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Tytuł:
Pathophysiology characterization of Alzheimer's disease in South China's aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS).
Autorzy:
Liu Z; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Shi D; Neurology Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, China.
Cai Y; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Li A; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Lan G; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Sun P; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Liu L; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Zhu Y; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Yang J; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Zhou Y; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Guo L; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Zhang L; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Deng S; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Chen S; Neurology Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, China.
Yu X; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
Chen X; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.; Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, 518000, China.
Zhao R; Department of Nuclear Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China.
Wang Q; Department of Neurology, University of Chinese Academy of Sciences-Shenzhen Hospital, Shenzhen, 518107, China.
Ran P; Department of Nuclear Medicine, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
Xu L; Department of Medical Imaging, University of Chinese Academy of Sciences-Shenzhen Hospital, Shenzhen, 518106, China.
Zhou L; Neurology Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518000, China.
Sun K; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
Wang X; Department of Nuclear Medicine, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China.
Peng Q; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.
Han Y; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China.; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.; School of Biomedical Engineering, Hainan University, Haikou, 570228, China.; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China.; National Clinical Research Center for Geriatric Diseases, Beijing, 100053, China.
Guo T; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, No.5 Kelian Road, Shenzhen, 518132, China. .; Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Apr 16; Vol. 16 (1), pp. 84. Date of Electronic Publication: 2024 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/epidemiology
Healthy Aging*
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/epidemiology
Humans ; Aged ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Positron-Emission Tomography ; Biomarkers ; tau Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer's disease.
Autorzy:
Wang X; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Zhang X; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Liu J; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Zhang J; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Liu C; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Cui Y; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Song Q; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Hou Y; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Wang Y; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Zhang Q; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Zhang Y; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Fan Y; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Jia J; National Clinical Research Center for Geriatric Disorders, 45 Changchun Street, Beijing, 100053, China. .; Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. .; Beijing Key Laboratory of Geriatric Cognitive Disorders, 45 Changchun Street, Beijing, 100053, China. .; Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. .; Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, 45 Changchun Street, Beijing, 100053, China. .; Key Laboratory of Neurodegenerative Diseases, Ministry of Education, 45 Changchun Street, Beijing, 100053, China. .
Wang P; Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, 45 Changchun Street, Beijing, 100053, China. .; National Clinical Research Center for Geriatric Disorders, 45 Changchun Street, Beijing, 100053, China. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Apr 13; Vol. 16 (1), pp. 82. Date of Electronic Publication: 2024 Apr 13.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/genetics
Membrane Glycoproteins*/cerebrospinal fluid
Membrane Glycoproteins*/chemistry
Nerve Tissue Proteins*/cerebrospinal fluid
Nerve Tissue Proteins*/chemistry
Humans ; Apolipoprotein E4 ; Biomarkers ; Early Diagnosis ; Glycoproteins ; Synaptic Vesicles/chemistry ; Synaptic Vesicles/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Subclinical epileptiform discharges in Alzheimer's disease are associated with increased hippocampal blood flow.
Autorzy:
Musaeus CS; Danish Dementia Research Centre (DDRC), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns vej 8, Copenhagen, 2100, Denmark. .
Kjaer TW; Danish Dementia Research Centre (DDRC), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns vej 8, Copenhagen, 2100, Denmark.
Lindberg U; Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, University of Copenhagen, Valdemar Hansens Vej 13, Glostrup, 2600, Denmark.
Vestergaard MB; Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, University of Copenhagen, Valdemar Hansens Vej 13, Glostrup, 2600, Denmark.
Bo H; Danish Dementia Research Centre (DDRC), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns vej 8, Copenhagen, 2100, Denmark.
Larsson W; Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, University of Copenhagen, Valdemar Hansens Vej 13, Glostrup, 2600, Denmark.
Press DZ; Berenson-Allen Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Andersen BB; Danish Dementia Research Centre (DDRC), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns vej 8, Copenhagen, 2100, Denmark.
Høgh P; Regional Dementia Research Centre, Department of Neurology, Zealand University Hospital, Vestermarksvej 11, Roskilde, 4000, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark.
Kidmose P; Department of Electrical and Computer Engineering, Aarhus University, Finlandsgade 22, Aarhus N, 8200, Denmark.
