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Tytuł:
GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15.
Autorzy:
Chang C; Department of Comparative Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Cheng YY; Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA.
Kamlapurkar S; Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA.
White S; Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA.
Tang PW; Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA; Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Elhaw AT; Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA; Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Javed Z; Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA; Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Aird KM; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA.
Mythreye K; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Phaëton R; Department of Obstetrics and Gynecology, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Hempel N; Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, PA, USA. Electronic address: .
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Źródło:
Gynecologic oncology [Gynecol Oncol] 2024 Feb 10; Vol. 185, pp. 8-16. Date of Electronic Publication: 2024 Feb 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression.
Autorzy:
Sugitani N; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Vendetti FP; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Cipriano AJ; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Pandya P; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Deppas JJ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Moiseeva TN; Tallinn University of Technology, Department of Chemistry and Biotechnology, Tallinn, Estonia.
Schamus-Haynes S; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wang Y; Department of Immunology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Palmer D; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Osmanbeyoglu HU; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biomedical Informatics, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Bostwick A; Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Center for Metabolic Disease Research, Philadelphia, PA, USA.
Snyder NW; Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Center for Metabolic Disease Research, Philadelphia, PA, USA.
Gong YN; Department of Immunology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Aird KM; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Delgoffe GM; Department of Immunology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Beumer JH; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Division of Hematology-Oncology, UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Bakkenist CJ; Department of Radiation Oncology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Sep 20; Vol. 40 (12), pp. 111371.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CD8-Positive T-Lymphocytes*/metabolism
CDC2 Protein Kinase*/metabolism
Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Death ; Cell Line, Tumor ; DNA ; DNA Damage ; DNA-Directed DNA Polymerase/metabolism ; Deoxyuridine ; Genomics ; Interferon-alpha/metabolism ; Interferon-beta ; Mice ; Nucleotides/metabolism ; Protein Kinase Inhibitors/pharmacology ; RNA ; Thymidine/pharmacology
Czasopismo naukowe
Tytuł:
53BP1: guarding the genome with a novel liquid weapon.
Autorzy:
Tangudu NK; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Aird KM; Department of Pharmacology & Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 May 10; Vol. 5 (1), pp. 435. Date of Electronic Publication: 2022 May 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms:
Genome*
Czasopismo naukowe
Tytuł:
Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion.
Autorzy:
Tsao WC; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America.
Buj R; Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America.
Aird KM; Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America.; Penn State Cancer Institute, Pennsylvania State University, Hershey, Pennsylvania, United States of America.
Sidorova JM; Department of Pathology, University of Washington, Seattle, Washington, United States of America.
Eckert KA; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America.; Penn State Cancer Institute, Pennsylvania State University, Hershey, Pennsylvania, United States of America.
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Źródło:
PloS one [PLoS One] 2021 May 07; Vol. 16 (5), pp. e0251188. Date of Electronic Publication: 2021 May 07 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Repair/*genetics
DNA Replication/*genetics
DNA-Directed DNA Polymerase/*genetics
Genes, ras/*genetics
Cell Line ; DNA Damage/genetics ; Fibroblasts/metabolism ; Humans
Czasopismo naukowe
Tytuł:
Loss of p16: A Bouncer of the Immunological Surveillance?
Autorzy:
Leon KE; UPMC Hillman Cancer Center, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Biomedical Sciences Graduate Program, Penn State College of Medicine, Hershey, PA 15213, USA.
Tangudu NK; UPMC Hillman Cancer Center, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Aird KM; UPMC Hillman Cancer Center, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Buj R; UPMC Hillman Cancer Center, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
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Źródło:
Life (Basel, Switzerland) [Life (Basel)] 2021 Apr 02; Vol. 11 (4). Date of Electronic Publication: 2021 Apr 02.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.
Autorzy:
Chen CW; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Buj R; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Dahl ES; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Leon KE; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Aird KM; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
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Źródło:
Heliyon [Heliyon] 2020 Sep 29; Vol. 6 (9), pp. e05097. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers.
Autorzy:
Aronson MR; Department of Biomedical Engineering, Penn State University, University Park, PA 16802 USA.
Dahl ES; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033 USA.
Halle JA; Department of Biomedical Engineering, Penn State University, University Park, PA 16802 USA.
Simonson AW; Department of Biomedical Engineering, Penn State University, University Park, PA 16802 USA.
Gogal RA; Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802 USA.
Glick AB; Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802 USA.; Huck Institutes of the Life Sciences, Penn State University, University Park, PA 16802 USA.
Aird KM; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033 USA.
Medina SH; Department of Biomedical Engineering, Penn State University, University Park, PA 16802 USA.; Huck Institutes of the Life Sciences, Penn State University, University Park, PA 16802 USA.; Department of Biomedical Engineering, The Pennsylvania State University, Suite 122, CBE Building, University Park, PA 16802-4400 USA.
