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Tytuł :
Liver-specific Bid silencing inhibits APAP-induced cell death in mice.
Autorzy :
Maxa M; Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, 18057, Rostock, Germany.
Schaeper U; Silence Therapeutics GmbH, Berlin, Germany.
Dames S; Silence Therapeutics GmbH, Berlin, Germany.
Vollmar B; Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, 18057, Rostock, Germany.
Kuhla A; Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, 18057, Rostock, Germany. .
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Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2019 Dec; Vol. 24 (11-12), pp. 934-945.
Typ publikacji :
Journal Article
MeSH Terms :
Acetaminophen/*toxicity
Apoptosis/*genetics
BH3 Interacting Domain Death Agonist Protein/*metabolism
Chemical and Drug Induced Liver Injury/*metabolism
Hepatocytes/*metabolism
Liver Failure, Acute/*chemically induced
Animals ; BH3 Interacting Domain Death Agonist Protein/genetics ; Chemical and Drug Induced Liver Injury/enzymology ; Chemical and Drug Induced Liver Injury/genetics ; Cytochrome P450 Family 2/metabolism ; Glutathione/metabolism ; HMGB1 Protein/metabolism ; Hepatocytes/pathology ; Inflammation/complications ; Inflammation/metabolism ; Liver/enzymology ; Liver/metabolism ; Liver/pathology ; Liver Failure, Acute/enzymology ; Liver Failure, Acute/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Necrosis/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Polyethyleneimine-polyethylene glycol copolymer targeted by anti-HER2 nanobody for specific delivery of transcriptionally targeted tBid containing construct.
Autorzy :
Saqafi B; a Faculty of Medical Sciences, Department of Medical Biotechnology , Tarbiat Modares University , Tehran , Iran.
Rahbarizadeh F; a Faculty of Medical Sciences, Department of Medical Biotechnology , Tarbiat Modares University , Tehran , Iran.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 501-511.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological*/chemistry
Antineoplastic Agents, Immunological*/pharmacology
BH3 Interacting Domain Death Agonist Protein*/biosynthesis
BH3 Interacting Domain Death Agonist Protein*/genetics
Gene Transfer Techniques*
Genetic Therapy*
Polyethylene Glycols*/chemistry
Polyethylene Glycols*/pharmacology
Single-Domain Antibodies*/chemistry
Single-Domain Antibodies*/pharmacology
Polyethyleneimine/*analogs & derivatives
Receptor, ErbB-2/*antagonists & inhibitors
Transcription, Genetic/*drug effects
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/therapy ; Female ; Humans ; Polyethyleneimine/chemistry ; Polyethyleneimine/pharmacology ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism
Czasopismo naukowe
Tytuł :
Menadione-induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation.
Autorzy :
Božič J; Department of Biochemistry and Molecular and Structural Biology, Jožef Stefan Institute, Ljubljana, Slovenia.; Jožef Stefan International Postgraduate School, Ljubljana, Slovenia.
Bidovec K; Department of Biochemistry and Molecular and Structural Biology, Jožef Stefan Institute, Ljubljana, Slovenia.; Jožef Stefan International Postgraduate School, Ljubljana, Slovenia.
Vizovišek M; Department of Biochemistry and Molecular and Structural Biology, Jožef Stefan Institute, Ljubljana, Slovenia.
Dolenc I; Department of Biochemistry and Molecular and Structural Biology, Jožef Stefan Institute, Ljubljana, Slovenia.
