- Tytuł:
- The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia.
- Autorzy:
- Źródło:
- Scientific reports [Sci Rep] 2015 Dec 17; Vol. 5, pp. 18137. Date of Electronic Publication: 2015 Dec 17.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Xenograft Model Antitumor Assays*
Aminopyridines/*pharmacology
Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitorsLeukemia, Myeloid, Acute /*drug therapy
Morpholines/*pharmacology
Adult ; Aged ; Animals ; Blotting, Western ; Cell Line, Tumor ; Cell Survival/drug effects ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Dose-Response Relationship, Drug ; Female ; HL-60 Cells ; Humans ;Leukemia, Myeloid, Acute /metabolism ;Leukemia, Myeloid, Acute /pathology ; Male ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Middle Aged ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism ; Time Factors ; U937 Cells
Czasopismo naukowe