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Wyszukujesz frazę ""Alzheimer Disease"" wg kryterium: Temat


Tytuł :
Left Ear Hearing Predicts Functional Activity in the Brains of Patients with Alzheimer's Disease Dementia.
Autorzy :
Aylward A; Division of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
Naidu SR; Department of Communication Sciences and Disorders, University of Utah, Salt Lake City, UT, USA.
Mellum C; Department of Communication Sciences and Disorders, University of Utah, Salt Lake City, UT, USA.
King JB; Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.
Jones KG; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Anderson JS; Department of Radiology and Imaging Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.
Foster NL; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Gurgel RK; Division of Otolaryngology - Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
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Źródło :
The Annals of otology, rhinology, and laryngology [Ann Otol Rhinol Laryngol] 2021 Apr; Vol. 130 (4), pp. 343-349. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/complications
Alzheimer Disease*/physiopathology
Hearing Loss, Central*/diagnosis
Hearing Loss, Central*/etiology
Hearing Loss, Central*/physiopathology
Hearing Loss, Unilateral*/diagnosis
Hearing Loss, Unilateral*/etiology
Hearing Loss, Unilateral*/physiopathology
Auditory Pathways/*physiopathology
Magnetic Resonance Imaging/*methods
Aged ; Audiometry, Pure-Tone/methods ; Connectome/methods ; Correlation of Data ; Female ; Functional Neuroimaging/methods ; Humans ; Male ; Speech Perception/physiology
Czasopismo naukowe
Tytuł :
Clinical and Biological Correlates of White Matter Hyperintensities in Patients With Behavioral-Variant Frontotemporal Dementia and Alzheimer Disease.
Autorzy :
Huynh K; From the School of Psychology (K.H., O.P., R.L.-R.), Brain and Mind Centre (K.H., O.P., J.K., C.D.-S., G.M.H., J.R.H., R.L.-R.), Central Clinical School (J.K., C.D.-S., G.M.H., J.R.H.), The University of Sydney; and the School of Medical Sciences (J.K., C.D.-S., G.M.H., J.R.H.), University of New South Wales, Sydney, Australia.
Piguet O; From the School of Psychology (K.H., O.P., R.L.-R.), Brain and Mind Centre (K.H., O.P., J.K., C.D.-S., G.M.H., J.R.H., R.L.-R.), Central Clinical School (J.K., C.D.-S., G.M.H., J.R.H.), The University of Sydney; and the School of Medical Sciences (J.K., C.D.-S., G.M.H., J.R.H.), University of New South Wales, Sydney, Australia.
Kwok J; From the School of Psychology (K.H., O.P., R.L.-R.), Brain and Mind Centre (K.H., O.P., J.K., C.D.-S., G.M.H., J.R.H., R.L.-R.), Central Clinical School (J.K., C.D.-S., G.M.H., J.R.H.), The University of Sydney; and the School of Medical Sciences (J.K., C.D.-S., G.M.H., J.R.H.), University of New South Wales, Sydney, Australia.
Dobson-Stone C; From the School of Psychology (K.H., O.P., R.L.-R.), Brain and Mind Centre (K.H., O.P., J.K., C.D.-S., G.M.H., J.R.H., R.L.-R.), Central Clinical School (J.K., C.D.-S., G.M.H., J.R.H.), The University of Sydney; and the School of Medical Sciences (J.K., C.D.-S., G.M.H., J.R.H.), University of New South Wales, Sydney, Australia.
Halliday GM; From the School of Psychology (K.H., O.P., R.L.-R.), Brain and Mind Centre (K.H., O.P., J.K., C.D.-S., G.M.H., J.R.H., R.L.-R.), Central Clinical School (J.K., C.D.-S., G.M.H., J.R.H.), The University of Sydney; and the School of Medical Sciences (J.K., C.D.-S., G.M.H., J.R.H.), University of New South Wales, Sydney, Australia.
