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Tytuł :
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Türkeş C; Department of Biochemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Demir Y; Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, Ardahan, Turkey.
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Beydemir Ş; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.; The Rectorate of Bilecik Şeyh Edebali University, Bilecik, Turkey.
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Źródło :
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Dec; Vol. 354 (12), pp. e2100294. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy.
Autorzy :
Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Radwan MO; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt.
Sever B; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.
Hamdy AK; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Emirdağ S; Chemistry Department, Faculty of Science, Ege University, Izmir 35040, Turkey.
Ulusoy NG; Chemistry Department, Faculty of Science, Ege University, Izmir 35040, Turkey.
Sozer E; Chemistry Department, Faculty of Science, Ege University, Izmir 35040, Turkey.
Can M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Engineering Sciences, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir 35620, Turkey.
Yayli N; Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey.
Araki N; Department of Tumor Genetics and Biology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Altintop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 11; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article
MeSH Terms :
Pentacyclic Triterpenes/*chemistry
Apoptosis/drug effects ; Binding Sites ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Glioma/metabolism ; Glioma/pathology ; Half-Life ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Molecular Docking Simulation ; Pentacyclic Triterpenes/metabolism ; Pentacyclic Triterpenes/pharmacology
Czasopismo naukowe
Tytuł :
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey. Electronic address: .
Demir Y; Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, 75700, Ardahan, Turkey.
Yılmaz N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Beydemir Ş; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey; The Rectorate of Bilecik Şeyh Edebali University, 11230, Bilecik, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Aug 25; Vol. 345, pp. 109576. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Drug Design*
Microwaves*
Aldehyde Reductase/*antagonists & inhibitors
Pyrazoles/*chemical synthesis
Pyrazoles/*pharmacology
Aldehyde Reductase/chemistry ; Aldehyde Reductase/metabolism ; Chemistry Techniques, Synthetic ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Molecular Docking Simulation ; Protein Conformation ; Pyrazoles/chemistry ; Pyrazoles/metabolism
Czasopismo naukowe
Tytuł :
A new series of benzoxazole-based SIRT1 modulators for targeted therapy of non-small-cell lung cancer.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
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Źródło :
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Jan; Vol. 354 (1), pp. e2000235. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Benzoxazoles/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
A549 Cells ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Benzoxazoles/chemical synthesis ; Benzoxazoles/chemistry ; Carcinoma, Non-Small-Cell Lung/pathology ; Computer Simulation ; Dose-Response Relationship, Drug ; Drug Design ; Humans ; Lung Neoplasms/pathology ; Mice ; Molecular Targeted Therapy ; NIH 3T3 Cells ; Sirtuin 1/drug effects ; Sirtuin 1/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-Small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into Their Anticancer Potencies.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Çiftçi GA; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
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Źródło :
Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2021; Vol. 17 (10), pp. 1104-1128.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Carcinoma, Non-Small-Cell Lung*/drug therapy
Colorectal Neoplasms*/drug therapy
Lung Neoplasms*/drug therapy
Apoptosis ; Caco-2 Cells ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Humans ; Lung ; Molecular Docking Simulation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
A New Series of Antileukemic Agents: Design, Synthesis, In Vitro and In Silico Evaluation of Thiazole-Based ABL1 Kinase Inhibitors.
Autorzy :
Zeytün E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir 26470, Turkey.
Ellakwa DE; Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Ocak Z; Department of Microbiology, Kocaeli State Hospital, Kocaeli 41300, Turkey.
Ciftci HI; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
Otsuka M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
Radwan MO; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-Ku, Kumamoto 8620973, Japan.
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Źródło :
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2021; Vol. 21 (9), pp. 1099-1109.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-abl/*antagonists & inhibitors
Thiazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-abl/metabolism ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. Electronic address: .
Türkeş C; Department of Biochemistry, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey. Electronic address: .
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.
Demir Y; Department of Pharmacy Services, Nihat Delibalta Göle Vocational High School, Ardahan University, Ardahan 75700, Turkey.