Hemmsen MC; T&W Engineering, Borupvang 2, Lillerød, 3450, Denmark.
Rank ML; T&W Engineering, Borupvang 2, Lillerød, 3450, Denmark.
Hasselbalch SG; Danish Dementia Research Centre (DDRC), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns vej 8, Copenhagen, 2100, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark.
Waldemar G; Danish Dementia Research Centre (DDRC), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns vej 8, Copenhagen, 2100, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark.
Frederiksen KS; Danish Dementia Research Centre (DDRC), Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Inge Lehmanns vej 8, Copenhagen, 2100, Denmark.; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200, Denmark.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Apr 12; Vol. 16 (1), pp. 80. Date of Electronic Publication: 2024 Apr 12.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnostic imaging
Epilepsy*/diagnostic imaging
Humans ; Hippocampus/diagnostic imaging ; Temporal Lobe ; Cerebrovascular Circulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer's disease.
Autorzy:
Liu C; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Cárdenas-Rivera A; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Teitelbaum S; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Birmingham A; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Alfadhel M; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Yaseen MA; Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Apr 10; Vol. 16 (1), pp. 78. Date of Electronic Publication: 2024 Apr 10.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Mice ; Animals ; Mice, Transgenic ; Neuroinflammatory Diseases ; Cerebrovascular Circulation/physiology ; Disease Models, Animal ; Oxygen
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pathophysiological subtypes of mild cognitive impairment due to Alzheimer's disease identified by CSF proteomics.
Autorzy:
Moutinho D; Faculty of Medicine, University of Lisbon, 1649-028, Lisbon, Portugal.
Mendes VM; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
Caula A; LASIGE, Faculty of Sciences, University of Lisbon, 1649-028, Lisbon, Portugal.; Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Madeira SC; LASIGE, Faculty of Sciences, University of Lisbon, 1649-028, Lisbon, Portugal.
Baldeiras I; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Guerreiro M; Faculty of Medicine, University of Lisbon, 1649-028, Lisbon, Portugal.
Cardoso S; Faculty of Medicine, University of Lisbon, 1649-028, Lisbon, Portugal.
Gobom J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, S-431 80, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, S-431 80, Mölndal, Sweden.
Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, S-431 80, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, S-431 80, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin-Madison, Madison, WI, 53792, USA.; UK Dementia Research Institute at UCL, London, WC1N 3BG, UK.
Santana I; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Department of Neurology, Hospital and University Centre of Coimbra, Coimbra, Portugal.
De Mendonça A; Faculty of Medicine, University of Lisbon, 1649-028, Lisbon, Portugal.
Aidos H; LASIGE, Faculty of Sciences, University of Lisbon, 1649-028, Lisbon, Portugal.
Manadas B; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal. .; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2024 Apr 09; Vol. 13 (1), pp. 19. Date of Electronic Publication: 2024 Apr 09.
Typ publikacji:
Letter
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnosis
Cognitive Dysfunction*/diagnosis
Humans ; Proteomics ; tau Proteins
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biomarker profiling to determine clinical impact of microRNAs in cognitive disorders.
Autorzy:
Zhai W; Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, Changchun, 130021, China.; Department of Neurology, Cognitive Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Zhao M; Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, Changchun, 130021, China.; Department of Neurology, Cognitive Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Wei C; Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, Changchun, 130021, China.; Department of Neurology, Cognitive Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Zhang G; Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, Changchun, 130021, China.; Department of Neurology, Cognitive Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Qi Y; Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, Changchun, 130021, China.; Department of Neurology, Cognitive Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Zhao A; Department of Urology, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, Suzhou, 215000, China.
Sun L; Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, Changchun, 130021, China. .; Department of Neurology, Cognitive Center, The First Hospital of Jilin University, Jilin University, Changchun, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 09; Vol. 14 (1), pp. 8270. Date of Electronic Publication: 2024 Apr 09.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
Cognition Disorders*/etiology
Cognitive Dysfunction*/diagnosis
Cognitive Dysfunction*/genetics
Cognitive Dysfunction*/complications
Alzheimer Disease*/diagnosis
Alzheimer Disease*/genetics
Alzheimer Disease*/complications
Stroke*/complications
Humans ; Aged ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of the COVID-19 pandemic on mortality and loss to follow-up among patients with dementia receiving anti-dementia medications.