Hodges JR; From the School of Psychology (K.H., O.P., R.L.-R.), Brain and Mind Centre (K.H., O.P., J.K., C.D.-S., G.M.H., J.R.H., R.L.-R.), Central Clinical School (J.K., C.D.-S., G.M.H., J.R.H.), The University of Sydney; and the School of Medical Sciences (J.K., C.D.-S., G.M.H., J.R.H.), University of New South Wales, Sydney, Australia.
Landin-Romero R; From the School of Psychology (K.H., O.P., R.L.-R.), Brain and Mind Centre (K.H., O.P., J.K., C.D.-S., G.M.H., J.R.H., R.L.-R.), Central Clinical School (J.K., C.D.-S., G.M.H., J.R.H.), The University of Sydney; and the School of Medical Sciences (J.K., C.D.-S., G.M.H., J.R.H.), University of New South Wales, Sydney, Australia. .
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Źródło :
Neurology [Neurology] 2021 Mar 30; Vol. 96 (13), pp. e1743-e1754. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Cerebral Cortical Thinning/*diagnostic imaging
Frontotemporal Dementia/*diagnostic imaging
Leukoencephalopathies/*diagnostic imaging
White Matter/*diagnostic imaging
Aged ; Alzheimer Disease/genetics ; Alzheimer Disease/physiopathology ; Atrophy ; Brain Cortical Thickness ; C9orf72 Protein/genetics ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Cerebral Cortical Thinning/physiopathology ; Female ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/physiopathology ; Humans ; Leukoencephalopathies/genetics ; Leukoencephalopathies/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Organ Size ; Progranulins/genetics ; Severity of Illness Index ; Spatial Analysis ; White Matter/pathology ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease.
Autorzy :
Zheng K; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hu F; Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Zhou Y; Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Zhang J; Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Zheng J; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lai C; Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Xiong W; Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Cui K; Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Hu YZ; Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Institute of Geriatrics, Chinese PLA General Hospital and Chinese PLA Medical Academy, Beijing, P. R. China.
Han ZT; Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Institute of Geriatrics, Chinese PLA General Hospital and Chinese PLA Medical Academy, Beijing, P. R. China.
Zhang HH; Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Institute of Geriatrics, Chinese PLA General Hospital and Chinese PLA Medical Academy, Beijing, P. R. China.
Chen JG; The Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, P. R. China.
Man HY; Department of Biology, Boston University, Boston, MA, USA.
Liu D; The Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, P. R. China.
Lu Y; The Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, P. R. China. .
Zhu LQ; Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China. .; The Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, P. R. China. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1903. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*genetics
Cytoskeletal Proteins/*genetics
Memory Disorders/*genetics
MicroRNAs/*genetics
Synapses/*metabolism
rho-Associated Kinases/*genetics
Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Animals ; Cells, Cultured ; Cytoskeletal Proteins/metabolism ; Disease Models, Animal ; Hippocampus/cytology ; Hippocampus/metabolism ; Male ; Maze Learning/physiology ; Memory Disorders/metabolism ; Memory Disorders/physiopathology ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neurons/metabolism ; Neurons/physiology ; Phosphorylation ; Signal Transduction/genetics ; Signal Transduction/physiology ; Synapses/physiology ; rho-Associated Kinases/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Amyloid PET Imaging in Self-Identified Non-Hispanic Black Participants of the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study.
Autorzy :
Deters KD; From the Department of Neurology and Neurological Sciences (K.D.D., V.N., M.D.G., E.C.M.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (R.A.S.), Brigham and Women's Hospital, Massachusetts General Hospital, Boston; Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, and The Institute for Genomic Medicine (R.M.), Columbia University Medical Center and The New York Presbyterian Hospital, New York; and Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute (T.H.), Nashville, TN. .
