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Tytuł :
A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells.
Autorzy :
Jinnouchi F; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Yamauchi T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Yurino A; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Nunomura T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Nakano M; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Iwamoto C; Department of Surgery and Oncology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Obara T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Miyawaki K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.; Department of Pathology, Kurume University School of Medicine, Kurume, Japan; and.
Kikushige Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Kato K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Maeda T; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Baba E; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Takenaka K; Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan.
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Źródło :
Blood [Blood] 2020 May 07; Vol. 135 (19), pp. 1661-1672.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoiesis*
Phagocytosis*
Antigens, Differentiation/*physiology
Colonic Neoplasms/*pathology
Hematopoietic Stem Cells/*pathology
Leukemia, Myeloid, Acute/*pathology
Neoplastic Stem Cells/*pathology
Receptors, Immunologic/*physiology
Animals ; Apoptosis ; Cell Proliferation ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Female ; Gene Knock-In Techniques ; Hematopoietic Stem Cells/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Neoplastic Stem Cells/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.
Autorzy :
Elbadry MI; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.; Department of Internal Medicine, Division of Hematology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Mizumaki H; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Hosokawa K; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Espinoza JL; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Nakagawa N; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Chonabayashi K; Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Yoshida Y; Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Katagiri T; Clinical Laboratory Sciences, Kanazawa University Graduate School, Kanazawa, Japan.
Hosomichi K; Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
Zaimoku Y; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Imi T; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Nguyen MAT; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.; Department of Pediatrics, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Fujii Y; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto., Japan.
Tajima A; Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto., Japan.; Department of Medicine, Center for Hematology and Regenerative Medicine (HERM), Karolinska Institute, Stockholm, Sweden.
Takenaka K; Medicine and Biosystemic Science, Kyushu University Graduate School, Fukuoka, Japan.
Akashi K; Medicine and Biosystemic Science, Kyushu University Graduate School, Fukuoka, Japan.
Nakao S; Hematology/Respiratory Medicine, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan .
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Źródło :
Haematologica [Haematologica] 2019 Oct; Vol. 104 (10), pp. e447-e450. Date of Electronic Publication: 2019 Mar 19.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Anemia, Aplastic*/genetics
Anemia, Aplastic*/metabolism
Anemia, Aplastic*/pathology
HLA-B Antigens/*genetics
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*metabolism
Animals ; HLA-B Antigens/metabolism ; Humans ; Male ; Mice ; Mice, Inbred NOD
SCR Disease Name :
Aplastic anemia, idiopathic
Raport
Tytuł :
CD34-selected versus unmanipulated autologous haematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: a post hoc analysis of a phase I/II clinical trial conducted in Japan.
Autorzy :
Ayano M; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. .; Department of Cancer Stem Cell Research, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. .
Tsukamoto H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; Present Address: Department of Rheumatology, Shin-Kokura Hospital, 1-3-1 Kanada, Kokurakita-ku, Kitakyushu, 803-8505, Japan.
Mitoma H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Kimoto Y; Department of Internal Medicine, Kyushu University Beppu Hospital, 4546 Tsurumibaru, Tsurumi, Beppu, 874-0838, Japan.
Akahoshi M; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Arinobu Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Horiuchi T; Department of Internal Medicine, Kyushu University Beppu Hospital, 4546 Tsurumibaru, Tsurumi, Beppu, 874-0838, Japan.
Niiro H; Department of Medical Education, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Nagafuji K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; Present Address: Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Harada M; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; Present Address: Medical Center for Karatsu-Higashimatsuura Medical Association, 2566-11 Chiyoda-machi, Karatsu, 847-0041, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
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Źródło :
Arthritis research & therapy [Arthritis Res Ther] 2019 Jan 22; Vol. 21 (1), pp. 30. Date of Electronic Publication: 2019 Jan 22.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD34/*blood
Hematopoietic Stem Cell Transplantation/*methods
Hematopoietic Stem Cells/*metabolism
Scleroderma, Systemic/*therapy
Adult ; Cyclophosphamide/therapeutic use ; Disease-Free Survival ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Japan ; Male ; Middle Aged ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/statistics & numerical data ; Scleroderma, Systemic/pathology ; Severity of Illness Index ; Transplantation Conditioning/methods ; Transplantation, Autologous
Czasopismo naukowe
Tytuł :
Notch1 expression is regulated at the post-transcriptional level by the 3' untranslated region in hematopoietic stem cell development.