Autorzy:
Kwon HS; Department of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea.
Sung W; Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Park KU; Claim Data Analyst, Seoul, Republic of Korea.
Kim SH; Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea.
Koh SH; Department of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea.
Lim JS; Department of Neurology, Asan Medical Center, 88 Olympic-ro 43-gil Songpa-gu, Seoul, 05505, Republic of Korea. .
Choi H; Department of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 05; Vol. 14 (1), pp. 7986. Date of Electronic Publication: 2024 Apr 05.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/epidemiology
Alzheimer Disease*/drug therapy
Alzheimer Disease*/epidemiology
Humans ; Female ; Pandemics ; Follow-Up Studies ; Comorbidity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol.
Autorzy:
Svensson JE; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.
Bolin M; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Thor D; Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Williams PA; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
Brautaset R; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
Carlsson M; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Sörensson P; Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Marlevi D; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Spin-Neto R; Department of Dentistry and Oral Health, Section for Oral Radiology, Aarhus University, Aarhus C, Denmark.
Probst M; Department of Diagnostic and Interventional Neuroradiology, Klinikum Rechts Der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
Hagman G; Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Neurobiology, Care Sciences, and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Morén AF; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Kivipelto M; Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Neurobiology, Care Sciences, and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Faculty of Medicine, Imperial College London, London, UK.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Plavén-Sigray P; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. .; Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. .
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Źródło:
BMC neurology [BMC Neurol] 2024 Apr 04; Vol. 24 (1), pp. 111. Date of Electronic Publication: 2024 Apr 04.
Typ publikacji:
Clinical Trial Protocol; Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/drug therapy
Alzheimer Disease*/complications
Cognition Disorders*
Animals ; Mice ; Humans ; Aging ; Positron-Emission Tomography/methods ; Glucose/metabolism ; TOR Serine-Threonine Kinases ; Amyloid beta-Peptides/cerebrospinal fluid ; Clinical Trials, Phase II as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis.
Autorzy:
Terron HM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Parikh SJ; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Abdul-Hay SO; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Sahara T; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Kang D; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Saftig P; Institut für Biochemie, Christian-Albrechts-Universität zu Kiel, D-24098, Kiel, Germany.
LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697, USA.
Lane S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Leissring MA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA. .; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Apr 04; Vol. 16 (1), pp. 70. Date of Electronic Publication: 2024 Apr 04.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Tauopathies*/genetics
Tauopathies*/metabolism
Aged ; Animals ; Humans ; Mice ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Cathepsin D ; Disease Models, Animal ; Mice, Knockout ; Mice, Transgenic ; tau Proteins/genetics ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
[1- C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects.
Autorzy:
Mehta NH; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; Harvard Medical School, Boston, MA, USA.
Wang X; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Keil SA; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Xi K; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Zhou L; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Lee K; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; Weill Cornell Medicine, School of Medicine New York, New York, NY, USA.
Tan W; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Spector E; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; University of Michigan, Ann Arbor, MI, USA.
Goldan A; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Kelly J; Department of Radiology, Molecule Imaging Innovations Institute, Weill Cornell Medicine, New York, NY, USA.
Karakatsanis NA; Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Mozley PD; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; Radiopharm Theranostics, New York, NY, USA.
Nehmeh S; Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Chazen JL; Department of Radiology, Hospital for Special Surgery, New York, NY, USA.
Morin S; Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Babich J; Ratio Therapeutics, Boston Mass, USA.
Ivanidze J; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Pahlajani S; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Tanzi EB; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Saint-Louis L; Lenox Hill Radiology, New York, NY, USA.
Butler T; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Chen K; College of Health Solutions, Arizona State University, Downtown Phoenix Campus, Arizona, USA.
Rusinek H; Department of Radiology, NYU Langone Health, New York, NY, USA.
Carare RO; Faculty of Medicine, University of Southampton, Southampton, UK.
Li Y; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.
Chiang GC; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA.; Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
de Leon MJ; Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, 407 East 61 Street, 10065, New York, NY, USA. .
