Autor: "Aleo SJ" - OpacWWW

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Tytuł:: Coenzyme Q biosynthesis inhibition induces HIF-1α stabilization and metabolic switch toward glycolysis.
Autorzy:: Liparulo I; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Bergamini C; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Bortolus M; Department of Chemistry, University of Padova, Italy.
Calonghi N; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Gasparre G; Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Italy.
Kurelac I; Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Italy.
Masin L; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Rizzardi N; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Rugolo M; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Wang W; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Aleo SJ; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Kiwan A; Department of Chemistry 'Giacomo Ciamician', University of Bologna, Italy.
Torri C; Department of Chemistry 'Giacomo Ciamician', University of Bologna, Italy.
Zanna C; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.
Fato R; Department of Pharmacy and Biotechnology-FABIT, University of Bologna, Italy.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2021 Mar; Vol. 288 (6), pp. 1956-1974. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Energy Metabolism*
Glycolysis*
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Ubiquinone/*analogs & derivatives
Alkyl and Aryl Transferases/antagonists & inhibitors ; Alkyl and Aryl Transferases/metabolism ; Ataxia/metabolism ; Cell Line, Tumor ; Cholesterol/metabolism ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Diseases/metabolism ; Muscle Weakness/metabolism ; Nitrobenzoates/pharmacology ; Protein Stability/drug effects ; Ubiquinone/antagonists & inhibitors ; Ubiquinone/biosynthesis ; Ubiquinone/deficiency ; Ubiquinone/metabolism
SCR Disease Name:: Coenzyme Q10 Deficiency

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