Napolioni V; From the Department of Neurology and Neurological Sciences (K.D.D., V.N., M.D.G., E.C.M.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (R.A.S.), Brigham and Women's Hospital, Massachusetts General Hospital, Boston; Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, and The Institute for Genomic Medicine (R.M.), Columbia University Medical Center and The New York Presbyterian Hospital, New York; and Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute (T.H.), Nashville, TN.
Sperling RA; From the Department of Neurology and Neurological Sciences (K.D.D., V.N., M.D.G., E.C.M.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (R.A.S.), Brigham and Women's Hospital, Massachusetts General Hospital, Boston; Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, and The Institute for Genomic Medicine (R.M.), Columbia University Medical Center and The New York Presbyterian Hospital, New York; and Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute (T.H.), Nashville, TN.
Greicius MD; From the Department of Neurology and Neurological Sciences (K.D.D., V.N., M.D.G., E.C.M.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (R.A.S.), Brigham and Women's Hospital, Massachusetts General Hospital, Boston; Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, and The Institute for Genomic Medicine (R.M.), Columbia University Medical Center and The New York Presbyterian Hospital, New York; and Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute (T.H.), Nashville, TN.
Mayeux R; From the Department of Neurology and Neurological Sciences (K.D.D., V.N., M.D.G., E.C.M.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (R.A.S.), Brigham and Women's Hospital, Massachusetts General Hospital, Boston; Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, and The Institute for Genomic Medicine (R.M.), Columbia University Medical Center and The New York Presbyterian Hospital, New York; and Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute (T.H.), Nashville, TN.
Hohman T; From the Department of Neurology and Neurological Sciences (K.D.D., V.N., M.D.G., E.C.M.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (R.A.S.), Brigham and Women's Hospital, Massachusetts General Hospital, Boston; Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, and The Institute for Genomic Medicine (R.M.), Columbia University Medical Center and The New York Presbyterian Hospital, New York; and Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute (T.H.), Nashville, TN.
Mormino EC; From the Department of Neurology and Neurological Sciences (K.D.D., V.N., M.D.G., E.C.M.), Stanford University School of Medicine, Palo Alto, CA; Department of Neurology (R.A.S.), Brigham and Women's Hospital, Massachusetts General Hospital, Boston; Department of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, and The Institute for Genomic Medicine (R.M.), Columbia University Medical Center and The New York Presbyterian Hospital, New York; and Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute (T.H.), Nashville, TN.
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Źródło :
Neurology [Neurology] 2021 Mar 16; Vol. 96 (11), pp. e1491-e1500. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*ethnology
Alzheimer Disease/*pathology
Amyloidogenic Proteins/*metabolism
Brain/*pathology
African Americans ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Amyloidogenic Proteins/analysis ; Apolipoproteins E/genetics ; Biomarkers/analysis ; Biomarkers/metabolism ; Brain/diagnostic imaging ; Female ; Humans ; Male ; Positron-Emission Tomography ; United States
Czasopismo naukowe
Tytuł :
[Protective function of electroacupuncture on young mouse model of Alzheimer's disease and proteomic study].
Autorzy :
Zhang SJ; School of Basic Medicine, Henan University of CM, Zhengzhou 450046, China.
Sun NN; School of Basic Medicine, Henan University of CM, Zhengzhou 450046, China.
Gao JF; School of Basic Medicine, Henan University of CM, Zhengzhou 450046, China.
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Źródło :
Zhongguo zhen jiu = Chinese acupuncture & moxibustion [Zhongguo Zhen Jiu] 2021 Mar 12; Vol. 41 (3), pp. 295-302.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/genetics
Alzheimer Disease*/therapy
Electroacupuncture*
Amyloid beta-Peptides/genetics ; Animals ; Disease Models, Animal ; Hippocampus ; Male ; Mice ; Mice, Inbred C57BL ; Proteomics
Czasopismo naukowe
Tytuł :
Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease.
Autorzy :
Trelle AN; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA. .