Autorzy :
Mizuno S; Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan.; Department of Cancer Immunology and AIDs, Dana-Farber Cancer Institute, Boston, USA.
Iino T; Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan.; Department of Cancer Immunology and AIDs, Dana-Farber Cancer Institute, Boston, USA.
Ozawa H; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.; Department of Cancer Immunology and AIDs, Dana-Farber Cancer Institute, Boston, USA.
Arinobu Y; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.; Department of Cancer Immunology and AIDs, Dana-Farber Cancer Institute, Boston, USA.
Chong Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; Department of Cancer Immunology and AIDs, Dana-Farber Cancer Institute, Boston, USA.
Akashi K; Center for Advanced Medical Innovation, Kyushu University, Fukuoka, Japan. akashi@med.kyushu-u.ac.jp.; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. akashi@med.kyushu-u.ac.jp.; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan. akashi@med.kyushu-u.ac.jp.; Department of Cancer Immunology and AIDs, Dana-Farber Cancer Institute, Boston, USA. akashi@med.kyushu-u.ac.jp.
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Źródło :
International journal of hematology [Int J Hematol] 2018 Mar; Vol. 107 (3), pp. 311-319. Date of Electronic Publication: 2017 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
3' Untranslated Regions/*physiology
Gene Expression/*genetics
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*cytology
Hematopoietic Stem Cells/*metabolism
Receptor, Notch1/*genetics
Receptor, Notch1/*metabolism
Transcription, Genetic/*genetics
Animals ; Cell Division/genetics ; Cells, Cultured ; Mice, Congenic ; Mice, Inbred C57BL ; RNA, Messenger/metabolism ; Receptor, Notch1/physiology ; Stem Cell Niche/genetics
Czasopismo naukowe
Tytuł :
Mobilization of human immature hematopoietic progenitors through combinatory use of bortezomib and immunomodulatory drugs.
Autorzy :
Tochigi T; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Aoki T; Department of Hematology, Harasanshin Hospital, Fukuoka, Japan.
Kikushige Y; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan. .
Kamimura T; Department of Hematology, Harasanshin Hospital, Fukuoka, Japan.
Ito Y; Department of Hematology, Harasanshin Hospital, Fukuoka, Japan.
Shima T; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Yamauchi T; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Mori Y; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Yoshimoto G; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Kamezaki K; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Kato K; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Takenaka K; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Iwasaki H; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Akashi K; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan.
Miyamoto T; Department of Medicine and Biosystemic Sciences, Kyushu University Graduate School of Medicine, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
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Źródło :
International journal of hematology [Int J Hematol] 2017 Apr; Vol. 105 (4), pp. 423-432. Date of Electronic Publication: 2016 Nov 21.
Typ publikacji :
Journal Article
MeSH Terms :
Bortezomib/*adverse effects
Hematopoietic Stem Cell Mobilization/*methods
Hematopoietic Stem Cells/*drug effects
Immunologic Factors/*adverse effects
Aged ; Antigens, CD34/drug effects ; Blood Cells/drug effects ; Bone Marrow Cells/drug effects ; Bortezomib/therapeutic use ; Dexamethasone/adverse effects ; Dexamethasone/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Immunologic Factors/therapeutic use ; Lenalidomide ; Male ; Middle Aged ; Multiple Myeloma/drug therapy ; Receptors, CXCR4/drug effects ; Thalidomide/adverse effects ; Thalidomide/analogs & derivatives ; Thalidomide/therapeutic use
Czasopismo naukowe
Tytuł :
A Transcriptional Switch Point During Hematopoietic Stem and Progenitor Cell Ontogeny.
Autorzy :
Sugiyama D; 1 Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University , Fukuoka, Japan .; 2 Center for Clinical and Translational Research, Kyushu University , Fukuoka, Japan .; 3 Department of Clinical Study, Center for Advanced Medical Innovation, Kyushu University , Fukuoka, Japan .
Joshi A; 4 The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh , Easter Bush Campus, Midlothian, United Kingdom .
Kulkeaw K; 1 Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University , Fukuoka, Japan .
Tan KS; 1 Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University , Fukuoka, Japan .
Yokoo-Inoue T; 1 Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University , Fukuoka, Japan .
Mizuochi-Yanagi C; 1 Department of Research and Development of Next Generation Medicine, Faculty of Medical Sciences, Kyushu University , Fukuoka, Japan .
