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Wyświetlanie 1-16 z 16
Tytuł :
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
Autorzy :
Amiable, Claire
Paoletti, Julie
Haouz, Ahmed
Padilla, André
Labesse, Gilles
Kaminski, Pierre-Alexandre
Pochet, Sylvie
Pokaż więcej
Temat :
MESH: Drug Design
MESH : Enzyme Inhibitors/pharmacology
MESH : Antineoplastic Agents/metabolism
MESH : Enzyme Inhibitors/metabolism
MESH : Antineoplastic Agents/pharmacology
MESH : Proto-Oncogene Proteins/antagonists & inhibitors
MESH: Nuclear Proteins/metabolism
MESH : Animals
MESH : Nuclear Proteins/metabolism
MESH: Proto-Oncogene Proteins/chemistry
MESH: Nuclear Proteins/antagonists & inhibitors
MESH : Cell Line, Tumor
Inhibitor
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
MESH: Nuclear Proteins/chemistry
MESH : Protein Conformation
MESH : Antineoplastic Agents/chemical synthesis
MESH: Proto-Oncogene Proteins/antagonists & inhibitors
MESH: Antineoplastic Agents/metabolism
MESH: N-Glycosyl Hydrolases/metabolism
MESH: Rats
MESH: Molecular Targeted Therapy
MESH : Molecular Docking Simulation
MESH : Proto-Oncogene Proteins/chemistry
MESH : Enzyme Inhibitors/chemical synthesis
MESH: N-Glycosyl Hydrolases/antagonists & inhibitors
MESH: Purine Nucleotides/chemical synthesis
MESH: Chemistry Techniques, Synthetic
MESH : Chemistry Techniques, Synthetic
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
MESH : Humans
MESH: Antineoplastic Agents/chemistry
MESH: Purine Nucleotides/pharmacology
MESH : Drug Screening Assays, Antitumor
MESH : Purine Nucleotides/pharmacology
MESH: Cell Line, Tumor
MESH: Molecular Docking Simulation
MESH: Animals
MESH : Antineoplastic Agents/chemistry
MESH : Nuclear Proteins/chemistry
MESH: Purine Nucleotides/chemistry
MESH: Enzyme Inhibitors/chemistry
MESH : Enzyme Inhibitors/chemistry
MESH : Proto-Oncogene Proteins/metabolism
Nucleoside analogues
MESH : Purine Nucleotides/metabolism
MESH : Purine Nucleotides/chemistry
MESH: Enzyme Inhibitors/chemical synthesis
DNPH1
MESH: Enzyme Inhibitors/metabolism
MESH: Protein Conformation
MESH : Drug Design
MESH: Proto-Oncogene Proteins/metabolism
Cross-coupling reaction
MESH: Enzyme Inhibitors/pharmacology
MESH : Purine Nucleotides/chemical synthesis
MESH: Humans
MESH: Purine Nucleotides/metabolism
MESH: Antineoplastic Agents/pharmacology
MESH : Molecular Targeted Therapy
MESH : N-Glycosyl Hydrolases/chemistry
MESH: N-Glycosyl Hydrolases/chemistry
MESH : Rats
MESH : N-Glycosyl Hydrolases/metabolism
MESH: Antineoplastic Agents/chemical synthesis
MESH : N-Glycosyl Hydrolases/antagonists & inhibitors
MESH: Drug Screening Assays, Antitumor
Crystal structure
Cancer
MESH: Structure-Activity Relationship
MESH : Nuclear Proteins/antagonists & inhibitors
MESH : Structure-Activity Relationship
Źródło :
European Journal of Medicinal Chemistry, Elsevier, 2014, 85, pp.418-37. ⟨10.1016/j.ejmech.2014.07.110⟩
European Journal of Medicinal Chemistry, Elsevier, 2014, 85, pp.418-37. 〈10.1016/j.ejmech.2014.07.110〉
European Journal of Medicinal Chemistry
Tytuł :
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
Autorzy :
Amiable, Claire
Paoletti, Julie
Haouz, Ahmed
Padilla, André
Labesse, Gilles
Kaminski, Pierre Alexandre
Pochet, Sylvie
Pokaż więcej
Temat :
Cancer
Cross-coupling reaction
Crystal structure
DNPH1
Inhibitor
Nucleoside analogues
MESH: Animals
MESH: Antineoplastic Agents/chemical synthesis
MESH: Enzyme Inhibitors/chemistry
MESH: Enzyme Inhibitors/metabolism
MESH: Enzyme Inhibitors/pharmacology
MESH: Humans
MESH: Molecular Docking Simulation
MESH: Molecular Targeted Therapy
MESH: N-Glycosyl Hydrolases/antagonists & inhibitors
MESH: N-Glycosyl Hydrolases/chemistry
MESH: N-Glycosyl Hydrolases/metabolism
MESH: Nuclear Proteins/antagonists & inhibitors