Carr VA; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Wilson EN; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Swarovski MS; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Hunt MP; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Toueg TN; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Tran TT; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Channappa D; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Corso NK; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Thieu MK; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Jayakumar M; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Nadiadwala A; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Guo W; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Tanner NJ; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Bernstein JD; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Litovsky CP; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Guerin SA; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Khazenzon AM; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Harrison MB; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Rutt BK; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Deutsch GK; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Chin FT; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Davidzon GA; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Hall JN; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Sha SJ; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Fredericks CA; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Andreasson KI; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Kerchner GA; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Wagner AD; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
Mormino EC; From the Department of Psychology (A.N.T., V.A.C., M.P.H., T.T.T., M.K.T., M.J., W.G., N.J.T., J.D.B., C.P.L., S.A.G., A.M.K., M.B.H., A.D.W.), Stanford University; and Department of Neurology and Neurological Sciences (E.N.W., M.S.S., T.N.T., D.C., N.K.C., A.N., G.K.D., J.N.H., S.J.S., C.A.F., K.I.A., G.A.K., E.C.M.) and Division of Nuclear Medicine & Molecular Imaging Division, Department of Radiology (B.K.R., F.T.C., G.A.D.), Stanford Medical School, CA.
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Źródło :
Neurology [Neurology] 2021 Mar 09; Vol. 96 (10), pp. e1470-e1481. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*cerebrospinal fluid
Biomarkers/*cerebrospinal fluid
Hippocampus/*physiopathology
Memory Disorders/*cerebrospinal fluid
Memory Disorders/*psychology
Aged ; Aged, 80 and over ; Aging/psychology ; Alzheimer Disease/physiopathology ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/cerebrospinal fluid ; Association Learning ; Cross-Sectional Studies ; Cues ; Discrimination, Psychological ; Female ; Humans ; Male ; Memory ; Memory Disorders/physiopathology ; Memory, Episodic ; Mental Recall ; Middle Aged ; Neuropsychological Tests ; Peptide Fragments/cerebrospinal fluid ; Psychomotor Performance ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
Temporal Dynamics of β-Amyloid Accumulation in Aging and Alzheimer Disease.
Autorzy :
Jagust WJ; From the Helen Wills Neuroscience Institute, University of California, Berkeley; and Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA. .
Landau SM; From the Helen Wills Neuroscience Institute, University of California, Berkeley; and Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA.
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Corporate Authors :
Alzheimer's Disease Neuroimaging Initiative
Źródło :
Neurology [Neurology] 2021 Mar 02; Vol. 96 (9), pp. e1347-e1357. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*metabolism
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*metabolism
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Aniline Compounds ; Apolipoprotein E4/genetics ; Carbolines ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/psychology ; Ethylene Glycols ; Female ; Follow-Up Studies ; Heterozygote ; Humans ; Longitudinal Studies ; Male ; Neuropsychological Tests ; Positron-Emission Tomography ; Sex Characteristics ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
[The Use of Artificial Intelligence in Alzheimer's Disease - Personalized Diagnostics and Therapy].
Autorzy :
Wiltfang J; Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Göttingen.; Deutsches Zentrum für Neurodegenerative Erkrankungen, Standort Göttingen (DZNE-Göttingen).
Esselmann H; Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Göttingen.
Barnikol UB; Angewandte Ethik in der translationalen Krebsforschung, Clearingstelle Ethik, Centrum für Integrierte Onkologie (CIO), Uniklinik Köln.
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Transliterated Title :
Der Einsatz von Künstlicher Intelligenz bei Alzheimer-Krankheit – Personalisierte Diagnostik und Therapie.
Źródło :
Psychiatrische Praxis [Psychiatr Prax] 2021 Mar; Vol. 48 (S 01), pp. S31-S36. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/diagnosis
Alzheimer Disease*/therapy
Artificial Intelligence ; Germany ; Humans
Czasopismo naukowe
Tytuł :
New insights into atypical Alzheimer's disease in the era of biomarkers.
Autorzy :
Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: .