Stoka V; Department of Biochemistry and Molecular and Structural Biology, Jožef Stefan Institute, Ljubljana, Slovenia.; Jožef Stefan International Postgraduate School, Ljubljana, Slovenia.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2019 Jun; Vol. 120 (6), pp. 10662-10669. Date of Electronic Publication: 2019 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
BH3 Interacting Domain Death Agonist Protein/*genetics
Cystatin B/*genetics
Lysosomes/*drug effects
Vitamin K 3/*pharmacology
Amino Acid Chloromethyl Ketones/pharmacology ; Apoptosis/genetics ; Apoptosomes/drug effects ; Apoptosomes/metabolism ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cathepsin B/antagonists & inhibitors ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Cathepsin C/antagonists & inhibitors ; Cathepsin C/genetics ; Cathepsin C/metabolism ; Cathepsin D/antagonists & inhibitors ; Cathepsin D/genetics ; Cathepsin D/metabolism ; Cathepsins/antagonists & inhibitors ; Cathepsins/genetics ; Cathepsins/metabolism ; Cystatin B/metabolism ; Humans ; Leucine/analogs & derivatives ; Leucine/pharmacology ; Lysosomes/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Pepstatins/pharmacology ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Protease Inhibitors/pharmacology ; Proteolysis/drug effects ; Signal Transduction ; U937 Cells
Czasopismo naukowe
Tytuł :
Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.
Autorzy :
Salisbury-Ruf CT; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
Bertram CC; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
Vergeade A; Department of Pharmacology, Vanderbilt University, Nashville, United States.
Lark DS; Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Shi Q; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Heberling ML; Department of Biological Sciences, Vanderbilt University, Nashville, United States.
Fortune NL; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Okoye GD; Division of Cardiovascular Medicine and Cardio-oncology Program, Vanderbilt University Medical Center, Nashville, United States.
Jerome WG; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States.
Wells QS; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Fessel J; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Moslehi J; Division of Cardiovascular Medicine and Cardio-oncology Program, Vanderbilt University Medical Center, Nashville, United States.
Chen H; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, United States.
Roberts LJ 2nd; Department of Pharmacology, Vanderbilt University, Nashville, United States.; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
Boutaud O; Department of Pharmacology, Vanderbilt University, Nashville, United States.
Gamazon ER; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, United States.; Clare Hall, University of Cambridge, Cambridge, United Kingdom.
Zinkel SS; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.; Department of Medicine, Vanderbilt University Medical Center, Nashville, United States.
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Źródło :
ELife [Elife] 2018 Oct 03; Vol. 7. Date of Electronic Publication: 2018 Oct 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genomics*
BH3 Interacting Domain Death Agonist Protein/*metabolism
Heart Diseases/*genetics
Heart Diseases/*prevention & control
Mitochondria/*metabolism
Mitochondria/*ultrastructure
Animals ; Apoptosis ; BH3 Interacting Domain Death Agonist Protein/chemistry ; Beclin-1/metabolism ; Cell Respiration ; Fibrosis ; Gene Expression Regulation ; Genome-Wide Association Study ; Heart Diseases/pathology ; Heart Ventricles/pathology ; Humans ; Mice, Inbred C57BL ; Mitochondrial Proton-Translocating ATPases ; Mutation/genetics ; Myeloid Progenitor Cells/metabolism ; Myocardial Infarction/genetics ; Myocardial Infarction/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/ultrastructure ; Polymorphism, Single Nucleotide/genetics ; Protein Multimerization ; Protein Structure, Secondary ; Protein Subunits/metabolism ; Reactive Oxygen Species/metabolism ; Reproducibility of Results ; Up-Regulation
Czasopismo naukowe
Tytuł :
Lipoprotein Particle Formation by Proapoptotic tBid.
Autorzy :
Ekanayake V; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Nisan D; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Ryzhov P; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Yao Y; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Marassi FM; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2018 Aug 07; Vol. 115 (3), pp. 533-542. Date of Electronic Publication: 2018 Jun 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Sequence Deletion*
BH3 Interacting Domain Death Agonist Protein/*genetics
BH3 Interacting Domain Death Agonist Protein/*metabolism
Lipoproteins/*metabolism
Amino Acid Sequence ; Apoptosis ; BH3 Interacting Domain Death Agonist Protein/chemistry ; Lipoproteins/chemistry ; Permeability ; Protein Binding ; Protein Conformation, alpha-Helical ; Solubility
Czasopismo naukowe
Tytuł :
Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins.
