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Wyszukujesz frazę ""Alzheimer Disease metabolism"" wg kryterium: Temat


Tytuł :
Inhibition of 14-3-3/Tau by hybrid small-molecule peptides operating via two different binding modes
Index Terms :
14-3-3
drug discovery
inhibitors
peptide chemistry
protein-protein interactions
tau
Phosphorylation
Magnetic Resonance Spectroscopy
Humans
Crystallography, X-Ray
Drug Discovery
Microtubules/metabolism
Protein Binding
14-3-3 Proteins/chemistry
tau Proteins/chemistry
Alzheimer Disease/metabolism
Neurofibrillary Tangles/metabolism
Cognitive Neuroscience
Biochemistry
Physiology
Cell Biology
Research Support, Non-U.S. Gov't
Journal Article
Tijdschriftartikel
Article
Źródło :
ACS Chemical Neuroscience vol.9 (2018) date: 2018-11-21 nr.11 p.2639–2654 [ISSN 1948-7193]
URL :
https://research.tue.nl/en/publications/inhibition-of-1433tau-by-hybrid-smallmolecule-peptides-operating-via-two-different-binding-modes(7429ef0b-4c10-440d-a801-302f4de9450d).html">https://research.tue.nl/en/publications/inhibition-of-1433tau-by-hybrid-smallmolecule-peptides-operating-via-two-different-binding-modes(7429ef0b-4c10-440d-a801-302f4de9450d).html
https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf">https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf
https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf">https://pure.tue.nl/ws/files/116540431/acschemneuro.8b00118.pdf
Zasób elektroniczny
Tytuł :
Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression.
Index Terms :
Aged; Aged, 80 and over; Aging; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/metabolism; Animals; Disease Models, Animal; Disease Progression; Female; Hippocampus/metabolism; Humans; Long-Term Potentiation/physiology; Male; Mice, Inbred C57BL; Plaque, Amyloid/metabolism; tau Proteins/metabolism
info:eu-repo/semantics/article
article
URL :
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EAEAF744C4EF1">http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_EAEAF744C4EF1
Zasób elektroniczny
Tytuł :
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Index Terms :
Neurologie
Neuropathologie
Acetylation
Adult
Aged
Aged, 80 and over
Alzheimer Disease -- metabolism
Animals
Biological Markers -- metabolism
Brain -- metabolism
Cell Line, Tumor
Disease Models, Animal
Female
Humans
Male
Mice
Mice, Transgenic
Middle Aged
Oxidation-Reduction
Peptidylprolyl Isomerase -- metabolism
Phosphorylation -- physiology
Proline -- metabolism
Protein Processing, Post-Translational -- physiology
Proteome
Serine -- metabolism
Tauopathies -- metabolism
tau Proteins -- metabolism
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/177456">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/177456
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Zasób elektroniczny
Tytuł :
Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.
Index Terms :
Medicine and Health Sciences
Adolescent
Adult
Age Factors
Aldehydes: metabolism
Alzheimer Disease: metabolism; pathology
Amyloid beta-Peptides: metabolism
Biological Markers: metabolism
Down Syndrome: metabolism; pathology
Female
Frontal Lobe: metabolism; pathology
Humans
Male
Middle Aged
Nitrosation
Oxidation-Reduction
Oxidative Stress: physiology
Superoxide Dismutase: metabolism
Tyrosine: analogs & derivatives; metabolism
article
Źródło :
Biochimica et biophysica acta vol 1822, no 2, 130-138; 0006-3002
URL :
http://www.escholarship.org/uc/item/5k03z6vd">http://www.escholarship.org/uc/item/5k03z6vd
Zasób elektroniczny
Tytuł :
Has removal of excess cysteine led to the evolution of pheomelanin? Pheomelanogenesis as an excretory mechanism for cysteine.
Index Terms :
Cancérologie
Alzheimer Disease -- metabolism -- physiopathology
Cysteine -- metabolism
Cysteine Dioxygenase -- metabolism
Diet
Evolution, Molecular
Glutathione -- metabolism
Humans
Melanins -- genetics -- metabolism
Melanocytes -- cytology -- metabolism
Oxidative Stress
Parkinson Disease -- metabolism -- physiopathology
Selection, Genetic
Temperature
Ultraviolet Rays -- adverse effects
Excess amino acids
Oxidative stress
Pheomelanogenesis
Pigmentation
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/144326">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/144326
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Zasób elektroniczny
Tytuł :
Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.