Yong KXX; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Apostolova LG; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Bouwman FH; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam University Medical Center, Amsterdam, Netherlands.
Carrillo M; Alzheimer's Association, Chicago, IL, USA.
Dickerson BC; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Rabinovici GD; Department of Neurology, Radiology, and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Schott JM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Jones DT; Department of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
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Źródło :
The Lancet. Neurology [Lancet Neurol] 2021 Mar; Vol. 20 (3), pp. 222-234.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Biomarkers*
Alzheimer Disease/*diagnosis
Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/classification ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Neuroimaging/methods
Czasopismo naukowe
Tytuł :
Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways.
Autorzy :
Mohamed EA; Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt. Electronic address: .
Ahmed HI; Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Zaky HS; Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Badr AM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh, Saudi Arabia; Department of Pharmacology and Toxicology, College of Pharmacy, Ain Shams University, Heliopolis, Cairo, Egypt.
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113468. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Degeneration*
Alzheimer Disease/*drug therapy
Antioxidants/*pharmacology
Behavior, Animal/*drug effects
Hippocampus/*drug effects
Memory/*drug effects
Memory Disorders/*prevention & control
Neuroprotective Agents/*pharmacology
Nootropic Agents/*pharmacology
Oxidative Stress/*drug effects
Sesame Oil/*pharmacology
Signal Transduction/*drug effects
Alzheimer Disease/enzymology ; Alzheimer Disease/pathology ; Alzheimer Disease/psychology ; Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Disease Models, Animal ; Hippocampus/enzymology ; Hippocampus/pathology ; Hippocampus/physiopathology ; Male ; Memory Disorders/enzymology ; Memory Disorders/pathology ; Memory Disorders/psychology ; NF-kappa B/metabolism ; PPAR gamma/metabolism ; Rats, Sprague-Dawley ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype.
Autorzy :
Buciuc M; Department of Neurology, Mayo Clinic, Rochester, MN.
Whitwell JL; Department of Radiology, Mayo Clinic, Rochester, MN.
Kasanuki K; Department of Neuroscience, Mayo Clinic, Jacksonville, FL.; Department of Neuropsychiatry, St. Marianna University School of Medicine, Kawasaki, Japan.
Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN.
Machulda MM; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
Duffy JR; Department of Neurology, Mayo Clinic, Rochester, MN.
Strand EA; Department of Neurology, Mayo Clinic, Rochester, MN.
Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, MN.
Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL.
Rush BK; Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL.
Franczak MB; Department of Neurology, Medical College of Wisconsin, Milwaukee, WI.
Flanagan ME; Department of Pathology, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
Baker MC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL.
Rademakers R; Department of Neuroscience, Mayo Clinic, Jacksonville, FL.
Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL.
Ghetti BF; Department of Pathology & Laboratory Medicine, Indiana University, Indianapolis, IN.
Parisi JE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Raghunathan A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Bigio EH; Department of Pathology, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL.
Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL.
Josephs KA; Department of Neurology, Mayo Clinic, Rochester, MN.
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Źródło :
Annals of neurology [Ann Neurol] 2021 Mar; Vol. 89 (3), pp. 520-533. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Aphasia, Primary Progressive/*diagnostic imaging
Lewy Body Disease/*diagnostic imaging
Aged ; Aged, 80 and over ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Aphasia, Primary Progressive/pathology ; Aphasia, Primary Progressive/physiopathology ; Female ; Fluorodeoxyglucose F18 ; Frontotemporal Lobar Degeneration/diagnostic imaging ; Frontotemporal Lobar Degeneration/pathology ; Frontotemporal Lobar Degeneration/physiopathology ; Humans ; Language Tests ; Lewy Body Disease/pathology ; Lewy Body Disease/physiopathology ; Male ; Middle Aged ; Positron-Emission Tomography ; Radiopharmaceuticals
Czasopismo naukowe
Tytuł :
Biomarkers of Alzheimer's disease in severe obstructive sleep apnea-hypopnea syndrome in the Chinese population.
