100, France; Université Paris-Saclay, INSERM, Univ Evry, Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques, Corbeil-Essonnes 91100, France. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2021 Nov 04; Vol. 108 (11), pp. 2171-2185. Date of Electronic Publication: 2021 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Neurites*/drug effects
Induced Pluripotent Stem Cells/*cytology
Neurons/*cytology
Wolfram Syndrome/*pathology
CRISPR-Cas Systems ; Case-Control Studies ; Endoplasmic Reticulum Stress ; Gene Expression Regulation ; Humans ; Valproic Acid/pharmacology ; Wolfram Syndrome/genetics
Czasopismo naukowe
Tytuł :
Sugar-Sweetened Beverage Intake Linked to Early-Onset Colorectal Cancer Risk.
Autorzy :
Rosenberg K
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Źródło :
The American journal of nursing [Am J Nurs] 2021 Oct 01; Vol. 121 (10), pp. 52.
Typ publikacji :
Journal Article
MeSH Terms :
Age of Onset*
Colorectal Neoplasms/*diagnosis
Sugar-Sweetened Beverages/*adverse effects
Adolescent ; Adult ; Female ; Humans ; Sex Factors ; Sugar-Sweetened Beverages/statistics & numerical data
Czasopismo naukowe
Tytuł :
Colorectal Cancer, Age, and Obesity-Related Comorbidities: A Large Database Study.
Autorzy :
Elangovan A; Department of Internal Medicine-Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Skeans J; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Landsman M; Department of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Ali SMJ; Department of Internal Medicine, Saint Vincent Hospital, Worchester, MA, USA.
Elangovan AG; Texas A&M University, College Station, TX, USA.
Kaelber DC; Department of Internal Medicine-Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Sandhu DS; Department of Gastroenterology, Hepatology and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Cooper GS; Division of Gastroenterology, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Wearn 244, Cleveland, OH, 44106-5066, USA. .
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Źródło :
Digestive diseases and sciences [Dig Dis Sci] 2021 Sep; Vol. 66 (9), pp. 3156-3163. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Age of Onset*
Colorectal Neoplasms*/diagnosis
Colorectal Neoplasms*/epidemiology
Obesity*/diagnosis
Obesity*/epidemiology
Diabetes Mellitus, Type 2/*epidemiology
Hypertension/*epidemiology
Smoking/*epidemiology
Age Factors ; Aged ; Body Mass Index ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; United States/epidemiology ; Young Adult
Czasopismo naukowe
Tytuł :
Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia.
Autorzy :
Wilson RS; From the Rush Alzheimer's Disease Center (R.S.W., T.W., L.Y., F.G., D.A.B., P.A.B.), Department of Neurological Sciences (R.S.W., T.W., L.Y., F.G., D.A.B.), and Department of Psychiatry and Behavioral Sciences (R.S.W., P.A.B.), Rush University Medical Center, Chicago, IL. .
Wang T; From the Rush Alzheimer's Disease Center (R.S.W., T.W., L.Y., F.G., D.A.B., P.A.B.), Department of Neurological Sciences (R.S.W., T.W., L.Y., F.G., D.A.B.), and Department of Psychiatry and Behavioral Sciences (R.S.W., P.A.B.), Rush University Medical Center, Chicago, IL.
Yu L; From the Rush Alzheimer's Disease Center (R.S.W., T.W., L.Y., F.G., D.A.B., P.A.B.), Department of Neurological Sciences (R.S.W., T.W., L.Y., F.G., D.A.B.), and Department of Psychiatry and Behavioral Sciences (R.S.W., P.A.B.), Rush University Medical Center, Chicago, IL.
Grodstein F; From the Rush Alzheimer's Disease Center (R.S.W., T.W., L.Y., F.G., D.A.B., P.A.B.), Department of Neurological Sciences (R.S.W., T.W., L.Y., F.G., D.A.B.), and Department of Psychiatry and Behavioral Sciences (R.S.W., P.A.B.), Rush University Medical Center, Chicago, IL.
Bennett DA; From the Rush Alzheimer's Disease Center (R.S.W., T.W., L.Y., F.G., D.A.B., P.A.B.), Department of Neurological Sciences (R.S.W., T.W., L.Y., F.G., D.A.B.), and Department of Psychiatry and Behavioral Sciences (R.S.W., P.A.B.), Rush University Medical Center, Chicago, IL.