Autorzy :
Crabtree MD; From the Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Mendonça CATF; From the Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Bubb QR; From the Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Clarke J; From the Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Jun 22; Vol. 293 (25), pp. 9718-9723. Date of Electronic Publication: 2018 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Folding*
Apoptosis Regulatory Proteins/*metabolism
BH3 Interacting Domain Death Agonist Protein/*metabolism
Intrinsically Disordered Proteins/*metabolism
Myeloid Cell Leukemia Sequence 1 Protein/*metabolism
Tumor Suppressor Proteins/*metabolism
Animals ; Apoptosis Regulatory Proteins/chemistry ; BH3 Interacting Domain Death Agonist Protein/chemistry ; Crystallography, X-Ray ; Intrinsically Disordered Proteins/chemistry ; Kinetics ; Mice ; Models, Molecular ; Myeloid Cell Leukemia Sequence 1 Protein/chemistry ; Protein Binding ; Protein Conformation ; Signal Transduction ; Thermodynamics ; Tumor Suppressor Proteins/chemistry
Czasopismo naukowe
Tytuł :
Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.
Autorzy :
Ma ZW; Department of Pharmacology III, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Liu DX; Department of Pharmacology III, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2018 Jun; Vol. 39 (6), pp. 1012-1021. Date of Electronic Publication: 2017 Dec 21.
Typ publikacji :
Journal Article
MeSH Terms :
BH3 Interacting Domain Death Agonist Protein/*metabolism
Intracellular Signaling Peptides and Proteins/*pharmacology
Membrane Potential, Mitochondrial/*drug effects
Mitochondrial Membranes/*drug effects
Neuroprotective Agents/*pharmacology
bcl-2-Associated X Protein/*metabolism
Animals ; Apoptosis/drug effects ; BH3 Interacting Domain Death Agonist Protein/genetics ; Cytochromes c/metabolism ; Fluorescence Resonance Energy Transfer ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Lipid Bilayers ; Mitochondrial Membranes/metabolism ; Neuroprotective Agents/metabolism ; Protein Binding ; Protein Multimerization ; Protein Transport ; Single Molecule Imaging ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level.
Autorzy :
Kønig SM; Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen, Denmark.
Rissler V; Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen, Denmark.
Terkelsen T; Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen, Denmark.
Lambrughi M; Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen, Denmark.
Papaleo E; Computational Biology Laboratory, Danish Cancer Society Research Center, Copenhagen, Denmark.; Translational Disease Systems Biology, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research University of Copenhagen, Copenhagen, Denmark.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2019 Dec 11; Vol. 15 (12), pp. e1007485. Date of Electronic Publication: 2019 Dec 11 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genes, bcl-2*
Breast Neoplasms/*genetics
Breast Neoplasms/*metabolism
Proto-Oncogene Proteins c-bcl-2/*genetics
Proto-Oncogene Proteins c-bcl-2/*metabolism
Apoptosis/genetics ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; BH3 Interacting Domain Death Agonist Protein/chemistry ; BH3 Interacting Domain Death Agonist Protein/genetics ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Breast Neoplasms/pathology ; Computational Biology ; Female ; Humans ; Minor Histocompatibility Antigens/chemistry ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/metabolism ; Models, Molecular ; Mutation ; Protein Interaction Domains and Motifs ; Protein Interaction Maps ; Protein Stability ; Proto-Oncogene Proteins c-bcl-2/chemistry ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Differential role of FL-BID and t-BID during verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.
Autorzy :
Debernardi J; UMR 8126, CNRS, Univ Paris Sud, Université Paris-Saclay, Institut Gustave Roussy, Villejuif, 94805, France.
Hollville E; UMR 8126, CNRS, Univ Paris Sud, Université Paris-Saclay, Institut Gustave Roussy, Villejuif, 94805, France.
Lipinski M; UMR 8126, CNRS, Univ Paris Sud, Université Paris-Saclay, Institut Gustave Roussy, Villejuif, 94805, France.
Wiels J; UMR 8126, CNRS, Univ Paris Sud, Université Paris-Saclay, Institut Gustave Roussy, Villejuif, 94805, France. .
Robert A; UMR 8126, CNRS, Univ Paris Sud, Université Paris-Saclay, Institut Gustave Roussy, Villejuif, 94805, France.
