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Wyszukujesz frazę ""Alkynes"" wg kryterium: Temat


Tytuł :
Drug Distribution in Living Cells via Label-Free Molecular Fingerprint.
Autorzy :
El-Mashtoly SF; Center for Protein Diagnostics, Ruhr University Bochum, Gesundheitscampus 4, 44801 Bochum, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3472-3474. Date of Electronic Publication: 2020 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*analysis
Imidazoles/*analysis
Pyridazines/*analysis
Alkynes/pharmacokinetics ; Cell Line, Tumor ; Cell Survival ; Humans ; Imidazoles/pharmacokinetics ; Pyridazines/pharmacokinetics ; Spectrum Analysis, Raman/methods
Czasopismo naukowe
Tytuł :
Synthesis of propargylamines via the A multicomponent reaction and their biological evaluation as potential anticancer agents.
Autorzy :
Martinez-Amezaga M; Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. .
Giordano RA; Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina.
Prada Gori DN; Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. .
Permingeat Squizatto C; Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. .
Giolito MV; Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina.
Scharovsky OG; Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina.
Rozados VR; Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina.
Rico MJ; Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, 2000 Rosario, Argentina.
Mata EG; Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. .
Delpiccolo CML; Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. .
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2020 Apr 01; Vol. 18 (13), pp. 2475-2486.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkynes/*pharmacology
Antineoplastic Agents/*pharmacology
Propylamines/*pharmacology
Pyrrolidines/*pharmacology
Alkynes/chemical synthesis ; Animals ; Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Molecular Structure ; Propylamines/chemical synthesis ; Pyrrolidines/chemical synthesis ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o -Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders.
Autorzy :
Xie Z; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Wu B; Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Liu Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.; School of Pharmacy , Fudan University , Shanghai 201203 , China.
Ren W; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.
Tong L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Xiang C; Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Wei A; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.
Gao Y; Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Zeng L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.
Xie H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Tang W; Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
Hu Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica , Chinese Academy of Sciences , No. 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park , Shanghai 201203 , China.; University of Chinese Academy of Sciences , 19 Yuquan Road , Beijing 100049 , China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Feb 13; Vol. 63 (3), pp. 1397-1414. Date of Electronic Publication: 2020 Jan 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkynes/*therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Inflammation/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Pyridines/*therapeutic use
Receptor, Macrophage Colony-Stimulating Factor/*antagonists & inhibitors
Alkynes/chemical synthesis ; Alkynes/pharmacokinetics ; Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/pharmacokinetics ; Female ; Inflammation/chemically induced ; Lipopolysaccharides ; Mice ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/pharmacokinetics ; Pyridines/chemical synthesis ; Pyridines/pharmacokinetics ; RAW 264.7 Cells ; Rats, Sprague-Dawley ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/pharmacokinetics ; Small Molecule Libraries/therapeutic use ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
OPA-Based Bifunctional Linker for Protein Labeling and Profiling.
Autorzy :
Zhang Q; Department of Chemistry, State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , People's Republic of China, SAR.
Zhang Y; Department of Chemistry, State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , People's Republic of China, SAR.
Liu H; Department of Chemistry, State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , People's Republic of China, SAR.
Chow HY; Department of Chemistry, State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , People's Republic of China, SAR.
Tian R; Department of Chemistry , Southern University of Science and Technology , Shenzhen , People's Republic of China.
Eva Fung YM; Department of Chemistry, State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , People's Republic of China, SAR.
Li X; Department of Chemistry, State Key Laboratory of Synthetic Chemistry , The University of Hong Kong , Hong Kong , People's Republic of China, SAR.
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Źródło :
Biochemistry [Biochemistry] 2020 Jan 21; Vol. 59 (2), pp. 175-178. Date of Electronic Publication: 2019 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*chemistry
Lysine/*chemistry
Molecular Probes/*chemistry
Proteins/*chemistry
o-Phthalaldehyde/*analogs & derivatives
Alkynes/chemical synthesis ; Animals ; Bacteria/chemistry ; Chickens ; Molecular Probes/chemical synthesis ; o-Phthalaldehyde/chemical synthesis
Czasopismo naukowe
Tytuł :
Inhibition of endogenous hydrogen sulfide biosynthesis enhances the anti-cancer effect of 3,3'-diindolylmethane in human gastric cancer cells.
Autorzy :
Ye F; Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China; Department of Clinical Laboratory Center, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang, China.
Li X; Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Sun K; Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Xu W; Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Shi H; School of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China.
