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Wyszukujesz frazę ""Alzheimer Disease"" wg kryterium: Temat


Tytuł:
Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer's disease.
Autorzy:
Cao W; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Ji Z; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Zhu S; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Wang M; Department of Rehabilitation, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Sun R; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2024 Jan 02; Vol. 17 (1), pp. 6. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/genetics
Neurodegenerative Diseases*
Animals ; Mice ; Sirtuin 2/genetics ; Gene Expression Profiling ; Protein Interaction Maps/genetics ; Computational Biology ; RNA, Messenger ; Gene Regulatory Networks
Czasopismo naukowe
Tytuł:
Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer's Disease in individuals of African Ancestry.
Autorzy:
Nuytemans K; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Rajabli F; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Jean-Francois M; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Kurup JT; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Adams LD; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Starks TD; Maya Angelou Center for Health Equity, Wake Forest University, Winston-Salem, NC, USA.
Whitehead PL; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Kunkle BW; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Caban-Holt A; Maya Angelou Center for Health Equity, Wake Forest University, Winston-Salem, NC, USA.
Haines JL; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Cuccaro ML; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Vance JM; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Byrd GS; Maya Angelou Center for Health Equity, Wake Forest University, Winston-Salem, NC, USA.
Beecham GW; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Reitz C; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Departments of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Pericak-Vance MA; John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA; Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address: .
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Corporate Authors:
NIA-LOAD Family-Based Study
Alzheimer’s Disease Sequencing Project
Źródło:
Neurobiology of aging [Neurobiol Aging] 2024 Jan; Vol. 133, pp. 125-133. Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/epidemiology
Humans ; Lod Score ; Genetic Linkage/genetics ; Haplotypes ; Chromosomes ; Genetic Predisposition to Disease/genetics
Czasopismo naukowe
Tytuł:
The effect of black mulberry (Morus nigra) consumption on cognition in patients with mild-to-moderate Alzheimer's dementia: A pilot feasibility study.
Autorzy:
Güçer Öz Y; Yuksek Ihtisas University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Türkiye; Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Türkiye.
Naharcı Mİ; University of Health Sciences Gülhane Training and Research Hospital, Department of Geriatrics, Ankara, Türkiye.
Çelebi F; University of Health Sciences Gülhane Training and Research Hospital, Department of Geriatrics, Ankara, Türkiye.
Rakıcıoğlu N; Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Türkiye.
Göktaş Z; Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Türkiye. Electronic address: .
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Źródło:
Geriatric nursing (New York, N.Y.) [Geriatr Nurs] 2024 Jan-Feb; Vol. 55, pp. 229-236. Date of Electronic Publication: 2023 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/psychology
Morus*
Humans ; Aged ; Feasibility Studies ; Cognition ; Neuropsychological Tests
Czasopismo naukowe
Tytuł:
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease.
Autorzy:
Rahmani F; Washington University School of Medicine, St. Louis, Missouri, USA.
Brier MR; Washington University School of Medicine, St. Louis, Missouri, USA.
Gordon BA; Washington University School of Medicine, St. Louis, Missouri, USA.
McKay N; Washington University School of Medicine, St. Louis, Missouri, USA.
Flores S; Washington University School of Medicine, St. Louis, Missouri, USA.
Keefe S; Washington University School of Medicine, St. Louis, Missouri, USA.
Hornbeck R; Washington University School of Medicine, St. Louis, Missouri, USA.
Ances B; Washington University School of Medicine, St. Louis, Missouri, USA.
Joseph-Mathurin N; Washington University School of Medicine, St. Louis, Missouri, USA.
Xiong C; Washington University School of Medicine, St. Louis, Missouri, USA.
Wang G; Washington University School of Medicine, St. Louis, Missouri, USA.
Raji CA; Washington University School of Medicine, St. Louis, Missouri, USA.
Libre-Guerra JJ; Washington University School of Medicine, St. Louis, Missouri, USA.
Perrin RJ; Washington University School of Medicine, St. Louis, Missouri, USA.
McDade E; Washington University School of Medicine, St. Louis, Missouri, USA.
Daniels A; Washington University School of Medicine, St. Louis, Missouri, USA.
Karch C; Washington University School of Medicine, St. Louis, Missouri, USA.
Day GS; Mayo Clinic, Department of Neurology, Jacksonville, Florida, USA.
Brickman AM; Taub Institute for Research on Alzheimer's Disease & the Aging Brain, and Department of Neurology College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Fulham M; Royal Prince Alfred Hospital (RPA), Sydney, Australia.
