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Wyszukujesz frazę ""Alzheimer disease"" wg kryterium: Temat


Tytuł :
Ochratoxin A-induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies.
Autorzy :
Niaz K; Department of Pharmacology and Toxicology, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, 63100, Pakistan. .
Shah SZA; Department of Pathology, Faculty of Veterinary Science, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, 63100, Pakistan.
Khan F; The Institute of Pharmaceutical Sciences (TIPS), School of Pharmacy, International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran, 1417614411, Iran.; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, 1417614411, Iran.
Bule M; Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Oromia, Ethiopia.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2020 Dec; Vol. 27 (36), pp. 44673-44700. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease*/chemically induced
Alzheimer Disease*/genetics
Ochratoxins*
DNA Damage ; Epigenesis, Genetic ; Female ; Humans ; Male
Czasopismo naukowe
Tytuł :
The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review.
Autorzy :
Zhang S; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao.
Zhu Q; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao.
Chen JY; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao.
OuYang D; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao.
Lu JH; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Dec; Vol. 79, pp. 153316. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Alzheimer Disease/*drug therapy
Catechin/*analogs & derivatives
Neuroprotective Agents/*pharmacology
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/metabolism ; Animals ; Antioxidants/pharmacology ; Blood-Brain Barrier/drug effects ; Catechin/pharmacokinetics ; Catechin/pharmacology ; Cognition/drug effects ; Disease Models, Animal ; Humans ; Neuroprotective Agents/pharmacokinetics ; Phosphorylation/drug effects
Czasopismo naukowe
Tytuł :
L-serine synthesis via the phosphorylated pathway in humans.
Autorzy :
Murtas G; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.
Marcone GL; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.
Sacchi S; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.
Pollegioni L; Department of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Dec; Vol. 77 (24), pp. 5131-5148. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*genetics
Brain/*metabolism
Receptors, N-Methyl-D-Aspartate/*genetics
Serine/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Brain/pathology ; Glycolysis/genetics ; Humans ; Neurons/metabolism ; Neurons/pathology ; Phosphoglycerate Dehydrogenase/genetics ; Phosphorylation/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Serine/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta 1-42 infused rat model.
Autorzy :
Elibol B; Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, 34093 Istanbul, Turkey. Electronic address: .
Beker M; Department of Medical Biology, Faculty of Medicine, University of Health Sciences Turkey, 34668 Istanbul, Turkey.
Terzioglu-Usak S; Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, 34093 Istanbul, Turkey.
Dalli T; Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, 34093 Istanbul, Turkey.
Kilic U; Department of Medical Biology, Faculty of Medicine, University of Health Sciences Turkey, 34668 Istanbul, Turkey.
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2020 Dec; Vol. 79, pp. 153324. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Benzoquinones/*pharmacology
Hippocampus/*drug effects
Neuroprotective Agents/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/pharmacology ; Animals ; Cell Survival/drug effects ; Disease Models, Animal ; Female ; Gene Expression Regulation/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; MAP Kinase Signaling System/drug effects ; Maze Learning/drug effects ; Memory/drug effects ; Neurons/drug effects ; Peptide Fragments/pharmacology ; Phosphorylation/drug effects ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model.
Autorzy :
Cirrito JR; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia. .
Wallace CE; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
Yan P; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
Davis TA; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
Gardiner WD; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
Doherty BM; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
King D; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
Yuede CM; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
Lee JM; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
Sheline YI; From the Department of Neurology (J.R.C., T.A.D., W.D.G., B.M.D., D.K., C.M.Y., J.-M.L.), The Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO; Center for Neuromodulation in Depression and Stress, Department of Psychiatry (C.E.W., P.Y., Y.I.S.), and Departments of Psychiatry, Radiology, and Neurology (Y.I.S.), University of Pennsylvania, Philadelphia.
