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Tytuł :
Hypertension is associated with blunted NO-mediated leg vasodilator responsiveness that is reversed by high-intensity training in postmenopausal women.
Autorzy :
Gunnarsson TP; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Ehlers TS; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Baasch-Skytte T; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Lund AP; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Tamariz-Ellemann A; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Gliemann L; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Nyberg M; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Bangsbo J; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2020 Dec 01; Vol. 319 (6), pp. R712-R723. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Intensity Interval Training*
Postmenopause*
Vasodilation*/drug effects
Hypertension/*therapy
Lower Extremity/*blood supply
Nitric Oxide/*metabolism
Acetylcholine/administration & dosage ; Age Factors ; Aged ; Female ; Humans ; Hypertension/metabolism ; Hypertension/physiopathology ; Middle Aged ; Nitric Oxide Donors/administration & dosage ; Nitroprusside/administration & dosage ; Oxidative Stress ; Sex Factors ; Time Factors ; Treatment Outcome ; Vasodilator Agents/administration & dosage
Czasopismo naukowe
Tytuł :
Beyond oxygen transport: active role of erythrocytes in the regulation of blood flow.
Autorzy :
Richardson KJ; Biorheology Research Laboratory, Griffith University, Gold Coast, Australia.; Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
Kuck L; Biorheology Research Laboratory, Griffith University, Gold Coast, Australia.; Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
Simmonds MJ; Biorheology Research Laboratory, Griffith University, Gold Coast, Australia.; Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
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Źródło :
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2020 Oct 01; Vol. 319 (4), pp. H866-H872. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Blood Circulation*
Hemodynamics*
Adenosine Triphosphate/*blood
Erythrocytes/*metabolism
Nitric Oxide/*blood
Oxygen/*blood
Animals ; Blood Flow Velocity ; Humans ; Mechanotransduction, Cellular ; Vasodilation
Czasopismo naukowe
Tytuł :
Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Autorzy :
Dikalova A; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Aschner JL; Department of Pediatrics, Albert Einstein College of Medicine, New York, New York.; Department of Pediatrics, Hackensack Meridian Health School of Medicine at Seton Hall University, Nutley, New Jersey.
Kaplowitz MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Pediatrics, University of Utah Health, Salt Lake City, Utah.
Cunningham G; Division of Genetics and Metabolism, Children's National Medical Center, Washington, District of Columbia.
Summar M; Division of Genetics and Metabolism, Children's National Medical Center, Washington, District of Columbia.
Fike CD; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Pediatrics, University of Utah Health, Salt Lake City, Utah.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2020 Apr 01; Vol. 318 (4), pp. L762-L772. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Biopterin/*analogs & derivatives
Citrulline/*pharmacology
Hypertension, Pulmonary/*drug therapy
Hypoxia/*metabolism
Nitric Oxide/*metabolism
Signal Transduction/*drug effects
Animals ; Animals, Newborn ; Arginine/metabolism ; Biopterin/pharmacology ; Hypertension, Pulmonary/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Pulmonary Artery/drug effects ; Pulmonary Artery/metabolism ; Swine ; Vascular Resistance/drug effects
Czasopismo naukowe
Tytuł :
Alamandine enhances cardiomyocyte contractility in hypertensive rats through a nitric oxide-dependent activation of CaMKII.
Autorzy :
Jesus ICG; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; National Institute of Science and Technology in Nanobiopharmaceutics, Belo Horizonte, Brazil.
Mesquita TRR; Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, California.
Monteiro ALL; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Parreira AB; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Santos AK; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Coelho ELX; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Silva MM; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Souza LAC; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; National Institute of Science and Technology in Nanobiopharmaceutics, Belo Horizonte, Brazil.
Campagnole-Santos MJ; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; National Institute of Science and Technology in Nanobiopharmaceutics, Belo Horizonte, Brazil.
Santos RS; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; National Institute of Science and Technology in Nanobiopharmaceutics, Belo Horizonte, Brazil.