Beydemir Ş; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey; The Rectorate of Bilecik Şeyh Edebali University, Bilecik 11230, Turkey.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 15; Vol. 163, pp. 1970-1988. Date of Electronic Publication: 2020 Sep 13.
Typ publikacji :
Journal Article
MeSH Terms :
Carbonic Anhydrase Inhibitors/*chemistry
Carbonic Anhydrases/*chemistry
Cholinesterase Inhibitors/*chemistry
Thiazoles/*chemistry
Acetylcholinesterase/chemistry ; Acetylcholinesterase/drug effects ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemical synthesis ; Computer Simulation ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł :
In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey.
Ellakwa DE; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Cairo 11765, Egypt.
Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.
Radwan MO; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt.
Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.
Otsuka M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.
Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.
Ciftci HI; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Department of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.
Ali TFS; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto 862-0973, Japan.; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 07; Vol. 25 (21). Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Indoles/*pharmacology
Oxadiazoles/*pharmacology
A549 Cells ; Allosteric Site ; Animals ; Apoptosis ; Benzothiazoles/chemistry ; Catalytic Domain ; Cell Line, Tumor ; Cyclooxygenase 1/chemistry ; Cyclooxygenase 2/chemistry ; Drug Design ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; Erlotinib Hydrochloride/pharmacology ; HCT116 Cells ; Humans ; Inhibitory Concentration 50 ; Magnetic Resonance Spectroscopy ; Molecular Docking Simulation ; Molecular Structure ; Sheep ; Structure-Activity Relationship ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Soybir H; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Görgülü Ş; Medicinal Plant, Drug and Scientific Research and Application Center, Anadolu University, 26470 Eskişehir, Turkey.
Cantürk Z; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 28; Vol. 25 (21). Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*chemical synthesis
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Pyrazoles/*chemistry
Thiosemicarbazones/*chemical synthesis
Thiosemicarbazones/*pharmacology
Chemistry Techniques, Synthetic ; Dipeptidyl Peptidase 4/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Dipeptidyl-Peptidase IV Inhibitors/metabolism ; Molecular Docking Simulation ; Protein Conformation ; Thiosemicarbazones/chemistry ; Thiosemicarbazones/metabolism
Czasopismo naukowe
Tytuł :
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. Electronic address: .
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Demir Y; Department of Pharmacy Services, Nihat Delibalta Gole Vocational High School, Ardahan University, 75700 Ardahan, Turkey.
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Beydemir Ş; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey; The Rectorate of Bilecik Şeyh Edebali University, 11230 Bilecik, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Sep; Vol. 102, pp. 104110. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Aldehyde Reductase/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Thiazoles/*pharmacology
Aldehyde Reductase/metabolism ; Animals ; Cells, Cultured ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, 26470, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, 26470, Turkey. Electronic address: .
Radwan MO; Department of Drug Discovery, Science Farm Ltd., Kumamoto, 862-0976, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Labarotary, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, 12622, Cairo, Egypt.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, 26470, Turkey.
Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto, 862-0976, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Labarotary, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Labarotary, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan. Electronic address: .
Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto, 862-0976, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Labarotary, Faculty of Life Sciences, Kumamoto University, Kumamoto, 862-0973, Japan; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Nov 15; Vol. 182, pp. 111648. Date of Electronic Publication: 2019 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Receptor, ErbB-2/*antagonists & inhibitors
Thiazoles/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Receptor, ErbB-2/metabolism ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells.
Autorzy :
Akalin Çiftçi G; Anadolu University, Faculty of Pharmacy, Department of Biochemistry, Eskişehir, Turkey.
Sever B; Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskişehir, Turkey.
Altintop MD; Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskişehir, Turkey.
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Źródło :
Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2019 Jun; Vol. 16 (2), pp. 119-131. Date of Electronic Publication: 2019 Mar 27.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
In silico Molecular Docking and ADME Studies of 1,3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity.
Autorzy :
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Kucukoglu K; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bulent Ecevit University, Zonguldak, Turkey.
Nadaroglu H; Department of Food Technology, Erzurum Vocational Training School, Ataturk University, Erzurum, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
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Źródło :
Current computer-aided drug design [Curr Comput Aided Drug Des] 2019; Vol. 15 (2), pp. 136-144.
