Autor: "Almo, Steven C." - OpacWWW

Skocz do pozycji: 1.

Tytuł:: SARS-CoV-2 multi-antigen protein microarray for detailed characterization of antibody responses in COVID-19 patients.
Autorzy:: Celikgil A; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Massimi AB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Nakouzi A; Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Herrera NG; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Morano NC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Lee JH; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Yoon HA; Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Garforth SJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Feb 09; Vol. 18 (2), pp. e0276829. Date of Electronic Publication: 2023 Feb 09 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: COVID-19*/genetics
COVID-19*/immunology
COVID-19*/virology
SARS-CoV-2*/genetics
Humans ; Antibodies, Neutralizing/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; Antibody Formation/genetics ; Antibody Formation/immunology ; Immunoglobulin G ; Protein Array Analysis ; Spike Glycoprotein, Coronavirus

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Skocz do pozycji: 2.

Tytuł:: Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2.
Autorzy:: Cheshenko N; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Microbiology and Immunology, Louisiana State University Health Science Center-Shreveport, Shreveport, LA, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Herold BC; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA. .; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2022 Oct 16; Vol. 5 (1), pp. 1096. Date of Electronic Publication: 2022 Oct 16.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: SARS-CoV-2*
COVID-19 Drug Treatment*
Antiviral Agents/pharmacology ; Glycoproteins/metabolism ; Humans ; Phosphatidylinositols ; Phospholipase C gamma/metabolism ; Phospholipid Transfer Proteins ; Proto-Oncogene Proteins c-akt/metabolism ; Spike Glycoprotein, Coronavirus ; Staurosporine/pharmacology ; Viral Envelope Proteins/metabolism

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Skocz do pozycji: 3.

Tytuł:: Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes.
Autorzy:: Lasso G; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Khan S; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Allen SA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Mariano M; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, New York, United States of America.
Orner EP; Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Quiroz JA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Quevedo G; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Massimi A; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Hegde A; Eastchester High School, 2 Stewart Place, Eastchester, New York, United States of America.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Malonis RJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Georgiev GI; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Tong K; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Herrera NG; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Morano NC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Garforth SJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Malaviya A; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Khokhar A; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Fels JM; Department of Cell Biology, Harvard Medical School, Boston, Cambridge, Massachusetts, United States of America.; Department of Microbiology, Harvard Medical School, Boston, Cambridge, Massachusetts, United States of America.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Cambridge, Massachusetts, United States of America.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Barnhill J; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, New York, United States of America.; Department of Radiology and Radiological Services, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Kelly L; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Daily JP; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Vergnolle O; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2022 Jan 18; Vol. 18 (1), pp. e1009778. Date of Electronic Publication: 2022 Jan 18 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: COVID-19*/diagnosis
COVID-19*/epidemiology
COVID-19*/immunology
COVID-19*/therapy
Antibodies, Viral/*blood
SARS-CoV-2/*immunology
Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Computational Biology ; Diagnosis, Computer-Assisted ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Spike Glycoprotein, Coronavirus/immunology ; Young Adult

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Skocz do pozycji: 4.

Tytuł:: Peptide-HLA-based immunotherapeutics platforms for direct modulation of antigen-specific T cells.
Autorzy:: Seidel RD; Cue Biopharma, Cambridge, MA, USA. .
Merazga Z; Cue Biopharma, Cambridge, MA, USA.
Thapa DR; Cue Biopharma, Cambridge, MA, USA.
Soriano J; Cue Biopharma, Cambridge, MA, USA.
Spaulding E; Cue Biopharma, Cambridge, MA, USA.
Vakkasoglu AS; Cue Biopharma, Cambridge, MA, USA.
Ruthardt P; Cue Biopharma, Cambridge, MA, USA.
Bautista W; Cue Biopharma, Cambridge, MA, USA.
Quayle SN; Cue Biopharma, Cambridge, MA, USA.
Kiener PA; BioKien LLC, Harpswell, ME, USA.
Low S; Cue Biopharma, Cambridge, MA, USA.
Ross JF; Cue Biopharma, Cambridge, MA, USA.
Cemerski S; Cue Biopharma, Cambridge, MA, USA.
Suri A; Cue Biopharma, Cambridge, MA, USA.
Almo SC; Albert Einstein College of Medicine, Bronx, NY, USA.
Chaparro RJ; Cue Biopharma, Cambridge, MA, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Sep 28; Vol. 11 (1), pp. 19220. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes/*immunology
Immunotherapy/*methods
Neoplasms/*therapy
Recombinant Fusion Proteins/*immunology
Animals ; B7-1 Antigen/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; HLA-A Antigens/genetics ; HLA-A Antigens/immunology ; Humans ; Lymphocyte Activation ; Mice ; Mice, Transgenic ; Mutation ; Neoplasms/immunology ; Peptides/genetics ; Peptides/immunology ; Primary Cell Culture ; Protein Engineering ; Recombinant Fusion Proteins/genetics

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Skocz do pozycji: 5.

