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Wyświetlanie 1-17 z 17
Tytuł :
TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion.
Autorzy :
Yamamoto M; 1Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.; 2Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.
Abe C; 1Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.
Wakinaga S; 1Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.
Sakane K; 1Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.
Yumiketa Y; 1Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.
Taguchi Y; 1Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.
Matsumura T; 3Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo 162-8640 Japan.
Ishikawa K; 4Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan.
Fujimoto J; 4Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan.
Semba K; 4Department of Life Science and Medical Bio-Science, Waseda University, Shinjuku-ku, Tokyo 162-8480 Japan.
Miyauchi M; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Kanagawa 230-0045 Japan.
Akiyama T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Kanagawa 230-0045 Japan.
Inoue JI; 1Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.; 2Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639 Japan.
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Źródło :
Communications biology [Commun Biol] 2019 Aug 06; Vol. 2, pp. 292. Date of Electronic Publication: 2019 Aug 06 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Epithelial Cells/*metabolism
Mammary Glands, Animal/*metabolism
Stem Cells/*metabolism
TNF Receptor-Associated Factor 6/*metabolism
Adipose Tissue/metabolism ; Adipose Tissue/transplantation ; Animals ; Apoptosis ; Cell Line ; Cyclin D1/metabolism ; Female ; Mammary Glands, Animal/growth & development ; Mice, Inbred BALB C ; Mice, Knockout ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphorylation ; Pregnancy ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor Activator of Nuclear Factor-kappa B/metabolism ; Retinoblastoma Protein/metabolism ; Signal Transduction ; TNF Receptor-Associated Factor 6/deficiency ; TNF Receptor-Associated Factor 6/genetics
Czasopismo naukowe
Tytuł :
Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire).
Autorzy :
Horie K; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Kudo T; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Yoshinaga R; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Akiyama N; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan.
Sasanuma H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Kobayashi TJ; Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan.
Shimbo M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Jeon H; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Miyao T; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan.
Miyauchi M; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan.
Shirakawa M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki 305-8505, Japan.
Shiba D; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki 305-8505, Japan.
Yoshida N; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Muratani M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Takahashi S; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan; Laboratory Animal Resource Center and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Akiyama T; Center for Integrative Medical Science, RIKEN, Yokohama 230-0045, Japan; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Japan. Electronic address: taishin.akiyama@riken.jp.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Jun 27; Vol. 501 (3), pp. 745-750.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*cytology
Hindlimb Suspension/*methods
Thymocytes/*cytology
Thymus Gland/*physiology
Transcription Factors/*analysis
Animals ; CD4 Antigens/analysis ; CD8 Antigens/analysis ; Cell Count ; Male ; Mice, Inbred C57BL ; Organ Size ; Thymus Gland/cytology ; Time Factors
Czasopismo naukowe
Tytuł :
Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.
Autorzy :
Akiyama N; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Takizawa N; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Miyauchi M; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Yanai H; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Tateishi R; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Shinzawa M; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Yoshinaga R; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Kurihara M; Division of Organic Chemistry, National Institute of Health Sciences, Kamiyoga, Setagaya, Tokyo 158-8501, Japan.
Demizu Y; Division of Organic Chemistry, National Institute of Health Sciences, Kamiyoga, Setagaya, Tokyo 158-8501, Japan.
Yasuda H; Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd., 50, Kano-cho, Nagahama, Shiga 526-0804, Japan.
Yagi S; Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Wu G; Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Matsumoto M; Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan.
Sakamoto R; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Yoshida N; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Penninger JM; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.
Kobayashi Y; Institute for Oral Science, Matsumoto Dental University, Hiro-oka, Shiojiri-shi, Nagano 399-0781, Japan.
Inoue J; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Akiyama T; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan taishin@ims.u-tokyo.ac.jp.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2016 Jul 25; Vol. 213 (8), pp. 1441-58. Date of Electronic Publication: 2016 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*immunology
Epithelial Cells/*immunology
Gene Expression Regulation/*immunology
Mouse Embryonic Stem Cells/*immunology
Thymus Gland/*immunology
Transcription Factors/*immunology
Animals ; Cell Differentiation/genetics ; Epithelial Cells/cytology ; Gene Expression Regulation/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mouse Embryonic Stem Cells/cytology ; Plant Lectins/genetics ; Plant Lectins/immunology ; Thymus Gland/cytology ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice.
Autorzy :
Tateishi R; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Akiyama N; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Miyauchi M; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Yoshinaga R; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
Sasanuma H; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo, Tokyo, Japan.
Kudo T; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Shimbo M; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Shinohara M; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; JST, PRESTO, Kawaguchi, Saitama, Japan.
Obata K; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Inoue J; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Shirakawa M; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Shiba D; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki, Japan.
Asahara H; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshida N; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The University of Tokyo, Tokyo, Japan.
Takahashi S; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Morita H; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan; Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Akiyama T; Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Mouse epigenetics project, ISS/Kibo experiment, Japan Aerospace Exploration Agency, JAXA, Tsukuba, Japan.