Boyle PA; From the Rush Alzheimer's Disease Center (R.S.W., T.W., L.Y., F.G., D.A.B., P.A.B.), Department of Neurological Sciences (R.S.W., T.W., L.Y., F.G., D.A.B.), and Department of Psychiatry and Behavioral Sciences (R.S.W., P.A.B.), Rush University Medical Center, Chicago, IL.
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Źródło :
Neurology [Neurology] 2021 Aug 31; Vol. 97 (9), pp. e922-e929. Date of Electronic Publication: 2021 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Age of Onset*
Cognition*
Life Style*
Alzheimer Disease/*epidemiology
Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Sociodemographic and Clinical Characteristics of 1350 Patients With Young Onset Dementia: A Comparison With Older Patients.
Autorzy :
Ryan B; Departments of Anatomy and Medical Imaging.; Brain Research New Zealand-Rangahau Roro Aotearoa, Auckland, New Zealand.
Martinez Ruiz A; Psychological Medicine.; Brain Research New Zealand-Rangahau Roro Aotearoa, Auckland, New Zealand.; Department of Demographic Epidemiology and Social Determinants, National Institute of Geriatrics of Mexico, Mexico City, Mexico.
Rivera-Rodriguez C; Statistics, University of Auckland.
Curtis M; Departments of Anatomy and Medical Imaging.; Brain Research New Zealand-Rangahau Roro Aotearoa, Auckland, New Zealand.
Cheung G; Psychological Medicine.; Brain Research New Zealand-Rangahau Roro Aotearoa, Auckland, New Zealand.
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Źródło :
Alzheimer disease and associated disorders [Alzheimer Dis Assoc Disord] 2021 Jul-Sep 01; Vol. 35 (3), pp. 200-207.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Nursing Homes*
Dementia/*diagnosis
Independent Living/*statistics & numerical data
Inpatients/*statistics & numerical data
Aged ; Caregivers/psychology ; Cross-Sectional Studies ; Depression/psychology ; Female ; Humans ; Male ; Middle Aged ; New Zealand ; Retrospective Studies ; Sex Factors ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł :
Genome-wide search for genes affecting the age at diagnosis of type 1 diabetes.
Autorzy :
Syreeni A; From the, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Sandholm N; From the, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Sidore C; Instituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.
Cucca F; Instituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.
Haukka J; From the, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Harjutsalo V; From the, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.
Groop PH; From the, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Department of Diabetes, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
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Corporate Authors :
FinnDiane Study Group
Źródło :
Journal of internal medicine [J Intern Med] 2021 May; Vol. 289 (5), pp. 662-674. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Genome-Wide Association Study*
Diabetes Mellitus, Type 1/*diagnosis
Diabetes Mellitus, Type 1/*genetics
Gene Expression Profiling ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł :
New Model for Estimation of the Age at Onset in Spinocerebellar Ataxia Type 3.
Autorzy :
Peng L; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Chen Z; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Long Z; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Liu M; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Lei L; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Wang C; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Peng H; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Shi Y; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Peng Y; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Deng Q; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Wang S; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Zou G; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Wan L; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Yuan H; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
He L; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Xie Y; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Tang Z; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Wan N; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Gong Y; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Hou X; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Shen L; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Xia K; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Li J; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Chen C; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Qiu R; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Klockgether T; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Tang B; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.
Jiang H; From the Department of Neurology (L.P., Z.C., M.L., L.L., H.P., Y.S., Y.P., Q.D., S.W., G.Z., L.W., H.Y., L.H., Y.X., Z.T., N.W., Y.G., X.H., L.S., J.L., B.T., H.J.), Department of Pathology (C.W.), National Clinical Research Center for Geriatric Disorders (Z.C., L.S., B.T., H.J.), Xiangya Hospital, Central South University; Department of Neurology (Z.L.), The Second Xiangya Hospital, Central South University; Key Laboratory of Hunan Province in Neurodegenerative Disorders (Z.C., L.S., J.L., B.T., H.J.), Center for Medical Genetics School of Life Sciences (K.X., J.L., C.C.), Hunan Key Laboratory of Medical Genetics (K.X., J.L., C.C.), School of Computer Science and Engineering (R.Q.), and School of Basic Medical Science (H.J.), Central South University, Changsha, Hunan, China; Department of Neurology (T.K.), University of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany. .