Tytuł:: Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex.
Autorzy:: Garrett-Thomson SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Massimi A; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Fedorov EV; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Scandiuzzi L; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Hillerich B; Cue BioPharma Inc., Cambridge, Massachusetts, United States of America.
Seidel RD 3rd; Cue BioPharma Inc., Cambridge, Massachusetts, United States of America.
Love JD; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Garforth SJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Guha C; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jun 04; Vol. 15 (6), pp. e0233578. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Antigen-Antibody Complex/*metabolism
B7-1 Antigen/*metabolism
B7-H1 Antigen/*metabolism
Mutant Proteins/*metabolism
Animals ; Antigens, Surface/metabolism ; B7-1 Antigen/genetics ; B7-H1 Antigen/genetics ; Binding Sites ; CD28 Antigens/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; CTLA-4 Antigen/metabolism ; HEK293 Cells ; Humans ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred C57BL ; Protein Binding ; Transfection

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Skocz do pozycji: 6.

Tytuł:: Structure of a single-chain H2A/H2B dimer.
Autorzy:: Warren C; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Shechter D; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.; Pokaż więcej
Źródło:: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2020 May 01; Vol. 76 (Pt 5), pp. 194-198. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji:: Journal Article
MeSH Terms:: Histones/*chemistry
Xenopus/*metabolism
Animals ; Crystallography, X-Ray ; Dimerization ; Escherichia coli/metabolism ; Histones/isolation & purification ; Hydrogen Bonding ; Protein Conformation ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Static Electricity

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Skocz do pozycji: 7.

Tytuł:: Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors.
Autorzy:: Lefurgy ST; Department of Chemistry, Hofstra University, Hempstead, NY 11549, USA.
Caselli E; Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Taracila MA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA.
Malashkevich VN; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Biju B; Department of Chemistry, Hofstra University, Hempstead, NY 11549, USA.
Papp-Wallace KM; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Prati F; Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bonomo RA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) Cleveland, OH 44106, USA.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 Apr 27; Vol. 10 (5). Date of Electronic Publication: 2020 Apr 27.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Anti-Bacterial Agents/*chemistry
Cephalothin/*analogs & derivatives
Enzyme Inhibitors/*chemistry
Escherichia coli Proteins/*chemistry
beta-Lactamases/*chemistry
Anti-Bacterial Agents/pharmacology ; Binding Sites ; Boronic Acids/chemistry ; Enzyme Inhibitors/pharmacology ; Escherichia coli Proteins/metabolism ; Molecular Docking Simulation ; Protein Binding ; beta-Lactamases/metabolism

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Skocz do pozycji: 8.

Tytuł:: The biosynthesis of methanobactin.
Autorzy:: Kenney GE; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Dassama LMK; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Pandelia ME; Department of Biochemistry, Brandeis University, Waltham, MA 02453, USA.
Gizzi AS; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Martinie RJ; Department of Chemistry and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Gao P; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
DeHart CJ; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Schachner LF; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Skinner OS; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Ro SY; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Zhu X; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Sadek M; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Thomas PM; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bollinger JM Jr; Department of Chemistry and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Krebs C; Department of Chemistry and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Kelleher NL; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Rosenzweig AC; Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Evanston, IL 60208, USA. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2018 Mar 23; Vol. 359 (6382), pp. 1411-1416.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Protein Processing, Post-Translational*
Copper/*metabolism
Methylosinus trichosporium/*metabolism
Oligopeptides/*biosynthesis
Amino Acid Sequence ; Genome, Bacterial ; Imidazoles/chemistry ; Imidazoles/metabolism ; Ligands ; Methylosinus trichosporium/genetics ; Oligopeptides/chemistry ; Oligopeptides/genetics ; Oligopeptides/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Protein Conformation, alpha-Helical ; Protein Multimerization

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Skocz do pozycji: 9.

Tytuł:: General principles of binding between cell surface receptors and multi-specific ligands: A computational study.
Autorzy:: Chen J; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Wu Y; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2017 Oct 10; Vol. 13 (10), pp. e1005805. Date of Electronic Publication: 2017 Oct 10 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Ligands*
Protein Binding*
Receptors, Cell Surface/*chemistry
Receptors, Cell Surface/*metabolism
Algorithms ; Binding Sites ; Computational Biology ; Molecular Dynamics Simulation ; Monte Carlo Method

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Skocz do pozycji: 10.

