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Wyszukujesz frazę ""Alzheimer Disease"" wg kryterium: Temat


Tytuł:
Association of Plasma Claudin-5 with Age and Alzheimer Disease.
Autorzy:
Tachibana K; Graduate School of Pharmaceutical Sciences, Osaka University, Suita 565-0871, Osaka, Japan.
Hirayama R; Graduate School of Medicine, Osaka University, Suita 565-0871, Osaka, Japan.
Sato N; Graduate School of Medicine, Osaka University, Suita 565-0871, Osaka, Japan.; Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan.
Hattori K; Department of Bioresources, Medical Genome Center, National Center of Neurology and Psychiatry, Kodaira 187-8551, Tokyo, Japan.
Kato T; Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan.
Takeda H; Proteo-Science Center, Ehime University, Matsuyama 790-8577, Ehime, Japan.
Kondoh M; Graduate School of Pharmaceutical Sciences, Osaka University, Suita 565-0871, Osaka, Japan.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 24; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/blood
Alzheimer Disease*/diagnosis
Alzheimer Disease*/metabolism
Claudin-5*/blood
Claudin-5*/chemistry
Claudin-5*/metabolism
Cognitive Dysfunction*/blood
Cognitive Dysfunction*/diagnosis
Cognitive Dysfunction*/metabolism
Humans ; Amyloid beta-Peptides ; Biomarkers ; Blood-Brain Barrier ; Endothelial Cells ; tau Proteins
Czasopismo naukowe
Tytuł:
Bioinformatic identification and experiment validation reveal 6 hub genes, promising diagnostic and therapeutic targets for Alzheimer's disease.
Autorzy:
Cao W; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Ji Z; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Zhu S; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Wang M; Department of Rehabilitation, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China.
Sun R; Department of Neurology Second Ward, Zibo Municipal Hospital, No. 139, Huangong Road, Linzi District, Zibo City, 255400, Shandong Province, China. .
Źródło:
BMC medical genomics [BMC Med Genomics] 2024 Jan 02; Vol. 17 (1), pp. 6. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/genetics
Neurodegenerative Diseases*
Animals ; Mice ; Sirtuin 2/genetics ; Gene Expression Profiling ; Protein Interaction Maps/genetics ; Computational Biology ; RNA, Messenger ; Gene Regulatory Networks
Czasopismo naukowe
Tytuł:
Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer's disease.
Autorzy:
Verma P; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. .
Ranasinghe K; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Prasad J; Amador Valley High School, Pleasanton, CA, USA.
Cai C; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Xie X; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Lerner H; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Mizuiri D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Miller B; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Rankin K; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Vossel K; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.; Mary S. Easton Center for Alzheimer's Research and Care, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Cheung SW; Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, USA.; Surgical Services, Veterans Affairs, San Francisco, USA.
Nagarajan SS; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Raj A; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Mar 19; Vol. 16 (1), pp. 62. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnostic imaging
Cognition Disorders*
Cognitive Dysfunction*/diagnostic imaging
Humans ; Middle Aged ; Aged ; Brain/diagnostic imaging ; Cognition
Czasopismo naukowe
Tytuł:
Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer's disease in patients with mild cognitive symptoms.
Autorzy:
Arvidsson I; Centre for Mathematical Sciences, Lund University, Lund, Sweden. .
Strandberg O; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Cullen N; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Tideman P; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Heyden A; Centre for Mathematical Sciences, Lund University, Lund, Sweden.
Åström K; Centre for Mathematical Sciences, Lund University, Lund, Sweden.
Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden. .; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden. .; Department of Neurology, Skåne University Hospital, Lund, Sweden. .
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Mar 19; Vol. 16 (1), pp. 61. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnostic imaging
Deep Learning*
Cognitive Dysfunction*/diagnosis
Humans ; Biomarkers ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Brain/pathology ; Cognition ; Atrophy/pathology ; Disease Progression
Czasopismo naukowe
Tytuł:
Monoclonal antibody therapy for Alzheimer's disease focusing on intracerebral targets.
Autorzy:
Gu X; College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
Qi L; New Drug Screening Center, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China.
Qi Q; Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.; The Academy of Integrative Medicine of Fudan University, Shanghai, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Zhou J; Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.; The Academy of Integrative Medicine of Fudan University, Shanghai, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Chen S; Postdoctoral Station of Xiamen University, Fujian, China.