Yasuda K; 5 Cell Innovator Ltd. , Fukuoka, Japan .
Doi A; 5 Cell Innovator Ltd. , Fukuoka, Japan .
Iino T; 3 Department of Clinical Study, Center for Advanced Medical Innovation, Kyushu University , Fukuoka, Japan .
Itoh M; 6 RIKEN Preventive Medicine and Diagnosis Innovation Program , Yokohama, Japan .; 7 RIKEN Center for Life Science Technologies , Division of Genomic Technologies, Yokohama, Japan .; 8 RIKEN Yokohama Institute , Omics Science Center, Yokohama, Kanagawa, Japan.
Nagao-Sato S; 8 RIKEN Yokohama Institute , Omics Science Center, Yokohama, Kanagawa, Japan.
Tani K; 9 Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University , Fukuoka, Japan .
Akashi K; 10 Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences , Fukuoka, Japan .
Hayashizaki Y; 6 RIKEN Preventive Medicine and Diagnosis Innovation Program , Yokohama, Japan .; 7 RIKEN Center for Life Science Technologies , Division of Genomic Technologies, Yokohama, Japan .
Suzuki H; 7 RIKEN Center for Life Science Technologies , Division of Genomic Technologies, Yokohama, Japan .
Kawaji H; 6 RIKEN Preventive Medicine and Diagnosis Innovation Program , Yokohama, Japan .; 7 RIKEN Center for Life Science Technologies , Division of Genomic Technologies, Yokohama, Japan .; 8 RIKEN Yokohama Institute , Omics Science Center, Yokohama, Kanagawa, Japan.
Carninci P; 6 RIKEN Preventive Medicine and Diagnosis Innovation Program , Yokohama, Japan .; 7 RIKEN Center for Life Science Technologies , Division of Genomic Technologies, Yokohama, Japan .; 8 RIKEN Yokohama Institute , Omics Science Center, Yokohama, Kanagawa, Japan.
Forrest AR; 7 RIKEN Center for Life Science Technologies , Division of Genomic Technologies, Yokohama, Japan .
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Źródło :
Stem cells and development [Stem Cells Dev] 2017 Mar 01; Vol. 26 (5), pp. 314-327. Date of Electronic Publication: 2017 Jan 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Hematopoietic Stem Cells/*cytology
Hematopoietic Stem Cells/*metabolism
Animals ; Aorta/cytology ; Cell Separation ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Gonads/cytology ; Mesonephros/cytology ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Oligonucleotide Array Sequence Analysis ; RNA Caps/metabolism ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Progress in the leukemic stem cell study and a novel therapeutic approach targeting leukemic stem cells.
Autorzy :
Kikushige Y; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science.
Miyamoto T; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science.
Akashi K; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science.
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Źródło :
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2017; Vol. 58 (10), pp. 1838-1843.
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoietic Stem Cells*
Leukemia*/diagnosis
Neoplastic Stem Cells*
Animals ; Humans ; Prognosis
Czasopismo naukowe
Tytuł :
Preserved in vivo reconstitution ability of PBSCs cryopreserved for a decade at -80 °C.
Autorzy :
Shima T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Iwasaki H; Center for Cellular and Molecular Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Yamauchi T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Kadowaki M; Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Kiyosuke M; Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Mochimaru T; Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Takenaka K; Center for Cellular and Molecular Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medicine, Fukuoka, Japan.; Center for Cellular and Molecular Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Teshima T; Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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Źródło :
Bone marrow transplantation [Bone Marrow Transplant] 2015 Sep; Vol. 50 (9), pp. 1195-200. Date of Electronic Publication: 2015 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryopreservation*
Antigens, CD34/*metabolism
Hematopoietic Stem Cells/*metabolism
Adult ; Aged ; Animals ; Cell Differentiation ; Cell Survival ; Female ; Hematologic Neoplasms/blood ; Hematologic Neoplasms/metabolism ; Heterografts ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Peripheral Blood Stem Cell Transplantation ; Time Factors
Czasopismo naukowe
Tytuł :
CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor.
