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Tytuł:
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2.
Autorzy:
Esteban-Lopez M; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Wilson KJ; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Myhr C; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Kaftanovskaya EM; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Henderson MJ; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Southall NT; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Xu X; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Wang A; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Hu X; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Barnaeva E; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Ye W; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
George ER; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Sherrill JT; Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Ferrer M; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
Morello R; Department of Physiology & Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Agoulnik IU; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.; Biomolecular Sciences Institute, Florida International University, Miami, FL, USA.
Marugan JJ; Early Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA. .
Agoulnik AI; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. alexander.agoulnik@fiu.edu.; Biomolecular Sciences Institute, Florida International University, Miami, FL, USA. alexander.agoulnik@fiu.edu.
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Źródło:
Communications biology [Commun Biol] 2022 Nov 04; Vol. 5 (1), pp. 1183. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Relaxin*/pharmacology
Male ; Adult ; Humans ; Mice ; Animals ; Insulin/pharmacology ; Receptors, G-Protein-Coupled/physiology ; Testis ; Gonadal Steroid Hormones ; Receptors, Peptide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
INPP4B protects from metabolic syndrome and associated disorders.
Autorzy:
Zhang M; Department of Medicine, Duke University, Durham, NC, USA.
Ceyhan Y; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Kaftanovskaya EM; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Vasquez JL; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Vacher J; Department of Medicine, Institut de Recherches Cliniques de Montréal, Université de Montréal, Montréal, QC, Canada.
Knop FK; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Nathanson L; Institute for Neuro Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL, USA.
Agoulnik AI; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.; Biomolecular Sciences Institute, Florida International University, Miami, FL, USA.
Ittmann MM; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.; Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, TX, USA.
Agoulnik IU; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. .; Biomolecular Sciences Institute, Florida International University, Miami, FL, USA. .; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. .
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Źródło:
Communications biology [Commun Biol] 2021 Mar 26; Vol. 4 (1), pp. 416. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Metabolic Syndrome/*therapy
Phosphoric Monoester Hydrolases/*genetics
Protective Agents/*pharmacology
Animals ; Diet, High-Fat/adverse effects ; Male ; Mice ; Phosphoric Monoester Hydrolases/metabolism ; Phosphoric Monoester Hydrolases/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.
Autorzy:
Kothandapani A; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Lewis SR; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Noel JL; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Zacharski A; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Krellwitz K; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Baines A; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Winske S; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Vezina CM; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Kaftanovskaya EM; Department of Human and Molecular Genetics, Florida International University, Miami, Florida, United States of America.
Agoulnik AI; Department of Human and Molecular Genetics, Florida International University, Miami, Florida, United States of America.
Merton EM; Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America.
Cohn MJ; Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America.
Jorgensen JS; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2020 Jun 04; Vol. 16 (6), pp. e1008810. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Developmental*
Cryptorchidism/*genetics
Leydig Cells/*pathology
Nerve Tissue Proteins/*metabolism
Sex Differentiation/*genetics
Zinc Finger Protein Gli3/*metabolism
Animals ; Cryptorchidism/pathology ; Disease Models, Animal ; Hedgehog Proteins/metabolism ; Humans ; Insulin/metabolism ; Leydig Cells/metabolism ; Male ; Mice ; Mice, Transgenic ; Mutation ; Nerve Tissue Proteins/genetics ; Proteins/metabolism ; Signal Transduction/genetics ; Testosterone/metabolism ; Zinc Finger Protein Gli3/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
Autorzy:
Ceyhan Y; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.
Zhang M; Division of Medical Oncology, Department of Medicine, Duke University, Durham, NC, United States of America.
Guo J; Department of Oncological Sciences and Huntsman Cancer Institute, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT, United States of America.; Department of Surgery (Andrology/Urology), Center for Reconstructive Urology and Men's Health, University of Utah Health Sciences Center, Salt Lake City, UT, United States of America.
Sandoval CG; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.
Vacher J; Department of Medicine, Institut de Recherches Cliniques de Montréal, Université de Montréal, Montréal, Québec, Canada.
Kaftanovskaya EM; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.
Agoulnik AI; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.; Biomolecular Science Institute, Florida International University, Miami, FL, United States of America.
Agoulnik IU; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.; Biomolecular Science Institute, Florida International University, Miami, FL, United States of America.
