Kinome-Wide Virtual Screening by Multi-Task Deep Learning.
Autorzy:
Hu J; Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. AllenBK; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Institute for Data Science & Computing, University of Miami, Miami, FL 33136, USA. Stathias V; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Ayad NG; Center for Therapeutic Innovation Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Miami Project to Cure Paralysis, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Schürer SC; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Institute for Data Science & Computing, University of Miami, Miami, FL 33136, USA.; Center for Therapeutic Innovation Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.
Autorzy:
AllenBK; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, US.; Center for Computational Science, University of Miami, Miami, FL, US.; Center for Therapeutic Innovation Miller School of Medicine, University of Miami, Miami, FL, US.; Miami Project to Cure Paralysis, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, US. Mehta S; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, US.; Center for Computational Science, University of Miami, Miami, FL, US.; Department of Applied Chemistry, Delhi Technological University, Delhi, India. Ember SW; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, US. Schonbrunn E; Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, US. Ayad N; Center for Therapeutic Innovation Miller School of Medicine, University of Miami, Miami, FL, US.; Miami Project to Cure Paralysis, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, US. Schürer SC; Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, US.; Center for Computational Science, University of Miami, Miami, FL, US.; Center for Therapeutic Innovation Miller School of Medicine, University of Miami, Miami, FL, US.
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Źródło:
Scientific reports [Sci Rep] 2015 Nov 24; Vol. 5, pp. 16924. Date of Electronic Publication: 2015 Nov 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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