Autorzy :
Kong W; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu, 610041, Sichuan, People's Republic of China.
Zheng Y; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu, 610041, Sichuan, People's Republic of China. .
Xu W; Department of Biostatistics, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5G2M9, Canada. .
Gu H; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu, 610041, Sichuan, People's Republic of China.
Wu J; Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu, 610041, Sichuan, People's Republic of China.
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Źródło :
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2021 Mar; Vol. 278 (3), pp. 865-872. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/diagnosis
Alzheimer Disease*/epidemiology
Sleep Apnea, Obstructive*/diagnosis
Sleep Apnea, Obstructive*/epidemiology
Biomarkers ; China/epidemiology ; Disorders of Excessive Somnolence ; Humans
Czasopismo naukowe
Tytuł :
Treatment pathway analysis of newly diagnosed dementia patients in four electronic health record databases in Europe.
Autorzy :
James G; AstraZeneca, Academy House, 136 Hills Road, Cambridge, CB2 8PA, UK. .
Collin E; Servier, Paris, France.
Lawrance M; GlaxoSmithKline, Stevenage, UK.
Mueller A; Boehringer Ingelheim, Ingelheim Am Rhein, Germany.
Podhorna J; Boehringer Ingelheim, Ingelheim Am Rhein, Germany.
Zaremba-Pechmann L; Boehringer Ingelheim, Ingelheim Am Rhein, Germany.
Rijnbeek P; Erasmus Medical Centre, Rotterdam, The Netherlands.
van der Lei J; Erasmus Medical Centre, Rotterdam, The Netherlands.
Avillach P; Erasmus Medical Centre, Rotterdam, The Netherlands.; Harvard Medical School, Cambridge, USA.
Pedersen L; Aarhus University, Aarhus, Denmark.
Ansell D; The Health Improvement Network, London, UK.
Pasqua A; Health Search Database, Florence, Italy.
Mosseveld M; Erasmus Medical Centre, Rotterdam, The Netherlands.
Grosdidier S; Erasmus Medical Centre, Rotterdam, The Netherlands.
Gungabissoon U; GlaxoSmithKline, Stevenage, UK.
Egger P; GlaxoSmithKline, Stevenage, UK.
Stewart R; King's College London, London, UK.; South London and Maudsley NHS Foundation, London, UK.
Celis-Morales C; University of Glasgow, Glasgow, UK.
Alexander M; GlaxoSmithKline, Stevenage, UK.
Novak G; Janssen Pharmaceutical, New York, USA.
Gordon MF; Teva Pharmaceuticals, Inc, Frazer, USA.
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Źródło :
Social psychiatry and psychiatric epidemiology [Soc Psychiatry Psychiatr Epidemiol] 2021 Mar; Vol. 56 (3), pp. 409-416. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/diagnosis
Alzheimer Disease*/drug therapy
Electronic Health Records*
Europe ; Galantamine ; Humans ; Indans ; Italy ; Netherlands ; Phenylcarbamates ; Piperidines ; Retrospective Studies
Czasopismo naukowe
Tytuł :
PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome.
Autorzy :
Zammit MD; University of Wisconsin-Madison, Waisman Center, 1500 Highland Avenue, Madison, WI 53705, United States. Electronic address: .
Tudorascu DL; University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, United States. Electronic address: .
Laymon CM; University of Pittsburgh, Department of Radiology, Pittsburgh, PA, United States; University of Pittsburgh, Department of Bioengineering, Pittsburgh, PA, United States. Electronic address: .
Hartley SL; University of Wisconsin-Madison, Waisman Center, 1500 Highland Avenue, Madison, WI 53705, United States. Electronic address: .
Zaman SH; Cambridge Intellectual Disability Research Group, University of Cambridge, Cambridge, United Kingdom. Electronic address: .
Ances BM; Washington University in St. Louis Department of Neurology, St. Louis, MO, United States. Electronic address: .