Jack CR Jr; Mayo Clinic, Rochester, Minnesota, USA.
la La Fougère C; Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE) Tuebingen, Tübingen, Germany.; Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.
Reischl G; Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE) Tuebingen, Tübingen, Germany.; Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.
Schofield PR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Oh H; Brown University, Providence, Rhode Island, USA.
Levin J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), site Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Vöglein J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), site Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Cash DM; UK Dementia Research Institute at University College London, London, UK.; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Yakushev I; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), site Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Ikeuchi T; Niigata University, Brain Research Institute, Niigata, Japan.
Klunk WE; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Morris JC; Washington University School of Medicine, St. Louis, Missouri, USA.
Bateman RJ; Washington University School of Medicine, St. Louis, Missouri, USA.
Benzinger TLS; Washington University School of Medicine, St. Louis, Missouri, USA.
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Corporate Authors:
Dominantly Inherited Alzheimer Network (DIAN)
Źródło:
Human brain mapping [Hum Brain Mapp] 2023 Dec 15; Vol. 44 (18), pp. 6375-6387. Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Alzheimer Disease*/complications
Humans ; Amyloid beta-Peptides ; Magnetic Resonance Imaging/methods ; Positron-Emission Tomography ; Biomarkers ; Atrophy ; tau Proteins
Czasopismo naukowe
Tytuł:
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Autorzy:
Du Y; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Bradshaw WJ; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK.
Leisner TM; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Annor-Gyamfi JK; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Structural Genomics Consortium, Chapel Hill, North Carolina, USA.
Qian K; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Bashore FM; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Structural Genomics Consortium, Chapel Hill, North Carolina, USA.
Sikdar A; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Nwogbo FO; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Ivanov AA; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Frye SV; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA.
Gileadi O; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK.
Brennan PE; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK.
Levey AI; Department of Neurology, Emory Goizueta Alzheimer's Disease Research Center, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia, USA.
Axtman AD; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Structural Genomics Consortium, Chapel Hill, North Carolina, USA. Electronic address: .
Pearce KH; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chapel Hill, North Carolina, USA. Electronic address: .
Fu H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA; Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: .
Katis VL; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK. Electronic address: .
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Corporate Authors:
Emory-Sage-SGC TREAT-AD Center
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105382. Date of Electronic Publication: 2023 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Alzheimer Disease*/pathology
Protein Binding*/drug effects
Humans ; FERM Domains ; Hyaluronan Receptors/metabolism ; Proteomics
Czasopismo naukowe
Tytuł:
Genome-wide epistasis analysis reveals gene-gene interaction network on an intermediate endophenotype P-tau/Aβ 42 ratio in ADNI cohort.
Autorzy:
Zhang Q; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Liu J; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Liu H; College of Intelligent Systems Science and Engineering, Harbin Engineering University, 145 Nantong Street, Harbin, China.
Ao L; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Xi Y; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Chen D; School of Automation Engineering, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China. .; College of Intelligent Systems Science and Engineering, Harbin Engineering University, 145 Nantong Street, Harbin, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 17; Vol. 14 (1), pp. 3984. Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/cerebrospinal fluid
Humans ; Aged ; Epistasis, Genetic ; Endophenotypes ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/cerebrospinal fluid ; Genome-Wide Association Study ; tau Proteins/genetics ; tau Proteins/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Peptide Fragments/genetics
Czasopismo naukowe
Tytuł:
The search for clarity regarding "clinically meaningful outcomes" in Alzheimer disease clinical trials: CLARITY-AD and Beyond.
Autorzy:
Tarawneh R; Department of Neurology and Center for Memory and Aging, University of New Mexico, Albuquerque, NM, USA. .
Pankratz VS; Department of Internal Medicine, Division of Epidemiology, Biostatistics, and Preventive Medicine, University of New Mexico, Albuquerque, NM, USA.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 16; Vol. 16 (1), pp. 37. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Letter
MeSH Terms:
Alzheimer Disease*/drug therapy
Cognitive Dysfunction*/drug therapy
Humans ; Brain ; Disease Progression
Opinia redakcyjna
Tytuł:
Life course plasma metabolomic signatures of genetic liability to Alzheimer's disease.
Autorzy:
Compton H; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.
Smith ML; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Bull C; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Translational Health Sciences, University of Bristol, Bristol, UK.
Korologou-Linden R; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Ben-Shlomo Y; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.
Bell JA; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Williams DM; MRC Unit for Lifelong Health & Ageing at UCL, University College London, London, UK.