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Źródło :
Oncogene [Oncogene] 2018 May; Vol. 37 (18), pp. 2410-2421. Date of Electronic Publication: 2018 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
BH3 Interacting Domain Death Agonist Protein/*physiology
Burkitt Lymphoma/*pathology
Shiga Toxins/*pharmacology
Apoptosis/genetics ; BH3 Interacting Domain Death Agonist Protein/chemistry ; BH3 Interacting Domain Death Agonist Protein/genetics ; Burkitt Lymphoma/genetics ; Caspase 8/metabolism ; HEK293 Cells ; Humans ; Protein Domains/genetics ; Protein Domains/physiology ; Protein Isoforms/physiology ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Tumor Cells, Cultured ; bcl-2 Homologous Antagonist-Killer Protein/physiology ; bcl-2-Associated X Protein/physiology
Czasopismo naukowe
Tytuł :
Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.
Autorzy :
Wicki S; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland. .
Gurzeler U; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland. .
Corazza N; Institute of Pathology, University of Bern, 3008 Bern, Switzerland. .
Genitsch V; Institute of Pathology, University of Bern, 3008 Bern, Switzerland. .
Wong WW; Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland. .
Kaufmann T; Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2018 Feb 28; Vol. 19 (3). Date of Electronic Publication: 2018 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
BH3 Interacting Domain Death Agonist Protein/*deficiency
Dextran Sulfate/*adverse effects
Fas Ligand Protein/*metabolism
Neutrophils/*drug effects
Neutrophils/*metabolism
Weight Loss/*drug effects
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; BH3 Interacting Domain Death Agonist Protein/genetics ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Caspase Inhibitors/metabolism ; Cell Death/genetics ; Colitis/etiology ; Colitis/metabolism ; Colitis/pathology ; Lipopolysaccharides/immunology ; Mice ; Neutrophils/immunology ; Protein Binding ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł :
Improved cytotoxicity of novel TRAIL variants produced as recombinant fusion proteins.
Autorzy :
Figiel M; Department of Physical Biochemistry, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Bonarek P; Department of Physical Biochemistry, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Górecki A; Department of Physical Biochemistry, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Pawlak SD; Drug Discovery Department, Adamed Group, Pienków 149, 05-152 Czosnów, Poland.
Zerek B; Drug Discovery Department, Adamed Group, Pienków 149, 05-152 Czosnów, Poland.
Checinska B; Drug Discovery Department, Adamed Group, Pienków 149, 05-152 Czosnów, Poland.
Pieczykolan J; Drug Discovery Department, Adamed Group, Pienków 149, 05-152 Czosnów, Poland.
Dziedzicka-Wasylewska M; Department of Physical Biochemistry, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
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Źródło :
Protein engineering, design & selection : PEDS [Protein Eng Des Sel] 2018 Feb 01; Vol. 31 (2), pp. 37-46.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
BH3 Interacting Domain Death Agonist Protein*/biosynthesis
BH3 Interacting Domain Death Agonist Protein*/chemistry
BH3 Interacting Domain Death Agonist Protein*/isolation & purification
BH3 Interacting Domain Death Agonist Protein*/pharmacology
Cytotoxins*/biosynthesis
Cytotoxins*/chemistry
Cytotoxins*/isolation & purification
Cytotoxins*/pharmacology
Recombinant Fusion Proteins*/biosynthesis
Recombinant Fusion Proteins*/chemistry
Recombinant Fusion Proteins*/isolation & purification
Recombinant Fusion Proteins*/pharmacology
TNF-Related Apoptosis-Inducing Ligand*/biosynthesis
TNF-Related Apoptosis-Inducing Ligand*/chemistry
TNF-Related Apoptosis-Inducing Ligand*/isolation & purification
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
A549 Cells ; Hep G2 Cells ; Humans ; Protein Domains
Czasopismo naukowe
Tytuł :
MicroRNA-500a Promotes the Progression of Hepatocellular Carcinoma by Post-Transcriptionally Targeting BID.