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Źródło :
Neurology [Neurology] 2020 Nov 10; Vol. 95 (19), pp. e2666-e2674. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*drug effects
Brain/*drug effects
Citalopram/*pharmacology
Peptide Fragments/*drug effects
Plaque, Amyloid/*pathology
Serotonin Uptake Inhibitors/*pharmacology
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Extracellular Fluid ; Intravital Microscopy ; Mice ; Microdialysis ; Microscopy, Fluorescence, Multiphoton ; Peptide Fragments/metabolism ; Plaque, Amyloid/metabolism ; Presenilin-1/genetics
Czasopismo naukowe
Tytuł :
Amyloid-PET and F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.
Autorzy :
Chételat G; Normandie Université, Université de Caen, Institut National de la Santé et de la Recherche Médicale, Unité 1237, Groupement d'Intérêt Public Cyceron, Caen, France. Electronic address: .
Arbizu J; Department of Nuclear Medicine, University of Navarra, Clinica Universidad de Navarra, Pamplona, Spain.
Barthel H; Department of Nuclear Medicine, University Hospital of Leipzig, Leipzig, Germany.
Garibotto V; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals and NIMTlab, Geneva University, Geneva, Switzerland.
Law I; Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Morbelli S; Nuclear Medicine Unit, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico San Martino, Genova, Italy.
van de Giessen E; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Agosta F; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Istituto di Ricovero e Cura a Carattere, San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Institutes of Neurology and Healthcare Engineering, University College London, London, UK.
Brooks DJ; Institute of Neuroscience, Newcastle University, Newcastle, UK; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark.
Carrillo MC; Alzheimer's Association, Chicago, IL, USA.
Dubois B; Centre des Maladies Cognitives et Comportementales, University Hospital of Pitié Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne-Université, Paris, France.
Fjell AM; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway, Oslo; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Frisoni GB; Memory Clinic, Department of Rehabilitation and Geriatrics, Geneva University and University Hospitals, Geneva, Switzerland.
Hansson O; Clinical Memory Research Unit, Lund University, Malmö, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Herholz K; Wolfson Molecular Imaging Centre, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
Hutton BF; Institute of Nuclear Medicine, University College London, London, UK.
Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Lammertsma AA; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Landau SM; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Minoshima S; Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Nobili F; UO Clinica Neurologica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico San Martino, Genova, Italy; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Child and Mother Health, University of Genoa, Genova, Italy.
Nordberg A; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Ossenkoppele R; Department of Neurology, Alzheimer Center, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; Clinical Memory Research Unit, Lund University, Lund, Sweden.
Oyen WJG; Humanitas University and Humanitas Clinical and Research Center, Department of Nuclear Medicine, Milan, Italy; Rijnstate, Department of Radiology and Nuclear Medicine, Arnhem, Netherlands; Radboud UMC, Department of Radiology and Nuclear Medicine, Nijmegen, Netherlands.
Perani D; Vita-Salute San Raffaele University, Nuclear Medicine Unit, San Raffaele Hospital, Division of Neuroscience San Raffaele Scientific Institute, Milan, Italy.
Rabinovici GD; Departments of Neurology, Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Scheltens P; Department of Neurology, Alzheimer Center, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Villemagne VL; Department of Molecular Imaging & Therapy, Austin Health, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, VIC, Australia; School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Zetterberg H; Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at University College London, London, UK.
Drzezga A; Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany; German Center for Neurodegenerative Diseases, Bonn-Cologne, Germany; Institute of Neuroscience and Medicine, Molecular Organization of the Brain, Forschungszentrum Jülich, Germany.
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Źródło :
The Lancet. Neurology [Lancet Neurol] 2020 Nov; Vol. 19 (11), pp. 951-962.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Fluorodeoxyglucose F18*
Alzheimer Disease/*metabolism
Amyloid beta-Protein Precursor/*metabolism
Dementia, Vascular/*metabolism
Positron-Emission Tomography/*methods
Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Brain/diagnostic imaging ; Brain/metabolism ; Dementia, Vascular/diagnostic imaging ; Dementia, Vascular/psychology ; Diagnosis, Differential ; Humans ; Male
Czasopismo naukowe
Tytuł :
Double hit viral parasitism, polymicrobial CNS residency and perturbed proteostasis in Alzheimer's disease: A data driven, in silico analysis of gene expression data.