Autorzy :
Cenini, Giovanna
Pokaż więcej
Index Terms :
Adolescent
Adult
Age Factors
Aldehydes: metabolism
Alzheimer Disease: metabolism
pathology
Amyloid beta-Peptides: metabolism
Biological Markers: metabolism
Down Syndrome: metabolism
Female
Frontal Lobe: metabolism
Humans
Male
Middle Aged
Nitrosation
Oxidation-Reduction
Oxidative Stress: physiology
Superoxide Dismutase: metabolism
Tyrosine: analogs & derivatives
metabolism
article
Źródło :
Biochimica et biophysica acta vol 1822, iss 2, 130-138 0006-3002
URL :
https://escholarship.org/uc/item/5k03z6vd">https://escholarship.org/uc/item/5k03z6vd
https://escholarship.org/">https://escholarship.org/
Zasób elektroniczny
Tytuł :
High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
Index Terms :
Biochimie
Alzheimer Disease -- metabolism
Amyloid beta-Peptides -- chemistry -- metabolism
Apolipoprotein E3 -- genetics -- metabolism
Apolipoprotein E4 -- genetics -- metabolism
Blotting, Western
Electrophoresis
Humans
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Thiazoles -- metabolism
Amyloid cascade
Infrared spectroscopy
Mechanism of apoE pathogenicity
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/98266">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/98266
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Zasób elektroniczny
Tytuł :
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
Index Terms :
Sciences bio-médicales et agricoles
Alzheimer Disease -- metabolism
Alzheimer Disease -- psychology
Amyloid beta-Protein -- metabolism
Animals
Gene Deletion
Hippocampus -- metabolism
Hippocampus -- physiopathology
Insulin Receptor Substrate Proteins -- genetics
Insulin Receptor Substrate Proteins -- metabolism
Memory
Mice
Mice, Transgenic
Phosphorylation
tau Proteins -- metabolism
Abeta
Alzheimer's disease
APP
Diabetes
GSK-3
Insulin signalling
Irs2
PP2a
Tau
Transthyretin
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50365">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50365
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Zasób elektroniczny
Tytuł :
Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide.
Index Terms :
Chimie
Alzheimer Disease -- metabolism
Amino Acid Sequence
Amyloid beta-Peptides -- chemistry
Amyloid beta-Peptides -- metabolism
Humans
Molecular Sequence Data
Peptide Fragments -- chemistry
Peptide Fragments -- metabolism
Protein Folding
Protein Structure, Secondary
Spectroscopy, Fourier Transform Infrared
Alzheimer's disease
Amyloid β-peptide
Antiparallel β-sheet
Infrared spectroscopy
Oligomeric Aβ
OmpF
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/74178">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/74178
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Zasób elektroniczny
Tytuł :
Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin
Index Terms :
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Alzheimer Disease/metabolism
Astrocytes/metabolism
Biomarkers/metabolism
Cell Differentiation
Child
Child, Preschool
Female
Humans
Male
Microtubule-Associated Proteins/metabolism
Middle Aged
Neocortex/metabolism
Neurodegenerative Diseases/metabolism
Neuropeptides/metabolism
Artikel
Article
Źródło :
Brain vol.130 (2007) nr.Pt 12 p.3321-35 [ISSN 0006-8950]
URL :
https://pure.knaw.nl/portal/en/publications/82773405-f918-4a3b-acde-f49d7edf7c62">https://pure.knaw.nl/portal/en/publications/82773405-f918-4a3b-acde-f49d7edf7c62
Zasób elektroniczny
Tytuł :
Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration.
Autorzy :
Tan, Z
Pokaż więcej
Index Terms :
Alzheimer Disease: metabolism
pathology
Animals
Base Sequence
Cell Line
Tumor
Cells
Cultured
Female
Gene Expression Regulation: drug effects
Mice
Inbred C57BL
Microtubules: physiology
ultrastructure
Mitochondria: pathology
physiology
Molecular Sequence Data
Mutation: genetics
Nerve Degeneration: pathology
physiopathology
Neurons: pathology
Pregnancy
Proteasome Endopeptidase Complex: physiology
RNA
Messenger: genetics
metabolism
Small Interfering: pharmacology
Rats
Sprague-Dawley
Transfection
Tumor Suppressor Protein p53: genetics
Ubiquitin: genetics
article
Źródło :
Cell death and differentiation vol 14, iss 10, 1721-1732 1350-9047
URL :
https://escholarship.org/uc/item/3cr530cj">https://escholarship.org/uc/item/3cr530cj
https://escholarship.org/">https://escholarship.org/
Zasób elektroniczny
Tytuł :
Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimer's disease.
Index Terms :
Sciences bio-médicales et agricoles
Médecine pathologie humaine
Alzheimer Disease -- immunology
Alzheimer Disease -- metabolism
Alzheimer Disease -- pathology
Brain -- metabolism
Brain -- pathology
Humans
Neurofibrillary Tangles -- immunology
Neurofibrillary Tangles -- metabolism
Neurofibrillary Tangles -- pathology
tau Proteins -- immunology
tau Proteins -- metabolism
Alzheimer's disease
Microtubules
Neurofibrillary tangles
Phosphorylation
Tau proteins
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50358">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50358
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Zasób elektroniczny
Tytuł :
Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.
Index Terms :
Sciences bio-médicales et agricoles
Alzheimer Disease -- metabolism
Amyloid beta-Protein Precursor -- biosynthesis
Amyloid beta-Protein Precursor -- metabolism
Amyloid beta-Protein Precursor -- toxicity
Animals
Calcium -- chemistry
Calcium -- metabolism
Calcium -- physiology
Cell Polarity -- physiology
Cells, Cultured
Cytosol -- metabolism
Humans
Intracellular Fluid -- metabolism
Membrane Potentials -- physiology
Neurons -- metabolism
Phosphorylation
Potassium Chloride -- chemistry
Rats
Time Factors
tau Proteins -- metabolism
info:eu-repo/semantics/article
info:ulb-repo/semantics/articlePeerReview
info:ulb-repo/semantics/openurl/article
URL :
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50360">http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50360
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL">http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
Zasób elektroniczny

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