Guatimosim S; Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; National Institute of Science and Technology in Nanobiopharmaceutics, Belo Horizonte, Brazil.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Apr 01; Vol. 318 (4), pp. C740-C750. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Myocytes, Cardiac/*drug effects
Nitric Oxide/*metabolism
Oligopeptides/*pharmacology
Sarcoplasmic Reticulum/*drug effects
Animals ; Calcium-Binding Proteins ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Hypertension/drug therapy ; Hypertension/metabolism ; Male ; Myocytes, Cardiac/metabolism ; Phosphorylation/drug effects ; Rats ; Sarcoplasmic Reticulum/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
NO-mediated activation of K ATP channels contributes to cutaneous thermal hyperemia in young adults.
Autorzy :
Fujii N; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.; Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Ontario, Canada.
McGarr GW; Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Ontario, Canada.
Kenny GP; Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Ontario, Canada.
Amano T; Laboratory for Exercise and Environmental Physiology, Faculty of Education, Niigata University, Niigata, Japan.
Honda Y; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Kondo N; Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.
Nishiyasu T; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2020 Feb 01; Vol. 318 (2), pp. R390-R398. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microcirculation*/drug effects
Vasodilation*/drug effects
Hyperemia/*enzymology
KATP Channels/*metabolism
Microvessels/*enzymology
Nitric Oxide/*metabolism
Nitric Oxide Synthase/*metabolism
Skin/*blood supply
Adult ; Blood Flow Velocity ; Enzyme Inhibitors/administration & dosage ; Female ; Humans ; Hyperemia/etiology ; Hyperemia/physiopathology ; Hypothermia, Induced ; Ion Channel Gating ; KATP Channels/antagonists & inhibitors ; Male ; Microvessels/drug effects ; Microvessels/physiopathology ; Nitric Oxide Donors/administration & dosage ; Nitric Oxide Synthase/antagonists & inhibitors ; Potassium Channel Blockers/administration & dosage ; Signal Transduction ; Vasodilator Agents/administration & dosage ; Young Adult
Czasopismo naukowe
Tytuł :
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Autorzy :
Tejero J; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, Pennsylvania ; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania ; Department of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Medicine, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Shiva S; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, Pennsylvania ; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania ; Department of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Medicine, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Gladwin MT; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, Pennsylvania ; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania ; Department of Pharmacology and Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Medicine, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
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Źródło :
Physiological reviews [Physiol Rev] 2019 Jan 01; Vol. 99 (1), pp. 311-379.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cardiovascular Diseases/*metabolism
Cardiovascular System/*metabolism
Nitric Oxide/*metabolism
Oxidative Stress/*physiology
Reactive Oxygen Species/*metabolism
Animals ; Humans ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Impact of different fixed flow sampling protocols on flow-independent exhaled nitric oxide parameter estimates using the Bayesian dynamic two-compartment model.
Autorzy :
Muchmore P; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Xu S; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Marjoram P; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Rappaport EB; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Weng J; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Molshatzki N; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Eckel SP; Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
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Źródło :
Physiological reports [Physiol Rep] 2020 Jan; Vol. 8 (1), pp. e14336.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Asthma/*metabolism
Breath Tests/*methods
Bronchi/*metabolism
Nitric Oxide/*analysis
Pulmonary Alveoli/*metabolism
Adolescent ; Bayes Theorem ; Exhalation ; Female ; Humans ; Male ; Markov Chains ; Monte Carlo Method ; Nitric Oxide/metabolism
Czasopismo naukowe
Tytuł :
Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload.