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Źródło :
Neurology [Neurology] 2021 Jun 08; Vol. 96 (23), pp. e2885-e2895. Date of Electronic Publication: 2021 Apr 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Ataxin-3*/genetics
Models, Statistical*
Repressor Proteins*/genetics
Trinucleotide Repeat Expansion*/genetics
Machado-Joseph Disease/*epidemiology
Adolescent ; Adult ; Age Factors ; China/epidemiology ; Cohort Studies ; Humans ; Middle Aged ; Survival Analysis ; Young Adult
Czasopismo naukowe
Tytuł :
Examining early and late onset of multimorbidity in the Canadian Longitudinal Study on Aging.
Autorzy :
Nicholson K; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Griffith LE; Department of Health Research Methods, Evidence, and Impact, McMaster Institute for Research on Aging, Labarge Centre for Mobility in Aging, McMaster University, Hamilton, Ontario, Canada.
Sohel N; Department of Health Research Methods, Evidence, and Impact, McMaster Institute for Research on Aging, Labarge Centre for Mobility in Aging, McMaster University, Hamilton, Ontario, Canada.
Raina P; Department of Health Research Methods, Evidence, and Impact, McMaster Institute for Research on Aging, Labarge Centre for Mobility in Aging, McMaster University, Hamilton, Ontario, Canada.
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Źródło :
Journal of the American Geriatrics Society [J Am Geriatr Soc] 2021 Jun; Vol. 69 (6), pp. 1579-1591. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Activities of Daily Living*
Age of Onset*
Diagnostic Self Evaluation*
Multimorbidity/*trends
Multiple Chronic Conditions/*epidemiology
Aged ; Aged, 80 and over ; Aging ; Canada/epidemiology ; Cross-Sectional Studies ; Disabled Persons ; Female ; Frailty ; Humans ; Independent Living ; Longitudinal Studies ; Male
Czasopismo naukowe
Tytuł :
Adrenoleukodystrophy siblings with a novel ABCD1 missense variant presenting with phenotypic differences: a case report and literature review.
Autorzy :
Shibata Y; Division of Clinical Genetics, Hokkaido University Hospital, Sapporo, Japan.
Matsushima M; Division of Clinical Genetics, Hokkaido University Hospital, Sapporo, Japan.; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Matsukawa T; Department of Molecular Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ishiura H; Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tsuji S; Department of Molecular Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Institute of Medical Genomics, International University of Health and Welfare, Chiba, Japan.
Yabe I; Division of Clinical Genetics, Hokkaido University Hospital, Sapporo, Japan. .; Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. .
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Źródło :
Journal of human genetics [J Hum Genet] 2021 May; Vol. 66 (5), pp. 535-537. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Case Reports; Comparative Study; Journal Article; Review
MeSH Terms :
Age of Onset*
Amino Acid Substitution*
Mutation, Missense*
Point Mutation*
ATP Binding Cassette Transporter, Subfamily D, Member 1/*genetics
Adrenoleukodystrophy/*genetics
Adrenoleukodystrophy/classification ; Adrenoleukodystrophy/complications ; Adrenoleukodystrophy/pathology ; Brain Stem/diagnostic imaging ; Brain Stem/pathology ; Cerebellum/diagnostic imaging ; Cerebellum/pathology ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Fatal Outcome ; Humans ; Lipoma/complications ; Male ; Memory Disorders/genetics ; Neuroimaging ; Pedigree ; Phenotype ; Siblings ; Soft Tissue Neoplasms/complications ; Spinal Dysraphism/complications ; Strabismus/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis.
Autorzy :
Ojavee SE; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. .
Kousathanas A; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Trejo Banos D; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Orliac EJ; Scientific Computing and Research Support Unit, University of Lausanne, Lausanne, Switzerland.
Patxot M; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Läll K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Fischer K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia.
