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Wyszukujesz frazę ""Alzheimer Disease"" wg kryterium: Temat


Starter badań:

Tytuł:
Mapping the genetic landscape of early-onset Alzheimer's disease in a cohort of 36 families.
Autorzy:
Mol MO; Alzheimer Center Erasmus MC, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands. .
van der Lee SJ; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Hulsman M; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.
Pijnenburg YAL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Scheltens P; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Seelaar H; Alzheimer Center Erasmus MC, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
van Swieten JC; Alzheimer Center Erasmus MC, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Kaat LD; Alzheimer Center Erasmus MC, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Holstege H; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands.
van Rooij JGJ; Alzheimer Center Erasmus MC, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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Corporate Authors:
Netherlands Brain Bank
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Jun 01; Vol. 14 (1), pp. 77. Date of Electronic Publication: 2022 Jun 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Apolipoproteins E/genetics ; Cohort Studies ; Heterozygote ; Humans ; LDL-Receptor Related Proteins/genetics ; Membrane Transport Proteins/genetics ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł:
Association of non-alcoholic fatty liver disease with incident dementia later in life among elder adults.
Autorzy:
Jeong S; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.; Department of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam, Korea.
Oh YH; Department of Family Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Korea.
Choi S; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Chang J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Kim SM; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Son JS; Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Lee G; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.; Estherformula Medical Food R&D Center, Seoul, Korea.
Ahn JC; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Lee DH; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
Koo BK; Division of Endocrinology, Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.
Kim W; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Park SM; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.; Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
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Źródło:
Clinical and molecular hepatology [Clin Mol Hepatol] 2022 Jul; Vol. 28 (3), pp. 510-521. Date of Electronic Publication: 2022 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnosis
Alzheimer Disease*/epidemiology
Non-alcoholic Fatty Liver Disease*/complications
Non-alcoholic Fatty Liver Disease*/diagnosis
Non-alcoholic Fatty Liver Disease*/epidemiology
Adult ; Aged ; Databases, Factual ; Humans ; Proportional Hazards Models ; Risk Factors
Czasopismo naukowe
Tytuł:
Comment on NATSEM's report on the economic and societal cost of Alzheimer disease in Australia.
Autorzy:
Valenzuela M; Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney, Sydney, NSW.
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Źródło:
The Medical journal of Australia [Med J Aust] 2022 Jun 06; Vol. 216 (10), pp. 540. Date of Electronic Publication: 2022 May 14.
Typ publikacji:
Letter
MeSH Terms:
Alzheimer Disease*/epidemiology
Alzheimer Disease*/therapy
Australia/epidemiology ; Caregivers ; Cost of Illness ; Humans
Opinia redakcyjna
Tytuł:
Peripheral monocyte-derived cells counter amyloid plaque pathogenesis in a mouse model of Alzheimer's disease.
Autorzy:
Yan P; Department of Neurology.; Hope Center for Neurological Disorders, and.
Kim KW; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, Illinois, USA.
Xiao Q; Department of Neurology.; Hope Center for Neurological Disorders, and.
Ma X; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.; John Cochran VA Medical Center, St. Louis, Missouri, USA.
Czerniewski LR; Department of Neurology.; Hope Center for Neurological Disorders, and.
Liu H; Department of Neurology.; Hope Center for Neurological Disorders, and.
Rawnsley DR; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Yan Y; Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.
Randolph GJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Epelman S; Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.
Lee JM; Department of Neurology.; Hope Center for Neurological Disorders, and.
Diwan A; Hope Center for Neurological Disorders, and.; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.; John Cochran VA Medical Center, St. Louis, Missouri, USA.
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Źródło:
The Journal of clinical investigation [J Clin Invest] 2022 Jun 01; Vol. 132 (11).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Plaque, Amyloid*/pathology
Amyloid beta-Peptides/metabolism ; Animals ; Brain/metabolism ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Microglia/metabolism ; Monocytes/metabolism
Czasopismo naukowe
Tytuł:
Possible role of endocannabinoids in olfactory and taste dysfunctions in Alzheimer's and Parkinson's patients and volumetric changes in the brain.
Autorzy:
Petekkaya E; Department of Anatomy, Faculty of Medicine, Kastamonu University, Kastamonu, Turkey. Electronic address: .
Kuş B; Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Doğan S; Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Bayaroğulları H; Department of Radiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Mutlu T; Department of Neurology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Murat Melek İ; Department of Neurology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Arpacı A; Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey. Electronic address: .