Typ publikacji :
Journal Article
MeSH Terms :
Aryldialkylphosphatase/*blood
Enzyme Activators/*pharmacology
Thiadiazoles/*pharmacology
Aryldialkylphosphatase/chemistry ; Enzyme Activation/drug effects ; Enzyme Activators/chemistry ; Humans ; Kinetics ; Molecular Docking Simulation ; Thiadiazoles/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and Evaluation of a New Series of Thiazolyl-pyrazoline Derivatives as Cholinesterase Inhibitors.
Autorzy :
Temel HE; Anadolu University, Faculty of Pharmacy, Department of Biochemistry, Eskişehir, Turkey.
Altintop MD; Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskişehir, Turkey.
Özdemir A; Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eskişehir, Turkey.
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Źródło :
Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2018 Dec; Vol. 15 (3), pp. 333-338. Date of Electronic Publication: 2018 Nov 20.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress.
Autorzy :
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. .
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. .
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. .
Kaya Tilki E; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. .
Dikmen M; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. .
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2018 Aug 27; Vol. 23 (9). Date of Electronic Publication: 2018 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Neuroprotective Agents/*chemistry
Neuroprotective Agents/*pharmacology
Oxidative Stress/*drug effects
Oxidopamine/*adverse effects
Pyrazoles/*chemistry
Pyrazoles/*pharmacology
Animals ; Cell Line ; Cell Survival/drug effects ; Chemistry Techniques, Synthetic ; Drug Design ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotective Agents/chemical synthesis ; Pyrazoles/chemical synthesis ; Rats ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Tytuł :
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors.
Autorzy :
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey. Electronic address: .
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Turan-Zitouni G; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Kaplancıklı ZA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2018 Jul 15; Vol. 155, pp. 905-924. Date of Electronic Publication: 2018 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Focal Adhesion Kinase 1/*antagonists & inhibitors
Oxadiazoles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Focal Adhesion Kinase 1/metabolism ; Humans ; Mice ; Molecular Structure ; NIH 3T3 Cells ; Oxadiazoles/chemical synthesis ; Oxadiazoles/chemistry ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors.
Autorzy :
Altintop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Osmaniye D; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Sağlık BN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
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Źródło :
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2018 Jul; Vol. 351 (7), pp. e1800082. Date of Electronic Publication: 2018 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Drug Design*
Monoamine Oxidase Inhibitors/*pharmacology
Pyrroles/*pharmacology
Fluorometry ; Humans ; In Vitro Techniques ; Inhibitory Concentration 50 ; Kinetics ; Molecular Docking Simulation ; Monoamine Oxidase/drug effects ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors.
Autorzy :
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
Akalın Çiftçi G; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2018 May 31; Vol. 23 (6). Date of Electronic Publication: 2018 May 31.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*chemical synthesis
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Thiazoles/*chemical synthesis
Thiazoles/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Mice ; Models, Molecular ; Molecular Conformation ; NIH 3T3 Cells ; Protein Binding ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-akt/chemistry ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents.
Autorzy :
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Ilgın S; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Atlı Ö; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Turan-Zitouni G; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Kaplancıklı ZA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
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Źródło :
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2018; Vol. 18 (11), pp. 1606-1616.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Thiadiazoles/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Flow Cytometry ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Mice ; Molecular Structure ; NIH 3T3 Cells ; Structure-Activity Relationship ; Thiadiazoles/chemical synthesis ; Thiadiazoles/chemistry
Czasopismo naukowe
Tytuł :
Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents.
Autorzy :
Özdemir A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Gökbulut S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Sever B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Çiftçi GA; Department of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Altıntop MD; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
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Źródło :
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2018; Vol. 18 (10), pp. 1394-1404.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Indans/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; Indans/chemical synthesis ; Indans/chemistry ; MCF-7 Cells ; Mice ; Molecular Conformation ; Molecular Docking Simulation ; NIH 3T3 Cells ; Structure-Activity Relationship
Czasopismo naukowe

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