- Tytuł:
- Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors.
- Autorzy:
- Źródło:
- PloS one [PLoS One] 2013 Jun 19; Vol. 8 (6), pp. e65988. Date of Electronic Publication: 2013 Jun 19 (Print Publication: 2013).
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Mutation*
Arginine/*geneticsChymases /*metabolism
Enzyme Inhibitors/*pharmacology
Lysine/*genetics
Angiotensin I/metabolism ;Chymases /chemistry ;Chymases /genetics ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Oxazoles/chemistry ; Oxazoles/pharmacology ; Phenotype ; Substrate Specificity ; Sulfonamides/chemistry ; Sulfonamides/pharmacology
Czasopismo naukowe