Autorzy :
Vavougios GD; Department of Neurology, Athens Naval Hospital, P.C. 115 21, Athens, Greece; Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, P.C, 41500, Larissa, Greece; Department of Computer Science and Telecommunications, University of Thessaly, Papasiopoulou 2 - 4, P.C. 35 131 Galaneika, Lamia, Greece. Electronic address: .
Nday C; Laboratory of Medical Physics, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, P.C. 5414, Thessaloniki, Greece.
Pelidou SH; Department of Neurology, Faculty of Medicine, University of Ioannina, P.C. 45110, Ioannina, Greece.
Zarogiannis SG; Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS, Larissa, 41500, Greece.
Gourgoulianis KI; Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Biopolis, P.C, 41500, Larissa, Greece.
Stamoulis G; Department of Electrical and Computer Engineering, University of Thessaly, 37 Glavani - 28th October Str, Deligiorgi Building, 4th floor, P.C. 382 21, Volos, Greece.
Doskas T; Department of Neurology, Athens Naval Hospital, P.C. 115 21, Athens, Greece.
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Źródło :
Molecular immunology [Mol Immunol] 2020 Nov; Vol. 127, pp. 124-135. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Gene Expression Regulation*
Alzheimer Disease/*genetics
Alzheimer Disease/*virology
Central Nervous System/*virology
Coinfection/*complications
Parasites/*physiology
Proteostasis/*genetics
Alzheimer Disease/microbiology ; Animals ; Central Nervous System/immunology ; Entorhinal Cortex/pathology ; Gene Expression Profiling ; Gene Ontology ; Humans ; Nerve Tissue Proteins/metabolism ; Neurofibrillary Tangles/pathology ; Oligopeptides/metabolism ; Protein Interaction Maps ; Software
Czasopismo naukowe
Tytuł :
Worsening behavioural and psychological symptoms of dementia during the coronavirus disease 2019 pandemic.
Autorzy :
Shea YF; Division of Geriatrics, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Shum CK; Division of Geriatrics, Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China.
Wan WH; School of Nursing, University of Hong Kong, Hong Kong, China.
Chan MMK; School of Nursing, University of Hong Kong, Hong Kong, China.
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Źródło :
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society [Psychogeriatrics] 2020 Nov; Vol. 20 (6), pp. 916-917. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Coronavirus Infections*/prevention & control
Pandemics*/prevention & control
Pneumonia, Viral*/prevention & control
Social Isolation*
Symptom Flare Up*
Alzheimer Disease/*physiopathology
Aged ; Aged, 80 and over ; Alzheimer Disease/drug therapy ; Alzheimer Disease/psychology ; Female ; Humans ; Infection Control ; Male
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Association between APOE ε2 and Aβ burden in patients with Alzheimer- and vascular-type cognitive impairment.
Autorzy :
Lee JS; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA. .
Lee H; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA. .
Park S; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Choe Y; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Park YH; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Cheon BK; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Hahn A; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Ossenkoppele R; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Kim HJ; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Kim S; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Yoo H; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Jang H; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Cho SH; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Kim SJ; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Kim JP; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Jung YH; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Park KC; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
DeCarli C; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Weiner MW; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Na DL; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Seo SW; From the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA. .