Wang L; Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.; The Academy of Integrative Medicine of Fudan University, Shanghai, China.; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Źródło:
Bioscience trends [Biosci Trends] 2024 Mar 19; Vol. 18 (1), pp. 49-65. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
United States ; Humans ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Immunotherapy ; Inflammation/drug therapy
Czasopismo naukowe
Tytuł:
Predicting long-term progression of Alzheimer's disease using a multimodal deep learning model incorporating interaction effects.
Autorzy:
Wang Y; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Gao R; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Wei T; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Johnston L; School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China.
Yuan X; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Zhang Y; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China.
Yu Z; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China. .; SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China. .; School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China. .; Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .
Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Journal of translational medicine [J Transl Med] 2024 Mar 11; Vol. 22 (1), pp. 265. Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Multicenter Study; Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Deep Learning*
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/genetics
Cognitive Dysfunction*/pathology
Humans ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Disease Progression
Czasopismo naukowe
Tytuł:
Exploring Spoken Discourse and Its Neural Correlates in Women With Alzheimer's Disease With Low Levels of Education and Socioeconomic Status.
Autorzy:
Malcorra BLC; Department of Linguistics, School of Humanities, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
García AO; Centre de recherche du Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal, Hôpital du Sacré-Cœur de Montréal, Québec, Canada.; École d'orthophonie et d'audiologie, Faculté de médecine, Université de Montréal, Québec, Canada.
Marcotte K; Centre de recherche du Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal, Hôpital du Sacré-Cœur de Montréal, Québec, Canada.; École d'orthophonie et d'audiologie, Faculté de médecine, Université de Montréal, Québec, Canada.
de Paz H; Centre de recherche du Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal, Hôpital du Sacré-Cœur de Montréal, Québec, Canada.; École d'orthophonie et d'audiologie, Faculté de médecine, Université de Montréal, Québec, Canada.
Schilling LP; Graduate Course in Medicine and Healthy Sciences, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.; Graduate Course in Biomedical Gerontology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.; Brain Institute of Rio Grande do Sul (InsCer)Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.; Institute of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
da Silva Filho IG; Graduate Course in Biomedical Gerontology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Soder R; Graduate Course in Medicine and Healthy Sciences, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.; Brain Institute of Rio Grande do Sul (InsCer)Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
da Rosa Franco A; Center for Biomedical Imaging and Neuromodulation, The Nathan S. Kline for Psychiatric Research, Orangeburg, NY.; Center for the Developing Brain, Child Mind Institute, New York, NY.; Department of Psychiatry, NYU Grossman School of Medicine, New York.
Loureiro F; Graduate Course in Biomedical Gerontology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Hübner LC; Department of Linguistics, School of Humanities, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.; Institute of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.; National Council for Scientific and Technological Development (CNPq), Brasília, DF, Brazil.
Źródło:
American journal of speech-language pathology [Am J Speech Lang Pathol] 2024 Mar 07; Vol. 33 (2), pp. 893-911. Date of Electronic Publication: 2023 Dec 29.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/psychology
Humans ; Female ; Brain ; Hippocampus/pathology ; Educational Status ; Social Class ; Magnetic Resonance Imaging/methods
Czasopismo naukowe
Tytuł:
Neuroanatomical and neurocognitive correlates of delusion in Alzheimer's disease and mild cognitive impairment.
Autorzy:
Kwak S; Department of Psychology, Pusan National University, Busan, Republic of Korea.
Kim H; Department of Psychiatry, Seoul National University College of Medicine & SMG-SNU Boramae Medical Center, Seoul, 07061, Republic of Korea.
Kim KY; Department of Psychiatry, Seoul National University College of Medicine & SMG-SNU Boramae Medical Center, Seoul, 07061, Republic of Korea.
Oh DY; Department of Psychiatry, Seoul National University College of Medicine & SMG-SNU Boramae Medical Center, Seoul, 07061, Republic of Korea.
Lee D; Department of Psychiatry, Seoul National University College of Medicine & SMG-SNU Boramae Medical Center, Seoul, 07061, Republic of Korea.
Nam G; Department of Psychiatry, Seoul National University College of Medicine & SMG-SNU Boramae Medical Center, Seoul, 07061, Republic of Korea.
Lee JY; Department of Psychiatry, Seoul National University College of Medicine & SMG-SNU Boramae Medical Center, Seoul, 07061, Republic of Korea. .; Department of Medical Device Development, Seoul National University College of Medicine, Seoul, Republic of Korea. .