Johnson SC; University of Wisconsin-Madison, Alzheimer's Disease Research Center, Madison, WI, United States. Electronic address: .
Stone CK; University of Wisconsin-Madison, Department of Medicine, Madison, WI, United States. Electronic address: .
Mathis CA; University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, United States. Electronic address: .
Klunk WE; University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, United States.
Cohen AD; University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, United States. Electronic address: .
Handen BL; University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, United States. Electronic address: .
Christian BT; University of Wisconsin-Madison, Waisman Center, 1500 Highland Avenue, Madison, WI 53705, United States. Electronic address: .
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Źródło :
NeuroImage [Neuroimage] 2021 Mar; Vol. 228, pp. 117728. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Amyloid beta-Peptides/*metabolism
Brain/*diagnostic imaging
Down Syndrome/*complications
Down Syndrome/*diagnostic imaging
Adult ; Alzheimer Disease/etiology ; Alzheimer Disease/pathology ; Brain/metabolism ; Brain/pathology ; Disease Progression ; Down Syndrome/pathology ; Female ; Humans ; Longitudinal Studies ; Male ; Positron-Emission Tomography
Czasopismo naukowe
Tytuł :
Clinical Relevance of [ F]FDG PET/CT Imaging on the Management of Patients with Dementia.
Autorzy :
Librizzi D; Department of Nuclear Medicine, Philipps-University of Marburg, 35043 Marburg, Germany.
Cabanel N; Department of Psychiatry and Psychotherapy, Philipps-University of Marburg, 35039 Marburg, Germany.; Marburg Center for Mind, Brain and Behavior-MCMBB, University of Marburg, 35032 Marburg, Germany.
Zavorotnyy M; Department of Psychiatry and Psychotherapy, Philipps-University of Marburg, 35039 Marburg, Germany.; Department of Psychiatry and Psychotherapy, Psychiatric Services Aargau, Academic Hospital of the University of Zurich, 5210 Windisch, Switzerland.; Marburg Center for Mind, Brain and Behavior-MCMBB, University of Marburg, 35032 Marburg, Germany.
Riehl E; Department of Nuclear Medicine, Philipps-University of Marburg, 35043 Marburg, Germany.
Kircher T; Department of Psychiatry and Psychotherapy, Philipps-University of Marburg, 35039 Marburg, Germany.; Marburg Center for Mind, Brain and Behavior-MCMBB, University of Marburg, 35032 Marburg, Germany.
Luster M; Department of Nuclear Medicine, Philipps-University of Marburg, 35043 Marburg, Germany.
Hooshyar Yousefi B; Department of Nuclear Medicine, Philipps-University of Marburg, 35043 Marburg, Germany.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 26; Vol. 26 (5). Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Cognitive Dysfunction/*diagnostic imaging
Dementia/*diagnostic imaging
Fluorodeoxyglucose F18/*administration & dosage
Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Alzheimer Disease/physiopathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/isolation & purification ; Brain/diagnostic imaging ; Brain/physiopathology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/physiopathology ; Dementia/diagnosis ; Dementia/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; tau Proteins/genetics ; tau Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
Imaging Techniques in Alzheimer's Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring.
Autorzy :
van Oostveen WM; Faculty of Science, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
de Lange ECM; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre of Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 20; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Early Diagnosis*
Neuroimaging*
Alzheimer Disease/*diagnosis
Alzheimer Disease/*diagnostic imaging
Alzheimer Disease/pathology ; Amyloid/metabolism ; Biomarkers/metabolism ; Humans ; Longitudinal Studies
Czasopismo naukowe
Tytuł :
Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment.
Autorzy :
Therriault J; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Pascoal TA; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Benedet AL; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Tissot C; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Savard M; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Chamoun M; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Lussier F; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Kang MS; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Berzgin G; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Wang T; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Fernandes-Arias J; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Massarweh G; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Soucy JP; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Vitali P; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Saha-Chaudhuri P; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Gauthier S; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada.