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Źródło :
Neurology [Neurology] 2020 Oct 27; Vol. 95 (17), pp. e2354-e2365. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*genetics
Amyloid beta-Peptides/*genetics
Apolipoprotein E2/*genetics
Dementia, Vascular/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/epidemiology ; Body Burden ; Cognitive Dysfunction/genetics ; Cross-Sectional Studies ; Dementia, Vascular/diagnostic imaging ; Dementia, Vascular/epidemiology ; Female ; Genetic Predisposition to Disease ; Genotype ; Heterozygote ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Positron-Emission Tomography ; Prevalence
Czasopismo naukowe
Tytuł :
Sex differences in CSF biomarkers vary by Alzheimer disease stage and APOE ε4 genotype.
Autorzy :
Babapour Mofrad R; From the Neurochemistry Laboratory and Biobank (R.B.M., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center; Department of Epidemiology and Biostatistics (W.M.v.d.F., S.A.M.S.), Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center; Alzheimer Center and Department of Neurology Amsterdam (R.B.M., B.M.T., P.S., W.M.v.d.F., S.A.M.S.), Department of Neurology, Neuroscience Campus Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam; Department of Radiology and Nuclear Medicine (F.B.), Amsterdam UMC Location VUmc, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Massachusetts General Hospital (S.A.M.S.), Department of Neurology/Harvard Medical School, Boston. ..nl.
Tijms BM; From the Neurochemistry Laboratory and Biobank (R.B.M., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center; Department of Epidemiology and Biostatistics (W.M.v.d.F., S.A.M.S.), Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center; Alzheimer Center and Department of Neurology Amsterdam (R.B.M., B.M.T., P.S., W.M.v.d.F., S.A.M.S.), Department of Neurology, Neuroscience Campus Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam; Department of Radiology and Nuclear Medicine (F.B.), Amsterdam UMC Location VUmc, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Massachusetts General Hospital (S.A.M.S.), Department of Neurology/Harvard Medical School, Boston.
Scheltens P; From the Neurochemistry Laboratory and Biobank (R.B.M., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center; Department of Epidemiology and Biostatistics (W.M.v.d.F., S.A.M.S.), Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center; Alzheimer Center and Department of Neurology Amsterdam (R.B.M., B.M.T., P.S., W.M.v.d.F., S.A.M.S.), Department of Neurology, Neuroscience Campus Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam; Department of Radiology and Nuclear Medicine (F.B.), Amsterdam UMC Location VUmc, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Massachusetts General Hospital (S.A.M.S.), Department of Neurology/Harvard Medical School, Boston.
Barkhof F; From the Neurochemistry Laboratory and Biobank (R.B.M., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center; Department of Epidemiology and Biostatistics (W.M.v.d.F., S.A.M.S.), Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center; Alzheimer Center and Department of Neurology Amsterdam (R.B.M., B.M.T., P.S., W.M.v.d.F., S.A.M.S.), Department of Neurology, Neuroscience Campus Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam; Department of Radiology and Nuclear Medicine (F.B.), Amsterdam UMC Location VUmc, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Massachusetts General Hospital (S.A.M.S.), Department of Neurology/Harvard Medical School, Boston.
van der Flier WM; From the Neurochemistry Laboratory and Biobank (R.B.M., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center; Department of Epidemiology and Biostatistics (W.M.v.d.F., S.A.M.S.), Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center; Alzheimer Center and Department of Neurology Amsterdam (R.B.M., B.M.T., P.S., W.M.v.d.F., S.A.M.S.), Department of Neurology, Neuroscience Campus Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam; Department of Radiology and Nuclear Medicine (F.B.), Amsterdam UMC Location VUmc, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Massachusetts General Hospital (S.A.M.S.), Department of Neurology/Harvard Medical School, Boston.
Sikkes SAM; From the Neurochemistry Laboratory and Biobank (R.B.M., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center; Department of Epidemiology and Biostatistics (W.M.v.d.F., S.A.M.S.), Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center; Alzheimer Center and Department of Neurology Amsterdam (R.B.M., B.M.T., P.S., W.M.v.d.F., S.A.M.S.), Department of Neurology, Neuroscience Campus Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam; Department of Radiology and Nuclear Medicine (F.B.), Amsterdam UMC Location VUmc, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Massachusetts General Hospital (S.A.M.S.), Department of Neurology/Harvard Medical School, Boston.