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Źródło:
Cellular and molecular bioengineering [Cell Mol Bioeng] 2020 Jun 24; Vol. 13 (5), pp. 447-461. Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
NFATC4 promotes quiescence and chemotherapy resistance in ovarian cancer.
Autorzy:
Cole AJ; Department of Internal Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Iyengar M; Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA.
Panesso-Gómez S; Department of Internal Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
O'Hayer P; Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA.
Chan D; Department of Internal Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Delgoffe GM; Tumor Microenvironment Center, UPMC Hillman Cancer Center; and Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Aird KM; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Yoon E; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan, USA.
Bai S; Department of Internal Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Buckanovich RJ; Department of Internal Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
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Źródło:
JCI insight [JCI Insight] 2020 Apr 09; Vol. 5 (7). Date of Electronic Publication: 2020 Apr 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Drug Resistance, Neoplasm*
Resting Phase, Cell Cycle*
NFATC Transcription Factors/*metabolism
Neoplasm Proteins/*metabolism
Neoplastic Stem Cells/*metabolism
Ovarian Neoplasms/*metabolism
Cell Line, Tumor ; Cisplatin/pharmacology ; Female ; Humans ; Neoplastic Stem Cells/pathology ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology
Czasopismo naukowe
Tytuł:
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence.
Autorzy:
Zhao B; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Liu P; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Fukumoto T; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Nacarelli T; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Fatkhutdinov N; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Wu S; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Lin J; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Aird KM; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Tang HY; Proteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, 19104, USA.
Liu Q; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Speicher DW; Proteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, 19104, USA.; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Zhang R; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA. .
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Źródło:
Nature communications [Nat Commun] 2020 Feb 19; Vol. 11 (1), pp. 908. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cellular Senescence/*immunology
DNA Topoisomerases, Type I/*metabolism
HMGB2 Protein/*metabolism
Nucleotidyltransferases/*metabolism
Animals ; B7-H1 Antigen/immunology ; Cell Line ; Chromatin/immunology ; Chromatin/metabolism ; Cytosol/immunology ; Cytosol/metabolism ; DNA/immunology ; DNA/metabolism ; DNA Damage/immunology ; DNA Topoisomerases, Type I/genetics ; Gene Knockdown Techniques ; HMGB2 Protein/genetics ; Humans ; Inflammation ; Mice ; Mice, Inbred C57BL ; Mutation ; Neoplasms/immunology ; Nucleotidyltransferases/genetics ; Protein Binding ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
p16: cycling off the beaten path.
Autorzy:
Buj R; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Aird KM; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
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Źródło:
Molecular & cellular oncology [Mol Cell Oncol] 2019 Oct 15; Vol. 6 (6), pp. e1677140. Date of Electronic Publication: 2019 Oct 15 (Print Publication: 2019).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.
Autorzy:
Buj R; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Chen CW; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Dahl ES; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Leon KE; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Kuskovsky R; A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
Maglakelidze N; MSTP Program, Penn State College of Medicine, Hershey, PA 17033, USA.
Navaratnarajah M; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Zhang G; Molecular and Cellular Oncogenesis Program and Melanoma Research Institute, The Wistar Institute, Philadelphia, PA 19104, USA.
Doan MT; A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
Jiang H; A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
Zaleski M; Department of Pathology, Penn State College of Medicine, Hershey, PA 17033, USA.
Kutzler L; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Lacko H; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
Lu Y; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mills GB; Department of Cell, Developmental & Cancer Biology, Oregon Health and Sciences University, Portland, OR 97201, USA.
Gowda R; Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA.
Robertson GP; Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA.
Warrick JI; Department of Pathology, Penn State College of Medicine, Hershey, PA 17033, USA.
Herlyn M; Molecular and Cellular Oncogenesis Program and Melanoma Research Institute, The Wistar Institute, Philadelphia, PA 19104, USA.
Imamura Y; Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA.
Kimball SR; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA.
DeGraff DJ; Department of Pathology, Penn State College of Medicine, Hershey, PA 17033, USA.
Snyder NW; A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
Aird KM; Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2019 Aug 20; Vol. 28 (8), pp. 1971-1980.e8.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclin-Dependent Kinase Inhibitor p16/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Nucleotides/*metabolism
Aldose-Ketose Isomerases/metabolism ; Animals ; Cell Line ; Cellular Senescence ; Gene Knockdown Techniques ; Humans ; Male ; Mice, SCID ; Pentose Phosphate Pathway ; Protein Biosynthesis
Czasopismo naukowe
Tytuł:
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment.