Autorzy :
Miyawaki K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Arinobu Y
Iwasaki H
Kohno K
Tsuzuki H
Iino T
Shima T
Kikushige Y
Takenaka K
Miyamoto T
Akashi K
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Źródło :
Stem cells (Dayton, Ohio) [Stem Cells] 2015 Mar; Vol. 33 (3), pp. 976-87.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoiesis/*physiology
Hematopoietic Stem Cells/*cytology
Leukemia, Myeloid/*pathology
Myeloid Progenitor Cells/*cytology
Platelet Membrane Glycoprotein IIb/*metabolism
Animals ; Cell Differentiation/physiology ; Cell Lineage ; Cells, Cultured ; Gene Expression Profiling ; Hematopoietic Stem Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myeloid Progenitor Cells/metabolism
Czasopismo naukowe
Tytuł :
The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.
Autorzy :
Shima T; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan; Center for Cellular and Molecular Medicine, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Kikushige Y; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Yuda J; Center for Cellular and Molecular Medicine, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Tochigi T; Center for Cellular and Molecular Medicine, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Yoshimoto G; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Kato K; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Takenaka K; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Iwasaki H; Center for Cellular and Molecular Medicine, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Mizuno S; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Goto N; Cancer Research Institute of Kanazawa University, Ishikawa, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan; Center for Cellular and Molecular Medicine, Graduate School of Medical Sciences, Kyushu University Graduate School of Medicine, Fukuoka, Japan. Electronic address: akashi@med.kyushu-u.ac.jp.
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Źródło :
Experimental hematology [Exp Hematol] 2014 Nov; Vol. 42 (11), pp. 955-65.e1-5. Date of Electronic Publication: 2014 Aug 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic*
Mutation*
Core Binding Factor Alpha 2 Subunit/*genetics
Hematopoietic Stem Cells/*metabolism
Leukemia, Myeloid, Acute/*genetics
Proto-Oncogene Proteins/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Transcription Factors/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cell Proliferation ; Cell Survival ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Chromosomes, Human, Pair 21 ; Chromosomes, Human, Pair 8 ; Core Binding Factor Alpha 2 Subunit/metabolism ; Female ; Hematopoietic Stem Cells/pathology ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Male ; Middle Aged ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-kit/metabolism ; RUNX1 Translocation Partner 1 Protein ; Signal Transduction ; Transcription Factors/metabolism ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
Acquired initiating mutations in early hematopoietic cells of CLL patients.
Autorzy :
Damm F; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif;
Mylonas E; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif;
Cosson A; INSERM U1138; Université Pierre et Marie Curie-Paris 6;
Yoshida K; Cancer Genomics Project, Graduate School of Medicine; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto;
Della Valle V; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif; Université Paris-Sud;
Mouly E; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif; Université Paris-Sud;
Diop M; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif;
Scourzic L; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif; Université Paris-Sud;
Shiraishi Y; Laboratory of DNA Information Analysis and Laboratory of Sequence Data Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo;
Chiba K; Laboratory of DNA Information Analysis and Laboratory of Sequence Data Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo;
Tanaka H; Laboratory of DNA Information Analysis and Laboratory of Sequence Data Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo;
Miyano S; Laboratory of DNA Information Analysis and Laboratory of Sequence Data Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo;
Kikushige Y; Medicine and Biosystemic Science; and Center for Cellular and Molecular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Davi F; INSERM U1138; Université Pierre et Marie Curie-Paris 6; Service d'Hématologie Biologique, Hôpital Pitié-Salpêtrière, APHP;
Lambert J; Université Paris Diderot, Hôpital Saint-Louis, SBIM;
Gautheret D; Institut Gustave Roussy, Villejuif; Université Paris-Sud, Institut de Génétique et Microbiologie, CNRS UMR 8621, Orsay;
Merle-Béral H; INSERM U1138; Université Pierre et Marie Curie-Paris 6; Service d'Hématologie Biologique, Hôpital Pitié-Salpêtrière, APHP;
Sutton L; Service d'Hématologie Clinique, Centre Hospitalier Victor Dupouy, Argenteuil, France;
Dessen P; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif;
Solary E; INSERM U1009; Institut Gustave Roussy, Villejuif; Ligue Nationale Contre le Cancer, Equipe labellisée, Paris; Université Paris-Sud;
Akashi K; Medicine and Biosystemic Science; and Center for Cellular and Molecular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Vainchenker W; INSERM U1009; Institut Gustave Roussy, Villejuif; Université Paris-Sud;
Mercher T; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif; Université Paris-Sud;
Droin N; INSERM U1009; Institut Gustave Roussy, Villejuif; Université Paris-Sud;
Ogawa S; Cancer Genomics Project, Graduate School of Medicine; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto; .
