Temat: "Alzheimer Disease metabolism" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Inhibition of 14-3-3/Tau by hybrid small-molecule peptides operating via two different binding modes
Index Terms :: 14-3-3
drug discovery
inhibitors
peptide chemistry
protein-protein interactions
tau
Phosphorylation
Magnetic Resonance Spectroscopy
Humans
Crystallography, X-Ray
Drug Discovery
Microtubules/metabolism
Protein Binding
14-3-3 Proteins/chemistry
tau Proteins/chemistry
Alzheimer Disease/metabolism
Neurofibrillary Tangles/metabolism
Cognitive Neuroscience
Biochemistry
Physiology
Cell Biology
Research Support, Non-U.S. Gov't
Journal Article
Tijdschriftartikel
Article
Źródło :: ACS Chemical Neuroscience vol.9 (2018) date: 2018-11-21 nr.11 p.2639–2654 [ISSN 1948-7193]
URL :: https://research.tue.nl/en/publications/inhibition-of-1433tau-by-hybrid-smallmolecule-peptides-operating-via-two-different-binding-modes(7429ef0b-4c10-440d-a801-302f4de9450d).html">https://research.tue.nl/en/publications/inhibition-of-1433tau-by-hybrid-smallmolecule-peptides-operating-via-two-different-binding-modes(7429ef0b-4c10-440d-a801-302f4de9450d).html
https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf">https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf
https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf">https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf
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Skocz do pozycji: 2 2.

Tytuł :: Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.
Index Terms :: Aged; Aged, 80 and over; Aging; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/metabolism; Animals; Disease Models, Animal; Disease Progression; Female; Hippocampus/metabolism; Humans; Long-Term Potentiation/physiology; Male; Mice, Inbred C57BL; Plaque, Amyloid/metabolism; tau Proteins/metabolism
info:eu-repo/semantics/article
article
URL :: http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EAEAF744C4EF1">http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EAEAF744C4EF1
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Skocz do pozycji: 3 3.

Tytuł :: Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.
Index Terms :: Alzheimers Disease
Amyloid
Neurochemistry
Oxidative Stress
Protein Structure
Aggregation
Catechol
Flavonoid
Alzheimer Disease/drug therapy
Alzheimer Disease/metabolism
Amyloid/antagonists & inhibitors
Amyloid/chemistry
Amyloid/metabolism
Amyloid beta-Peptides/antagonists & inhibitors
Amyloid beta-Peptides/chemistry
Amyloid beta-Peptides/metabolism
Catechols/chemistry
Catechols/metabolism
Humans
Lysine/chemistry
Lysine/metabolism
Norleucine/chemistry
Norleucine/metabolism
Peptide Fragments/antagonists & inhibitors
Peptide Fragments/chemistry
Peptide Fragments/metabolism
Quercetin/analogs & derivatives
Quercetin/chemistry
Quercetin/metabolism
Journal Article
URL :: http://hdl.handle.net/2433/190494">http://hdl.handle.net/2433/190494
10.1074/jbc.M113.464222
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Skocz do pozycji: 4 4.