Teunissen CE; From the Neurochemistry Laboratory and Biobank (R.B.M., C.E.T.), Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center; Department of Epidemiology and Biostatistics (W.M.v.d.F., S.A.M.S.), Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center; Alzheimer Center and Department of Neurology Amsterdam (R.B.M., B.M.T., P.S., W.M.v.d.F., S.A.M.S.), Department of Neurology, Neuroscience Campus Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, VU University Medical Center, Amsterdam; Department of Radiology and Nuclear Medicine (F.B.), Amsterdam UMC Location VUmc, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; Massachusetts General Hospital (S.A.M.S.), Department of Neurology/Harvard Medical School, Boston.
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Źródło :
Neurology [Neurology] 2020 Oct 27; Vol. 95 (17), pp. e2378-e2388. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*cerebrospinal fluid
Alzheimer Disease/*genetics
Apolipoprotein E4/*genetics
Biomarkers/*cerebrospinal fluid
Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/cerebrospinal fluid ; Cognitive Dysfunction/cerebrospinal fluid ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/genetics ; Disease Progression ; Female ; Genotype ; Heterozygote ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Peptide Fragments/cerebrospinal fluid ; Phosphorylation ; Sex Characteristics ; tau Proteins/cerebrospinal fluid
Czasopismo naukowe
Tytuł :
Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults.
Autorzy :
Weigand AJ; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Bondi MW; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Thomas KR; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Campbell NL; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Galasko DR; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Salmon DP; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Sewell D; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Brewer JB; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Feldman HH; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN.
Delano-Wood L; From the San Diego Joint Doctoral Program in Clinical Psychology (A.J.W.), San Diego State University/University of California; Veterans Affairs San Diego Healthcare System (M.W.B., D.R.G., L.D.-W.); Department of Psychiatry (M.W.B., K.R.T., D.R.G., D.S., L.D.-W.), Alzheimer's Disease Research Center (M.W.B., D.R.G., D.P.S., D.S., J.B.B., H.H.F., L.D.-W.), and Department of Neurosciences (D.R.G., D.P.S., J.B.B., H.H.F.), University of California, San Diego; Center for Aging Research (N.L.C.), Regenstrief Institute, Inc. and Indiana University, Indianapolis; and Department of Pharmacy Practice (N.L.C.), Purdue University, West Lafayette, IN. .
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Corporate Authors :
Alzheimer's Disease Neuroimaging Initiative
Źródło :
Neurology [Neurology] 2020 Oct 20; Vol. 95 (16), pp. e2295-e2304. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alzheimer Disease/*epidemiology
Cholinergic Antagonists/*adverse effects
Cognitive Dysfunction/*epidemiology
Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/genetics ; Apolipoproteins E/genetics ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/genetics ; Disease Progression ; Female ; Genetic Predisposition to Disease ; Humans ; Incidence ; Male
Czasopismo naukowe
Tytuł :
Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets.
Autorzy :
Sierksma A; VIB Center for Brain & Disease Research, Leuven, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven (University of Leuven), Leuven, Belgium.
Escott-Price V; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. .; UK Dementia Research Institute, Cardiff University, Cardiff, UK.
De Strooper B; VIB Center for Brain & Disease Research, Leuven, Belgium. .; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven (University of Leuven), Leuven, Belgium.; UK Dementia Research Institute, University College London, London, UK.
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Źródło :
Science (New York, N.Y.) [Science] 2020 Oct 02; Vol. 370 (6512), pp. 61-66.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Development*
Genetic Predisposition to Disease*
Translational Medical Research*
Alzheimer Disease/*drug therapy
Alzheimer Disease/*genetics
Alzheimer Disease/prevention & control ; Animals ; Disease Models, Animal ; Genetic Variation ; Humans ; Mice ; Mice, Transgenic ; Molecular Targeted Therapy ; Risk
Czasopismo naukowe
Tytuł :
Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.