Nguyen-Khac F; INSERM U1138; Université Pierre et Marie Curie-Paris 6; Service d'Hématologie Biologique, Hôpital Pitié-Salpêtrière, APHP; .
Bernard OA; Institut National de la Santé et de la Recherche Medicale (INSERM) U985; Institut Gustave Roussy, Villejuif; Ligue Nationale Contre le Cancer, Equipe labellisée, Paris; Université Paris-Sud; .
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Źródło :
Cancer discovery [Cancer Discov] 2014 Sep; Vol. 4 (9), pp. 1088-101. Date of Electronic Publication: 2014 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Hematopoietic Stem Cells/*metabolism
Hematopoietic Stem Cells/*pathology
Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Cluster Analysis ; Gene Expression Profiling ; Humans ; Immunoglobulin Heavy Chains/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Multipotent Stem Cells/metabolism ; Multipotent Stem Cells/pathology ; Phosphoproteins/genetics ; RNA Splicing Factors ; Receptors, Antigen, B-Cell/metabolism ; Ribonucleoprotein, U2 Small Nuclear/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.
Autorzy :
Iwamoto C; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Takenaka K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Urata S; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Yamauchi T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Shima T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Kuriyama T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Daitoku S; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Saito Y; Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Iwasaki H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Kitabayashi I; Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan.
Itoh K; Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan.
Kishimoto J; Digital Medicine Initiative, Kyushu University, Fukuoka, Japan.
Kohda D; Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Matozaki T; Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. Electronic address: akashi@med.kyushu-u.ac.jp.
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Źródło :
Experimental hematology [Exp Hematol] 2014 Mar; Vol. 42 (3), pp. 163-171.e1. Date of Electronic Publication: 2013 Nov 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD47 Antigen/*immunology
Hematopoietic Stem Cells/*immunology
Macrophages/*immunology
Phagocytosis/*immunology
Receptors, Immunologic/*immunology
Amino Acid Sequence ; Animals ; Binding, Competitive/immunology ; CD47 Antigen/metabolism ; Cells, Cultured ; Graft Survival/immunology ; HeLa Cells ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Macrophages/cytology ; Macrophages/metabolism ; Mice ; Mice, 129 Strain ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Inbred NOD ; Molecular Sequence Data ; Polymorphism, Single Nucleotide/immunology ; Protein Binding/immunology ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
A novel filtration method for cord blood processing using a polyester fabric filter.
Autorzy :
Shima T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Forraz N
Sato N
Yamauchi T
Iwasaki H
Takenaka K
Akashi K
McGuckin C
Teshima T
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Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2013 Aug; Vol. 35 (4), pp. 436-46. Date of Electronic Publication: 2012 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Separation/*instrumentation
Fetal Blood/*cytology
Hematopoietic Stem Cells/*cytology
Hemofiltration/*instrumentation
Antigens, CD34/metabolism ; Biomarkers/metabolism ; Cell Count ; Cell Separation/methods ; Fetal Blood/metabolism ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/metabolism ; Hemofiltration/methods ; Humans ; Polyesters/chemistry
Czasopismo naukowe
Tytuł :
Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker⁺ cardiomyocytes in vivo.
Autorzy :
Fukata M; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan. />Ishikawa F
Najima Y
Yamauchi T
Saito Y
Takenaka K
Miyawaki K
Shimazu H
Shimoda K
Kanemaru T
Nakamura K
Odashiro K
Nagafuji K
Harada M
Akashi K
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Źródło :
PloS one [PLoS One] 2013 May 07; Vol. 8 (5), pp. e62506. Date of Electronic Publication: 2013 May 07 (Print Publication: 2013).
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Bone Marrow Cells/*cytology
Hematopoietic Stem Cells/*cytology
Myocytes, Cardiac/*cytology
Animals ; Biomarkers/metabolism ; Cell Differentiation ; Cell Fusion ; Cell Lineage ; Fetal Blood/cytology ; Humans ; Mice ; Mice, Inbred C57BL ; Myeloid Cells/cytology ; Myocytes, Cardiac/metabolism
Czasopismo naukowe
Tytuł :
Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.