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Źródło:
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2022 Jun; Vol. 100, pp. 52-58. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnostic imaging
Olfaction Disorders*/complications
Olfaction Disorders*/etiology
Parkinson Disease*/complications
Parkinson Disease*/diagnostic imaging
Endocannabinoids ; Humans ; Olfactory Bulb/diagnostic imaging ; Smell ; Taste ; Taste Disorders/complications ; Taste Disorders/etiology
Czasopismo naukowe
Tytuł:
Chemical analysis of amyloid β aggregation inhibitors derived from Geranium thunbergii.
Autorzy:
Kubo K; Graduate School of Engineering, Muroran Institute of Technology, 27-1Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan.
Watanabe H; Graduate School of Engineering, Muroran Institute of Technology, 27-1Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan.
Kumeta H; Graduate Schol of Life Science, Hokaido University, Kita 10, Nishi 8, Kita-ku, Saporo, Hokkaido 060-0808, Japan.
Aizawa T; Graduate Schol of Life Science, Hokaido University, Kita 10, Nishi 8, Kita-ku, Saporo, Hokkaido 060-0808, Japan.
Seki C; Graduate School of Engineering, Muroran Institute of Technology, 27-1Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan.
Nakano H; Graduate School of Engineering, Muroran Institute of Technology, 27-1Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan.
Tokuraku K; Graduate School of Engineering, Muroran Institute of Technology, 27-1Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan.
Uwai K; Graduate School of Engineering, Muroran Institute of Technology, 27-1Mizumoto-cho, Muroran, Hokkaido 050-8585, Japan. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Aug 15; Vol. 68, pp. 116840. Date of Electronic Publication: 2022 May 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Geranium*/chemistry
Geranium*/metabolism
Amyloid/metabolism ; Amyloid beta-Peptides/metabolism ; Humans ; Neurons/metabolism ; Peptide Fragments/metabolism ; Plant Extracts/pharmacology
Czasopismo naukowe
Tytuł:
Assisting dementia diagnosis through the electrochemical immunosensing of glial fibrillary acidic protein.
Autorzy:
Ozcelikay G; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey; Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28014, Madrid, Spain.
Gamella M; Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28014, Madrid, Spain.
Unal MA; Ankara University, Stem Cell Institute, 06520, Ankara, Turkey.
Gucuyener K; Gazi University, Faculty of Medicine, Department of Pediatric Neurology, 06510, Ankara, Turkey.
Montero-Calle A; Chronic Disease Programme, UFIEC, Institute of Health Carlos III, Majadahonda, 28220, Madrid, Spain.
Barderas R; Chronic Disease Programme, UFIEC, Institute of Health Carlos III, Majadahonda, 28220, Madrid, Spain.
Pingarrón JM; Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28014, Madrid, Spain.
Campuzano S; Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28014, Madrid, Spain. Electronic address: .
Ozkan SA; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey. Electronic address: .
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Źródło:
Talanta [Talanta] 2022 Aug 15; Vol. 246, pp. 123526. Date of Electronic Publication: 2022 May 05.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Biosensing Techniques*/methods
Antibodies ; Carbon/chemistry ; Electrochemical Techniques/methods ; Electrodes ; Glial Fibrillary Acidic Protein ; Humans ; Hydrogen Peroxide/chemistry ; Immunoassay ; Intermediate Filaments ; Limit of Detection
Czasopismo naukowe
Tytuł:
Structure-based discovery and development of novel O-GlcNAcase inhibitors for the treatment of Alzheimer's disease.
Autorzy:
Li X; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.
Han J; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.
Bujaranipalli S; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.
He J; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.
Kim EY; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea.
Kim H; Medifron DBT, Seoul, 08502, Republic of Korea.
Im JH; Medifron DBT, Seoul, 08502, Republic of Korea.
Cho WJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju, 61186, Republic of Korea. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Aug 05; Vol. 238, pp. 114444. Date of Electronic Publication: 2022 May 13.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
tau Proteins*/metabolism
Animals ; Mice ; Molecular Docking Simulation ; beta-N-Acetylhexosaminidases/metabolism
Czasopismo naukowe
Tytuł:
Diaminocyclopentane-derived O -GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease.
Autorzy:
Weber P; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010, Graz, Austria.
Mészáros Z; Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic. .; Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 1903/3, CZ-16628, Praha 6, Czech Republic.
