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Wyświetlanie 1-17 z 17
Tytuł :
Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity.
Autorzy :
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. Electronic address: .
Sayed AM; Biochemistry Laboratory, Chemistry Department, Faculty of Science, Assiut University, Egypt.
El-Bahrawy AH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
Omar ZMM; Department of Pharmacology, College of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
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Źródło :
Life sciences [Life Sci] 2021 Jun 15; Vol. 275, pp. 119349. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*chemically induced
Diosmin/*therapeutic use
Gentamicins/*toxicity
Kelch-Like ECH-Associated Protein 1/*metabolism
Oncogene Protein v-akt/*metabolism
PPAR gamma/*metabolism
Signal Transduction/*drug effects
Acute Kidney Injury/pathology ; Acute Kidney Injury/prevention & control ; Animals ; Blotting, Western ; Creatinine/blood ; Diosmin/pharmacology ; Kidney/drug effects ; Kidney/pathology ; Male ; NF-E2-Related Factor 2/metabolism ; Rats ; Rats, Wistar ; Urea/blood ; Uric Acid/blood
Czasopismo naukowe
Tytuł :
Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling.
Autorzy :
Abdel-Wahab BA; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia; Department of Medical Pharmacology, College of Medicine, Assiut University, Assiut, Egypt. Electronic address: .
Walbi IA; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Albarqi HA; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 May; Vol. 151, pp. 112133. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.
Autorzy :
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
El-Bahrawy AH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Omar ZMM; Department of Pharmacology, College of Medicine, Al-Azhar University, Assiut, Egypt.
Rashwan EK; Department of Physiology, College of Medicine, Al-Azhar University, Assiut, Egypt.
Abdel-Wahab BA; Department of Pharmacology, School of Pharmacy, Najran University, Najran, Saudi Arabia.; Department of Pharmacology, Assiut University, Assiut, Egypt.
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 May; Vol. 35 (5), pp. e22738. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges.
Autorzy :
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt. .
Mohammedsaleh ZM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Ali MM; Pre-graduated students, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Ghogar OM; Pre-graduated students, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
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Źródło :
World journal of gastroenterology [World J Gastroenterol] 2021 Apr 21; Vol. 27 (15), pp. 1531-1552.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19*
SARS-CoV-2*
Cytokine Release Syndrome ; Humans ; Inflammation ; Liver ; Peptidyl-Dipeptidase A ; Prospective Studies
Czasopismo naukowe
Tytuł :
Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1/2 signaling pathways.
Autorzy :
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Abdel-Wahab BA; Department of Pharmacology, School of Pharmacy, Najran University, P.O. 1988, Najran, Saudi Arabia.; Department of Medical Pharmacology, College of Medicine, Assiut University, Assiut, Egypt.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. .
Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Kozman MR; Clinical Pharmacology Department, Faculty of Pharmacy, Misr University for Science and Technology, Cairo, Egypt.
Sharkawi SMZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Apr 01. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Regulation of IL-6/STAT-3/Wnt axis by nifuroxazide dampens colon ulcer in acetic acid-induced ulcerative colitis model: Novel mechanistic insight.
Autorzy :
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. Electronic address: .
M Elfiky M; Human Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin ElKoum-Menoufia, Egypt.
Fadda WA; Human Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin ElKoum-Menoufia, Egypt; Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
Ali HS; Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Pharmacology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Mahmoud AR; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt; Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
Mohammedsaleh ZM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
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Źródło :
Life sciences [Life Sci] 2021 Jul 01; Vol. 276, pp. 119433. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
Acetic Acid/*toxicity
Colitis, Ulcerative/*prevention & control
Gene Expression Regulation/*drug effects
Hydroxybenzoates/*pharmacology
Interleukin-6/*metabolism
Nitrofurans/*pharmacology
STAT3 Transcription Factor/*metabolism
Wnt1 Protein/*metabolism
Animals ; Anti-Bacterial Agents/toxicity ; Anti-Infective Agents/pharmacology ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Disease Models, Animal ; Interleukin-6/genetics ; Male ; Rats ; Rats, Wistar ; STAT3 Transcription Factor/genetics ; Wnt1 Protein/genetics
Czasopismo naukowe
Tytuł :
Rebamipide potentially mitigates methotrexate-induced nephrotoxicity via inhibition of oxidative stress and inflammation: A molecular and histochemical study.