Tytuł:: The hidden treasure in your data: phasing with unexpected weak anomalous scatterers from routine data sets.
Autorzy:: Hegde RP; Division of Biological Sciences, Poornaprajna Institute of Scientific Research, #4, 16th Cross, Sadashivnagar, Bangalore 560 080, India.
Fedorov AA; Department of Biochemistry, Albert Einstein College of Medicine, Ullmann Building, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA.
Sauder JM; Lilly Biotechnology Center, Eli Lilly and Company, 10290 Campus Point Drive, San Diego, CA 92121, USA.
Burley SK; RCSB Protein Data Bank, Center for Integrative Proteomics Research, Rutgers University, The State University of New Jersey, 174 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Ullmann Building, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA.
Ramagopal UA; Division of Biological Sciences, Poornaprajna Institute of Scientific Research, #4, 16th Cross, Sadashivnagar, Bangalore 560 080, India.; Pokaż więcej
Źródło:: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2017 Apr 01; Vol. 73 (Pt 4), pp. 184-195. Date of Electronic Publication: 2017 Mar 22.
Typ publikacji:: Journal Article
MeSH Terms:: Archaeal Proteins/*chemistry
Bacterial Proteins/*chemistry
Calcium/*chemistry
Egg Proteins/*chemistry
Muramidase/*chemistry
Sulfur/*chemistry
Animals ; Archaeal Proteins/genetics ; Archaeal Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cations, Divalent ; Chickens/metabolism ; Cloning, Molecular ; Crystallization ; Crystallography, X-Ray ; Egg Proteins/genetics ; Egg Proteins/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Muramidase/genetics ; Muramidase/metabolism ; Protein Conformation ; Pseudomonas syringae/chemistry ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Thermoplasmales/chemistry ; X-Ray Diffraction ; X-Rays

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Skocz do pozycji: 11.

Tytuł:: Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go?
Autorzy:: Liu W; a Department of Biochemistry , Albert Einstein College of Medicine , Bronx , NY , USA.; b Department of Microbiology and Immunology , Albert Einstein College of Medicine , Bronx , NY , USA.
Almo SC; a Department of Biochemistry , Albert Einstein College of Medicine , Bronx , NY , USA.
Zang X; b Department of Microbiology and Immunology , Albert Einstein College of Medicine , Bronx , NY , USA.; c Department of Medicine , Albert Einstein College of Medicine , Bronx , NY , USA.; d Department of Urology , Albert Einstein College of Medicine , Bronx , NY , USA.; Pokaż więcej
Źródło:: Immunological investigations [Immunol Invest] 2016 Nov; Vol. 45 (8), pp. 813-831. Date of Electronic Publication: 2016 Jul 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Autoimmune Diseases/*immunology
Communicable Diseases/*immunology
Costimulatory and Inhibitory T-Cell Receptors/*immunology
Neoplasms/*immunology
T-Lymphocytes, Regulatory/*immunology
Adaptive Immunity ; Animals ; Autoimmune Diseases/pathology ; Communicable Diseases/pathology ; Costimulatory and Inhibitory T-Cell Receptors/genetics ; Gene Expression Regulation/immunology ; Homeostasis/immunology ; Humans ; Immune Tolerance ; Immunity, Innate ; Neoplasms/pathology ; Signal Transduction ; T-Lymphocytes, Regulatory/pathology

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Skocz do pozycji: 12.

Tytuł:: A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals.
Autorzy:: McClelland EE; Department of Biology, Middle Tennessee State University, Murfreesboro, Tennessee, United States of America.
Ramagopal UA; Department of Biochemistry and Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Rivera J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Cox J; Department of Biochemistry, University of Utah, Salt Lake City, Utah, United States of America.
Nakouzi A; Department of Biochemistry and Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Prabu MM; M&P Associates Inc., Murfreesboro, Tennesee, United States of America.
Almo SC; Department of Biochemistry and Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Casadevall A; Department of Molecular Microbiology and Immunology, John Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2016 Sep 01; Vol. 12 (9), pp. e1005849. Date of Electronic Publication: 2016 Sep 01 (Print Publication: 2016).
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Fungal*
Cryptococcosis/*microbiology
Cryptococcus neoformans/*genetics
Cryptococcus neoformans/*pathogenicity
Fungal Proteins/*metabolism
Animals ; Brain/pathology ; Cryptococcus neoformans/metabolism ; Disease Models, Animal ; Energy Metabolism ; Female ; Fungal Proteins/chemistry ; Fungal Proteins/genetics ; Humans ; Lung/microbiology ; Macrophages/microbiology ; Metabolomics ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Oligonucleotide Array Sequence Analysis ; Sequence Deletion ; Virulence ; Virulence Factors/chemistry ; Virulence Factors/genetics ; Virulence Factors/metabolism

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Skocz do pozycji: 13.