Jagečić D; Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 3, HR-10000, Zagreb, Croatia.
Hribljan V; Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 3, HR-10000, Zagreb, Croatia.
Mitrečić D; Laboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 3, HR-10000, Zagreb, Croatia.
Bojarová P; Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic. .
Slámová K; Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic. .
Vrba J; Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, CZ-77515, Olomouc, Czech Republic.
Kulik N; Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic. .
Křen V; Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic. .
Stütz AE; Glycogroup, Institute of Chemistry and Technology of Biobased Systems, Graz University of Technology, Stremayrgasse 9, A-8010, Graz, Austria.
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Źródło:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Aug 04; Vol. 58 (63), pp. 8838-8841. Date of Electronic Publication: 2022 Aug 04.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Acetylglucosaminidase ; Animals ; Enzyme Inhibitors/pharmacology ; Humans ; Mice ; beta-N-Acetylhexosaminidases ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł:
Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study.
Autorzy:
Yuan S; Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, 510630, Guangdong Province, China.
Ma W; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'An, 710061, Shaanxi Province, China.
Yang R; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'An, 710061, Shaanxi Province, China.
Xu F; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'An, 710061, Shaanxi Province, China.
Han D; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'An, 710061, Shaanxi Province, China.
Huang T; Department of Clinical Research, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, 510630, Guangdong Province, China.
Peng M; Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, 510630, Guangdong Province, China.
Xu A; Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, 510630, Guangdong Province, China.
Lyu J; Department of Clinical Research, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, 510630, Guangdong Province, China. .
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Źródło:
BMC geriatrics [BMC Geriatr] 2022 Aug 02; Vol. 22 (1), pp. 638. Date of Electronic Publication: 2022 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/epidemiology
Alzheimer Disease*/genetics
Biological Specimen Banks ; Genetic Predisposition to Disease ; Humans ; Sleep/genetics ; United Kingdom/epidemiology
Czasopismo naukowe
Tytuł:
Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer's Disease (NorAD): study protocol for a randomised clinical trial and COVID-19 amendments.
Autorzy:
Hoang K; Department of Brain Sciences, Imperial College London, London, UK. .; Imperial College Healthcare NHS Trust, London, UK. .
Watt H; Department of Public Health and Primary Care, Imperial College London, London, UK.
Golemme M; UK Dementia Research Institute Care Research and Technology Centre, Imperial College London and the University of Surrey, London, UK.
Perry RJ; Department of Brain Sciences, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK.
Ritchie C; Edinburgh Dementia Prevention and Centre for Clinical Brain Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Wilson D; UK Dementia Research Institute Care Research and Technology Centre, Imperial College London and the University of Surrey, London, UK.
Pickett J; Department of Brain Sciences, Imperial College London, London, UK.
Fox C; Norwich Medical School, University of East Anglia, Norfolk, UK.
Howard R; Division of Psychiatry, University College London, Maple House 149 Tottenham Court Road, London, W1T 7NF, UK.
Malhotra PA; Department of Brain Sciences, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK.; UK Dementia Research Institute Care Research and Technology Centre, Imperial College London and the University of Surrey, London, UK.
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Źródło:
Trials [Trials] 2022 Aug 01; Vol. 23 (1), pp. 623. Date of Electronic Publication: 2022 Aug 01.
Typ publikacji:
Clinical Trial Protocol; Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/drug therapy
Attention Deficit Disorder with Hyperactivity*/diagnosis
COVID-19*
Activities of Daily Living ; Cholinesterase Inhibitors/therapeutic use ; Clinical Trials, Phase III as Topic ; Delayed-Action Preparations/therapeutic use ; Double-Blind Method ; Guanfacine/adverse effects ; Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.
Autorzy:
Lee A; Department of Neuroscience, Columbia University Medical Center New York, New York, NY, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.; The Integrated Graduate Program in Cellular, Molecular, and Biomedical Studies, Columbia University Medical Center, New York, NY, USA.
Kondapalli C; Department of Neuroscience, Columbia University Medical Center New York, New York, NY, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.
Virga DM; Department of Neuroscience, Columbia University Medical Center New York, New York, NY, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.; Department of Biological Sciences, Columbia University, New York, NY, USA.
Lewis TL Jr; Department of Neuroscience, Columbia University Medical Center New York, New York, NY, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA.; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Koo SY; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.
Ashok A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.