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Źródło:
Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Apr 02; Vol. 21 (1), pp. 30. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Neurodegenerative Diseases*/metabolism
Alzheimer Disease*/metabolism
Animals ; Humans ; Turbinates/metabolism ; Turbinates/pathology ; Butanols/metabolism ; Thiazoles/metabolism ; Positron-Emission Tomography/methods ; Aging ; Brain/metabolism ; 1-Butanol/metabolism ; Amyloid beta-Peptides/metabolism ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders.
Autorzy:
Momota Y; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.; Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-Ku, Chiba-Shi, Chiba, 263-8555, Japan.
Bun S; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan. .
Hirano J; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan. .
Kamiya K; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Ueda R; Office of Radiation Technology, Keio University Hospital, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Iwabuchi Y; Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Takahata K; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.; Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-Ku, Chiba-Shi, Chiba, 263-8555, Japan.
Yamamoto Y; Department of Functional Brain Imaging Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-Ku, Chiba-Shi, Chiba, 263-8555, Japan.
Tezuka T; Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Kubota M; Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Seki M; Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Shikimoto R; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Mimura Y; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Kishimoto T; Psychiatry Department, Donald and Barbara Zucker School of Medicine, Hempstead, NY, 11549, USA.; Hills Joint Research Laboratory for Future Preventive Medicine and Wellness, Keio University School of Medicine, Mori JP Tower F7, 1-3-1 Azabudai, Minato-ku, Tokyo, 106-0041, Japan.
Tabuchi H; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Jinzaki M; Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Ito D; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.; Memory Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Mimura M; Center for Preventive Medicine, Keio University, Mori JP Tower 7th Floor, 1-3-1 Azabudai, Minato-ku, Tokyo, 106-0041, Japan.
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 01; Vol. 14 (1), pp. 7633. Date of Electronic Publication: 2024 Apr 01.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/pathology
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/pathology
Humans ; Brain/pathology ; Amyloid beta-Peptides ; Magnetic Resonance Imaging/methods ; Machine Learning ; Apolipoproteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neuromodulation by nanozymes and ultrasound during Alzheimer's disease management.
Autorzy:
Karthika V; Department of Biomedical Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Badrinathan Sridharan; Department of Biomedical Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Nam JW; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Kim D; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan, 48513, Republic of Korea.
Gyun Lim H; Department of Biomedical Engineering, Pukyong National University, Busan, 48513, Republic of Korea. .; Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan, 48513, Republic of Korea. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2024 Mar 30; Vol. 22 (1), pp. 139. Date of Electronic Publication: 2024 Mar 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Nanostructures*
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/therapy
Neurodegenerative Diseases*
Humans ; Catalysis ; Metals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer's disease.
Autorzy:
Ng RC; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, UK.
Jian M; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ma OK; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Xiang AW; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Bunting M; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Kwan JS; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Wong CW; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Yick LW; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chung SK; Faculty of Medicine, Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery at Macau University of Science and Technology, Taipa, Macao, China.
Lam KS; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Research Center of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Pokfulam, Hong Kong, China.
Alexander IE; Gene Therapy Research Unit, Faculty of Medicine and Health, Children's Medical Research Institute and Sydney Children's Hospitals Network, The University of Sydney, Westmead, NSW, Australia.
Xu A; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China.; Research Center of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Pokfulam, Hong Kong, China.
Chan KH; Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 4/F, Professorial Block, 102 Pokfulam Road, Hong Kong, Special Administrative Region, China. .; Neuroimmunology and Neuroinflammation Research Laboratory, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. .; Research Center of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Pokfulam, Hong Kong, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 27; Vol. 21 (1), pp. 77. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/therapy
Alzheimer Disease*/pathology
Mice ; Animals ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Adiponectin/genetics ; Adiponectin/pharmacology ; Microglia ; Liver/pathology ; Amyloid beta-Peptides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health.
Autorzy:
Smith HM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Moodie JE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Monterrubio-Gómez K; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Gadd DA; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Chybowska AD; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Redmond P; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Page D; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Taylor A; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Corley J; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Harris SE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Valdés Hernández M; Centre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Muñoz Maniega S; Centre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Bastin ME; Centre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Wardlaw JM; Centre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Deary IJ; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Boardman JP; Centre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Mullin DS; Centre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Russ TC; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Cox SR; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. .