Tytuł:: Structure of an ABC transporter solute-binding protein specific for the amino sugars glucosamine and galactosamine.
Autorzy:: Yadava U; Department of Physics, DDU Gorakhpur University, Gorakhpur 273 009, India.
Vetting MW; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Al Obaidi N; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Carter MS; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Gerlt JA; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Pokaż więcej
Źródło:: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2016 Jun; Vol. 72 (Pt 6), pp. 467-72. Date of Electronic Publication: 2016 May 23.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: ATP-Binding Cassette Transporters/*chemistry
Galactosamine/*metabolism
Glucosamine/*metabolism
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Cloning, Molecular ; Electrophoresis, Polyacrylamide Gel

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Skocz do pozycji: 14.

Tytuł:: Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation.
Autorzy:: Vetting MW; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bouvier JT; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Gerlt JA; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Pokaż więcej
Źródło:: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2016 Jan; Vol. 72 (Pt 1), pp. 36-41. Date of Electronic Publication: 2016 Jan 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Agrobacterium tumefaciens/*enzymology
Bacterial Proteins/*chemistry
Intramolecular Oxidoreductases/*chemistry
Bacterial Proteins/isolation & purification ; Calcium/chemistry ; Catalytic Domain ; Crystallization ; Crystallography, X-Ray ; Intramolecular Oxidoreductases/isolation & purification ; Models, Molecular ; Pectins/chemistry ; Protein Binding ; Protein Structure, Quaternary ; Proteolysis

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Pełny tekst Szczegóły

Skocz do pozycji: 15.

Tytuł:: Orange fluorescent proteins: structural studies of LSSmOrange, PSmOrange and PSmOrange2.
Autorzy:: Pletnev S; Leidos Biomedical Research Inc., Basic Research Program, Argonne, Illinois, United States of America; Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, Illinois, United States of America.
Shcherbakova DM; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Subach OM; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America; Department of Nano, Bio, Information and Cognitive Technologies, Moscow Institute of Physics and Technology, Moscow, Russian Federation.
Pletneva NV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
Malashkevich VN; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Dauter Z; Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, Illinois, United States of America.
Verkhusha VV; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Jun 24; Vol. 9 (6), pp. e99136. Date of Electronic Publication: 2014 Jun 24 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Luminescent Proteins/*chemistry
Luminescent Proteins/*genetics
Amino Acid Substitution ; Crystallography, X-Ray ; Models, Molecular ; Mutation ; Phenotype ; Photochemical Processes ; Phylogeny

Czasopismo naukowe

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Pełny tekst Szczegóły

Skocz do pozycji: 16.

Tytuł:: Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.
Autorzy:: Mashiyama ST; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America.
Malabanan MM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Akiva E; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America.
Bhosle R; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Branch MC; Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America.
Hillerich B; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Jagessar K; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Kim J; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Patskovsky Y; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Seidel RD; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Stead M; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Toro R; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Vetting MW; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Armstrong RN; Departments of Biochemistry and Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Babbitt PC; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2014 Apr 22; Vol. 12 (4), pp. e1001843. Date of Electronic Publication: 2014 Apr 22 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Models, Molecular*
Glutathione Transferase/*genetics
Glutathione Transferase/*ultrastructure
Amino Acid Sequence ; Base Sequence ; Binding Sites ; Computational Biology ; Databases, Protein ; Glutathione/chemistry ; Protein Structure, Tertiary ; Sequence Alignment ; Structure-Activity Relationship

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Pełny tekst Szczegóły

Skocz do pozycji: 17.

Tytuł:: Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase.
Autorzy:: Donaldson TM; Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Ting LM; Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Zhan C; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Shi W; National Synchrotron Light Source, Brookhaven National Laboratory, Brookhaven, New York, United States of America.
Zheng R; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America.
Kim K; Departments of Medicine, Pathology, and of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Jan 08; Vol. 9 (1), pp. e84384. Date of Electronic Publication: 2014 Jan 08 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Methylthioinosine/*analogs & derivatives
Plasmodium falciparum/*enzymology
Purine-Nucleoside Phosphorylase/*chemistry
Purine-Nucleoside Phosphorylase/*metabolism
Amino Acid Sequence ; Catalytic Domain ; Kinetics ; Methylthioinosine/metabolism ; Models, Molecular ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Mutation ; Purine-Nucleoside Phosphorylase/antagonists & inhibitors ; Purine-Nucleoside Phosphorylase/genetics ; Pyrimidinones/metabolism ; Pyrimidinones/pharmacology ; Structure-Activity Relationship ; Substrate Specificity