Mairet-Coello G; UCB Biopharma, Braine l'Alleud, Belgium.
Herzig S; Molecular & Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Foretz M; Institut Cochin, Université de Paris, CNRS, INSERM, Paris, France.
Viollet B; Institut Cochin, Université de Paris, CNRS, INSERM, Paris, France.
Shaw R; Molecular & Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Sproul A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
Polleux F; Department of Neuroscience, Columbia University Medical Center New York, New York, NY, USA. .; Mortimer B. Zuckerman Mind Brain Behavior Institute, New York, NY, USA. .; Kavli Institute for Brain Sciences, Columbia University Medical Center, New York, NY, USA. .
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Źródło:
Nature communications [Nat Commun] 2022 Aug 01; Vol. 13 (1), pp. 4444. Date of Electronic Publication: 2022 Aug 01.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Mitophagy*
AMP-Activated Protein Kinases/metabolism ; Amyloid beta-Peptides/metabolism ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Mitochondrial Dynamics ; Peptide Fragments ; Synapses/metabolism
Czasopismo naukowe
Tytuł:
Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer's disease.
Autorzy:
Kim M; Department of Artificial intelligence, Catholic University of Korea, Bucheon, Republic of Korea.
Wu R; School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, USA.
Yao X; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA.
Saykin AJ; Indiana Alzheimer Disease Center and Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.
Moore JH; Department of Computational Biomedicine, Cedars Sinai Medical Center, West Hollywood, USA.
Shen L; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA. .
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Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
BMC medical genomics [BMC Med Genomics] 2022 Aug 01; Vol. 15 (Suppl 2), pp. 168. Date of Electronic Publication: 2022 Aug 01.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Brain/diagnostic imaging ; Endophenotypes ; Genetic Markers ; Genetic Predisposition to Disease ; Genome-Wide Association Study/methods ; Humans ; Neuroimaging ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Tytuł:
Potential eligibility for Aducanumab therapy in an Irish specialist cognitive service-Utilising cerebrospinal fluid biomarkers and appropriate use criteria.
Autorzy:
Togher Z; Department of Neurology, Tallaght University Hospital, Dublin, Ireland.
Dolphin H; Institute of Memory and Cognition, Tallaght University Hospital, Dublin, Ireland.
Russell C; Department of Neurology, Tallaght University Hospital, Dublin, Ireland.
Ryan M; Department of Neurology, Tallaght University Hospital, Dublin, Ireland.
Kennelly SP; Institute of Memory and Cognition, Tallaght University Hospital, Dublin, Ireland.
O'Dowd S; Department of Neurology, Tallaght University Hospital, Dublin, Ireland.; Institute of Memory and Cognition, Tallaght University Hospital, Dublin, Ireland.
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Źródło:
International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2022 Aug; Vol. 37 (8).
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/cerebrospinal fluid
Alzheimer Disease*/drug therapy
Amyloid beta-Peptides*/cerebrospinal fluid
Aged ; Antibodies, Monoclonal, Humanized ; Biomarkers/cerebrospinal fluid ; Cognition ; Humans ; Peptide Fragments/cerebrospinal fluid ; Retrospective Studies ; United States ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł:
Development of informant-reported or self-reported MCI-J questionnaire.
Autorzy:
Asada T; Memory Clinic Ochanomizu, Tokyo, Japan.; Tokyo Medical and Dental University, Tokyo, Japan.
Kakuma T; Biostatistics Center, Kurume University School of Medicine, Kurume, Japan.
Ota M; Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Jon Lebowitz A; Department of General Education, Jichi Medical University, Shimotsuke, Japan.
Shibata N; Mental Clinic, Juntendo Tokyo Koto Geriatric Medical Center, Koto-ku, Japan.
Niizato K; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Setagaya-ku, Japan.
Izumimoto N; Division of Internal Medicine, Yokufukai Hospital, Tokyo, Japan.
Abe Y; Division of Internal Medicine, Yokufukai Hospital, Tokyo, Japan.
Tanaka M; Brain Functions Laboratory Inc, Yokohama, Japan.
Arai T; Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
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Źródło:
International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2022 Aug; Vol. 37 (8).
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/psychology
Cognitive Dysfunction*/diagnosis
Cognitive Dysfunction*/psychology
Dementia*/diagnosis
Dementia*/psychology
Aged ; Humans ; Self Report ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł:
Association between obstructive sleep apnea and Alzheimer's disease-related blood and cerebrospinal fluid biomarkers: A meta-analysis.