Tytuł :: Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
Index Terms :: dementia with Lewy bodies
HtrA2/Omi
Lewy bodies
Parkinson’s disease
X-linked inhibitor of apoptosis protein
Aged
Aged, 80 and over
Alzheimer Disease/metabolism
Alzheimer Disease/pathology
Apoptosis/physiology
Brain Stem/metabolism
Brain Stem/pathology
Caspases/metabolism
Cerebral Cortex/metabolism
Cerebral Cortex/pathology
Dementia/metabolism
Dementia/pathology
Female
Humans
Immunohistochemistry
Lewy Bodies/metabolism
Lewy Bodies/pathology
Male
Middle Aged
Mitochondrial Proteins/metabolism
Parkinson Disease/metabolism
Parkinson Disease/pathology
X-Linked Inhibitor of Apoptosis Protein/immunology
X-Linked Inhibitor of Apoptosis Protein/metabolism
Journal Article
URL :: http://hdl.handle.net/2433/173729">http://hdl.handle.net/2433/173729
10.1097/WNR.0b013e32834f4066
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Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Index Terms :: Neurologie
Neuropathologie
Acetylation
Adult
Aged
Aged, 80 and over
Alzheimer Disease -- metabolism
Animals
Biological Markers -- metabolism
Brain -- metabolism
Cell Line, Tumor
Disease Models, Animal
Female
Humans
Male
Mice
Mice, Transgenic
Middle Aged
Oxidation-Reduction
Peptidylprolyl Isomerase -- metabolism
Phosphorylation -- physiology
Proline -- metabolism
Protein Processing, Post-Translational -- physiology
Proteome
Serine -- metabolism
Tauopathies -- metabolism
tau Proteins -- metabolism
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/177456">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/177456
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
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Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.
Index Terms :: Medicine and Health Sciences
Adolescent
Adult
Age Factors
Aldehydes: metabolism
Alzheimer Disease: metabolism; pathology
Amyloid beta-Peptides: metabolism
Biological Markers: metabolism
Down Syndrome: metabolism; pathology
Female
Frontal Lobe: metabolism; pathology
Humans
Male
Middle Aged
Nitrosation
Oxidation-Reduction
Oxidative Stress: physiology
Superoxide Dismutase: metabolism
Tyrosine: analogs & derivatives; metabolism
article
Źródło :: Biochimica et biophysica acta vol 1822, no 2, 130-138; 0006-3002
URL :: http://www.escholarship.org/uc/item/5k03z6vd">http://www.escholarship.org/uc/item/5k03z6vd
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Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Has removal of excess cysteine led to the evolution of pheomelanin? Pheomelanogenesis as an excretory mechanism for cysteine.
Index Terms :: Cancérologie
Alzheimer Disease -- metabolism -- physiopathology
Cysteine -- metabolism
Cysteine Dioxygenase -- metabolism
Diet
Evolution, Molecular
Glutathione -- metabolism
Humans
Melanins -- genetics -- metabolism
Melanocytes -- cytology -- metabolism
Oxidative Stress
Parkinson Disease -- metabolism -- physiopathology
Selection, Genetic
Temperature
Ultraviolet Rays -- adverse effects
Excess amino acids
Oxidative stress
Pheomelanogenesis
Pigmentation
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/144326">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/144326
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
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Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.
Autorzy :: Cenini, Giovanna; Pokaż więcej
Index Terms :: Adolescent
Adult
Age Factors
Aldehydes: metabolism
Alzheimer Disease: metabolism
pathology
Amyloid beta-Peptides: metabolism
Biological Markers: metabolism
Down Syndrome: metabolism
Female
Frontal Lobe: metabolism
Humans
Male
Middle Aged
Nitrosation
Oxidation-Reduction
Oxidative Stress: physiology
Superoxide Dismutase: metabolism
Tyrosine: analogs & derivatives
metabolism
article
Źródło :: Biochimica et biophysica acta vol 1822, iss 2, 130-138 0006-3002
URL :: https://escholarship.org/uc/item/5k03z6vd">https://escholarship.org/uc/item/5k03z6vd
https://escholarship.org/">https://escholarship.org/
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Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
Index Terms :: Biochimie
Alzheimer Disease -- metabolism
Amyloid beta-Peptides -- chemistry -- metabolism
Apolipoprotein E3 -- genetics -- metabolism
Apolipoprotein E4 -- genetics -- metabolism
Blotting, Western
Electrophoresis
Humans
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Thiazoles -- metabolism
Amyloid cascade
Infrared spectroscopy
Mechanism of apoE pathogenicity
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/98266">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/98266
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
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Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2.
Index Terms :: Abeta
Alzheimer’s disease
BACE-1
COX-2
mPGES-2
PGE2
Alzheimer Disease/metabolism
Amino Acid Sequence
Amyloid Precursor Protein Secretases/genetics
Amyloid Precursor Protein Secretases/metabolism
Amyloid beta-Protein/metabolism
Amyloid beta-Protein/pharmacology
Animals
Apoptosis
Cyclooxygenase 2/metabolism
Humans
Intramolecular Oxidoreductases/genetics
Intramolecular Oxidoreductases/metabolism
Molecular Sequence Data
Neurons/drug effects
Neurons/metabolism
Rats
Journal Article
Źródło :: Biochemical and biophysical research communications
URL :: http://hdl.handle.net/2433/120619">http://hdl.handle.net/2433/120619
10.1016/j.bbrc.2010.02.069
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Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2.
Index Terms :: Abeta
Alzheimer’s disease
BACE-1
COX-2
mPGES-2
PGE2
Alzheimer Disease/metabolism
Amino Acid Sequence
Amyloid Precursor Protein Secretases/genetics
Amyloid Precursor Protein Secretases/metabolism
Amyloid beta-Protein/metabolism
Amyloid beta-Protein/pharmacology
Animals
Apoptosis
Cyclooxygenase 2/metabolism
Humans
Intramolecular Oxidoreductases/genetics
Intramolecular Oxidoreductases/metabolism
Molecular Sequence Data
Neurons/drug effects
Neurons/metabolism
Rats
Journal Article
URL :: http://hdl.handle.net/2433/120619">http://hdl.handle.net/2433/120619
10.1016/j.bbrc.2010.02.069
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Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
Index Terms :: Sciences bio-médicales et agricoles
Alzheimer Disease -- metabolism
Alzheimer Disease -- psychology
Amyloid beta-Protein -- metabolism
Animals
Gene Deletion
Hippocampus -- metabolism
Hippocampus -- physiopathology
Insulin Receptor Substrate Proteins -- genetics
Insulin Receptor Substrate Proteins -- metabolism
Memory
Mice
Mice, Transgenic
Phosphorylation
tau Proteins -- metabolism
Abeta
Alzheimer's disease
APP
Diabetes
GSK-3
Insulin signalling
Irs2
PP2a
Tau
Transthyretin
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50365">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50365
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
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Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: [The precursor of amyloid peptide in Alzheimer disease : a protein with multiple functions].
Index Terms :: Alzheimer Disease - metabolism
Amyloid beta-Peptides - metabolism
Humans
Mice
Neurons - metabolism
Rats
Amyloid beta-Protein Precursor - genetics, metabolism
Animals
Calcium - antagonists & inhibitors, metabolism
Calcium Signaling
Cells, Cultured
Cerebral Cortex - metabolism
Cholesterol - metabolism
Homeostasis
info:eu-repo/semantics/article
URL :: http://hdl.handle.net/2078.1/93964">http://hdl.handle.net/2078.1/93964
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Skocz do pozycji: 14 14.