Autorzy :
Zambom FFF; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Oliveira KC; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Foresto-Neto O; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Faustino VD; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Ávila VF; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Albino AH; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Arias SCA; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Volpini RA; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Malheiros DMAC; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Saraiva Camara NO; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Zatz R; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Fujihara CK; Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2019 Oct 01; Vol. 317 (4), pp. F1058-F1067. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Nitric Oxide/*antagonists & inhibitors
Renal Insufficiency, Chronic/*physiopathology
Sodium Chloride, Dietary/*pharmacology
Allopurinol/pharmacology ; Animals ; Enzyme Inhibitors/pharmacology ; Hypertension/drug therapy ; Interleukin-1beta/antagonists & inhibitors ; Interleukin-1beta/metabolism ; Male ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; NG-Nitroarginine Methyl Ester/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nitric Oxide Synthase/antagonists & inhibitors ; Pyrrolidines/pharmacology ; Rats ; Rats, Wistar ; Renal Insufficiency, Chronic/chemically induced ; Renal Insufficiency, Chronic/drug therapy ; Signal Transduction/drug effects ; Thiocarbamates/pharmacology ; Toll-Like Receptor 4/antagonists & inhibitors ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
The contribution of collecting duct NOS1 to the concentrating mechanisms in male and female mice.
Autorzy :
Mendoza LD; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Hyndman KA; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2019 Sep 01; Vol. 317 (3), pp. F547-F559. Date of Electronic Publication: 2019 Jun 26.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diuresis*/drug effects
Kidney Concentrating Ability*/drug effects
Dehydration/*enzymology
Kidney Tubules, Collecting/*enzymology
Nitric Oxide/*metabolism
Nitric Oxide Synthase Type I/*metabolism
Animals ; Antidiuretic Agents/pharmacology ; Aquaporin 2/genetics ; Aquaporin 2/metabolism ; Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Deamino Arginine Vasopressin/pharmacology ; Dehydration/physiopathology ; Disease Models, Animal ; Female ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Kidney Tubules, Collecting/drug effects ; Male ; Mice, Knockout ; Nitric Oxide Synthase Type I/deficiency ; Nitric Oxide Synthase Type I/genetics ; Organism Hydration Status ; Osmolar Concentration ; Sex Factors ; Signal Transduction ; Urodynamics ; Water Deprivation
Czasopismo naukowe
Tytuł :
Urinary dysfunction in transgenic sickle cell mice: model of idiopathic overactive bladder syndrome.
Autorzy :
Karakus S; James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Anele UA; James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
Silva FH; James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Hematology and Hemotherapy Center, University of Campinas, Campinas, São Paulo, Brazil.
Musicki B; James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Burnett AL; James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2019 Sep 01; Vol. 317 (3), pp. F540-F546. Date of Electronic Publication: 2019 Jun 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Urodynamics*
Anemia, Sickle Cell/*complications
Nitric Oxide/*metabolism
Urinary Bladder/*metabolism
Urinary Bladder, Overactive/*etiology
Anemia, Sickle Cell/genetics ; Animals ; Disease Models, Animal ; Hemoglobin A/genetics ; Hemoglobin A/metabolism ; Hemoglobins/genetics ; Hemoglobins/metabolism ; Humans ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle Contraction ; Muscle Relaxation ; Nitric Oxide Synthase Type I/deficiency ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type III/deficiency ; Nitric Oxide Synthase Type III/genetics ; Signal Transduction ; Urinary Bladder/physiopathology ; Urinary Bladder, Overactive/metabolism ; Urinary Bladder, Overactive/physiopathology
Czasopismo naukowe
Tytuł :
Reduced endothelial nitric oxide synthase activation contributes to cardiovascular injury during chronic kidney disease progression.
Autorzy :
Amador-Martínez I; Laboratorio de Fisiología Cardiovascular y Trasplante Renal, Unidad de Medicina Translacional, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Cardiología Ignacio Chávez , Mexico City, Mexico.; Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , Mexico City, Mexico.
Pérez-Villalva R; Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , Mexico City, Mexico.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City, Mexico.
Uribe N; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City, Mexico.
Cortés-González C; Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología , Mexico City, Mexico.
Bobadilla NA; Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , Mexico City, Mexico.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City, Mexico.