Kutalik Z; University Center for Primary Care and Public Health, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Robinson MR; Institute of Science and Technology Austria, Klosterneuburg, Austria. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 20; Vol. 12 (1), pp. 2337. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Genome, Human*
Models, Genetic*
Multifactorial Inheritance*
Age Factors ; Algorithms ; Bayes Theorem ; Cardiovascular Diseases/genetics ; Computer Simulation ; Databases, Genetic ; Diabetes Mellitus, Type 2/genetics ; Estonia ; Female ; Genetic Association Studies ; Genome-Wide Association Study ; Genomics ; Humans ; Hypertension/genetics ; Menarche/genetics ; Menopause/genetics ; Phenotype ; Polymorphism, Single Nucleotide ; United Kingdom
Czasopismo naukowe
Tytuł :
Late-onset versus early-onset systemic lupus: characteristics and outcome in a national multicentre register (RELESSER).
Autorzy :
Riveros Frutos A; Rheumatology Department, Germans Trias i Pujol University Hospital, Badalona, Spain.; Medicine Department, Universidad Autonoma de Barcelona, Barcelona, Spain.
Holgado S; Rheumatology Department, Germans Trias i Pujol University Hospital, Badalona, Spain.
Sanvisens Bergé A; Internal Medicine Department, Institut de Recerca Germans Trias i Pujol (IGTP), Spain.
Casas I; Preventive Department, Germans Trias i Pujol University Hospital, Badalona, Spain.
Olivé A; Rheumatology Department, Germans Trias i Pujol University Hospital, Badalona, Spain.
López-Longo FJ; Rheumatology Department, Gregorio Marañón University Hospital, Madrid, Spain.
Calvo-Alén J; Rheumatology Department, Araba University Hospital, Vitoria, Spain.
Galindo M; Rheumatology Department, Doce de Octubre University Hospital, Madrid, Spain.
Fernández-Nebro A; Rheumatology Department, Carlos Haya University Hospital, Málaga, Spain.
Pego-Reigosa JM; Rheumatology Department, University Hospital Complex, Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Spain.
Rúa-Figueroa I; Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain.
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Corporate Authors :
RELESSER Group
Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2021 Apr 06; Vol. 60 (4), pp. 1793-1803.
Typ publikacji :
Journal Article
MeSH Terms :
Age of Onset*
Lupus Erythematosus, Systemic/*diagnosis
Lupus Erythematosus, Systemic/*epidemiology
Adult ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Continental Population Groups ; Cross-Sectional Studies ; Delayed Diagnosis ; Depression/epidemiology ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Lupus Coagulation Inhibitor/blood ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Middle Aged ; Registries ; Retrospective Studies ; Serositis/epidemiology ; Sex Distribution ; Spain/epidemiology ; Thrombosis/epidemiology
Czasopismo naukowe
Tytuł :
Comparison of the urgent referral for suspected breast cancer process with patient age and a predictive multivariable model.
Autorzy :
Ramzi S; Primrose Breast Care Centre, Derriford Hospital, University Hospitals Plymouth NHS Trust,  UK.
Cant PJ; Primrose Breast Care Centre, Derriford Hospital, University Hospitals Plymouth NHS Trust,  UK.
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Źródło :
BJS open [BJS Open] 2021 Mar 05; Vol. 5 (2).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Guideline Adherence*
Practice Guidelines as Topic*
Referral and Consultation*/economics
Breast Neoplasms/*diagnosis
Adult ; Aged ; Cost-Benefit Analysis ; Female ; Humans ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Sensitivity and Specificity ; United Kingdom
Czasopismo naukowe
Tytuł :
The relationship between BRCA-associated breast cancer and age factors: an analysis of the Japanese HBOC consortium database.
Autorzy :
Okano M; Department of Surgery, Hoshi General Hospital, Fukushima, Japan. .; Department of Breast Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan. .
Nomizu T; Department of Surgery, Hoshi General Hospital, Fukushima, Japan.
Tachibana K; Department of Surgery, Hoshi General Hospital, Fukushima, Japan.; Department of Breast Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
Nagatsuka M; Department of Surgery, Hoshi General Hospital, Fukushima, Japan.
Matsuzaki M; Department of Surgery, Hoshi General Hospital, Fukushima, Japan.