Autorzy :
Bao L; National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China.; Department of Pharmacy, No. 411 Hospital, Second Military Medical University, Shanghai, China.
Zhang M; National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China.
Han S; Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Zhan Y; National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China.; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guo W; Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Teng F; Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Liu F; Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Guo M; National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China.; Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Zhang L; Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Ding G; Department of Liver Surgery and Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Wang Q; National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2018; Vol. 47 (5), pp. 2046-2055. Date of Electronic Publication: 2018 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
BH3 Interacting Domain Death Agonist Protein/*metabolism
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
RNA, Neoplasm/*metabolism
BH3 Interacting Domain Death Agonist Protein/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; HEK293 Cells ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł :
Allosteric Regulation of BH3 Proteins in Bcl-x L Complexes Enables Switch-like Activation of Bax.
Autorzy :
Bogner C; Sunnybrook Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada; Third Department of Medicine, Klinikum Rechts der Isar, Technische Universität München, München 80333, Germany.
Kale J; Sunnybrook Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.
Pogmore J; Sunnybrook Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.
Chi X; Sunnybrook Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada.
Shamas-Din A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Fradin C; Departments of Biomedical Sciences and Biochemistry, McMaster University, Hamilton, ON L8S 4L8, Canada; Departments of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4L8, Canada.
Leber B; Departments of Biomedical Sciences and Biochemistry, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Andrews DW; Sunnybrook Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada; Departments of Biomedical Sciences and Biochemistry, McMaster University, Hamilton, ON L8S 4L8, Canada. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Feb 20; Vol. 77 (4), pp. 901-912.e9. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
bcl-2-Associated X Protein/*metabolism
bcl-X Protein/*metabolism
Allosteric Regulation ; Animals ; Apoptosis ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Cell Line ; Humans ; Mice ; Mitochondrial Membranes/metabolism ; bcl-Associated Death Protein/metabolism ; bcl-X Protein/chemistry
Czasopismo naukowe
Tytuł :
Caspase-7 mediates caspase-1-induced apoptosis independently of Bid.
Autorzy :
Mahib MR; Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh.
Hosojima S; Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Kushiyama H; Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Kinoshita T; Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Shiroishi T; RIKEN BioResource Research Center, Ibaraki, Japan.
Suda T; Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Tsuchiya K; Division of Immunology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Institute for Frontier Science Initiative (InFiniti), Kanazawa University, Kanazawa, Japan.
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Źródło :
Microbiology and immunology [Microbiol Immunol] 2020 Feb; Vol. 64 (2), pp. 143-152. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/physiology
BH3 Interacting Domain Death Agonist Protein/*metabolism
Caspase 1/*metabolism
Caspase 7/*metabolism
Inflammasomes/*metabolism
Animals ; Caspase 3/metabolism ; Cell Line ; Immunity, Innate ; Intracellular Signaling Peptides and Proteins/metabolism ; Metabolic Networks and Pathways ; Mice ; Mice, Inbred C57BL ; Phosphate-Binding Proteins/metabolism ; Pyroptosis/physiology
Czasopismo naukowe
Tytuł :
Glucocorticoid and progesterone mechanisms in photoreceptor survival.
Autorzy :
Marquioni-Ramella MD; Instituto de Investigaciones en Medicina Translational (IIMT), Facultad de Ciencias Biomédicas, Universidad Austral, CONICET, Pilar, B1629AHJ, Buenos Aires, Argentina.
Cubilla MA; Instituto de Investigaciones en Medicina Translational (IIMT), Facultad de Ciencias Biomédicas, Universidad Austral, CONICET, Pilar, B1629AHJ, Buenos Aires, Argentina.
Bermúdez V; Instituto de Investigaciones en Medicina Translational (IIMT), Facultad de Ciencias Biomédicas, Universidad Austral, CONICET, Pilar, B1629AHJ, Buenos Aires, Argentina.
Tate PS; Instituto de Investigaciones en Medicina Translational (IIMT), Facultad de Ciencias Biomédicas, Universidad Austral, CONICET, Pilar, B1629AHJ, Buenos Aires, Argentina.