Bian J; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Lu R; Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China; Center for Experimental Research, Affiliated Kunshan Hospital, Jiangsu University, Kunshan, Suzhou, Jiangsu, China.
Ye Y; Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118348. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Anticarcinogenic Agents/*pharmacology
Hydrogen Sulfide/*antagonists & inhibitors
Indoles/*pharmacology
Stomach Neoplasms/*drug therapy
Alkynes/administration & dosage ; Alkynes/pharmacology ; Aminooxyacetic Acid/administration & dosage ; Aminooxyacetic Acid/pharmacology ; Anticarcinogenic Agents/administration & dosage ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cystathionine beta-Synthase/metabolism ; Cystathionine gamma-Lyase/metabolism ; Drug Synergism ; Glycine/administration & dosage ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Humans ; Hydrogen Sulfide/metabolism ; Indoles/administration & dosage ; Stomach Neoplasms/pathology ; Tumor Suppressor Protein p53/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Length effects of cylindrical polymer brushes on their in vitro and in vivo properties.
Autorzy :
Zhang Z; Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, People's Republic of China. .
Zhang L; Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, People's Republic of China. .
Zhao J; Jiangsu Key Laboratory of Phylogenomics and Comparative Genomics, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, Jiangsu, People's Republic of China.
Li C; Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, People's Republic of China. .
Wu W; Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, People's Republic of China. .
Jiang X; Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, People's Republic of China. .
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Źródło :
Biomaterials science [Biomater Sci] 2019 Dec 01; Vol. 7 (12), pp. 5124-5131. Date of Electronic Publication: 2019 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*chemical synthesis
Azides/*chemistry
Nanotubes/*chemistry
Alkynes/chemistry ; Alkynes/pharmacokinetics ; Animals ; Anisotropy ; Cell Line ; Click Chemistry ; Human Umbilical Vein Endothelial Cells ; Humans ; Mice ; Polymerization ; Solubility
Czasopismo naukowe
Tytuł :
High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N -Methyltransferase (NNMT).
Autorzy :
Policarpo RL
Decultot L
May E
Kuzmič P; BioKin Ltd. , Watertown , Massachusetts 02472 , United States.
Carlson S
Huang D
Chu V
Wright BA
Dhakshinamoorthy S; Jubilant Biosys Ltd. , Yeshwantpur, Bangalore , 560 022 Karnataka , India.
Kannt A; Sanofi Research and Development , Industriepark Hoechst, H823 , D-65926 Frankfurt am Main , Germany.
Rani S; Jubilant Biosys Ltd. , Yeshwantpur, Bangalore , 560 022 Karnataka , India.
Dittakavi S; Jubilant Biosys Ltd. , Yeshwantpur, Bangalore , 560 022 Karnataka , India.
Panarese JD
Gaudet R
Shair MD
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2019 Nov 14; Vol. 62 (21), pp. 9837-9873. Date of Electronic Publication: 2019 Oct 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alkynes/*chemistry
Alkynes/*pharmacology
Enzyme Inhibitors/*chemistry
Enzyme Inhibitors/*pharmacology
Nicotinamide N-Methyltransferase/*antagonists & inhibitors
Nicotinamide N-Methyltransferase/*metabolism
Alkanes/chemistry ; Alkynes/metabolism ; Enzyme Inhibitors/metabolism ; Enzyme Stability ; Humans ; K562 Cells ; Molecular Docking Simulation ; Nicotinamide N-Methyltransferase/chemistry ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship ; Temperature
Czasopismo naukowe
Tytuł :
13-Tetradecenyl acetate, a female-produced sex pheromone component of the economically important click beetle Melanotus communis (Gyllenhal) (Coleoptera: Elateridae).
Autorzy :
Williams L 3rd; USDA-ARS U.S. Vegetable Laboratory, Charleston, SC, 29414, USA. .
Serrano JM; Department of Entomology, University of California, Riverside, CA, 92521, USA.; USDA-ARS Temperate Tree Fruit and Vegetable Research Laboratory, Wapato, WA, 98951, USA.
Johnson PJ; Insect Biodiversity Laboratory, South Dakota State University, Brookings, SD, 57007, USA.
Millar JG; Department of Entomology, University of California, Riverside, CA, 92521, USA.