Anderson EL; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK. .; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. .; Division of Psychiatry, University College London, 149 Tottenham Court Road, London, W1T 7NF, UK. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 16; Vol. 14 (1), pp. 3896. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Child ; Humans ; Genotype ; Longitudinal Studies ; Life Change Events ; Apolipoproteins E/genetics ; Apolipoprotein E4/genetics
Czasopismo naukowe
Tytuł:
Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort.
Autorzy:
Sáez ME; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Centro Andaluz de Estudios Bioinformáticos (CAEBI), Seville, Spain.
García-Sánchez A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
de Rojas I; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Alarcón-Martín E; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Martínez J; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Cano A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
García-González P; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Puerta R; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Olivé C; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Capdevila M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
García-Gutiérrez F; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Castilla-Martí M; Clínica Oftalmológica Dr. Castilla, Barcelona, Spain.; Vista Alpina Eye Clinic, Visp, Switzerland.
Castilla-Martí L; PhD Programme in Surgery and Morphological Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain.; Hôpital ophtalmique Jules-Gonin, Fondation asiles des aveugles, University of Lausanne, Lausanne, Switzerland.
Espinosa A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Alegret M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Ricciardi M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Pytel V; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Valero S; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Tárraga L; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Boada M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Ruiz A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain. .; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. .; Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA. .
Marquié M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 16; Vol. 16 (1), pp. 38. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Genome-Wide Association Study*
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Alzheimer Disease*/complications
Humans ; Genetic Risk Score ; Nerve Fibers ; Tomography, Optical Coherence/methods ; Cognition
Czasopismo naukowe
Tytuł:
Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer's disease.
Autorzy:
Walker L; Translational and Clinical Research Institute, Newcastle University, Edwardson building, Campus for Ageing and Vitality, Newcastle-upon-Tyne, NE4 5PL, UK. .
Simpson H; Translational and Clinical Research Institute, Newcastle University, Edwardson building, Campus for Ageing and Vitality, Newcastle-upon-Tyne, NE4 5PL, UK.
Thomas AJ; Translational and Clinical Research Institute, Newcastle University, Edwardson building, Campus for Ageing and Vitality, Newcastle-upon-Tyne, NE4 5PL, UK.
Attems J; Translational and Clinical Research Institute, Newcastle University, Edwardson building, Campus for Ageing and Vitality, Newcastle-upon-Tyne, NE4 5PL, UK.
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 15; Vol. 12 (1), pp. 28. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/epidemiology
Alzheimer Disease*/complications
Lewy Body Disease*/pathology
Dementia*/pathology
Parkinson Disease*/pathology
Cerebral Amyloid Angiopathy*/complications
Humans ; Amyloid beta-Peptides ; Prevalence
Czasopismo naukowe
Tytuł:
Colony Stimulating Factor-1 Receptor: An emerging target for neuroinflammation PET imaging and AD therapy.
Autorzy:
Adhikari A; Department of Chemistry, Graphic Era Hill University, Clement Town, Dehradun, Uttarakhand, India. Electronic address: .
Chauhan K; Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km 107 carretera, Tijuana-Ensenada, Baja California 22860, Mexico.
Adhikari M; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Tiwari AK; Department of Chemistry, Babasaheb, Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India.
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Feb 15; Vol. 100, pp. 117628. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Neurodegenerative Diseases*/diagnostic imaging
Neurodegenerative Diseases*/drug therapy
Neurodegenerative Diseases*/metabolism
Humans ; Aged ; Neuroinflammatory Diseases ; Amyloid beta-Peptides/metabolism ; Positron-Emission Tomography/methods ; Receptor Protein-Tyrosine Kinases/metabolism ; Colony-Stimulating Factors/metabolism ; Microglia/metabolism
Czasopismo naukowe
Tytuł:
Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils.
Autorzy:
Elbatrawy AA; Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Ademoye TA; Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Alnakhala H; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Tripathi A; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Zami A; Molecular Evolution, Protein Engineering, and Production facility in Discovery Park, Purdue University, West Lafayette, IN 47907, USA.
Ostafe R; Molecular Evolution, Protein Engineering, and Production facility in Discovery Park, Purdue University, West Lafayette, IN 47907, USA.
Dettmer U; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Fortin JS; Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA. Electronic address: .
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Źródło:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Feb 15; Vol. 100, pp. 117613. Date of Electronic Publication: 2024 Jan 28.
Typ publikacji:
Journal Article
MeSH Terms:
Parkinson Disease*/metabolism
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Humans ; alpha-Synuclein/metabolism ; tau Proteins/metabolism ; Benzothiazoles/pharmacology
Czasopismo naukowe
Tytuł:
Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and β-secretase inhibitors.
