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    Wyświetlanie 1-17 z 17
    Tytuł:
    Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection.
    Autorzy:
    Perelman SS; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
    Abrams ME; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
    Eitson JL; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
    Chen D; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
    Jimenez A; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
    Mettlen M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
    Schoggins JW; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
    Alto NM; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2016 Dec 21; Vol. 12 (12), pp. e1006102. Date of Electronic Publication: 2016 Dec 21 (Print Publication: 2016).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Interferon Type I/*immunology
    Listeriosis/*immunology
    Virulence/*immunology
    Cell Line ; Flow Cytometry ; High-Throughput Nucleotide Sequencing ; Humans ; Immunoblotting ; Listeria monocytogenes/immunology ; Listeriosis/genetics ; Microscopy, Electron, Scanning ; Polymerase Chain Reaction ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration.
    Autorzy:
    Glotfelty LG; Department of Microbiology & Immunology, University of Illinois at Chicago, 835 S. Wolcott, (M/C 790), Chicago, IL, 60612, USA.
    Zahs A
    Hodges K
    Shan K
    Alto NM
    Hecht GA
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    Źródło:
    Cellular microbiology [Cell Microbiol] 2014 Dec; Vol. 16 (12), pp. 1767-83. Date of Electronic Publication: 2014 Aug 07.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Host-Pathogen Interactions*
    Enteropathogenic Escherichia coli/*growth & development
    Escherichia coli Proteins/*metabolism
    Microtubule-Associated Proteins/*metabolism
    Microtubules/*metabolism
    Tight Junctions/*physiology
    Virulence Factors/*metabolism
    Enteropathogenic Escherichia coli/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.
    Autorzy:
    Burnaevskiy N; Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA.
    Fox TG
    Plymire DA
    Ertelt JM
    Weigele BA
    Selyunin AS
    Way SS
    Patrie SM
    Alto NM
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    Źródło:
    Nature [Nature] 2013 Apr 04; Vol. 496 (7443), pp. 106-9. Date of Electronic Publication: 2013 Mar 27.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Protein Processing, Post-Translational*
    Proteolysis*
    Antigens, Bacterial/*metabolism
    Myristic Acid/*metabolism
    Shigella flexneri/*metabolism
    Virulence Factors/*metabolism
    ADP-Ribosylation Factor 1/chemistry ; ADP-Ribosylation Factor 1/metabolism ; ADP-Ribosylation Factors/metabolism ; Amino Acid Sequence ; Animals ; Asparagine/metabolism ; Autophagy ; Biocatalysis ; Cysteine Proteases/metabolism ; Dysentery, Bacillary ; Female ; Glycine/metabolism ; Golgi Apparatus/metabolism ; Golgi Apparatus/pathology ; HEK293 Cells ; HeLa Cells ; Humans ; Listeria monocytogenes/physiology ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Phagosomes/metabolism ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Alignment ; Shigella flexneri/enzymology ; Signal Transduction ; Substrate Specificity ; Virulence
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Express your LOV: an engineered flavoprotein as a reporter for protein expression and purification.
    Autorzy:
    Gawthorne JA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
    Reddick LE
    Akpunarlieva SN
    Beckham KS
    Christie JM
    Alto NM
    Gabrielsen M
    Roe AJ
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    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (12), pp. e52962. Date of Electronic Publication: 2012 Dec 27.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cysteine Endopeptidases/*genetics
    Escherichia coli Proteins/*genetics
    Flavoproteins/*genetics
    Golgi Apparatus/*genetics
    Viral Proteins/*genetics
    3C Viral Proteases ; Animals ; Cloning, Molecular ; Cysteine Endopeptidases/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Flavoproteins/metabolism ; Golgi Apparatus/metabolism ; Kidney/cytology ; Kidney/metabolism ; Rats ; Viral Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Mimicking GEFs: a common theme for bacterial pathogens.
    Autorzy:
    Orchard RC; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
    Alto NM
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    Źródło:
    Cellular microbiology [Cell Microbiol] 2012 Jan; Vol. 14 (1), pp. 10-8. Date of Electronic Publication: 2011 Dec 01.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Bacterial Secretion Systems*
    Bacterial Proteins/*metabolism
    Guanine Nucleotide Exchange Factors/*metabolism
    rho GTP-Binding Proteins/*metabolism
    Salmonella/metabolism ; Salmonella/pathogenicity ; Shigella/metabolism ; Shigella/pathogenicity ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.
    Autorzy:
    Selyunin AS; Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8816, USA.
    Sutton SE
    Weigele BA
    Reddick LE
    Orchard RC
    Bresson SM
    Tomchick DR
    Alto NM
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    Źródło:
    Nature [Nature] 2011 Jan 06; Vol. 469 (7328), pp. 107-11. Date of Electronic Publication: 2010 Dec 19.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Biocatalysis*
    Signal Transduction*
    ADP-Ribosylation Factors/*metabolism
    Escherichia coli O157/*chemistry
    Escherichia coli Proteins/*metabolism
    p21-Activated Kinases/*metabolism
    ADP-Ribosylation Factors/chemistry ; Allosteric Regulation ; Animals ; Biological Transport ; Catalytic Domain ; Cell Line ; Crystallography, X-Ray ; Endoplasmic Reticulum/metabolism ; Enzyme Activation ; Escherichia coli O157/metabolism ; Escherichia coli Proteins/chemistry ; Golgi Apparatus/metabolism ; Guanosine Triphosphate/chemistry ; Guanosine Triphosphate/metabolism ; Humans ; Hydrolysis ; Intracellular Membranes/metabolism ; Mice ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Interaction Mapping ; Protein Unfolding ; Rats ; Two-Hybrid System Techniques ; p21-Activated Kinases/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism.