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Źródło :
Scientific reports [Sci Rep] 2019 Nov 07; Vol. 9 (1), pp. 16197. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alkynes/*chemistry
Alkynes/*metabolism
Coleoptera/*metabolism
Ketones/*chemistry
Ketones/*metabolism
Sex Attractants/*biosynthesis
Sex Attractants/*chemistry
Alkynes/pharmacology ; Animals ; Biological Assay ; Coleoptera/drug effects ; Dose-Response Relationship, Drug ; Female ; Ketones/pharmacology ; Male ; Sex Attractants/pharmacology
Czasopismo naukowe
Tytuł :
Enzymatic control of cycloadduct conformation ensures reversible 1,3-dipolar cycloaddition in a prFMN-dependent decarboxylase.
Autorzy :
Bailey SS; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.
Payne KAP; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.
Saaret A; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.
Marshall SA; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.
Gostimskaya I; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.
Kosov I; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.
Fisher K; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK.
Hay S; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK. .
Leys D; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester, UK. .
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Źródło :
Nature chemistry [Nat Chem] 2019 Nov; Vol. 11 (11), pp. 1049-1057. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkynes/*metabolism
Carboxy-Lyases/*metabolism
Propionates/*metabolism
Alkynes/chemistry ; Biocatalysis ; Carboxy-Lyases/chemistry ; Carboxy-Lyases/isolation & purification ; Cycloaddition Reaction ; Density Functional Theory ; Models, Molecular ; Molecular Conformation ; Propionates/chemistry
Czasopismo naukowe
Tytuł :
Ruthenium-Catalyzed ( Z )-Selective Hydroboration of Terminal Alkynes with Naphthalene-1,8-diaminatoborane.
Autorzy :
Yamamoto K; Department of Chemistry, Faculty of Science , Tokyo University of Science , 1-3 Kagurazaka, Shinjuku-ku , Tokyo 162-8601 , Japan.
Mohara Y; Department of Chemistry, Faculty of Science , Tokyo University of Science , 1-3 Kagurazaka, Shinjuku-ku , Tokyo 162-8601 , Japan.
Mutoh Y; Department of Chemistry, Faculty of Science , Tokyo University of Science , 1-3 Kagurazaka, Shinjuku-ku , Tokyo 162-8601 , Japan.
Saito S; Department of Chemistry, Faculty of Science , Tokyo University of Science , 1-3 Kagurazaka, Shinjuku-ku , Tokyo 162-8601 , Japan.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2019 Oct 30; Vol. 141 (43), pp. 17042-17047. Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkynes/*chemistry
Boron/*chemistry
Ruthenium/*chemistry
Stilbenes/*chemistry
Alkynes/chemical synthesis ; Antineoplastic Agents, Phytogenic/chemical synthesis ; Isomerism ; Methane/analogs & derivatives ; Methane/chemistry ; Molecular Structure ; Naphthalenes/chemistry ; Stilbenes/chemical synthesis
Czasopismo naukowe
Tytuł :
Gold-Catalyzed Silyl-Migrative Cyclization of Homopropargylic Alcohols Enabled by Bifunctional Biphenyl-2-ylphosphine and DFT Studies.
Autorzy :
Li T; College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , Henan 473061 , China.; Department of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106 , United States.
Yang Y; College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , Henan 473061 , China.
Li B; College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , Henan 473061 , China.
Bao X; College of Chemistry, Chemical Engineering and Materials Science , Soochow University , 199 Ren-Ai Road, Suzhou Industrial Park , Suzhou , Jiangsu 215123 , China.
Zhang L; Department of Chemistry and Biochemistry , University of California , Santa Barbara , California 93106 , United States.
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Źródło :
Organic letters [Org Lett] 2019 Oct 04; Vol. 21 (19), pp. 7791-7794. Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Density Functional Theory*
Alkynes/*chemical synthesis
Gold/*chemistry
Phosphines/*chemistry
Propanols/*chemical synthesis
Alkynes/chemistry ; Catalysis ; Cyclization ; Molecular Structure ; Propanols/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.
Autorzy :
Kumar B; Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India.
Kumar V; Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India.
Prashar V; Department of Animal Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, Punjab, India.
Saini S; Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India.
Dwivedi AR; Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India.
Bajaj B; Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India.
Mehta D; Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India.
Parkash J; Department of Animal Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, Punjab, India. Electronic address: .
Kumar V; Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, 151001, India. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Sep 01; Vol. 177, pp. 221-234. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Acetylcholinesterase/chemistry ; Alkynes/chemical synthesis ; Alkynes/chemistry ; Alkynes/toxicity ; Alzheimer Disease/drug therapy ; Catalytic Domain ; Cell Line, Tumor ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/toxicity ; Drug Design ; Humans ; Kinetics ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Monoamine Oxidase/chemistry ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Monoamine Oxidase Inhibitors/toxicity ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/toxicity ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Separation of triacylglycerols containing allenic and acetylenic fatty acids by enantiomeric liquid chromatography-mass spectrometry.
