Autor: "Alkhalaf LM" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate.
Autorzy :: Louka S; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.; Department of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Mancheste M13 9PL, United Kingdom.
Barry SM; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.
Heyes DJ; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.; Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Mubarak MQE; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.; Department of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Mancheste M13 9PL, United Kingdom.
Ali HS; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.; Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Alkhalaf LM; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.
Munro AW; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.; Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Scrutton NS; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.; Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Challis GL; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.; Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia.; ARC Centre for Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton, VIC 3800, Australia.
de Visser SP; The Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.; Department of Chemical Engineering and Analytical Science, The University of Manchester, Oxford Road, Mancheste M13 9PL, United Kingdom.; Pokaż więcej
Źródło :: Journal of the American Chemical Society [J Am Chem Soc] 2020 Sep 16; Vol. 142 (37), pp. 15764-15779. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :: Journal Article
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC.
Autorzy :: Alkhalaf LM; Department of Chemistry , University of Warwick , Coventry , CV4 7AL , U.K.
Barry SM; Department of Chemistry , University of Warwick , Coventry , CV4 7AL , U.K.
Rea D; School of Life Sciences , University of Warwick , Coventry , CV4 7AL , U.K.
Gallo A; Department of Chemistry , University of Warwick , Coventry , CV4 7AL , U.K.
Griffiths D; Department of Chemistry , University of Warwick , Coventry , CV4 7AL , U.K.
Lewandowski JR; Department of Chemistry , University of Warwick , Coventry , CV4 7AL , U.K.
Fulop V; School of Life Sciences , University of Warwick , Coventry , CV4 7AL , U.K.
Challis GL; Department of Chemistry , University of Warwick , Coventry , CV4 7AL , U.K.; Warwick Integrative Synthetic Biology Centre , University of Warwick , Coventry , CV4 7AL , U.K.; Department of Biochemistry and Molecular Biology , Monash University , Clayton , VIC 3800 , Australia.; Pokaż więcej
Źródło :: Journal of the American Chemical Society [J Am Chem Soc] 2019 Jan 09; Vol. 141 (1), pp. 216-222. Date of Electronic Publication: 2018 Dec 19.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cytochrome P-450 Enzyme System/*chemistry
Cytochrome P-450 Enzyme System/*metabolism
Indoles/*metabolism
Piperazines/*metabolism
Binding Sites ; Biocatalysis ; Hydroxylation ; Indoles/chemistry ; Models, Molecular ; Piperazines/chemistry ; Protein Conformation ; Substrate Specificity
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis.
Autorzy :: Perry C; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. l.alkhalaf..
de Los Santos ELC
Alkhalaf LM
Challis GL; Pokaż więcej
Źródło :: Natural product reports [Nat Prod Rep] 2018 Jul 18; Vol. 35 (7), pp. 622-632.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :: Biological Products/*metabolism
Electron Transport Complex III/*chemistry
Oxygenases/*chemistry
Oxygenases/*metabolism
Cyclization ; Electron Transport Complex III/metabolism ; Heme ; Heterocyclic Compounds, 3-Ring/chemistry ; Heterocyclic Compounds, 3-Ring/metabolism ; Hydroxylation ; Prodigiosin/analogs & derivatives ; Prodigiosin/biosynthesis ; Prodigiosin/chemistry ; Pyrroles/chemistry ; Pyrroles/metabolism ; Pyrrolnitrin/biosynthesis ; Spiro Compounds/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.
Autorzy :: Ronan JL; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Kadi N; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
McMahon SA; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
Naismith JH; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
Alkhalaf LM; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
Challis GL; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK .; Pokaż więcej
Źródło :: Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2018 Jun 05; Vol. 373 (1748).
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Acyltransferases/*metabolism
Deferoxamine/*metabolism
Fungal Proteins/*metabolism
Hydroxamic Acids/*metabolism
Streptomyces coelicolor/*metabolism
Ferric Compounds/metabolism ; Iron ; Receptors, Lipoprotein/metabolism ; Streptomyces coelicolor/enzymology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Mechanistic insights into class B radical-S-adenosylmethionine methylases: ubiquitous tailoring enzymes in natural product biosynthesis.