    Autorzy:
    Weflen AW; Department of Medicine, Section of Digestive Disease and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA.
    Alto NM
    Viswanathan VK
    Hecht G
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    Źródło:
    Cellular microbiology [Cell Microbiol] 2010 Jul; Vol. 12 (7), pp. 919-29. Date of Electronic Publication: 2010 Jan 20.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Carrier Proteins/*metabolism
    Cell Membrane/*metabolism
    Enteropathogenic Escherichia coli/*metabolism
    Enteropathogenic Escherichia coli/*pathogenicity
    Escherichia coli Proteins/*metabolism
    Vesicular Transport Proteins/*metabolism
    Blotting, Western ; Caco-2 Cells ; Carrier Proteins/genetics ; Cell Membrane/drug effects ; Chlorpromazine/pharmacology ; Enteropathogenic Escherichia coli/drug effects ; Escherichia coli Proteins/genetics ; HeLa Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence ; Protein Binding/genetics ; Protein Binding/physiology ; Sorting Nexins ; Vesicular Transport Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.
    Autorzy:
    Huang Z; National Institute of Biological Sciences, Zhong Guan Cun Life Science Park, Beijing, China.
    Sutton SE
    Wallenfang AJ
    Orchard RC
    Wu X
    Feng Y
    Chai J
    Alto NM
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    Źródło:
    Nature structural & molecular biology [Nat Struct Mol Biol] 2009 Aug; Vol. 16 (8), pp. 853-60. Date of Electronic Publication: 2009 Jul 20.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Escherichia coli Proteins/*metabolism
    Guanine Nucleotide Exchange Factors/*metabolism
    rho GTP-Binding Proteins/*metabolism
    Amino Acid Sequence ; Binding Sites/genetics ; Binding, Competitive ; Cell Line ; Crystallization ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Guanine Nucleotide Exchange Factors/chemistry ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Models, Molecular ; Molecular Sequence Data ; Protein Binding ; Protein Conformation ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Sequence Homology, Amino Acid ; Transfection ; cdc42 GTP-Binding Protein/chemistry ; cdc42 GTP-Binding Protein/genetics ; cdc42 GTP-Binding Protein/metabolism ; rho GTP-Binding Proteins/chemistry ; rho GTP-Binding Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Tight junctions and enteropathogenic E. coli.
    Autorzy:
    Weflen AW; Department of Medicine, Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
    Alto NM
    Hecht GA
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    Źródło:
    Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2009 May; Vol. 1165, pp. 169-74.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Enteropathogenic Escherichia coli/*metabolism
    Tight Junctions/*metabolism
    Amino Acid Sequence ; Animals ; Binding Sites ; Carrier Proteins/metabolism ; Enteropathogenic Escherichia coli/pathogenicity ; Escherichia coli Proteins/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins ; Mice ; Models, Biological ; Molecular Sequence Data ; NIH 3T3 Cells ; Vesicular Transport Proteins/metabolism ; Wiskott-Aldrich Syndrome Protein, Neuronal/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity.
    Autorzy:
    Hodges K; Section of Digestive Disease and Nutrition, Department Of Medicine, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, IL 60612, USA.
    Alto NM
    Ramaswamy K
    Dudeja PK
    Hecht G
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    Źródło:
    Cellular microbiology [Cell Microbiol] 2008 Aug; Vol. 10 (8), pp. 1735-45. Date of Electronic Publication: 2008 Apr 21.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Down-Regulation*
    Carrier Proteins/*metabolism
    Enteropathogenic Escherichia coli/*metabolism
    Escherichia coli Proteins/*metabolism
    Intestinal Mucosa/*microbiology
    Sodium-Hydrogen Exchangers/*metabolism
    Fibroblasts/microbiology ; Humans ; Intracellular Signaling Peptides and Proteins ; Sodium-Hydrogen Exchanger 3 ; Sorting Nexins ; Vesicular Transport Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Mimicking small G-proteins: an emerging theme from the bacterial virulence arsenal.
    Autorzy:
    Alto NM; Department of Microbiology, University of Texas Southwestern, Dallas, Texas 75235-9028, USA. neal.alto@utsouthwestern.edu
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    Źródło:
    Cellular microbiology [Cell Microbiol] 2008 Mar; Vol. 10 (3), pp. 566-75. Date of Electronic Publication: 2008 Jan 09.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Bacterial Proteins/*physiology
    Bacterial Proteins/*toxicity
    Enterobacteriaceae/*pathogenicity
    Monomeric GTP-Binding Proteins/*metabolism
    Humans ; Virulence
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-17 z 17

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