Autorzy :
Palyzová A; Institute of Microbiology, the Czech Academy of Sciences, 142 20 Prague 4, Vídeňská 1083, Czech Republic.
Řezanka T; Institute of Microbiology, the Czech Academy of Sciences, 142 20 Prague 4, Vídeňská 1083, Czech Republic. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2020 Jul 19; Vol. 1623, pp. 461161. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid*
Tandem Mass Spectrometry*
Fatty Acids/*analysis
Seeds/*chemistry
Triglycerides/*chemistry
Alkynes/analysis ; Alkynes/chemistry ; Chromatography, Liquid ; Chromatography, Reverse-Phase ; Fatty Acids/chemistry ; Linoleic Acid/analysis ; Oleic Acids/analysis ; Phosphatidylcholines/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Stereoisomerism ; Triglycerides/analysis ; Triglycerides/isolation & purification
Czasopismo naukowe
Tytuł :
Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation.
Autorzy :
Radhakrishnan S; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Electronic address: .
Syed R; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Department of Chemistry, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 085, India.
Takei H; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Kobayashi IS; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Nakamura E; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Sultana F; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Kamal A; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110 062, India.
Tenen DG; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address: .
Kobayashi SS; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Aug 15; Vol. 29 (16), pp. 2286-2289. Date of Electronic Publication: 2019 Jun 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkynes/*pharmacology
Antineoplastic Agents/*pharmacology
CCAAT-Enhancer-Binding Protein-alpha/*antagonists & inhibitors
Leukemia, Myeloid, Acute/*drug therapy
Quinazolinones/*pharmacology
Alkynes/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; CCAAT-Enhancer-Binding Protein-alpha/genetics ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HL-60 Cells ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Molecular Structure ; Quinazolinones/chemical synthesis ; Quinazolinones/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Utility of anthranilic acid and diethylacetylenedicarboxylate for the synthesis of nitrogenous organo/organometallic compounds as urease inhibitors.
Autorzy :
El-Zahabi HSA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Abdulwahab HG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Edrees MM; Department of Organic Chemistry, National Organization for Drug Control and Research, Giza, Egypt.; Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia.
Hegab AM; Developmental Pharmacology Department, National Organization for Drug Control and Research, Giza, Egypt.
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Źródło :
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2019 Jul; Vol. 352 (7), pp. e1800314. Date of Electronic Publication: 2019 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*pharmacology
Enzyme Inhibitors/*pharmacology
Organometallic Compounds/*pharmacology
Urease/*antagonists & inhibitors
ortho-Aminobenzoates/*pharmacology
Alkynes/chemistry ; Canavalia/enzymology ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Models, Molecular ; Molecular Structure ; Nitrogen Compounds ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Structure-Activity Relationship ; Urease/metabolism ; ortho-Aminobenzoates/chemistry
Czasopismo naukowe
Tytuł :
A Facile Enantioselective Alkynylation of Chromones.
Autorzy :
DeRatt LG; Florida Center for Heterocyclic Compounds & Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32607, USA.
Pappoppula M; Florida Center for Heterocyclic Compounds & Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32607, USA.
Aponick A; Florida Center for Heterocyclic Compounds & Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32607, USA.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Jun 17; Vol. 58 (25), pp. 8416-8420. Date of Electronic Publication: 2019 May 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alkynes/*chemical synthesis
Chromones/*chemistry
Alkynes/chemistry ; Molecular Structure ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Total Synthesis-Enabled Systematic Structure-Activity Relationship Study for Development of a Bioactive Alkyne-Tagged Derivative of Neolaxiflorin L.
Autorzy :
Zhang M; Laboratory of Chemical Genomics , Peking University Shenzhen Graduate School , Xili, Shenzhen 518055 , China.
Lee MM; Department of Applied Biology and Chemical Technology , Hong Kong Polytechnic University , Hung Hom , Hong Kong.
Ye W; Laboratory of Chemical Genomics , Peking University Shenzhen Graduate School , Xili, Shenzhen 518055 , China.
Wong WY; Department of Applied Biology and Chemical Technology , Hong Kong Polytechnic University , Hung Hom , Hong Kong.
Chan BD; Department of Applied Biology and Chemical Technology , Hong Kong Polytechnic University , Hung Hom , Hong Kong.
Chen S; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation) , Shenzhen Research Institute of The Hong Kong Polytechnic University , Shenzhen 518057 , China.