Autorzy :: Zhou S; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Alkhalaf LM; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
de Los Santos EL; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Challis GL; Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. Electronic address: .; Pokaż więcej
Źródło :: Current opinion in chemical biology [Curr Opin Chem Biol] 2016 Dec; Vol. 35, pp. 73-79. Date of Electronic Publication: 2016 Sep 12.
Typ publikacji :: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :: Biological Products/*metabolism
Methyltransferases/*metabolism
S-Adenosylmethionine/*metabolism
Methylation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: A pyridoxal phosphate-dependent enzyme that oxidizes an unactivated carbon-carbon bond.
Autorzy :: Du YL; Department of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada.
Singh R; Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.
Alkhalaf LM; Department of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada.
Kuatsjah E; Genome Science and Technology Program, The University of British Columbia, Vancouver, British Columbia, Canada.
He HY; Department of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada.
Eltis LD; Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.
Ryan KS; Department of Chemistry, The University of British Columbia, Vancouver, British Columbia, Canada.; Pokaż więcej
Źródło :: Nature chemical biology [Nat Chem Biol] 2016 Mar; Vol. 12 (3), pp. 194-9. Date of Electronic Publication: 2016 Jan 25.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Carbon/*chemistry
Oxidoreductases Acting on CH-CH Group Donors/*chemistry
Pyridoxal Phosphate/*chemistry
Arginine/chemistry ; Catalysis ; Deamination ; Kinetics ; Molecular Conformation ; Oxidation-Reduction ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Stereoisomerism ; Streptomyces griseus/enzymology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Synthetic Biology Approaches to New Bisindoles.
Autorzy :: Alkhalaf LM; University of British Columbia, Vancouver, BC, Canada.
Du YL; University of British Columbia, Vancouver, BC, Canada.
Ryan KS; University of British Columbia, Vancouver, BC, Canada. Electronic address: .; Pokaż więcej
Źródło :: Methods in enzymology [Methods Enzymol] 2016; Vol. 575, pp. 21-37. Date of Electronic Publication: 2016 Mar 24.
Typ publikacji :: Journal Article
MeSH Terms :: Antineoplastic Agents/*metabolism
Bacteria/*genetics
Bacteria/*metabolism
Biological Products/*metabolism
Genetic Engineering/*methods
Indoles/*metabolism
Antineoplastic Agents/chemistry ; Bacteria/chemistry ; Biological Products/chemistry ; Biosynthetic Pathways ; Indoles/chemistry ; Multigene Family ; Phylogeny ; Synthetic Biology/methods
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Biosynthetic manipulation of tryptophan in bacteria: pathways and mechanisms.
Autorzy :: Alkhalaf LM; Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 2K9, Canada.
Ryan KS; Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 2K9, Canada. Electronic address: .; Pokaż więcej
Źródło :: Chemistry & biology [Chem Biol] 2015 Mar 19; Vol. 22 (3), pp. 317-28.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Bacteria/*metabolism
Tryptophan/*metabolism
Bacteria/chemistry ; Tryptophan/biosynthesis ; Tryptophan/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
Autorzy :: Du YL; Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
Alkhalaf LM; Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
Ryan KS; Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada .; Pokaż więcej
Źródło :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Mar 03; Vol. 112 (9), pp. 2717-22. Date of Electronic Publication: 2015 Feb 17.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Bacterial Proteins/*metabolism
Escherichia coli/*metabolism
Oxazolone/*analogs & derivatives
Rhodococcus/*metabolism
Streptomyces griseus/*metabolism
Bacterial Proteins/genetics ; Base Sequence ; Cell-Free System/metabolism ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; Escherichia coli/genetics ; Indoles/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Molecular Sequence Data ; Oxazolone/metabolism ; Rhodococcus/genetics ; Streptomyces griseus/genetics
: Czasopismo naukowe

Szczegóły

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