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Źródło :
PloS one [PLoS One] 2015 Oct 29; Vol. 10 (10), pp. e0141650. Date of Electronic Publication: 2015 Oct 29 (Print Publication: 2015).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Count*
Hypergravity*
Epithelial Cells/*metabolism
T-Lymphocyte Subsets/*metabolism
Thymocytes/*metabolism
Thymus Gland/*cytology
Thymus Gland/*metabolism
Animals ; Biomarkers ; CD4 Antigens/metabolism ; CD8 Antigens/metabolism ; Gene Expression ; Immunophenotyping ; Mice ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor Activator of Nuclear Factor-kappa B/genetics ; Receptor Activator of Nuclear Factor-kappa B/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation.
Autorzy :
Akiyama N; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Shinzawa M; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Miyauchi M; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Yanai H; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Tateishi R; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Shimo Y; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Ohshima D; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Matsuo K; Laboratory of Cell and Tissue Biology, Graduate School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.
Sasaki I; Laboratory for Immune Regulation, World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Hoshino K; Laboratory for Immune Regulation, World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan Laboratory for Inflammatory Regulation, Research Center for Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Department of Immunology, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa 761-0793, Japan.
Wu G; Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Yagi S; Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Inoue J; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Kaisho T; Laboratory for Immune Regulation, World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan Laboratory for Inflammatory Regulation, Research Center for Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan taishin@ims.u-tokyo.ac.jp .
Akiyama T; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan taishin@ims.u-tokyo.ac.jp .
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Źródło :
The Journal of experimental medicine [J Exp Med] 2014 Nov 17; Vol. 211 (12), pp. 2425-38. Date of Electronic Publication: 2014 Nov 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*immunology
Immune Tolerance/*immunology
Proto-Oncogene Proteins c-ets/*immunology
Thymus Gland/*immunology
Animals ; Animals, Newborn ; B7-1 Antigen/immunology ; B7-1 Antigen/metabolism ; Blotting, Western ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Cells, Cultured ; Epithelial Cells/metabolism ; Feedback, Physiological ; Female ; Gene Expression/immunology ; Immune Tolerance/genetics ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Nude ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/metabolism ; Osteoprotegerin/genetics ; Osteoprotegerin/immunology ; Osteoprotegerin/metabolism ; Protein-Serine-Threonine Kinases/immunology ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-ets/genetics ; Proto-Oncogene Proteins c-ets/metabolism ; RANK Ligand/immunology ; RANK Ligand/metabolism ; Receptor Activator of Nuclear Factor-kappa B/genetics ; Receptor Activator of Nuclear Factor-kappa B/immunology ; Receptor Activator of Nuclear Factor-kappa B/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/immunology ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
Identification of transcription factors activated in thymic epithelial cells during embryonic thymus development.
Autorzy :
Akiyama T; Division of Cellular and Molecular Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo, 108-8639, Japan, taishin@ims.u-tokyo.ac.jp.
Qin J
Ohshima D
Inoue J
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2014; Vol. 1164, pp. 163-70.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*metabolism
Thymus Gland/*embryology
Transcription Factors/*metabolism
Animals ; Databases, Nucleic Acid ; Epithelial Cells/cytology ; Equipment Design ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Developmental ; Mice ; Organ Culture Techniques/instrumentation ; Organ Culture Techniques/methods ; RNA/genetics ; RNA/isolation & purification ; Thymus Gland/metabolism ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells.
Autorzy :
Wu G; Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences/Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Hirabayashi K
Sato S
Akiyama N
Akiyama T
Shiota K
Yagi S
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Źródło :
BMC immunology [BMC Immunol] 2012 Nov 02; Vol. 13, pp. 58. Date of Electronic Publication: 2012 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation/*genetics
Epithelial Cells/*metabolism
Thymus Gland/*cytology
Transcription Factors/*deficiency
Animals ; Biomarkers/metabolism ; Cell Separation ; Gene Expression Profiling ; Gene Expression Regulation ; Leukocyte Common Antigens/metabolism ; Mice ; Mice, Inbred C57BL ; Oligonucleotide Array Sequence Analysis ; Organ Specificity/genetics ; Stromal Cells/metabolism ; Transcription Factors/metabolism ; Transcription Initiation Site
Czasopismo naukowe
Tytuł :
[Regulation of central tolerance by RANKL signaling].
Autorzy :
Shinzawa M; Institute of Medical Science, University of Tokyo, Japan.
Akiyama T
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Źródło :
Clinical calcium [Clin Calcium] 2011 Aug; Vol. 21 (8), pp. 1193-9.
Typ publikacji :
English Abstract; Journal Article; Review
MeSH Terms :
Autoimmunity/*genetics
Cell Differentiation/*genetics
Epithelial Cells/*cytology
Epithelial Cells/*immunology
Immune Tolerance/*genetics
RANK Ligand/*physiology
Signal Transduction/*physiology
Thymus Gland/*cytology
Humans ; Thymus Gland/immunology
Czasopismo naukowe
Tytuł :
RANK signaling induces interferon-stimulated genes in the fetal thymic stroma.