Autorzy :
Elmansy RA; Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.; Anatomy Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Seleem HS; Histology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.; Histology Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Mahmoud AR; Anatomy Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
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Źródło :
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2021 Mar; Vol. 304 (3), pp. 647-661. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alanine/*analogs & derivatives
Antioxidants/*therapeutic use
Inflammation/*metabolism
Kidney/*drug effects
Kidney Diseases/*drug therapy
Methotrexate/*adverse effects
Oxidative Stress/*drug effects
Quinolones/*pharmacology
Alanine/pharmacology ; Alanine/therapeutic use ; Animals ; Antimetabolites, Antineoplastic/adverse effects ; Antioxidants/pharmacology ; Kidney/metabolism ; Kidney Diseases/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; Quinolones/therapeutic use ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.
Autorzy :
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. .
Kozman MR; Clinical Pharmacology Department, Faculty of Pharmacy, Misr University for Science and Technology, Cairo, Egypt.
Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Mar; Vol. 28 (9), pp. 11558-11571. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Gentamicins*/toxicity
NF-kappa B*/metabolism
Animals ; Kidney/metabolism ; Rats ; Signal Transduction ; Toll-Like Receptor 4 ; Umbelliferones/pharmacology
Czasopismo naukowe
Tytuł :
The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways.
Autorzy :
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt.
Saad Eldien HM; Department of Anatomy, College of Medicine, Jouf University, Saudi Arabia.
Mostafa NAM; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Almaeen AH; Department of Pathology, College of medicine, Jouf University, Saudi Arabia.
Marzouk MRA; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Eid KM; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ghoziz AHE; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ebrahiem AF; Post graduate student, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Hagag MG; Pharmacy student, Faculty of Pharmacy, Al- Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ghogar OM; Pharmacy student, Faculty of Pharmacy, Al- Azhar University, Assiut Branch, Assiut, 71524, Egypt.
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Źródło :
Current molecular pharmacology [Curr Mol Pharmacol] 2021; Vol. 14 (1), pp. 88-100.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
Autorzy :
Abdel-Wahab BA; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia.; Department of Medical Pharmacology, College of Medicine, Assiut University, Assiut, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Alkahtani SA; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Alshabi AM; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Mahnashi MH; Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
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Źródło :
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2020 Oct; Vol. 42 (5), pp. 493-503. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways.
Autorzy :
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt. Electronic address: .
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Bakr AG; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
El-Shoura EAM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
El-Gamal DA; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mahmoud AR; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Anatomy, Unaizah College of Medicine, Qassim University, Unaizah Al Qassim Region, Saudi Arabia.
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
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Źródło :
Life sciences [Life Sci] 2020 Aug 01; Vol. 254, pp. 117760. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury/*prevention & control
Gentamicins/*antagonists & inhibitors
Gentamicins/*toxicity
Hepatocytes/*drug effects
Signal Transduction/*drug effects
Ursodeoxycholic Acid/*pharmacology
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Drug Interactions ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Male ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Random Allocation ; Rats ; Rats, Wistar ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF-κB-p65/TLR-4, JAK1/STAT-3, Nrf-2, and PI3K/Akt/mTOR Signaling Pathways.
Autorzy :
Kamel EO; Department of Medical Histology and Cell Biology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Ahmed MA; Department of Pharmacology, Faculty of Medicine, Assiut University, Asyut, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
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Źródło :
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2020 Jul; Vol. 303 (7), pp. 1935-1949. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Liver/*blood supply
Perindopril/*pharmacology
Reperfusion Injury/*drug therapy
Signal Transduction/*drug effects
Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Biomarkers/blood ; Janus Kinase 1/metabolism ; Liver/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Perindopril/therapeutic use ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Reperfusion Injury/metabolism ; STAT3 Transcription Factor/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
Diosmin enhances the anti-angiogenic activity of sildenafil and pentoxifylline against hepatopulmonary syndrome via regulation of TNF-α/VEGF, IGF-1/PI3K/AKT, and FGF-1/ANG-2 signaling pathways.