Marazita MC; Instituto de Investigaciones en Medicina Translational (IIMT), Facultad de Ciencias Biomédicas, Universidad Austral, CONICET, Pilar, B1629AHJ, Buenos Aires, Argentina.
Suburo AM; Instituto de Investigaciones en Medicina Translational (IIMT), Facultad de Ciencias Biomédicas, Universidad Austral, CONICET, Pilar, B1629AHJ, Buenos Aires, Argentina. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2020 Jan; Vol. 190, pp. 107854. Date of Electronic Publication: 2019 Oct 25.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dexamethasone/*pharmacology
Glucocorticoids/*pharmacology
Photoreceptor Cells, Vertebrate/*drug effects
Progesterone/*pharmacology
Radiation Injuries, Experimental/*prevention & control
Retinal Degeneration/*prevention & control
Animals ; Apoptosis/drug effects ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Blotting, Western ; Caspase 3 ; Cell Survival/physiology ; Hormone Antagonists/toxicity ; Immunohistochemistry ; Light/adverse effects ; Male ; Mice, Inbred BALB C ; Mifepristone/toxicity ; Photoreceptor Cells, Vertebrate/metabolism ; Photoreceptor Cells, Vertebrate/radiation effects ; Radiation Injuries, Experimental/etiology ; Radiation Injuries, Experimental/metabolism ; Receptors, Glucocorticoid/metabolism ; Retinal Degeneration/etiology ; Retinal Degeneration/metabolism ; Rhodopsin/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Measurement of BH3-only protein tolerance.
Autorzy :
Dai H; Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Chinese Academy of Sciences, Hefei,China.; Cancer Hospital, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Ding H; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Peterson KL; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Meng XW; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Schneider PA; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Knorr KLB; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Kaufmann SH; Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
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Źródło :
Cell death and differentiation [Cell Death Differ] 2018 Feb; Vol. 25 (2), pp. 282-293. Date of Electronic Publication: 2017 Oct 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
BH3 Interacting Domain Death Agonist Protein/*analysis
BH3 Interacting Domain Death Agonist Protein/metabolism ; HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.
Autorzy :
Kim WS; Departments of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Lee KS; Departments of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Kim JH; Departments of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Kim CK; Departments of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Lee G; Departments of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Choe J; Departments of Immunology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Won MH; Departments of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Kim TH; Department of Biochemistry, Chosun University School of Medicine, Dong-Gu, Gwangju 501-759, South Korea.
Jeoung D; Departments of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Lee H; Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Kim JY; Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, Seoul, South Korea.
Ae Jeong M; Department of Anesthesiology and Pain Medicine, Hanyang University Hospital, Seoul, South Korea.
Ha KS; Departments of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea.
Kwon YG; Department of Biochemistry, College of Science and Biotechnology, Yonsei University, Seoul 120-749, South Korea.
Kim YM; Departments of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, South Korea. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2017 Nov; Vol. 112, pp. 567-577. Date of Electronic Publication: 2017 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
BH3 Interacting Domain Death Agonist Protein/*genetics
Caspase 8/*genetics
Cytochromes c/*genetics
Mitochondria, Liver/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Apoptosis/genetics ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Caspase 8/metabolism ; Cell Line, Tumor ; Cytochromes c/metabolism ; Fas-Associated Death Domain Protein/genetics ; Fas-Associated Death Domain Protein/metabolism ; Gene Expression Regulation ; HeLa Cells ; Humans ; Jurkat Cells ; Liver/cytology ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; TNF-Related Apoptosis-Inducing Ligand/genetics ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.
Autorzy :
Rigo A; Department of Medicine, Section of Hematology, Cancer Research and Cell Biology Laboratory, University of Verona, Verona, Italy.
Ferrarini I; Department of Medicine, Section of Hematology, Cancer Research and Cell Biology Laboratory, University of Verona, Verona, Italy. .
Lorenzetto E; Technology Platform Center, University of Verona, Verona, Italy.
Darra E; Department of Medicine, Section of Geriatric Medicine, University of Verona, Verona, Italy.