Autorzy:
Banoo R; Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India.
Nuthakki VK; Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India.
Wadje BN; Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, Telangana, India.
Sharma A; Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India.
Bharate SB; Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India; Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, Telangana, India. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Feb 15; Vol. 266, pp. 116131. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Cholinesterases*/metabolism
Humans ; Acetylcholinesterase/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Blood-Brain Barrier/metabolism ; Cholinesterase Inhibitors/chemistry ; Drug Design ; Indoles/pharmacology ; Indoles/metabolism ; Piperidines ; Structure-Activity Relationship ; Amides/chemistry ; Amides/pharmacology
Czasopismo naukowe
Tytuł:
The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease.
Autorzy:
Das S; Department of Laboratory Medicine, Neurochemistry Laboratory, Amsterdam, UMC location VrijeUniversiteit Amsterdam, Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.; ADx NeuroSciences, Technologiepark-Zwijnaarde 6, 9052, Gent, Belgium.
van Engelen ME; Neurology, Amsterdam UMC location VUmc, Alzheimer Center Amsterdam, VrijeUniversiteit Amsterdam, De Boelelaan 1118, Amsterdam, 1081 HZ, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands.
Goossens J; ADx NeuroSciences, Technologiepark-Zwijnaarde 6, 9052, Gent, Belgium.
Jacobs D; ADx NeuroSciences, Technologiepark-Zwijnaarde 6, 9052, Gent, Belgium.
Bongers B; Department of Laboratory Medicine, Neurochemistry Laboratory, Amsterdam, UMC location VrijeUniversiteit Amsterdam, Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
Fieldhouse JLP; Neurology, Amsterdam UMC location VUmc, Alzheimer Center Amsterdam, VrijeUniversiteit Amsterdam, De Boelelaan 1118, Amsterdam, 1081 HZ, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands.
Pijnenburg YAL; Neurology, Amsterdam UMC location VUmc, Alzheimer Center Amsterdam, VrijeUniversiteit Amsterdam, De Boelelaan 1118, Amsterdam, 1081 HZ, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands.
Teunissen CE; Department of Laboratory Medicine, Neurochemistry Laboratory, Amsterdam, UMC location VrijeUniversiteit Amsterdam, Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.; Neurology, Amsterdam UMC location VUmc, Alzheimer Center Amsterdam, VrijeUniversiteit Amsterdam, De Boelelaan 1118, Amsterdam, 1081 HZ, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands.
Vanmechelen E; ADx NeuroSciences, Technologiepark-Zwijnaarde 6, 9052, Gent, Belgium.
Verberk IMW; Department of Laboratory Medicine, Neurochemistry Laboratory, Amsterdam, UMC location VrijeUniversiteit Amsterdam, Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands. .; Neurology, Amsterdam UMC location VUmc, Alzheimer Center Amsterdam, VrijeUniversiteit Amsterdam, De Boelelaan 1118, Amsterdam, 1081 HZ, The Netherlands. .; Amsterdam Neuroscience, Neurodegeneration, De Boelelaan 1085, Amsterdam, 1081 HV, The Netherlands. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 14; Vol. 16 (1), pp. 34. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/cerebrospinal fluid
Frontotemporal Dementia*/pathology
Frontotemporal Lobar Degeneration*/diagnosis
Humans ; ROC Curve ; Neuropsychological Tests ; Biomarkers/cerebrospinal fluid
Czasopismo naukowe
Tytuł:
Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology.
Autorzy:
Wallace CH; Department of Biological Sciences, Hunter College CUNY and Graduate Center, 695 Park Ave., New York, NY, USA.
Oliveros G; Department of Biological Sciences, Hunter College CUNY and Graduate Center, 695 Park Ave., New York, NY, USA.
Xie L; Department of Computer Sciences, Hunter College CUNY, New York, NY, USA.
Serrano P; Department of Psychology, Hunter College CUNY, New York, NY, USA.
Rockwell P; Department of Biological Sciences, Hunter College CUNY and Graduate Center, 695 Park Ave., New York, NY, USA.
Figueiredo-Pereira M; Department of Biological Sciences, Hunter College CUNY and Graduate Center, 695 Park Ave., New York, NY, USA. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 14; Vol. 14 (1), pp. 3730. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Chalcones*
Female ; Rats ; Animals ; Rats, Transgenic ; Diazoxide/therapeutic use ; Rats, Inbred F344 ; Spatial Memory ; Biomarkers ; Disease Models, Animal ; Amyloid beta-Peptides
Czasopismo naukowe
Tytuł:
Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer's disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study.