Autorzy :
Luningham JM; Department of Population Health Sciences, Georgia State University School of Public Health, Atlanta, GA 30303, USA; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Chen J; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Tang S; Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA 30322, USA; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology and Taub Institute for Research on Alzheimer disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
Bennett DA; Rush Alzheimer disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Buchman AS; Rush Alzheimer disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Yang J; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2020 Oct 01; Vol. 107 (4), pp. 714-726. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Human*
Models, Statistical*
Quantitative Trait Loci*
Alzheimer Disease/*genetics
Apolipoprotein C-I/*genetics
Proteins/*genetics
Ribonucleases/*genetics
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Apolipoprotein C-I/metabolism ; Bayes Theorem ; Case-Control Studies ; Computer Simulation ; Female ; Gene Expression ; Genetic Markers ; Genome-Wide Association Study ; HLA-DRB1 Chains/genetics ; HLA-DRB1 Chains/metabolism ; Humans ; Male ; Neurofibrillary Tangles/metabolism ; Neurofibrillary Tangles/pathology ; Proteins/metabolism ; Ribonucleases/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
[Young onset dementia].
Autorzy :
Pawlowski M; Klinik für Neurologie mit Institut für Translationale Neurologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Deutschland. .
Johnen A
Duning T; Klinik für Neurologie mit Institut für Translationale Neurologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Deutschland. .
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Transliterated Title :
Früh beginnende Demenzen.
Źródło :
Der Nervenarzt [Nervenarzt] 2020 Oct; Vol. 91 (10), pp. 936-945.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease*
Frontotemporal Dementia*
Frontotemporal Lobar Degeneration*
Humans
Czasopismo naukowe
Tytuł :
[Sleep-disordered breathing and Alzheimer's disease biomarkers in older adults].
Autorzy :
André C; Normandie Univ, UNICAEN, Inserm, U1237, Physiopathologie et imagerie des maladies neurologiques (PhIND Physiopathology and imaging of neurological disorders), Institut « Sang et Cerveau » (Institute Blood and brain) @ Caen-Normandie, Cyceron, 14000 Caen, France. - Normandie Univ, UNICAEN, PSL Université, EPHE, Inserm, U1077, CHU de Caen, GIP Cyceron, NIMH, Boulevard Henri Becquerel, BP 5229, 14074 Caen Cedex 5, France.
Chételat G; Normandie Univ, UNICAEN, Inserm, U1237, Physiopathologie et imagerie des maladies neurologiques (PhIND Physiopathology and imaging of neurological disorders), Institut « Sang et Cerveau » (Institute Blood and brain) @ Caen-Normandie, Cyceron, 14000 Caen, France.
Rauchs G; Normandie Univ, UNICAEN, PSL Université, EPHE, Inserm, U1077, CHU de Caen, GIP Cyceron, NIMH, Boulevard Henri Becquerel, BP 5229, 14074 Caen Cedex 5, France.
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Transliterated Title :
Liens entre apnées du sommeil et altérations cérébrales évaluées par imagerie chez le sujet âgé.
Źródło :
Medecine sciences : M/S [Med Sci (Paris)] 2020 Oct; Vol. 36 (10), pp. 833-835. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Wiadomości
MeSH Terms :
Alzheimer Disease/*physiopathology
Biomarkers/*analysis
Sleep Apnea Syndromes/*psychology
Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Brain/diagnostic imaging ; Brain/pathology ; Humans ; Magnetic Resonance Imaging ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/diagnostic imaging
Periodyk
Tytuł :
Porphyromonas gingivalis and Alzheimer disease: Recent findings and potential therapies.
Autorzy :
Ryder MI; Division of Periodontology, Department of Orofacial Sciences School of Dentistry, University of California, San Francisco, CA.