Źródło:
BMC neurology [BMC Neurol] 2024 Mar 06; Vol. 24 (1), pp. 89. Date of Electronic Publication: 2024 Mar 06.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/diagnostic imaging
Cognitive Dysfunction*/diagnostic imaging
Humans ; Aged ; Delusions ; Cognition ; Brain/diagnostic imaging
Czasopismo naukowe
Tytuł:
A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer's disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial.
Autorzy:
Possemis N; Dept. of Psychiatry and Neuropsychology, School for Mental, Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.
Verhey F; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre+ (MUMC+), Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.
Prickaerts J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Blokland A; Faculty of Psychology and Neuroscience, Department of Neuropsychology & Psychopharmacology, EURON, Maastricht University, Maastricht, the Netherlands.
Ramakers I; Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre+ (MUMC+), Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands. .
Źródło:
Trials [Trials] 2024 Mar 04; Vol. 25 (1), pp. 162. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Clinical Trial Protocol; Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/drug therapy
Phosphodiesterase 4 Inhibitors*/adverse effects
Dementia*
Cognitive Dysfunction*/diagnosis
Cognitive Dysfunction*/drug therapy
Aminopyridines*
Benzamides*
Adult ; Aged ; Humans ; Randomized Controlled Trials as Topic ; Clinical Trials, Phase II as Topic ; Cyclopropanes
Czasopismo naukowe
Tytuł:
Genetic risk for Alzheimer's disease and adherence to the Mediterranean diet: results from the HELIAD study.
Autorzy:
Mamalaki E; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.
Charisis S; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.; Department of Neurology, UT Health San Antonio, San Antonio, TX, USA.
Mourtzi N; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.
Hatzimanolis A; Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.; Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece.
Ntanasi E; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.
Kosmidis MH; Lab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Constantinides VC; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.
Pantes G; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.
Kolovou D; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.
Dardiotis E; School of Medicine, University of Thessaly, Larissa, Greece.
Hadjigeorgiou G; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
Sakka P; Athens Association of Alzheimer's Disease and Related Disorders, Marousi, Greece.
Gu Y; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA.
Yannakoulia M; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
Scarmeas N; 1st Department of Neurology, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece.; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY, USA.
Źródło:
Nutritional neuroscience [Nutr Neurosci] 2024 Mar; Vol. 27 (3), pp. 289-299. Date of Electronic Publication: 2023 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/epidemiology
Alzheimer Disease*/genetics
Alzheimer Disease*/prevention & control
Diet, Mediterranean*
Cognition Disorders*
Humans ; Aged ; Longitudinal Studies ; Risk Factors
Czasopismo naukowe
Tytuł:
Progression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer's disease.
Autorzy:
Jönsson L; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, 171 64, Sweden. .
Ivkovic M; Novo Nordisk A/S, Søborg, Denmark.
Atri A; Banner Sun Health Research Institute and Banner Alzheimer's Institute, Banner Health, Sun City and Phoenix, AZ, USA.; Center for Brain/Mind Medicine, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Handels R; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, 171 64, Sweden.; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, Maastricht University Medical Centre+, Maastricht, MD, 6200, The Netherlands.
Gustavsson A; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, 171 64, Sweden.; Quantify Research, Hantverkargatan 8, Stockholm, 112 21, Sweden.
Hahn-Pedersen JH; Novo Nordisk A/S, Søborg, Denmark.
León T; Novo Nordisk A/S, Søborg, Denmark.
Lilja M; Quantify Research, Hantverkargatan 8, Stockholm, 112 21, Sweden.
Gundgaard J; Novo Nordisk A/S, Søborg, Denmark.
Raket LL; Novo Nordisk A/S, Søborg, Denmark.; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 29; Vol. 16 (1), pp. 48. Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/drug therapy
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/drug therapy
Humans ; Mental Status and Dementia Tests ; Research Design ; Disease Progression
Czasopismo naukowe
Tytuł:
Polygenic effects on the risk of Alzheimer's disease in the Japanese population.
Autorzy:
Kikuchi M; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, 6-2-3 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan. .; Department of Medical Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan. .
Miyashita A; Department of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata, 951-8585, Japan.
Hara N; Department of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata, 951-8585, Japan.
Kasuga K; Department of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata, 951-8585, Japan.
Saito Y; Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Institute of Geriatrics and Gerontology, Tokyo, Japan.
Murayama S; Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Institute of Geriatrics and Gerontology, Tokyo, Japan.; Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, Osaka, Japan.
Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Akatsu H; Department of General Medicine & General Internal Medicine, Nagoya City University Graduate School of Medicine, Nagoya, Japan.