Autorzy:
Worley BL; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Kim YS; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Mardini J; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Zaman R; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Leon KE; Department of Molecular and Cellular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Vallur PG; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Nduwumwami A; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Warrick JI; Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Timmins PF; Womens Cancer Care Associates, Albany, NY, USA.
Kesterson JP; Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Phaëton R; Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Lee NY; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Walter V; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Endres L; Department of Biology and Chemistry, SUNY Polytechnic Institute, Utica, NY, USA.
Mythreye K; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA.
Aird KM; Department of Molecular and Cellular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Hempel N; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, USA. Electronic address: .
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Źródło:
Redox biology [Redox Biol] 2019 Jul; Vol. 25, pp. 101051. Date of Electronic Publication: 2018 Nov 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Disease Progression*
Extracellular Space/*metabolism
Glutathione Peroxidase/*metabolism
Ovarian Neoplasms/*enzymology
Ovarian Neoplasms/*pathology
Antioxidants/metabolism ; Ascites/pathology ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Survival ; Clone Cells ; Female ; Humans ; Hydrogen Peroxide/toxicity ; Neoplasm Staging ; Oxidation-Reduction ; Oxidative Stress/drug effects
Czasopismo naukowe
Tytuł:
Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry.
Autorzy:
Kuskovsky R; AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104, USA.
Buj R; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Xu P; AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104, USA.
Hofbauer S; Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Doan MT; AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104, USA.
Jiang H; AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104, USA.
Bostwick A; AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104, USA.
Mesaros C; Centers for Cancer Pharmacology and Excellence in Environmental Toxicology, Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Aird KM; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
Snyder NW; AJ Drexel Autism Institute, Drexel University, 3020 Market St Suite 560, Philadelphia, PA, 19104, USA. Electronic address: .
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Źródło:
Analytical biochemistry [Anal Biochem] 2019 Mar 01; Vol. 568, pp. 65-72. Date of Electronic Publication: 2018 Dec 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Indicator Dilution Techniques*
Mass Spectrometry*
Deoxyribonucleotides/*analysis
Carbon Isotopes ; Cells, Cultured ; Chromatography, Liquid ; Deoxyribonucleotides/metabolism ; Humans ; Isotope Labeling ; Nitrogen Isotopes
Czasopismo naukowe
Tytuł:
Jumonji C Demethylases in Cellular Senescence.
Autorzy:
Leon KE; Department of Cellular & Molecular Physiology, Penn Stage College of Medicine, Hershey, PA 17033, USA. .
Aird KM; Department of Cellular & Molecular Physiology, Penn Stage College of Medicine, Hershey, PA 17033, USA. .
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Źródło:
Genes [Genes (Basel)] 2019 Jan 09; Vol. 10 (1). Date of Electronic Publication: 2019 Jan 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Cellular Senescence*
Jumonji Domain-Containing Histone Demethylases/*metabolism
Animals ; Carcinogenesis/genetics ; Chromatin Assembly and Disassembly ; Epigenesis, Genetic ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics
Czasopismo naukowe
Tytuł:
CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer.
Autorzy:
Singha B; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, 19104, USA.
Harper SL; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, 19104, USA.
Goldman AR; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, 19104, USA.
Bitler BG; Department of Obstetrics and Gynecology, University of Colorado, Aurora, Colorado, 80045, USA.
Aird KM; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, 17033, USA.
Borowsky ME; Helen F. Graham Cancer Center & Research Institute, Newark, Delaware, 19713, USA.
Cadungog MG; Helen F. Graham Cancer Center & Research Institute, Newark, Delaware, 19713, USA.
Liu Q; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, 19104, USA.
Zhang R; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania, 19104, USA.
Jean S; Helen F. Graham Cancer Center & Research Institute, Newark, Delaware, 19713, USA.
Drapkin R; Department of Obstetrics and Gynecology, Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, 19104, USA.
Speicher DW; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania, 19104, USA. .
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Źródło:
Scientific reports [Sci Rep] 2018 Oct 03; Vol. 8 (1), pp. 14725. Date of Electronic Publication: 2018 Oct 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CA-125 Antigen/*genetics
Carcinoma, Ovarian Epithelial/*genetics
Chloride Channels/*genetics
Membrane Proteins/*genetics
Aged ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; CA-125 Antigen/blood ; Carcinoma, Ovarian Epithelial/blood ; Carcinoma, Ovarian Epithelial/diagnosis ; Chloride Channels/blood ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Membrane Proteins/blood ; Middle Aged
Czasopismo naukowe
Tytuł:
Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease.
Autorzy:
Buj R; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, United States.
Aird KM; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, United States.
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Źródło:
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2018 Apr 18; Vol. 9, pp. 177. Date of Electronic Publication: 2018 Apr 18 (Print Publication: 2018).
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer.
Autorzy:
Dahl ES; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, United States.