Autorzy:
Kang J; Department of Respiratory, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Jilin Medical University, Jilin, Jilin 132013, China.
Tian Z; Department of Respiratory, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Wei J; Jilin Medical University, Jilin, Jilin 132013, China.
Mu Z; Department of Respiratory, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Liang J; Department of Pediatric Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: .
Li M; Department of Respiratory, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: .
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Źródło:
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2022 Aug; Vol. 102, pp. 87-94. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article; Meta-Analysis; Review
MeSH Terms:
Alzheimer Disease*/blood
Alzheimer Disease*/cerebrospinal fluid
Alzheimer Disease*/diagnosis
Sleep Apnea, Obstructive*/blood
Sleep Apnea, Obstructive*/cerebrospinal fluid
Sleep Apnea, Obstructive*/complications
Amyloid beta-Peptides/blood ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Humans ; Peptide Fragments/blood ; Peptide Fragments/cerebrospinal fluid ; tau Proteins/blood ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł:
A multi-target theranostic nano-composite against Alzheimer's disease fabricated by conjugating carbon dots and triple-functionalized human serum albumin.
Autorzy:
Wang W; Department of Biochemical Engineering, School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, China.
Lin X; Department of Biochemical Engineering, School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, China.
Dong X; Department of Biochemical Engineering, School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, China.
Sun Y; Department of Biochemical Engineering, School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, China. Electronic address: .
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Źródło:
Acta biomaterialia [Acta Biomater] 2022 Aug; Vol. 148, pp. 298-309. Date of Electronic Publication: 2022 Jun 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/drug therapy
Amyloid beta-Peptides*
Carbon ; Copper/pharmacology ; Humans ; Precision Medicine ; Reactive Oxygen Species ; Serum Albumin, Human
Czasopismo naukowe
Tytuł:
Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials.
Autorzy:
Ossenkoppele R; Clinical Memory Research Unit, Lund University, Malmö, Sweden; Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands. Electronic address: .
van der Kant R; Alzheimer Center Amsterdam, Department of Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands; Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands.
Hansson O; Clinical Memory Research Unit, Lund University, Malmö, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
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Źródło:
The Lancet. Neurology [Lancet Neurol] 2022 Aug; Vol. 21 (8), pp. 726-734. Date of Electronic Publication: 2022 May 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/metabolism
Alzheimer Disease*/therapy
Cognitive Dysfunction*/metabolism
Amyloid beta-Peptides/metabolism ; Biomarkers ; Brain/pathology ; Humans ; Neuroimaging ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł:
Nontoxic silicene photothermal agents with high near-infrared absorption for disassembly of Alzheimer's amyloid‑β fibrils.
Autorzy:
Liang X; Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology; School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China; Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong, China.
Wang Y; Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, DK-8000, Denmark.
Song J; Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology; School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China; Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong, China.
Xia D; Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology; School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, China. Electronic address: .
Li Q; Key Laboratory of Colloid and Interface Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, Shandong, China. Electronic address: .
Dong M; Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, DK-8000, Denmark. Electronic address: .
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Źródło:
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2022 Aug; Vol. 216, pp. 112575. Date of Electronic Publication: 2022 May 15.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Amyloid/chemistry ; Amyloid beta-Peptides/chemistry ; Circular Dichroism ; Humans ; Oxidation-Reduction
Czasopismo naukowe
Tytuł:
Coagulansin-A improves spatial memory in 5xFAD Tg mice by targeting Nrf-2/NF-κB and Bcl-2 pathway.
Autorzy:
Shal B; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Faculty of Health Sciences, IQRA University, Islamabad Campus, (Chak Shahzad), Islamabad, Pakistan.
Khan A; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Ullah Khan A; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Abasyn University, Peshawar, Pakistan.
Ullah R; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
Naveed M; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Ali G; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
Ul Islam S; Department of Pharmacy, Cecos University, Hayatabad, Peshawar 25,000, Pakistan.
Ul Haq I; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Mirza B; Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Khan S; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2022 Aug; Vol. 109, pp. 108860. Date of Electronic Publication: 2022 May 19.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Amyloid beta-Peptides*/metabolism
Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Disease Models, Animal ; GA-Binding Protein Transcription Factor ; Hydrogen Peroxide ; Mice ; Mice, Transgenic ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Spatial Memory ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe

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