Liparulo I; Department of Pharmacy and Biotechnology, FABIT, University of Bologna, Bologna, Italy.
Bergamini C; Department of Pharmacy and Biotechnology, FABIT, University of Bologna, Bologna, Italy.
Sissa C; Immunohematology, Azienda Ospedaliera Mantova, Mantova, Italy.
Cavalieri E; Department of Life and Reproduction Sciences, Section of Biochemistry, University of Verona, Verona, Italy.
Vinante F; Department of Medicine, Section of Hematology, Cancer Research and Cell Biology Laboratory, University of Verona, Verona, Italy.
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Źródło :
Cell death & disease [Cell Death Dis] 2019 Nov 26; Vol. 10 (12), pp. 889. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
BH3 Interacting Domain Death Agonist Protein/*metabolism
Lysosomes/*metabolism
Mitochondria/*metabolism
Monocyclic Sesquiterpenes/*pharmacology
Autophagy/drug effects ; Benzimidazoles/pharmacology ; Carbocyanines/pharmacology ; Cell Cycle/drug effects ; Cell Line ; G(M1) Ganglioside/metabolism ; Gene Knockdown Techniques ; Humans ; Lysosomes/drug effects ; Membrane Microdomains/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Membrane Proteins/metabolism ; Mitochondria/drug effects ; Protein Transport/drug effects
Czasopismo naukowe
Tytuł :
BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis.
Autorzy :
Huang K; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.
O'Neill KL; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.
Li J; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.
Zhou W; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.; Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Han N; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.; Department of Oncology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450014, Henan, China.
Pang X; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.
Wu W; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.; Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Struble L; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.
Borgstahl G; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.
Liu Z; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.; School of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Zhang L; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA.
Luo X; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA. .; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-7696, USA. .
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Źródło :
Cell research [Cell Res] 2019 Nov; Vol. 29 (11), pp. 942-952. Date of Electronic Publication: 2019 Sep 24.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
BH3 Interacting Domain Death Agonist Protein/*physiology
Bcl-2-Like Protein 11/*physiology
Mitochondria/*metabolism
Mitochondrial Membranes/*metabolism
HCT116 Cells ; HEK293 Cells ; Humans ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; bcl-2 Homologous Antagonist-Killer Protein/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation.
Autorzy :
Ma L; National Laboratory of Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.; University of Chinese Academy of Sciences , Beijing 100049 , China.
Hu S; National Laboratory of Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.
He X; National Laboratory of Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.; National Laboratory of Biomacromolecules, Institute of Biophysics , Chinese Academy of Sciences , Beijing 100101 , China.; University of Chinese Academy of Sciences , Beijing 100049 , China.
Yang N; National Laboratory of Biomacromolecules, Institute of Biophysics , Chinese Academy of Sciences , Beijing 100101 , China.; University of Chinese Academy of Sciences , Beijing 100049 , China.
Chen L; National Laboratory of Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.
Yang C; National Laboratory of Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.; University of Chinese Academy of Sciences , Beijing 100049 , China.
Ye F; National Laboratory of Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.; University of Chinese Academy of Sciences , Beijing 100049 , China.
Wei T; National Laboratory of Biomacromolecules, Institute of Biophysics , Chinese Academy of Sciences , Beijing 100101 , China.; University of Chinese Academy of Sciences , Beijing 100049 , China.
Li M; National Laboratory of Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics , Chinese Academy of Sciences , Beijing 100190 , China.; University of Chinese Academy of Sciences , Beijing 100049 , China.; Songshan Lake Materials Laboratory , Dongguan , Guangdong 523808 , China.
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Źródło :
Nano letters 2019 Oct 09; Vol. 19 (10), pp. 6937-6944. Date of Electronic Publication: 2019 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
BH3 Interacting Domain Death Agonist Protein/*chemistry
Lipid Bilayers/*chemistry
Animals ; Cell Membrane Permeability ; Fluorescence ; Graphite/chemistry ; Mice ; Models, Molecular ; Protein Conformation, alpha-Helical ; Protein Multimerization
Czasopismo naukowe

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