Autorzy :
Yamauchi T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Takenaka K
Urata S
Shima T
Kikushige Y
Tokuyama T
Iwamoto C
Nishihara M
Iwasaki H
Miyamoto T
Honma N
Nakao M
Matozaki T
Akashi K
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Źródło :
Blood [Blood] 2013 Feb 21; Vol. 121 (8), pp. 1316-25. Date of Electronic Publication: 2013 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cell Transplantation/*methods
Hematopoietic Stem Cells/*cytology
Hematopoietic Stem Cells/*immunology
Receptors, Immunologic/*genetics
Transplantation, Heterologous/*immunology
Transplantation, Heterologous/*methods
Animals ; Antibodies, Heterophile/immunology ; CD47 Antigen/immunology ; CD47 Antigen/metabolism ; Cell Lineage/immunology ; DNA-Binding Proteins/genetics ; Female ; Graft Survival/immunology ; Hematopoiesis/physiology ; Humans ; Lymphocytes/cytology ; Lymphocytes/immunology ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Models, Animal ; Phagocytosis/immunology ; Polymorphism, Genetic/immunology ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
Autorzy :
Kuriyama T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Takenaka K
Kohno K
Yamauchi T
Daitoku S
Yoshimoto G
Kikushige Y
Kishimoto J
Abe Y
Harada N
Miyamoto T
Iwasaki H
Teshima T
Akashi K
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Źródło :
Blood [Blood] 2012 Nov 08; Vol. 120 (19), pp. 4058-67. Date of Electronic Publication: 2012 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*/drug effects
CD47 Antigen/*metabolism
Cytophagocytosis/*immunology
Hematopoietic Stem Cells/*metabolism
Lymphohistiocytosis, Hemophagocytic/*etiology
ADP-ribosyl Cyclase 1/metabolism ; Adolescent ; Adult ; Aged ; Antigens, CD34/metabolism ; Antigens, Differentiation/genetics ; CD47 Antigen/genetics ; Cell Line ; Cytokines/pharmacology ; Humans ; Inflammation Mediators/pharmacology ; Macrophage Activation/immunology ; Macrophages/metabolism ; Middle Aged ; Models, Biological ; Mutation ; RNA Interference ; Receptors, Immunologic/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis.
Autorzy :
Mizuochi C; Department of Hematopoietic Stem Cells, SSP Stem Cell Unit, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.
Fraser ST
Biasch K
Horio Y
Kikushige Y
Tani K
Akashi K
Tavian M
Sugiyama D
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Źródło :
PloS one [PLoS One] 2012; Vol. 7 (4), pp. e35763. Date of Electronic Publication: 2012 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Embryonic Development*
Antigens, CD/*metabolism
Aorta/*metabolism
Endothelial Cells/*metabolism
Hematopoietic Stem Cells/*metabolism
Animals ; Antigens, CD/genetics ; Aorta/cytology ; Aorta/embryology ; Biomarkers/metabolism ; Cell Dedifferentiation ; Embryo, Mammalian ; Endothelial Cells/cytology ; Flow Cytometry ; Gene Expression ; Hematopoietic Stem Cells/cytology ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia.
Autorzy :
Kikushige Y; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan.
Ishikawa F
Miyamoto T
Shima T
Urata S
Yoshimoto G
Mori Y
Iino T
Yamauchi T
Eto T
Niiro H
Iwasaki H
Takenaka K
Akashi K
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Źródło :
Cancer cell [Cancer Cell] 2011 Aug 16; Vol. 20 (2), pp. 246-59.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cells/*cytology
Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
Animals ; Antigens, CD/immunology ; B-Lymphocytes/immunology ; Cell Lineage ; Humans ; Immunophenotyping ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Mice ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells.
Autorzy :
Tsukamoto H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. />Nagafuji K
Horiuchi T
Mitoma H
Niiro H
Arinobu Y
Inoue Y
To K
Miyamoto T
Iwasaki H
Teshima T
Harada M
Akashi K
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2011 May; Vol. 50 (5), pp. 944-52. Date of Electronic Publication: 2010 Dec 20.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cells*
CD4-Positive T-Lymphocytes/*transplantation
Hematopoietic Stem Cell Transplantation/*methods
Scleroderma, Systemic/*pathology
Scleroderma, Systemic/*therapy
Th1 Cells/*pathology
Adult ; Antibodies/blood ; CD4 Lymphocyte Count ; Cyclophosphamide/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Mucin-1/blood ; Nuclear Proteins/immunology ; Pulmonary Surfactant-Associated Protein D/blood ; Remission Induction ; Scleroderma, Systemic/immunology ; Treatment Outcome
Czasopismo naukowe

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