Barrera-Chimal J; Laboratorio de Fisiología Cardiovascular y Trasplante Renal, Unidad de Medicina Translacional, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Cardiología Ignacio Chávez , Mexico City, Mexico.; Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , Mexico City, Mexico.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2019 Aug 01; Vol. 317 (2), pp. F275-F285. Date of Electronic Publication: 2019 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Kidney Injury/*complications
Cardiomegaly/*etiology
Myocardium/*enzymology
Nitric Oxide/*metabolism
Nitric Oxide Synthase Type III/*metabolism
Renal Insufficiency, Chronic/*etiology
Acute Kidney Injury/drug therapy ; Acute Kidney Injury/enzymology ; Animals ; Arginine/pharmacology ; Cardiomegaly/enzymology ; Cardiomegaly/prevention & control ; Disease Models, Animal ; Disease Progression ; Down-Regulation ; Enzyme Activation ; Fibrosis ; HSP90 Heat-Shock Proteins/metabolism ; Male ; Natriuretic Peptide, Brain/metabolism ; Oxidative Stress ; Phosphorylation ; Rats, Wistar ; Renal Insufficiency, Chronic/enzymology ; Renal Insufficiency, Chronic/prevention & control ; Threonine ; Time Factors
Czasopismo naukowe
Tytuł :
H 2 O 2 -induced microvessel barrier dysfunction: the interplay between reactive oxygen species, nitric oxide, and peroxynitrite.
Autorzy :
Zhou X; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia.
Qian Y; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia.
Yuan D; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia.
Feng Q; Department of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania.
He P; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia.; Department of Cellular and Molecular Physiology, College of Medicine, Penn State University, Hershey, Pennsylvania.
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Źródło :
Physiological reports [Physiol Rep] 2019 Aug; Vol. 7 (16).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Capillary Permeability/*drug effects
Hydrogen Peroxide/*toxicity
Nitric Oxide/*metabolism
Peroxynitrous Acid/*metabolism
Reactive Oxygen Species/*toxicity
Animals ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Female ; Hydrogen Peroxide/metabolism ; Microvessels/drug effects ; Microvessels/metabolism ; Nitric Oxide/toxicity ; Peroxynitrous Acid/toxicity ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs.
Autorzy :
Monzon CM; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Garvin JL; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2019 Aug 01; Vol. 317 (2), pp. F411-F418. Date of Electronic Publication: 2019 Jun 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Renal Reabsorption*/drug effects
Second Messenger Systems*/drug effects
Claudins/*metabolism
Cyclic GMP/*metabolism
Loop of Henle/*metabolism
Nitric Oxide/*metabolism
Sodium/*metabolism
Animals ; Chlorides/metabolism ; Claudins/physiology ; Dibutyryl Cyclic GMP/pharmacology ; Loop of Henle/drug effects ; Male ; Membrane Potentials ; Nitric Oxide Donors/pharmacology ; Perfusion ; Rats, Sprague-Dawley ; Spermine/analogs & derivatives ; Spermine/pharmacology
Czasopismo naukowe
Tytuł :
Arginase: A Multifaceted Enzyme Important in Health and Disease.
Autorzy :
Caldwell RW; Department of Pharmacology & Toxicology, Vision Discovery Institute, Department of Medicine-Hematology and Oncology, Department of Occupational Therapy, School of Allied Health Sciences, and Vascular Biology Center, Medical College of Georgia, Augusta University , Augusta, Georgia ; and VA Medical Center, Augusta, Georgia.
Rodriguez PC; Department of Pharmacology & Toxicology, Vision Discovery Institute, Department of Medicine-Hematology and Oncology, Department of Occupational Therapy, School of Allied Health Sciences, and Vascular Biology Center, Medical College of Georgia, Augusta University , Augusta, Georgia ; and VA Medical Center, Augusta, Georgia.
Toque HA; Department of Pharmacology & Toxicology, Vision Discovery Institute, Department of Medicine-Hematology and Oncology, Department of Occupational Therapy, School of Allied Health Sciences, and Vascular Biology Center, Medical College of Georgia, Augusta University , Augusta, Georgia ; and VA Medical Center, Augusta, Georgia.