Autorzy :
Bakr AG; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
El-Bahrawy AH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Taha HH; Department of Biochemistry, Faculty of Pharmacy, Al Azhar University, Assiut, 71524, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Apr 15; Vol. 873, pp. 173008. Date of Electronic Publication: 2020 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Angiogenesis Inhibitors/*pharmacology
Diosmin/*pharmacology
Hepatopulmonary Syndrome/*drug therapy
Pentoxifylline/*pharmacology
Signal Transduction/*drug effects
Sildenafil Citrate/*pharmacology
Angiotensin II/metabolism ; Animals ; Drug Synergism ; Fibroblast Growth Factor 1/metabolism ; Hepatopulmonary Syndrome/pathology ; Insulin-Like Growth Factor I/metabolism ; Male ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Coenzyme Q 10 protects hepatocytes from ischemia reperfusion-induced apoptosis and oxidative stress via regulation of Bax/Bcl-2/PUMA and Nrf-2/FOXO-3/Sirt-1 signaling pathways.
Autorzy :
Mahmoud AR; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Anatomy, Unaizah College of Medicine, Qassim University, Unaizah Al Qassim Region, Saudi Arabia.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. Electronic address: .
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
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Źródło :
Tissue & cell [Tissue Cell] 2019 Oct; Vol. 60, pp. 1-13. Date of Electronic Publication: 2019 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Oxidative Stress/*drug effects
Reperfusion Injury/*drug therapy
Signal Transduction/*drug effects
Ubiquinone/*analogs & derivatives
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Apoptosis Regulatory Proteins/metabolism ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Liver/physiopathology ; Male ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Reperfusion Injury/pathology ; Ubiquinone/pharmacology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Reno-protective effects of ursodeoxycholic acid against gentamicin-induced nephrotoxicity through modulation of NF-κB, eNOS and caspase-3 expressions.
Autorzy :
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt. .
Elgamal DA; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ali SS; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ali FEM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
El-Shoura EAM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hemeida RAM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
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Źródło :
Cell and tissue research [Cell Tissue Res] 2018 Nov; Vol. 374 (2), pp. 367-387. Date of Electronic Publication: 2018 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Caspase 3/*metabolism
Gentamicins/*adverse effects
Kidney/*pathology
NF-kappa B/*metabolism
Nitric Oxide Synthase Type III/*metabolism
Ursodeoxycholic Acid/*pharmacology
Animals ; Biomarkers/metabolism ; Kidney/physiopathology ; Kidney/ultrastructure ; Kidney Function Tests ; Lipid Peroxidation/drug effects ; Male ; NF-kappa B/genetics ; Nitric Oxide/biosynthesis ; Nitrosative Stress/drug effects ; Oxidative Stress/drug effects ; Peroxidase/metabolism ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Hepatoprotective effects of diosmin and/or sildenafil against cholestatic liver cirrhosis: The role of Keap-1/Nrf-2 and P 38 -MAPK/NF-κB/iNOS signaling pathway.
Autorzy :
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. Electronic address: .
Azouz AA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.
Bakr AG; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Abo-Youssef AM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.
Hemeida RAM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Oct; Vol. 120, pp. 294-304. Date of Electronic Publication: 2018 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Cholestasis/*drug therapy
Diosmin/*therapeutic use
Kelch-Like ECH-Associated Protein 1/*metabolism
Liver/*drug effects
Liver Cirrhosis/*drug therapy
NF-E2-Related Factor 2/*metabolism
NF-kappa B/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Sildenafil Citrate/*therapeutic use
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Cholestasis/enzymology ; Cholestasis/metabolism ; Diosmin/pharmacology ; Drug Therapy, Combination ; Liver Cirrhosis/enzymology ; Liver Cirrhosis/metabolism ; Male ; Rats, Wistar ; Sildenafil Citrate/pharmacology
Czasopismo naukowe
Tytuł :
Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis.
Autorzy :
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt. Electronic address: .
Bakr AG; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Abo-Youssef AM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Azouz AA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Hemeida RAM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
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Źródło :
Life sciences [Life Sci] 2018 Aug 15; Vol. 207, pp. 50-60. Date of Electronic Publication: 2018 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Diosmin/*pharmacology
Globins/*metabolism
Kelch-Like ECH-Associated Protein 1/*metabolism
Liver Cirrhosis/*metabolism
NF-E2-Related Factor 2/*metabolism
Pentoxifylline/*pharmacology
Animals ; Cytoglobin ; Disease Progression ; Free Radicals ; Gene Expression Profiling ; Inflammation ; Liver/metabolism ; Liver Function Tests ; Male ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Oxidants/metabolism ; Oxidative Stress ; Rats ; Rats, Wistar ; Signal Transduction ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
    Wyświetlanie 1-17 z 17

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