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2024 Mar 25; Vol. 16 (1), pp. 46. Date of Electronic Publication: 2024 Mar 25.
Typ publikacji:
Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
Alzheimer Disease*/diagnosis
Alzheimer Disease*/genetics
Humans ; Cross-Sectional Studies ; Brain ; Cognition ; Biomarkers ; Blood Proteins ; Epigenesis, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alzheimer's Disease: A Molecular Model and Implied Path to Improved Therapy.
Autorzy:
Weaver-Rosen MS; Department of Microbiology, Immunology and Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Serwer P; Department of Biochemistry and Structural Biology, UT Health, San Antonio, TX 78229, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 20; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Humans ; Cryoelectron Microscopy ; Amyloid/metabolism ; Amyloidogenic Proteins ; Models, Molecular ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer's disease.
Autorzy:
Verma P; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. .
Ranasinghe K; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Prasad J; Amador Valley High School, Pleasanton, CA, USA.
Cai C; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Xie X; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Lerner H; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Mizuiri D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Miller B; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Rankin K; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Vossel K; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Mary S. Easton Center for Alzheimer's Research and Care, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Cheung SW; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, USA.; Surgical Services, Veterans Affairs, San Francisco, USA.
Nagarajan SS; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Raj A; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Mar 19; Vol. 16 (1), pp. 62. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnostic imaging
Cognition Disorders*
Cognitive Dysfunction*/diagnostic imaging
Humans ; Middle Aged ; Aged ; Brain/diagnostic imaging ; Cognition
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer's disease in patients with mild cognitive symptoms.
Autorzy:
Arvidsson I; Centre for Mathematical Sciences, Lund University, Lund, Sweden. .
Strandberg O; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Cullen N; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Tideman P; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Heyden A; Centre for Mathematical Sciences, Lund University, Lund, Sweden.
Åström K; Centre for Mathematical Sciences, Lund University, Lund, Sweden.
Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden. .; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden. .; Department of Neurology, Skåne University Hospital, Lund, Sweden. .
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Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Mar 19; Vol. 16 (1), pp. 61. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnostic imaging
Deep Learning*
Cognitive Dysfunction*/diagnosis
Humans ; Biomarkers ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Brain/pathology ; Cognition ; Atrophy/pathology ; Disease Progression
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Monoclonal antibody therapy for Alzheimer's disease focusing on intracerebral targets.
Autorzy:
Gu X; College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
Qi L; New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China.
Qi Q; Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.; The Academy of Integrative Medicine of Fudan University, Shanghai, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Zhou J; Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.; The Academy of Integrative Medicine of Fudan University, Shanghai, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Chen S; Postdoctoral Station of Xiamen University, Fujian, China.
Wang L; Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.; The Academy of Integrative Medicine of Fudan University, Shanghai, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
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Źródło:
Bioscience trends [Biosci Trends] 2024 Mar 19; Vol. 18 (1), pp. 49-65. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
United States ; Humans ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Immunotherapy ; Inflammation/drug therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models.
Autorzy:
Wang R; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; School of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian 116044, China.
Kang S; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Zhao Z; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; School of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian 116044, China.
Jin L; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Cui X; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Chen L; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Schachner M; Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Li S; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; Department of Biochemistry, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Guo Y; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; Department of Microecology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Zhao J; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 17; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Neural Cell Adhesion Molecule L1*
Neurodegenerative Diseases*
Neuroblastoma*
Caffeic Acids*
Succinates*
Humans ; Mice ; Animals ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Mice, Transgenic ; Disease Models, Animal ; Aspartic Acid Endopeptidases/metabolism ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predicting long-term progression of Alzheimer's disease using a multimodal deep learning model incorporating interaction effects.
Autorzy:
Wang Y; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Gao R; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Wei T; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Johnston L; School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China.
Yuan X; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Zhang Y; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Yu Z; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China. .; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China. .; School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China. .; Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
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Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Journal of translational medicine [J Transl Med] 2024 Mar 11; Vol. 22 (1), pp. 265. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Multicenter Study; Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Deep Learning*
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/genetics
Cognitive Dysfunction*/pathology
Humans ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Disease Progression
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 37038

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