Autorzy:
Tseng PH; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan.; Department of Nursing, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan.; Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan.
Huang WT; Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 707, Sec 3, Zhongyang Road, Hualien, 970, Taiwan.
Wang JH; Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 707, Sec 3, Zhongyang Road, Hualien, 970, Taiwan.
Huang BR; Department of Neurosurgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, 427, Taiwan.; School of Medicine, Tzu Chi University, Hualien, 970, Taiwan.
Huang HY; Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 707, Sec 3, Zhongyang Road, Hualien, 970, Taiwan. .
Tsai ST; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan. .; Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan. .; School of Medicine, Tzu Chi University, Hualien, 970, Taiwan. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Feb 14; Vol. 21 (1), pp. 16. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/epidemiology
Alzheimer Disease*/complications
Hydrocephalus, Normal Pressure*/epidemiology
Hydrocephalus, Normal Pressure*/surgery
Hydrocephalus, Normal Pressure*/complications
Dementia, Vascular*
Humans ; Cohort Studies ; Cerebrospinal Fluid Shunts
Czasopismo naukowe
Tytuł:
Impaired 24-h activity patterns are associated with an increased risk of Alzheimer's disease, Parkinson's disease, and cognitive decline.
Autorzy:
Winer JR; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA. .
Lok R; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Weed L; Department of Bioengineering, Stanford University, Stanford, CA, USA.
He Z; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA.
Poston KL; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Mormino EC; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA, 94304, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Zeitzer JM; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.; Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 14; Vol. 16 (1), pp. 35. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Parkinson Disease*/epidemiology
Alzheimer Disease*/epidemiology
Alzheimer Disease*/complications
Neurodegenerative Diseases*
Cognitive Dysfunction*/psychology
Humans ; Longitudinal Studies ; Prospective Studies
Czasopismo naukowe
Tytuł:
Disease-Associated Neurotoxic Astrocyte Markers in Alzheimer Disease Based on Integrative Single-Nucleus RNA Sequencing.
Autorzy:
Yu W; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong, Chongqing, 400016, China.
Li Y; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhong F; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong, Chongqing, 400016, China.
Deng Z; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong, Chongqing, 400016, China.
Wu J; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong, Chongqing, 400016, China.
Yu W; Institutes of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Lü Y; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong, Chongqing, 400016, China. .
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Źródło:
Cellular and molecular neurobiology [Cell Mol Neurobiol] 2024 Feb 12; Vol. 44 (1), pp. 20. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Neurodegenerative Diseases*/metabolism
Humans ; Mice ; Animals ; Astrocytes/metabolism ; Sequence Analysis, RNA ; RNA, Small Nuclear/metabolism ; Amyloid beta-Peptides/metabolism ; Carboxypeptidases/metabolism ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł:
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease.
Autorzy:
Raulin AC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Doss SV; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Heckman MG; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Craver EC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Li Z; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Ikezu TC; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA.
Sekiya H; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Biogen, Cambridge, MA, 02142, USA.
Martens YA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; SciNeuro Pharmaceuticals, Rockville, MD, 20850, USA.
Rosenberg CL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Kuchenbecker LA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
DeTure M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Reichard RR; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Nguyen AT; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Constantopoulos E; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Larsen RA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Kounaves EK; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Kanekiyo T; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Feb 09; Vol. 12 (1), pp. 25. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/pathology
Tauopathies*/pathology
Humans ; Apolipoprotein E4/genetics ; Amyloid beta-Peptides ; Apolipoproteins E/genetics ; Amyloid ; tau Proteins
Czasopismo naukowe
Tytuł:
Mendelian randomization to evaluate the effect of folic acid supplement on the risk of Alzheimer disease.
Autorzy:
Sun X; Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
He C; Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Yang S; Department of Laboratory Medicine, The people's Hospital of Liaoning Province, Shenyang, China.
Li W; Department of Laboratory Medicine, The people's Hospital of Liaoning Province, Shenyang, China.
Qu H; Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
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Źródło:
Medicine [Medicine (Baltimore)] 2024 Feb 09; Vol. 103 (6), pp. e37021.
Typ publikacji:
Journal Article
MeSH Terms:
Folic Acid*/therapeutic use
Alzheimer Disease*/epidemiology
Alzheimer Disease*/genetics
Alzheimer Disease*/prevention & control
Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Dietary Supplements
Czasopismo naukowe

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