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Źródło :
Journal of periodontology [J Periodontol] 2020 Oct; Vol. 91 Suppl 1, pp. S45-S49. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/drug therapy
Bacteroidaceae Infections*/drug therapy
Periodontitis*
Adhesins, Bacterial ; Animals ; Cysteine Endopeptidases ; Humans ; Mice ; Porphyromonas gingivalis
Czasopismo naukowe
Tytuł :
Role of environmental pollutants in Alzheimer's disease: a review.
Autorzy :
Mir RH; Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Kashmir, 190006, India. .
Sawhney G; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu, 180001, India.
Pottoo FH; Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O.BOX 1982, Dammam, 31441, Saudi Arabia.
Mohi-Ud-Din R; Pharmacognosy Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Kashmir, 190006, India.
Madishetti S; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu, 180001, India.
Jachak SM; Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali, Punjab, 160062, India.
Ahmed Z; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu, 180001, India.
Masoodi MH; Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Kashmir, 190006, India. .
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2020 Dec; Vol. 27 (36), pp. 44724-44742. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease*/chemically induced
Environmental Pollutants*
Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Humans ; Neurons/metabolism ; Prospective Studies
Czasopismo naukowe
Tytuł :
Textural Analysis: A look to the Future with Eye on the Past.
Autorzy :
Lobo R; Departments of radiology, University of Michigan, 1500 E. Medical Center Drive, B1 Taubman Center, Room 132, Ann Arbor, MI 48109-5338.
Ibrahim M; Departments of radiology, University of Michigan, 1500 E. Medical Center Drive, B1 Taubman Center, Room 132, Ann Arbor, MI 48109-5338. Electronic address: .
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Źródło :
Academic radiology [Acad Radiol] 2020 Dec; Vol. 27 (12), pp. 1784-1785. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Alzheimer Disease*
Forecasting ; Humans ; Magnetic Resonance Spectroscopy
Opinia redakcyjna
Tytuł :
Molecular mechanism of zinc neurotoxicity in Alzheimer's disease.
Autorzy :
Narayanan SE; P.G. Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Kannur, 670503, India.
Rehuman NA; Department of Pharmaceutical Chemistry, Dr. Joseph Mar Thoma Institute of Pharmaceutical Sciences & Research, Kayamkulam, Kerala, 690503, India.
Harilal S; Department of Pharmacy, Kerala University of Health Sciences, Thrissur, Kerala, India.
Vincent A; P.G. Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Kannur, 670503, India.
Rajamma RG; College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, 673008, India.
Behl T; Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Uddin MS; Department of Pharmacy, Southeast University, Dhaka, Bangladesh.; Pharmakon Neuroscience Research Network, Dhaka, Bangladesh.
Ashraf GM; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. .; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. .
Mathew B; Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, Kerala, 678557, India. .
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2020 Dec; Vol. 27 (35), pp. 43542-43552. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease*
Neurotoxicity Syndromes*
Cognition ; Humans ; Memory ; Zinc
Czasopismo naukowe
Tytuł :
Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer's Disease.
Autorzy :
Fancellu G; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.; Department of Earth Sciences, University of Pisa, Pisa, Italy.
Chand K; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Tomás D; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Orlandini E; Department of Earth Sciences, University of Pisa, Pisa, Italy.
Piemontese L; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'Aldo Moro', Bari, Italy.
Silva DF; CNC-Center for Neuroscience and Cell Biology, Universidade de Coimbra, Coimbra, Portugal.
Cardoso SM; CNC-Center for Neuroscience and Cell Biology, Universidade de Coimbra, Coimbra, Portugal.; Institute of Molecular and Cell Biology, Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal.
Chaves S; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
Santos MA; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 211-226.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Benzofurans/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Tacrine/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Animals ; Benzofurans/chemistry ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Humans ; Models, Molecular ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Structure-Activity Relationship ; Tacrine/chemistry
Czasopismo naukowe

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