Aird KM; Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, United States.
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Źródło:
Frontiers in oncology [Front Oncol] 2017 Nov 29; Vol. 7, pp. 291. Date of Electronic Publication: 2017 Nov 29 (Print Publication: 2017).
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Czasopismo naukowe
Tytuł:
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
Autorzy:
Kaur A; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.; University of the Sciences, Philadelphia, Pennsylvania 19104, USA.
Webster MR; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Marchbank K; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Behera R; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Ndoye A; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Kugel CH 3rd; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Dang VM; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Appleton J; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
O'Connell MP; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Cheng P; Department of Dermatology, University of Zurich, Zurich CH-8006, Switzerland.
Valiga AA; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Morissette R; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
McDonnell NB; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Ferrucci L; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Kossenkov AV; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Meeth K; Department of Dermatology and Pathology, Yale University, New Haven, Connecticut 06511, USA.
Tang HY; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Yin X; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Wood WH 3rd; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Lehrmann E; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Becker KG; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Flaherty KT; Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA.
Frederick DT; Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA.
Wargo JA; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Cooper ZA; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Tetzlaff MT; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Hudgens C; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Aird KM; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Zhang R; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Xu X; Departments of Surgery and Pathology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Liu Q; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Bartlett E; Departments of Surgery and Pathology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Karakousis G; Departments of Surgery and Pathology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Eroglu Z; Department of Medical Oncology, City of Hope Medical Center, Duarte, California 91010, USA.
Lo RS; Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles, Los Angeles, California 90095, USA.
Chan M; Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead 2145, Australia.
Menzies AM; Melanoma Institute Australia and The University of Sydney, Sydney 2000, Australia.
Long GV; Melanoma Institute Australia and The University of Sydney, Sydney 2000, Australia.
Johnson DB; Department of Medicine, Vanderbilt University Medical Center, Nashville Tennessee 37232, USA.
Sosman J; Department of Medicine, Vanderbilt University Medical Center, Nashville Tennessee 37232, USA.
Schilling B; Department of Dermatology, University Hospital, West German Cancer Center, University Duesburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Heidelberg 45127, Germany.
Schadendorf D; Department of Dermatology, University Hospital, West German Cancer Center, University Duesburg-Essen, Essen, Germany.; German Cancer Consortium (DKTK), Heidelberg 45127, Germany.
Speicher DW; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Bosenberg M; Department of Dermatology and Pathology, Yale University, New Haven, Connecticut 06511, USA.
Ribas A; Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles, Los Angeles, California 90095, USA.
Weeraratna AT; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
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Źródło:
Nature [Nature] 2016 Apr 14; Vol. 532 (7598), pp. 250-4. Date of Electronic Publication: 2016 Apr 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Neoplasm*
Neoplasm Metastasis*
Tumor Microenvironment*
Aging/*metabolism
Melanoma/*drug therapy
Melanoma/*pathology
Membrane Proteins/*metabolism
Adult ; Animals ; Cell Line, Tumor ; Culture Media, Conditioned/pharmacology ; DNA Damage ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism ; Disease Progression ; Fibroblasts/metabolism ; Humans ; Indoles/pharmacology ; Indoles/therapeutic use ; Male ; Melanoma/blood supply ; Melanoma/genetics ; Mice ; Microphthalmia-Associated Transcription Factor/metabolism ; Middle Aged ; Molecular Targeted Therapy ; Neovascularization, Pathologic ; Oxidative Stress ; Phenotype ; Reactive Oxygen Species/metabolism ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Vemurafenib ; Wnt Signaling Pathway ; Wnt1 Protein/antagonists & inhibitors ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł:
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Autorzy:
Zhang J; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Wang C; Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, China.
Chen X; Department of Molecular and Cellular Biology, The Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Takada M; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Fan C; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Zheng X; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Wen H; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA Department of Surgery, University of North Carolina, Chapel Hill, NC, USA.
Liu Y; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Wang C; Program of Radiation Protection and Drug Discovery, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China.
Pestell RG; Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Aird KM; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Kaelin WG Jr; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Liu XS; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, MA, USA.
Zhang Q; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA qing_.
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Źródło:
The EMBO journal [EMBO J] 2015 Dec 02; Vol. 34 (23), pp. 2953-70. Date of Electronic Publication: 2015 Oct 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms/*metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases/*metabolism
Mitochondria/*metabolism
NF-E2-Related Factor 1/*metabolism
Transcription Factors/*metabolism
Breast Neoplasms/genetics ; Cell Line, Tumor ; Female ; Humans ; Hypoxia-Inducible Factor-Proline Dioxygenases/genetics ; NF-E2-Related Factor 1/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Protein Binding ; Transcription Factors/genetics
Czasopismo naukowe

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