Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.
Autorzy:
Gudmundsdottir V; Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark. Pedersen HK; Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark. AllebrandtKV; Department of Translational Bioinformatics, R&D Operations, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany. Brorsson C; Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark. van Leeuwen N; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands. Banasik K; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, United Kingdom. Mahajan A; Oxford NIHR Biomedical Research Center, Oxford, United Kingdom. Groves CJ; Oxford Center for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom. van de Bunt M; Oxford NIHR Biomedical Research Center, Oxford, United Kingdom.; Oxford Center for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom. Dawed AY; Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom. Fritsche A; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Member of the German Centre for Diabetes Research (DZD), Tübingen, Germany. Staiger H; Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University, Tübingen, Germany. Simonis-Bik AMC; Department of Internal Medicine, Diabetes Center and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands. Deelen J; Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Max Planck Institute for Biology of Ageing, Cologne, Germany. Kramer MHH; Department of Internal Medicine, Diabetes Center and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands. Dietrich A; Department of Translational Bioinformatics, R&D Operations, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany. Hübschle T; Department GI Endocrinology, R&D Diabetes Division, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany. Willemsen G; Department of Biological Psychology, Vrije Universiteit and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. Häring HU; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Member of the German Centre for Diabetes Research (DZD), Tübingen, Germany. de Geus EJC; Department of Biological Psychology, Vrije Universiteit and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.; Netherlands Consortium for Healthy Aging, Leiden, The Netherlands. Boomsma DI; Department of Biological Psychology, Vrije Universiteit and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. Eekhoff EMW; Department of Internal Medicine, Diabetes Center and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands. Ferrer J; Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London, United Kingdom.; Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. McCarthy MI; Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford NIHR Biomedical Research Center, Oxford, United Kingdom.; Oxford Center for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom. Pearson ER; Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, United Kingdom. Gupta R; Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark. Brunak S; Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark.; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 't Hart LM; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.; Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło:
PloS one [PLoS One] 2018 Jan 02; Vol. 13 (1), pp. e0189886. Date of Electronic Publication: 2018 Jan 02 (Print Publication: 2018).
Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.
Autorzy:
Jones SE; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Wood AR; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Beaumont RN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Tuke MA; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Hu Y; 23andMe Inc., Mountain View, California, United States of America.; A9.com Inc, Palo Alto, California, United States of America. Teder-Laving M; Estonian Genome Center and Institute of Molecular and Cell Biology of University of Tartu, Estonian Biocentre, Tartu, Estonia. Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, Scotland. Roenneberg T; Institute of Medical Psychology, Ludwig-Maximilians-University, Munich, Germany. Wilson JF; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, Scotland.; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland. Del Greco F; Center for Biomedicine, European Academy of Bolzano, Bozen, Italy-affiliated Institute of the University of Lübeck, Lübeck, Germany. Hicks AA; Center for Biomedicine, European Academy of Bolzano, Bozen, Italy-affiliated Institute of the University of Lübeck, Lübeck, Germany. Shin C; Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.; Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea. Yun CH; Department of Neurology, Bundang Clinical Neuroscience Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Lee SK; Institute of Human Genomic Study, College of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea. Metspalu A; Estonian Genome Center and Institute of Molecular and Cell Biology of University of Tartu, Estonian Biocentre, Tartu, Estonia. Byrne EM; The University of Queensland, Queensland Brain Institute, Brisbane, Australia. Gehrman PR; Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Tiemeier H; Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.; Department of Psychiatry, Erasmus Medical Center, Rotterdam, Netherlands. AllebrandtKV; Institute of Medical Psychology, Ludwig-Maximilians-University, Munich, Germany. Freathy RM; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Murray A; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Hinds DA; 23andMe Inc., Mountain View, California, United States of America. Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom. Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom.
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Źródło:
PLoS genetics [PLoS Genet] 2016 Aug 05; Vol. 12 (8), pp. e1006125. Date of Electronic Publication: 2016 Aug 05 (Print Publication: 2016).
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