Zhu L; Laboratory of Chemical Genomics , Peking University Shenzhen Graduate School , Xili, Shenzhen 518055 , China.; Institute of Translational Medicine , Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Centre , Shenzhen 518035 , China.
Tai WC; Department of Applied Biology and Chemical Technology , Hong Kong Polytechnic University , Hung Hom , Hong Kong.; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation) , Shenzhen Research Institute of The Hong Kong Polytechnic University , Shenzhen 518057 , China.
Lee CS; Laboratory of Chemical Genomics , Peking University Shenzhen Graduate School , Xili, Shenzhen 518055 , China.; Department of Chemistry , Hong Kong Baptist University , Kowloon Tong , Hong Kong.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2019 Jun 07; Vol. 84 (11), pp. 7007-7016. Date of Electronic Publication: 2019 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alkynes/*pharmacology
Antineoplastic Agents, Phytogenic/*pharmacology
Diterpenes/*chemistry
Isodon/*chemistry
Alkynes/chemical synthesis ; Alkynes/chemistry ; Antineoplastic Agents, Phytogenic/chemical synthesis ; Antineoplastic Agents, Phytogenic/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Synthesis of an N-Heterocyclic Carbene-based Au(I) Coordinate Surfactant: Application for Alkyne Hydration Based on Au Nanoparticle Formation.
Autorzy :
Taira T; National Institute of Advanced Industrial Science and Technology (AIST).
Yanagimoto T; Faculty of Science and Technology, Tokyo University of Science.
Fouquet T; National Institute of Advanced Industrial Science and Technology (AIST).
Sakai K; Faculty of Science and Technology, Tokyo University of Science.
Sakai H; Faculty of Science and Technology, Tokyo University of Science.
Imura T; National Institute of Advanced Industrial Science and Technology (AIST).
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Źródło :
Journal of oleo science [J Oleo Sci] 2020 Aug 06; Vol. 69 (8), pp. 871-882. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*chemistry
Gold/*chemistry
Heterocyclic Compounds/*chemical synthesis
Metal Nanoparticles/*chemistry
Methane/*analogs & derivatives
Surface-Active Agents/*chemical synthesis
Catalysis ; Heterocyclic Compounds/chemistry ; Hydrogenation ; Hydrophobic and Hydrophilic Interactions ; Methane/chemical synthesis ; Methane/chemistry ; Micelles ; Surface-Active Agents/chemistry ; Water
Czasopismo naukowe
Tytuł :
Supersensitive Multifluorophore RNA-FISH for Early Virus Detection and Flow-FISH by Using Click Chemistry.
Autorzy :
Raddaoui N; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
Croce S; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.; Baseclick GmbH, Floriansbogen 2-4, 82061, Neuried (München, Germany.
Geiger F; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
Borodavka A; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.
Möckl L; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
Stazzoni S; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
Viverge B; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
Bräuchle C; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
Frischmuth T; Baseclick GmbH, Floriansbogen 2-4, 82061, Neuried (München, Germany.
Engelke H; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
Carell T; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377, Munich, Germany.
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Źródło :
Chembiochem : a European journal of chemical biology [Chembiochem] 2020 Aug 03; Vol. 21 (15), pp. 2214-2218. Date of Electronic Publication: 2020 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Early Diagnosis*
Click Chemistry/*methods
In Situ Hybridization, Fluorescence/*methods
Oligonucleotide Probes/*chemistry
RNA, Messenger/*analysis
RNA, Viral/*analysis
Alkynes/chemistry ; Betacoronavirus/genetics ; Coronavirus Infections/diagnosis ; Humans ; Oligodeoxyribonucleotides/chemistry ; Pandemics ; Pneumonia, Viral/diagnosis
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Alkane-, alkene-, alkyne-γ-lactones and ryanodane diterpenes from aeroponically grown Persea indica roots.
Autorzy :
Fraga BM; Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206, La Laguna, Tenerife, Canary Islands, Spain. Electronic address: .
Díaz CE; Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206, La Laguna, Tenerife, Canary Islands, Spain.
Bolaños P; Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206, La Laguna, Tenerife, Canary Islands, Spain.
Bailén M; Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, 28006, Madrid, Spain.
Andrés MF; Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, 28006, Madrid, Spain.
González-Coloma A; Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, 28006, Madrid, Spain. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2020 Aug; Vol. 176, pp. 112398. Date of Electronic Publication: 2020 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Diterpenes*
Persea*
Alkanes ; Alkenes ; Alkynes ; Animals ; Lactones ; Plant Roots
Czasopismo naukowe

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