Narayanan SP; Department of Pharmacology & Toxicology, Vision Discovery Institute, Department of Medicine-Hematology and Oncology, Department of Occupational Therapy, School of Allied Health Sciences, and Vascular Biology Center, Medical College of Georgia, Augusta University , Augusta, Georgia ; and VA Medical Center, Augusta, Georgia.
Caldwell RB; Department of Pharmacology & Toxicology, Vision Discovery Institute, Department of Medicine-Hematology and Oncology, Department of Occupational Therapy, School of Allied Health Sciences, and Vascular Biology Center, Medical College of Georgia, Augusta University , Augusta, Georgia ; and VA Medical Center, Augusta, Georgia.
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Źródło :
Physiological reviews [Physiol Rev] 2018 Apr 01; Vol. 98 (2), pp. 641-665.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Arginase/*metabolism
Endothelium, Vascular/*metabolism
Nitric Oxide/*metabolism
Reactive Oxygen Species/*metabolism
Urea/*metabolism
Animals ; Arginine/metabolism ; Endothelium, Vascular/physiopathology ; Humans
Czasopismo naukowe
Tytuł :
Endothelium-dependent impairments to cerebral vascular reactivity with type 2 diabetes mellitus in the Goto-Kakizaki rat.
Autorzy :
Halvorson BD; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario , London, Ontario , Canada.
Whitehead SN; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario , London, Ontario , Canada.
McGuire JJ; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario , London, Ontario , Canada.
Wiseman RW; Departments of Physiology and Radiology, Michigan State University , East Lansing, Michigan.
Frisbee JC; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario , London, Ontario , Canada.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2019 Jul 01; Vol. 317 (1), pp. R149-R159. Date of Electronic Publication: 2019 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*metabolism
Endothelium, Vascular/*physiopathology
Middle Cerebral Artery/*physiology
Nitric Oxide/*metabolism
Animals ; Aorta ; Blood Pressure ; Diabetes Mellitus, Type 2/pathology ; Male ; Middle Cerebral Artery/drug effects ; Nitroprusside/pharmacology ; Rats ; Rats, Inbred Strains ; Vasodilation ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Mechanisms of sex differences in exercise capacity.
Autorzy :
Oydanich M; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Babici D; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Zhang J; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Rynecki N; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Vatner DE; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
Vatner SF; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School , Newark, New Jersey.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2019 Jun 01; Vol. 316 (6), pp. R832-R838. Date of Electronic Publication: 2019 Apr 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Sex Characteristics*
Exercise Tolerance/*physiology
Nitric Oxide/*metabolism
Physical Conditioning, Animal/*physiology
Animals ; Estrogens/metabolism ; Exercise Tolerance/drug effects ; Female ; Male ; Mice, Inbred C57BL ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Synthase/drug effects ; Nitric Oxide Synthase/metabolism ; Ovariectomy/methods ; Sex Factors
Czasopismo naukowe
Tytuł :
Stimulation of constitutive nitric oxide uniquely and compensatorily regulates intestinal epithelial cell brush border membrane Na absorption.
Autorzy :
Palaniappan B; Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Manoharan P; Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Arthur S; Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Singh S; Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Murughiyan U; Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Sundaram U; Department of Clinical and Translational Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia.
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Źródło :
Physiological reports [Physiol Rep] 2019 May; Vol. 7 (9), pp. e14086.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Intestinal Absorption/*physiology
Intestine, Small/*metabolism
Nitric Oxide/*physiology
Sodium/*metabolism
Animals ; Cells, Cultured ; Intestinal Absorption/drug effects ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestine, Small/drug effects ; Microvilli/drug effects ; Microvilli/metabolism ; Nitroso Compounds/pharmacology ; Penicillamine/analogs & derivatives ; Penicillamine/pharmacology ; Rabbits ; Rats ; Sodium-Glucose Transporter 1/metabolism ; Sodium-Hydrogen Exchanger 3/metabolism ; Sodium-Hydrogen Exchangers/metabolism ; Sodium-Potassium-Exchanging ATPase/drug effects ; Sodium-Potassium-Exchanging ATPase/metabolism
Czasopismo naukowe
Tytuł :
Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.