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Źródło:
PloS one [PLoS One] 2020 May 15; Vol. 15 (5), pp. e0233163. Date of Electronic Publication: 2020 May 15 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Phosphoric Monoester Hydrolases/*metabolism
Spermatogenesis/*genetics
Spermatozoa/*metabolism
Testis/*metabolism
Animals ; Apoptosis/genetics ; Cytokines/metabolism ; Diet, High-Fat/adverse effects ; Gene Expression Regulation, Developmental/genetics ; Histones/metabolism ; Humans ; Male ; Meiosis/genetics ; Mice ; Mice, Knockout ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoric Monoester Hydrolases/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA-Seq ; Receptors, Androgen/metabolism ; Receptors, LH/genetics ; Receptors, LH/metabolism ; Single-Cell Analysis ; Sperm Count ; Testis/growth & development
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1.
Autorzy:
Agoulnik AI; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Agoulnik IU; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Hu X; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
Marugan J; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 May; Vol. 174 (10), pp. 977-989. Date of Electronic Publication: 2016 Nov 30.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms:
Receptors, G-Protein-Coupled/*agonists
Receptors, Peptide/*agonists
Animals ; Humans ; Molecular Weight ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Peptide/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Relaxin-like peptides in male reproduction - a human perspective.
Autorzy:
Ivell R; School of Biosciences, University of Nottingham, Nottingham, LE12 5RD, UK.; School of Veterinary and Medical Sciences, University of Nottingham, Nottingham, LE12 5RD, UK.
Agoulnik AI; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Anand-Ivell R; School of Biosciences, University of Nottingham, Nottingham, LE12 5RD, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2017 May; Vol. 174 (10), pp. 990-1001. Date of Electronic Publication: 2017 Feb 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Reproduction*
Relaxin/*metabolism
Animals ; Humans ; Male ; Relaxin/analogs & derivatives ; Relaxin/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice.
Autorzy:
Ferguson L; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America.
How JJ
Agoulnik AI
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Źródło:
PloS one [PLoS One] 2013 Oct 03; Vol. 8 (10), pp. e77351. Date of Electronic Publication: 2013 Oct 03 (Print Publication: 2013).
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Developmental*
Cryptorchidism/*pathology
Receptors, G-Protein-Coupled/*genetics
Spermatogonia/*pathology
Stem Cells/*pathology
Testis/*pathology
Age Factors ; Animals ; Apoptosis ; Cell Differentiation ; Cryptorchidism/genetics ; Cryptorchidism/metabolism ; Disease Models, Animal ; Fibroblast Growth Factor 2/genetics ; Fibroblast Growth Factor 2/metabolism ; Gene Expression Profiling ; Humans ; Inhibitor of Differentiation Proteins/genetics ; Inhibitor of Differentiation Proteins/metabolism ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Male ; Mice ; Mice, Knockout ; Promyelocytic Leukemia Zinc Finger Protein ; Proto-Oncogene Proteins c-ret/genetics ; Proto-Oncogene Proteins c-ret/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Receptors, G-Protein-Coupled/deficiency ; Sertoli Cells/metabolism ; Sertoli Cells/pathology ; Spermatogonia/growth & development ; Spermatogonia/metabolism ; Stem Cells/metabolism ; Testis/growth & development ; Testis/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice.
Autorzy:
Huang Z; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Rivas B
Agoulnik AI
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Źródło:
PloS one [PLoS One] 2013 Jul 30; Vol. 8 (7), pp. e71213. Date of Electronic Publication: 2013 Jul 30 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Germ Cells/*metabolism
Receptor, Notch1/*genetics
Receptor, Notch1/*metabolism
Spermatogenesis/*genetics
Animals ; Apoptosis/genetics ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Fertility/genetics ; Gene Deletion ; Gene Expression ; Gene Expression Regulation ; Gene Order ; Genetic Vectors/genetics ; Male ; Mice ; Mutation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Signal Transduction ; Testis/cytology ; Testis/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.
Autorzy:
Hodgson MC; Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, United States of America.
Vanostran G
Alghamdi S
Poppiti RJ
Agoulnik AI
Agoulnik IU
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Źródło:
PloS one [PLoS One] 2013 Apr 08; Vol. 8 (4), pp. e60455. Date of Electronic Publication: 2013 Apr 08 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Mammary Neoplasms, Experimental/*genetics
Mammary Neoplasms, Experimental/*pathology
Receptor, ErbB-2/*genetics
Receptors, Androgen/*genetics
Receptors, Androgen/*metabolism
Alleles ; Animals ; Estrogen Receptor alpha/metabolism ; Female ; Gene Knockout Techniques ; Humans ; Male ; Mammary Glands, Animal/metabolism ; Mammary Glands, Animal/pathology ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Transgenic ; Oncogenes/genetics ; Organ Specificity ; Rats ; Receptor, ErbB-3/genetics ; Receptors, Androgen/deficiency ; Receptors, Progesterone/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 30

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