Ozaki K; Medical Genome Center, National Center for Geriatrics and Gerontology, Research Institute, Aichi, Japan.; RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Niida S; Core Facility Administration, National Center for Geriatrics and Gerontology, Research Institute, Aichi, Japan.
Kuwano R; Social Welfare Corporation Asahigawaso, Asahigawaso Research Institute, Okayama, Japan.
Iwatsubo T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Nakaya A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, 6-2-3 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.
Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata, 951-8585, Japan. .
Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Japanese Alzheimer’s Disease Neuroimaging Initiative
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 27; Vol. 16 (1), pp. 45. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Alzheimer Disease*/cerebrospinal fluid
Cognitive Dysfunction*/diagnostic imaging
Cognitive Dysfunction*/genetics
Cognitive Dysfunction*/cerebrospinal fluid
Humans ; Genome-Wide Association Study ; Japan ; Biomarkers/cerebrospinal fluid ; Genetic Risk Score ; Apolipoproteins E/genetics
Czasopismo naukowe
Tytuł:
The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults.
Autorzy:
Rajendrakumar AL; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Arbeev KG; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA. .
Bagley O; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Yashin AI; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Ukraintseva S; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Corporate Authors:
Alzheimer’s Disease Neuroimaging Initiative
Źródło:
BMC neurology [BMC Neurol] 2024 Feb 27; Vol. 24 (1), pp. 78. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Cognitive Dysfunction*/diagnosis
Aged ; Humans ; Cognition ; Cross-Sectional Studies ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer's disease.
Autorzy:
Igeta Y; Department of Dementia, Dementia Center, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan. .; Division of Dementia Research, Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan. .
Hemmi I; Japanese Red Cross College of Nursing, 4-1-3 Hiroo, Shibuya-ku, Tokyo, 150-0012, Japan.
Yuyama K; Lipid Biofunction Section, Faculty of Advanced Life Science, Hokkaido University, Kita-21, Nishi-11, Kita-ku, Sapporo, 001-0021, Japan.
Ouchi Y; Department of Dementia, Dementia Center, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.; Division of Dementia Research, Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.
Źródło:
Scientific reports [Sci Rep] 2024 Feb 26; Vol. 14 (1), pp. 4658. Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnosis
Alzheimer Disease*/cerebrospinal fluid
Cognitive Dysfunction*/diagnosis
Cognitive Dysfunction*/cerebrospinal fluid
Humans ; Amyloid beta-Peptides/cerebrospinal fluid ; Odorants ; tau Proteins/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Apolipoprotein E4/genetics ; Peptide Fragments/cerebrospinal fluid
Czasopismo naukowe
Tytuł:
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease.
Autorzy:
Wang T; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Sobue A; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan. .; Medical Interactive Research and Academia Industry Collaboration Center, Research Institute of Environmental Medicine, Nagoya University, Aichi, Japan. .
Watanabe S; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.
Komine O; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.
Saido TC; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan.
Saito T; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan.; Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Yamanaka K; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi, 464-8601, Japan. .; Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Aichi, Japan. .; Institute for Glyco-Core Research (iGCORE), Nagoya University, Aichi, Japan. .; Center for One Medicine Innovative Translational Research (COMIT), Nagoya University, Nagoya, Aichi, Japan. .
Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Feb 21; Vol. 21 (1), pp. 55. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/complications
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/etiology
Mice ; Animals ; Dimethyl Fumarate/pharmacology ; Dimethyl Fumarate/therapeutic use ; Mice, Transgenic ; Neuroinflammatory Diseases ; NF-E2-Related Factor 2/metabolism ; Disease Models, Animal
Czasopismo naukowe
Tytuł:
Leading determinants of incident dementia among individuals with and without the apolipoprotein E ε4 genotype: a retrospective cohort study.
Autorzy:
Ye S; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.; Department of Ultrasound, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Roccati E; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, 7001, Australia.
Wang W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.
Zhu Z; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.; Centre for Eye Research Australia, Melbourne, VIC, 3002, Australia.
Kiburg K; Centre for Eye Research Australia, Melbourne, VIC, 3002, Australia.
Huang Y; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Zhang X; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Zhang X; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Liu J; Centre for Eye Research Australia, Melbourne, VIC, 3002, Australia.
Tang S; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Hu Y; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Ge Z; Monash e-Research Center, Faculty of Engineering, Airdoc Research, Nvidia AI Technology Research Center, Monash University, Melbourne, VIC, 3800, Australia.