Tytuł :: Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide.
Index Terms :: Chimie
Alzheimer Disease -- metabolism
Amino Acid Sequence
Amyloid beta-Peptides -- chemistry
Amyloid beta-Peptides -- metabolism
Humans
Molecular Sequence Data
Peptide Fragments -- chemistry
Peptide Fragments -- metabolism
Protein Folding
Protein Structure, Secondary
Spectroscopy, Fourier Transform Infrared
Alzheimer's disease
Amyloid β-peptide
Antiparallel β-sheet
Infrared spectroscopy
Oligomeric Aβ
OmpF
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/74178">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/74178
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
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Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: [The precursor of amyloid peptide in Alzheimer disease : a protein with multiple functions].
Index Terms :: Alzheimer Disease - metabolism
Amyloid beta-Peptides - metabolism
Humans
Mice
Neurons - metabolism
Rats
Amyloid beta-Protein Precursor - genetics, metabolism
Animals
Calcium - antagonists & inhibitors, metabolism
Calcium Signaling
Cells, Cultured
Cerebral Cortex - metabolism
Cholesterol - metabolism
Homeostasis
info:eu-repo/semantics/article
URL :: http://hdl.handle.net/2078.1/93964">http://hdl.handle.net/2078.1/93964
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Skocz do pozycji: 16 16.