Katagata N; Department of Surgery, Hoshi General Hospital, Fukushima, Japan.
Ohtake T; Department of Breast Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
Yokoyama S; Breast Center, Showa University, Tokyo, Japan.
Arai M; Diagnostics and Therapeutics of Intractable Diseases, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Nakamura S; Breast Center, Showa University, Tokyo, Japan.
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Źródło :
Journal of human genetics [J Hum Genet] 2021 Mar; Vol. 66 (3), pp. 307-314. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article
MeSH Terms :
Age of Onset*
Genes, BRCA1*
Genes, BRCA2*
Asian Continental Ancestry Group/*genetics
Breast Neoplasms/*genetics
Hereditary Breast and Ovarian Cancer Syndrome/*genetics
BRCA1 Protein ; BRCA2 Protein ; Breast Neoplasms/chemistry ; Breast Neoplasms/epidemiology ; Estrogens ; Female ; Genetic Predisposition to Disease ; Genetic Testing ; Germ-Line Mutation ; Hereditary Breast and Ovarian Cancer Syndrome/epidemiology ; Hereditary Breast and Ovarian Cancer Syndrome/ethnology ; Humans ; Japan/epidemiology ; Neoplasms, Hormone-Dependent/chemistry ; Neoplasms, Hormone-Dependent/epidemiology ; Neoplasms, Hormone-Dependent/genetics ; Prevalence ; Progesterone ; Receptor, ErbB-2/analysis ; Receptors, Estrogen/analysis ; Receptors, Progesterone/analysis ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Adults with a more extensive body involvement, moderate to extremely severe vitiligo and a prolonged clinical course have an early onset in childhood in addition to other prognostic factors as compared to individuals with later-onset vitiligo.
Autorzy :
Mahajan VK; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Verma YR; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Mehta KS; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Chauhan PS; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Sharma R; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Sharma A; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Sharma H; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
Rana A; Department of Dermatology, Venereology & Leprosy, Dr. Rajendra Prasad Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
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Źródło :
The Australasian journal of dermatology [Australas J Dermatol] 2021 Feb; Vol. 62 (1), pp. e24-e28. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Age of Onset*
Severity of Illness Index*
Vitiligo/*complications
Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Sex Factors ; Young Adult
Czasopismo naukowe
Tytuł :
A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.
Autorzy :
Sepulveda-Falla D; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. .; Neuroscience Group of Antioquia, Faculty of Medicine, University of Antioquia, Medellín, Colombia. .
Chavez-Gutierrez L; VIB Center for Brain and Disease Research, 3000, Leuven, Belgium.; Department of Neurology, KU Leuven, Leuven, Belgium.
Portelius E; Institute of Neuroscience and Physiology, Dept. of Psychiatry and Neurochemistry, The Sahlgrenska Academy At the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, 431 80, Mölndal, Sweden.
Vélez JI; Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; Universidad del Norte, Barranquilla, Colombia.
Dujardin S; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, USA.
Barrera-Ocampo A; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Facultad de Ciencias Naturales, Departamento de Ciencias Farmaceuticas, Universidad Icesi, Grupo Natura, Calle 18 No. 122 -135, Cali, Colombia.
Dinkel F; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hagel C; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Puig B; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mastronardi C; Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; GIPSI Group, Department of Psychiatry, Medical Research Institute, University of Antioquia, Medellín, Colombia.
Lopera F; Neuroscience Group of Antioquia, Faculty of Medicine, University of Antioquia, Medellín, Colombia.
Hyman BT; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegenerative Disease, Charlestown, USA.
Blennow K; Institute of Neuroscience and Physiology, Dept. of Psychiatry and Neurochemistry, The Sahlgrenska Academy At the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, 431 80, Mölndal, Sweden.
Arcos-Burgos M; GIPSI Group, Department of Psychiatry, Medical Research Institute, University of Antioquia, Medellín, Colombia.
de Strooper B; VIB Center for Brain and Disease Research, 3000, Leuven, Belgium.; Department of Neurology, KU Leuven, Leuven, Belgium.; UK Dementia Research Institute, University College London, Queen Square, London, WC1N 3BG, UK.
Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. .