Yu H; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. .
He M; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. mingguang_.; Centre for Eye Research Australia, Melbourne, VIC, 3002, Australia. mingguang_.; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China. mingguang_.
Shang X; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. .; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. .; Centre for Eye Research Australia, Melbourne, VIC, 3002, Australia. .; Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, VIC, 3050, Australia. .
Źródło:
BMC neurology [BMC Neurol] 2024 Feb 20; Vol. 24 (1), pp. 71. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Humans ; Apolipoprotein E4/genetics ; Biomarkers ; C-Reactive Protein/analysis ; Genotype ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Genome-wide epistasis analysis reveals gene-gene interaction network on an intermediate endophenotype P-tau/Aβ 42 ratio in ADNI cohort.
Autorzy:
Zhang Q; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Liu J; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Liu H; College of Intelligent Systems Science and Engineering, Harbin Engineering University, 145 Nantong Street, Harbin, China.
Ao L; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Xi Y; School of Computer Science, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China.
Chen D; School of Automation Engineering, Northeast Electric Power University, 169 Changchun Street, Jilin, 132012, China. .; College of Intelligent Systems Science and Engineering, Harbin Engineering University, 145 Nantong Street, Harbin, China. .
Źródło:
Scientific reports [Sci Rep] 2024 Feb 17; Vol. 14 (1), pp. 3984. Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/cerebrospinal fluid
Humans ; Aged ; Epistasis, Genetic ; Endophenotypes ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/cerebrospinal fluid ; Genome-Wide Association Study ; tau Proteins/genetics ; tau Proteins/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Peptide Fragments/genetics
Czasopismo naukowe
Tytuł:
The search for clarity regarding "clinically meaningful outcomes" in Alzheimer disease clinical trials: CLARITY-AD and Beyond.
Autorzy:
Tarawneh R; Department of Neurology and Center for Memory and Aging, University of New Mexico, Albuquerque, NM, USA. .
Pankratz VS; Department of Internal Medicine, Division of Epidemiology, Biostatistics, and Preventive Medicine, University of New Mexico, Albuquerque, NM, USA.
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 16; Vol. 16 (1), pp. 37. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Letter
MeSH Terms:
Alzheimer Disease*/drug therapy
Cognitive Dysfunction*/drug therapy
Humans ; Brain ; Disease Progression ; Clinical Trials as Topic
Opinia redakcyjna
Tytuł:
Life course plasma metabolomic signatures of genetic liability to Alzheimer's disease.
Autorzy:
Compton H; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.
Smith ML; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Bull C; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Translational Health Sciences, University of Bristol, Bristol, UK.
Korologou-Linden R; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Ben-Shlomo Y; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.
Bell JA; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Williams DM; MRC Unit for Lifelong Health & Ageing at UCL, University College London, London, UK.
Anderson EL; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK. .; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. .; Division of Psychiatry, University College London, 149 Tottenham Court Road, London, W1T 7NF, UK. .
Źródło:
Scientific reports [Sci Rep] 2024 Feb 16; Vol. 14 (1), pp. 3896. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Child ; Humans ; Genotype ; Longitudinal Studies ; Life Change Events ; Apolipoproteins E/genetics ; Apolipoprotein E4/genetics
Czasopismo naukowe
Tytuł:
Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort.
Autorzy:
Sáez ME; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Centro Andaluz de Estudios Bioinformáticos (CAEBI), Seville, Spain.
García-Sánchez A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
de Rojas I; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Alarcón-Martín E; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Martínez J; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Cano A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
García-González P; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Puerta R; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Olivé C; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Capdevila M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
García-Gutiérrez F; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Castilla-Martí M; Clínica Oftalmológica Dr. Castilla, Barcelona, Spain.; Vista Alpina Eye Clinic, Visp, Switzerland.
Castilla-Martí L; PhD Programme in Surgery and Morphological Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain.; Hôpital ophtalmique Jules-Gonin, Fondation asiles des aveugles, University of Lausanne, Lausanne, Switzerland.
Espinosa A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Alegret M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Ricciardi M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Pytel V; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Valero S; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Tárraga L; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Boada M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Ruiz A; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain. .; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. .; Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA. .
Marquié M; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Feb 16; Vol. 16 (1), pp. 38. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Genome-Wide Association Study*
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Alzheimer Disease*/complications
Humans ; Genetic Risk Score ; Nerve Fibers ; Tomography, Optical Coherence/methods ; Cognition
Czasopismo naukowe

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