Tytuł :: Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin
Index Terms :: Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Alzheimer Disease/metabolism
Astrocytes/metabolism
Biomarkers/metabolism
Cell Differentiation
Child
Child, Preschool
Female
Humans
Male
Microtubule-Associated Proteins/metabolism
Middle Aged
Neocortex/metabolism
Neurodegenerative Diseases/metabolism
Neuropeptides/metabolism
Artikel
Article
Źródło :: Brain vol.130 (2007) nr.Pt 12 p.3321-35 [ISSN 0006-8950]
URL :: https://pure.knaw.nl/portal/en/publications/82773405-f918-4a3b-acde-f49d7edf7c62">https://pure.knaw.nl/portal/en/publications/82773405-f918-4a3b-acde-f49d7edf7c62
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Skocz do pozycji: 17 17.

Tytuł :: Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.
Autorzy :: Tan, Z; Pokaż więcej
Index Terms :: Alzheimer Disease: metabolism
pathology
Animals
Base Sequence
Cell Line
Tumor
Cells
Cultured
Female
Gene Expression Regulation: drug effects
Mice
Inbred C57BL
Microtubules: physiology
ultrastructure
Mitochondria: pathology
physiology
Molecular Sequence Data
Mutation: genetics
Nerve Degeneration: pathology
physiopathology
Neurons: pathology
Pregnancy
Proteasome Endopeptidase Complex: physiology
RNA
Messenger: genetics
metabolism
Small Interfering: pharmacology
Rats
Sprague-Dawley
Transfection
Tumor Suppressor Protein p53: genetics
Ubiquitin: genetics
article
Źródło :: Cell death and differentiation vol 14, iss 10, 1721-1732 1350-9047
URL :: https://escholarship.org/uc/item/3cr530cj">https://escholarship.org/uc/item/3cr530cj
https://escholarship.org/">https://escholarship.org/
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Skocz do pozycji: 18 18.

Tytuł :: Developing therapeutics for the diseases of protein misfolding.
Index Terms :: Sciences bio-médicales et agricoles
Biochimie
Biologie
Biologie cellulaire
Biologie moléculaire
Biophysique
Sciences biomédicales
Sciences de la matière vivante
Alzheimer Disease -- drug therapy
Alzheimer Disease -- metabolism
Amyotrophic Lateral Sclerosis -- metabolism
Diabetes Mellitus, Type 2 -- metabolism
Drug Design
Humans
Huntington Disease -- metabolism
Immunization, Passive
Kinetics
Molecular Structure
Mutation
Nerve Tissue Proteins -- chemistry
Nerve Tissue Proteins -- metabolism
Neurodegenerative Diseases -- drug therapy
Neurodegenerative Diseases -- metabolism
Parkinson Disease -- metabolism
PrPSc Proteins -- chemistry
PrPSc Proteins -- immunology
Prion Diseases -- drug therapy
Prion Diseases -- metabolism
Protein Conformation -- drug effects
Protein Folding
Protein Structure, Secondary
info:eu-repo/semantics/article
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info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/59097">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/59097
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Skocz do pozycji: 19 19.

Tytuł :: Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimer's disease.
Index Terms :: Sciences bio-médicales et agricoles
Médecine pathologie humaine
Alzheimer Disease -- immunology
Alzheimer Disease -- metabolism
Alzheimer Disease -- pathology
Brain -- metabolism
Brain -- pathology
Humans
Neurofibrillary Tangles -- immunology
Neurofibrillary Tangles -- metabolism
Neurofibrillary Tangles -- pathology
tau Proteins -- immunology
tau Proteins -- metabolism
Alzheimer's disease
Microtubules
Neurofibrillary tangles
Phosphorylation
Tau proteins
info:eu-repo/semantics/article
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info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50358">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50358
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Skocz do pozycji: 20 20.

Tytuł :: Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.
Index Terms :: Sciences bio-médicales et agricoles
Alzheimer Disease -- metabolism
Amyloid beta-Protein Precursor -- biosynthesis
Amyloid beta-Protein Precursor -- metabolism
Amyloid beta-Protein Precursor -- toxicity
Animals
Calcium -- chemistry
Calcium -- metabolism
Calcium -- physiology
Cell Polarity -- physiology
Cells, Cultured
Cytosol -- metabolism
Humans
Intracellular Fluid -- metabolism
Membrane Potentials -- physiology
Neurons -- metabolism
Phosphorylation
Potassium Chloride -- chemistry
Rats
Time Factors
tau Proteins -- metabolism
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50360">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50360
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