Autorzy :
Ohshima D; Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo, Japan.
Qin J
Konno H
Hirosawa A
Shiraishi T
Yanai H
Shimo Y
Shinzawa M
Akiyama N
Yamashita R
Nakai K
Akiyama T
Inoue J
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2011 May 20; Vol. 408 (4), pp. 530-6. Date of Electronic Publication: 2011 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Epithelial Cells/*immunology
Interferon Type I/*immunology
Receptor Activator of Nuclear Factor-kappa B/*metabolism
Self Tolerance/*genetics
Thymus Gland/*immunology
Animals ; Fetus ; Mice ; Oligonucleotide Array Sequence Analysis ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Receptor Activator of Nuclear Factor-kappa B/genetics ; Receptor, Interferon alpha-beta/genetics ; Signal Transduction ; Stromal Cells/immunology ; TNF Receptor-Associated Factor 6/genetics ; TNF Receptor-Associated Factor 6/metabolism
Czasopismo naukowe
Tytuł :
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.
Autorzy :
Mouri Y; Division of Molecular Immunology, Institute for Enzyme Research, The University of Tokushima, Tokushima 770-8503, Japan.
Yano M
Shinzawa M
Shimo Y
Hirota F
Nishikawa Y
Nii T
Kiyonari H
Abe T
Uehara H
Izumi K
Tamada K
Chen L
Penninger JM
Inoue J
Akiyama T
Matsumoto M
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2011 May 01; Vol. 186 (9), pp. 5047-57. Date of Electronic Publication: 2011 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organogenesis*
Signal Transduction*
Cell Differentiation/*immunology
Epithelial Cells/*cytology
Lymphotoxin beta Receptor/*metabolism
Receptor Activator of Nuclear Factor-kappa B/*biosynthesis
Thymus Gland/*embryology
Animals ; CD40 Antigens/metabolism ; Embryo, Mammalian ; Flow Cytometry ; Gene Expression ; Gene Expression Regulation ; Immunohistochemistry ; Mice ; Mice, Knockout ; Reverse Transcriptase Polymerase Chain Reaction ; Self Tolerance/immunology ; Thymus Gland/cytology ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Autorzy :
Hikosaka Y; Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan.
Nitta T
Ohigashi I
Yano K
Ishimaru N
Hayashi Y
Matsumoto M
Matsuo K
Penninger JM
Takayanagi H
Yokota Y
Yamada H
Yoshikai Y
Inoue J
Akiyama T
Takahama Y
Pokaż więcej
Źródło :
Immunity [Immunity] 2008 Sep 19; Vol. 29 (3), pp. 438-50.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Cells/*immunology
RANK Ligand/*metabolism
Receptor Activator of Nuclear Factor-kappa B/*metabolism
T-Lymphocytes/*immunology
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Thymus Gland/*immunology
Transcription Factors/*metabolism
Animals ; Autoimmunity ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Mice ; Osteoprotegerin/metabolism ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Self Tolerance ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism ; Thymus Gland/cytology ; Thymus Gland/metabolism
Czasopismo naukowe
Tytuł :
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Autorzy :
Akiyama T; Division of Cellular and Molecular biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
Shimo Y
Yanai H
Qin J
Ohshima D
Maruyama Y
Asaumi Y
Kitazawa J
Takayanagi H
Penninger JM
Matsumoto M
Nitta T
Takahama Y
Inoue J
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Źródło :
Immunity [Immunity] 2008 Sep 19; Vol. 29 (3), pp. 423-37.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Self Tolerance*
CD40 Antigens/*metabolism
CD40 Ligand/*metabolism
Epithelial Cells/*cytology
Epithelial Cells/*immunology
Receptor Activator of Nuclear Factor-kappa B/*metabolism
Thymus Gland/*cytology
Animals ; Autoimmunity ; CD40 Antigens/deficiency ; Cell Differentiation ; Epithelial Cells/metabolism ; Mice ; Mice, Knockout ; NF-kappa B/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; RANK Ligand/deficiency ; RANK Ligand/metabolism ; Signal Transduction ; TNF Receptor-Associated Factor 6/metabolism ; Thymus Gland/embryology ; Thymus Gland/immunology ; Thymus Gland/physiology
Czasopismo naukowe
Tytuł :
Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire).
Autorzy :
Horie, Kenta
Kudo, Takashi
Yoshinaga, Riko
Akiyama, Nobuko
Sasanuma, Hiroki
Kobayashi, Tetsuya J.
Shimbo, Miki
Jeon, Hyojung
Miyao, Takahisa
Miyauchi, Maki
Shirakawa, Masaki
Shiba, Dai
Yoshida, Nobuaki
Muratani, Masafumi
Takahashi, Satoru
Akiyama, Taishin taishin.akiyama@riken.jp
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Źródło :
Biochemical & Biophysical Research Communications. Jun2018, Vol. 501 Issue 3, p745-750. 6p.
Czasopismo naukowe
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