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Źródło :
Acta neuropathologica [Acta Neuropathol] 2021 Feb; Vol. 141 (2), pp. 217-233. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Alzheimer Disease/*pathology
Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/psychology ; Amyloid beta-Protein Precursor/genetics ; Female ; Genotype ; Heterozygote ; Humans ; Male ; Middle Aged ; Models, Neurological ; Phenotype ; Phosphorylation ; Presenilin-1/genetics ; Proteasome Endopeptidase Complex ; Ubiquitination ; Whole Exome Sequencing ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Quality of Life in Advanced Dementia with Late Onset, Young Onset, and Very Young Onset.
Autorzy :
Hartmann J; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Roßmeier C; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Riedl L; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Dorn B; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Fischer J; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Slawik T; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Fleischhaker M; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Hartmann F; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Egert-Schwender S; Technical University of Munich, School of Medicine, Münchner Studienzentrum, Munich, Germany.
Kehl V; Technical University of Munich, School of Medicine, Institute of Medical Informatics, Statistics and Epidemiology, Munich, Germany.
Haller B; Technical University of Munich, School of Medicine, Institute of Medical Informatics, Statistics and Epidemiology, Munich, Germany.
Schneider-Schelte H; German Alzheimer Society, Berlin, Germany.
Dinkel A; Technical University of Munich, School of Medicine, Department of Psychosomatic Medicine and Psychotherapy, Munich, Germany.
Jox RJ; Palliative and Supportive Care Service, Chair in Geriatric Palliative Care, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Diehl-Schmid J; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
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Źródło :
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2021; Vol. 80 (1), pp. 283-297.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Quality of Life*
Dementia/*psychology
Adult ; Aged ; Aged, 80 and over ; Antipsychotic Agents/therapeutic use ; Behavioral Symptoms/etiology ; Behavioral Symptoms/psychology ; Caregivers ; Dementia/complications ; Dementia/drug therapy ; Disease Progression ; Female ; Germany ; Home Care Services ; Humans ; Individuality ; Male ; Middle Aged ; Pain/complications ; Pain/drug therapy ; Pain/psychology ; Palliative Care ; Psychotropic Drugs/therapeutic use
Czasopismo naukowe
Tytuł :
Early-Onset Subgroup of Type 2 Diabetes and Risk of Dementia, Alzheimer's Disease and Stroke: A Cohort Study.
Autorzy :
Wang K; Hong Liu, MD, PhD, Center of Medical Reproduction, the First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, Yuzhong District, Chongqing, China, 400016, .
Liu H
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Źródło :
The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2021; Vol. 8 (4), pp. 442-447.
Typ publikacji :
Journal Article
MeSH Terms :
Age of Onset*
Alzheimer Disease/*epidemiology
Dementia/*epidemiology
Diabetes Mellitus, Type 2/*complications
Stroke/*epidemiology
Age Factors ; Aged ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Risk Factors
Czasopismo naukowe
Tytuł :
How Do Persons with Young and Late Onset Dementia Die?
Autorzy :
Roβmeier C; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Hartmann J; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Riedl L; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Dorn B; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Fischer J; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Hartmann F; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.
Egert-Schwender S; Technical University of Munich, School of Medicine, Münchner Studienzentrum, Munich, Germany.
Kehl V; Technical University of Munich, School of Medicine, Institute of Medical Informatics, Statistics and Epidemiology, Munich, Germany.
Schneider-Schelte H; German Alzheimer Society, Berlin, Germany.
Jox RJ; Palliative and Supportive Care Service, Chair in Geriatric Palliative Care, Lausanne University Hospital, Lausanne, Switzerland.
Dinkel A; Technical University of Munich, School of Medicine, Department of Psychosomatic Medicine and Psychotherapy, Munich, Germany.
Diehl-Schmid J; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Pokaż więcej
Źródło :
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2021; Vol. 81 (2), pp. 843-852.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Age of Onset*
Caregivers/*psychology
Dementia/*psychology
Palliative Care/*psychology
Advance Care Planning ; Aged ; Aged, 80 and over ; Dementia/rehabilitation ; Female ; Humans ; Long-Term Care ; Male ; Quality of Life
Czasopismo naukowe

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