Autorzy :
Rogers RT; Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.
Sun MA; Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.
Yue Q; Department of Physiology, Emory University School of Medicine , Atlanta, Georgia.
Bao HF; Department of Physiology, Emory University School of Medicine , Atlanta, Georgia.
Sands JM; Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.; Department of Physiology, Emory University School of Medicine , Atlanta, Georgia.
Blount MA; Renal Division, Department of Medicine, Emory University School of Medicine , Atlanta, Georgia.; Department of Physiology, Emory University School of Medicine , Atlanta, Georgia.
Eaton DC; Department of Physiology, Emory University School of Medicine , Atlanta, Georgia.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2019 Mar 01; Vol. 316 (3), pp. F539-F549. Date of Electronic Publication: 2018 Dec 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Sodium Channels/*metabolism
Kidney Medulla/*metabolism
Membrane Transport Proteins/*metabolism
Nitric Oxide/*metabolism
Sodium/*metabolism
Animals ; Ion Transport/physiology ; Kidney Concentrating Ability/physiology ; Membrane Transport Proteins/genetics ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Angiotensin-(1-7) inhibits sodium transport via Mas receptor by increasing nitric oxide production in thick ascending limb.
Autorzy :
Dibo P; Department of Basic Research, J. Robert Cade Foundation, Cordoba, Argentina.
Marañón RO; Department of Medicine/Nephrology, University of Mississippi Medical Center, Jackson, Mississippi.; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi.
Chandrashekar K; Department of Medicine/Nephrology, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Mazzuferi F; Department of Basic Research, J. Robert Cade Foundation, Cordoba, Argentina.
Silva GB; Department of Basic Research, J. Robert Cade Foundation, Cordoba, Argentina.; Gabinete de Tecnología Médica (GATEME-UNSJ), Universidad Nacional de San Juan - Consejo Nacional de Investigaciones Científicas y Técnicas - CONICET, San Juan, Argentina.
Juncos LA; Department of Medicine/Nephrology, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Juncos LI; Department of Basic Research, J. Robert Cade Foundation, Cordoba, Argentina.
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Źródło :
Physiological reports [Physiol Rep] 2019 Mar; Vol. 7 (5), pp. e14015.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin I/*pharmacology
Loop of Henle/*drug effects
Natriuresis/*drug effects
Natriuretic Agents/*pharmacology
Nitric Oxide/*metabolism
Peptide Fragments/*pharmacology
Proto-Oncogene Proteins/*agonists
Receptors, G-Protein-Coupled/*agonists
Sodium/*metabolism
Animals ; Loop of Henle/metabolism ; Male ; Oxygen Consumption/drug effects ; Proto-Oncogene Proteins/metabolism ; Rats, Wistar ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
Nitric oxide mediates anomalous tubuloglomerular feedback in rats fed high-NaCl diet after subtotal nephrectomy.
Autorzy :
Thomson SC; Division of Nephrology-Hypertension, VA San Diego Healthcare System and University of California, San Diego School of Medicine , La Jolla, California.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2019 Feb 01; Vol. 316 (2), pp. F223-F230. Date of Electronic Publication: 2018 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Glomerular Filtration Rate*/drug effects
Nephrectomy*
Renal Reabsorption*/drug effects
Kidney Glomerulus/*metabolism
Kidney Tubules, Proximal/*metabolism
Nitric Oxide/*metabolism
Sodium Chloride, Dietary/*metabolism
Animals ; Diuretics/pharmacology ; Enzyme Inhibitors/pharmacology ; Feedback, Physiological ; Kidney Glomerulus/drug effects ; Kidney Tubules, Proximal/drug effects ; Male ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/metabolism ; Rats, Wistar ; Signal Transduction ; Sodium Chloride, Dietary/administration & dosage
Czasopismo naukowe

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