Rosa-Neto P; From the Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital (J.T., T.A.P., A.L.B., C.T., M.S., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., S.G., P.R.-N.), and the Departments of Neurology and Neurosurgery (J.T., T.A.P., A.L.B., C.T., M.C., F.L., M.S.K., G.B., T.W., J.F.-A., J.-P.S., P.V., S.G., P.R.-N.), Psychiatry (S.G., P.R.-N.), Radiochemistry (G.M.), and Epidemiology and Biostatistics (P.S.-C.), McGill University, Montreal; and Montreal Neurological Institute (J.T., T.A.P., A.L.B., C.T., F.L., M.S.K., G.B., T.W., J.F.-A., G.M., J.-P.S., P.R.-N.), Canada. .
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Źródło :
Neurology [Neurology] 2021 Feb 16; Vol. 96 (7), pp. e975-e985. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*diagnosis
Apolipoprotein E4/*genetics
Brain/*diagnostic imaging
Cognition/*physiology
Cognitive Dysfunction/*diagnosis
Age Factors ; Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/psychology ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Positron-Emission Tomography ; Sex Factors ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Machine learning identifies candidates for drug repurposing in Alzheimer's disease.
Autorzy :
Rodriguez S; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
Hug C; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.
Todorov P; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.
Moret N; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.
Boswell SA; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.
Evans K; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
Zhou G; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
Johnson NT; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.
Hyman BT; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
Sorger PK; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.
Albers MW; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA. .; Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA. .
Sokolov A; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1033. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Machine Learning*
Alzheimer Disease/*drug therapy
Drugs, Investigational/*pharmacology
Nerve Tissue Proteins/*genetics
Neuroprotective Agents/*pharmacology
Nootropic Agents/*pharmacology
Prescription Drugs/*pharmacology
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Drug Repositioning ; Drugs, Investigational/chemistry ; Gene Expression Profiling ; Gene Expression Regulation ; High-Throughput Screening Assays ; Humans ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/chemistry ; Nootropic Agents/chemistry ; Pharmacogenetics/methods ; Pharmacogenetics/statistics & numerical data ; Polypharmacology ; Prescription Drugs/chemistry ; Primary Cell Culture ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
Analyzing the effect of APOE on Alzheimer's disease progression using an event-based model for stratified populations.
Autorzy :
Venkatraghavan V; Biomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands. Electronic address: .
Klein S; Biomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Fani L; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Ham LS; Biomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Vrooman H; Biomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Ikram MK; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Neurology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
Niessen WJ; Biomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Quantitative Imaging Group, Dept. of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands.
Bron EE; Biomedical Imaging Group Rotterdam, Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands.
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Corporate Authors :
Alzheimer’s Disease Neuroimaging Initiative
Źródło :
NeuroImage [Neuroimage] 2021 Feb 15; Vol. 227, pp. 117646. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Algorithms*
Alzheimer Disease/*genetics
Alzheimer Disease/*pathology
Apolipoproteins E/*genetics
Aged ; Alzheimer Disease/physiopathology ; Brain/pathology ; Brain/physiopathology ; Disease Progression ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Neuroimaging/methods
Czasopismo naukowe
Tytuł :
Time between milestone events in the Alzheimer's disease amyloid cascade.
Autorzy :
Insel PS; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, United States. Electronic address: .
Donohue MC; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, CA, United States.
Berron D; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.
Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden; Department of Neurology, Skåne University Hospital, Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden. Electronic address: .
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Źródło :
NeuroImage [Neuroimage] 2021 Feb 15; Vol. 227, pp. 117676. Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*metabolism
tau Proteins/*metabolism
Aged ; Alzheimer Disease/complications ; Alzheimer Disease/metabolism ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Female ; Humans ; Male ; Positron-Emission Tomography ; Time Factors
Czasopismo naukowe

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