MESH: Antineoplastic Agents/chemistry
MESH: Nuclear Proteins/chemistry
MESH: Nuclear Proteins/metabolism
MESH: Protein Conformation
MESH: Proto-Oncogene Proteins/antagonists & inhibitors
MESH: Proto-Oncogene Proteins/chemistry
MESH: Proto-Oncogene Proteins/metabolism
MESH: Purine Nucleotides/chemical synthesis
MESH: Purine Nucleotides/chemistry
MESH: Purine Nucleotides/metabolism
MESH: Purine Nucleotides/pharmacology
MESH: Antineoplastic Agents/metabolism
MESH: Rats
MESH: Structure-Activity Relationship
MESH: Antineoplastic Agents/pharmacology
MESH: Cell Line, Tumor
MESH: Chemistry Techniques, Synthetic
MESH: Drug Design
MESH: Drug Screening Assays, Antitumor
MESH: Enzyme Inhibitors/chemical synthesis
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Źródło :
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 85, pp.418-37. ⟨10.1016/j.ejmech.2014.07.110⟩
Tytuł :
Structure of the oncoprotein Rcl bound to three nucleotide analogues.
Autorzy :
Padilla, André
Amiable, Claire
Pochet, Sylvie
Kaminski, Pierre Alexandre
Labesse, Gilles
Pokaż więcej
Temat :
[SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Źródło :
Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 2013, 69 (Pt 2), pp.247-55. ⟨10.1107/S0907444912045039⟩
Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 2013, 69 (Pt 2), pp.247-55. 〈10.1107/S0907444912045039〉
Acta Crystallographica Section D: Biological Crystallography
Tytuł :
ChemInform Abstract: Unprecedented Formation of 8(R),5′-O-Cycloribonucleosides Through a Triflation Reaction of Purine Ribonucleosides.
Autorzy :
Amiable, Claire
Pochet, Sylvie
Pokaż więcej
Źródło :
ChemInform; Aug2015, Vol. 46 Issue 32, pno-no, 1p
Czasopismo naukowe
Tytuł :
Structure of the oncoprotein Rcl bound to three nucleotide analogues.
Autorzy :
Padilla A; CNRS, UMR5048, Université Montpellier 1 et 2, Centre de Biochimie Structurale, F-34090 Montpellier, France.
Amiable C
Pochet S
Kaminski PA
Labesse G
Pokaż więcej
Źródło :
Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 2013 Feb; Vol. 69 (Pt 2), pp. 247-55. Date of Electronic Publication: 2013 Jan 19.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
N-Glycosyl Hydrolases/*chemistry
N-Glycosyl Hydrolases/*metabolism
Nucleotides/*chemistry
Oncogene Proteins/*chemistry
Oncogene Proteins/*metabolism
Acenaphthenes/chemistry ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/genetics ; Amino Acid Sequence ; Amino Acid Substitution/genetics ; Animals ; Crystallization ; Ligands ; Molecular Sequence Data ; N-Glycosyl Hydrolases/genetics ; Nucleotides/genetics ; Oncogene Proteins/genetics ; Organophosphonates/chemistry ; Phosphorylation ; Protein Binding/genetics ; Protein Interaction Mapping/methods ; Rats ; Ribonucleotides/chemistry ; Ribonucleotides/genetics ; Thionucleotides/chemistry ; Thionucleotides/genetics ; Thymidine/analogs & derivatives ; Thymidine/chemistry ; Thymidine/genetics ; X-Ray Diffraction
Czasopismo naukowe
Tytuł :
A pyridinium cation-π interaction sensor for the fluorescent detection of alkyl halides.
Autorzy :
Chen W; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK.
Elfeky SA
Nonne Y
Male L
Ahmed K
Amiable C
Axe P
Yamada S
James TD
Bull SD
Fossey JS
Pokaż więcej
Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2011 Jan 07; Vol. 47 (1), pp. 253-5. Date of Electronic Publication: 2010 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescence*
Fluorescent Dyes/*chemistry
Hydrocarbons, Halogenated/*analysis
Pyridines/*chemistry
Alkylation ; Cations/chemistry ; Crystallography, X-Ray ; Fluorescent Dyes/chemical synthesis ; Models, Molecular ; Molecular Structure ; Pyridines/chemical synthesis ; Solutions ; Spectrometry, Fluorescence
Czasopismo naukowe
    Wyświetlanie 1-16 z 16

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