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Tytuł :
Design and synthesis of 2-(2-isonicotinoylhydrazineylidene)propanamides as InhA inhibitors with high antitubercular activity.
Autorzy :
Pflégr V; Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic.
Horváth L; MTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd Research Network (ELKH), Institute of Chemistry, Eötvös Loránd University, Pázmány Péter Sétány 1/A, Budapest, H-1117, P.O. Box 32, 1518, Budapest 112, Hungary.
Stolaříková J; Laboratory for Mycobacterial Diagnostics and Tuberculosis, Regional Institute of Public Health in Ostrava, Partyzánské náměstí 7, 702 00, Ostrava, Czech Republic.
Pál A; Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH-1, Ilkovičova 6, 842 15, Bratislava, Slovakia.
Korduláková J; Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH-1, Ilkovičova 6, 842 15, Bratislava, Slovakia.
Bősze S; MTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd Research Network (ELKH), Institute of Chemistry, Eötvös Loránd University, Pázmány Péter Sétány 1/A, Budapest, H-1117, P.O. Box 32, 1518, Budapest 112, Hungary.
Vinšová J; Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic.
Krátký M; Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05, Hradec Králové, Czech Republic. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113668. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Amides/*chemistry
Antitubercular Agents/*chemical synthesis
Bacterial Proteins/*antagonists & inhibitors
Oxidoreductases/*antagonists & inhibitors
Amides/metabolism ; Amides/pharmacology ; Amides/therapeutic use ; Aniline Compounds/chemistry ; Antitubercular Agents/metabolism ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Bacterial Proteins/metabolism ; Cell Survival/drug effects ; Drug Resistance, Bacterial/drug effects ; Hep G2 Cells ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/metabolism ; Oxidoreductases/metabolism ; Pyruvic Acid/chemistry ; Structure-Activity Relationship ; Tuberculosis/drug therapy
Czasopismo naukowe
Tytuł :
Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation.
Autorzy :
D'Amico R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Monaco F; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98166 Messina, Italy.
Siracusa R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Cordaro M; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98166 Messina, Italy.
Fusco R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Peritore AF; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Gugliandolo E; Department of Veterinary Science, University of Messina, 98166 Messina, Italy.
Crupi R; Department of Veterinary Science, University of Messina, 98166 Messina, Italy.
Cuzzocrea S; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Di Paola R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Impellizzeri D; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Genovese T; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 21; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*therapeutic use
Blood Coagulation Disorders/*drug therapy
Disseminated Intravascular Coagulation/*drug therapy
Ethanolamines/*therapeutic use
Palmitic Acids/*therapeutic use
Sepsis/*complications
Amides/chemistry ; Amides/pharmacology ; Animals ; Blood Coagulation Disorders/etiology ; COVID-19/pathology ; COVID-19/virology ; Cytokines/blood ; Cytokines/metabolism ; Disease Models, Animal ; Disseminated Intravascular Coagulation/etiology ; Ethanolamines/chemistry ; Ethanolamines/pharmacology ; Fibrin Fibrinogen Degradation Products/metabolism ; Lipopolysaccharides/toxicity ; Lung/metabolism ; Lung/pathology ; Male ; Mast Cells/cytology ; Mast Cells/drug effects ; Mast Cells/metabolism ; Palmitic Acids/chemistry ; Palmitic Acids/pharmacology ; Partial Thromboplastin Time ; Prothrombin Time ; Rats ; Rats, Sprague-Dawley ; SARS-CoV-2/isolation & purification ; Sepsis/pathology ; Serine Proteases/metabolism
Czasopismo naukowe
Tytuł :
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Autorzy :
Ledneczki I; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary. Electronic address: .
Horváth A; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Tapolcsányi P; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Éles J; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Molnár KD; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Vágó I; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Visegrády A; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Kiss L; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Szigetvári Á; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Kóti J; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Krámos B; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Mahó S; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Holm P; Orion Corporation, Turku, Finland.
Kolok S; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Fodor L; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Thán M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Kostyalik D; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Balázs O; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Vastag M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Greiner I; Research Management, Gedeon Richter Plc., Budapest, Hungary.
Lévay G; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Lendvai B; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Némethy Z; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113560. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
High-Throughput Screening Assays*
Amides/*pharmacology
Oxalic Acid/*pharmacology
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Allosteric Regulation/drug effects ; Amides/chemical synthesis ; Amides/chemistry ; Animals ; Dose-Response Relationship, Drug ; Humans ; Male ; Molecular Structure ; Oxalic Acid/chemical synthesis ; Oxalic Acid/chemistry ; Rats ; Rats, Wistar ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis.
Autorzy :
Li P; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Wang B; Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing, 101149, PR China.
Fu L; Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing, 101149, PR China.
Guo K; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Ma C; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Wang B; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Lin Z; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China.
Li G; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China. Electronic address: .
Huang H; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China; Chinese Academy of Medical Sciences Key Laboratory of Anti-DR TB Innovative Drug Research, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, 100050, PR China. Electronic address: .
Lu Y; Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing, 101149, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113603. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*pharmacology
Antitubercular Agents/*pharmacology
Benzopyrans/*pharmacology
Esters/*pharmacology
Mycobacterium tuberculosis/*drug effects
Amides/chemistry ; Amides/metabolism ; Antitubercular Agents/chemistry ; Antitubercular Agents/metabolism ; Benzopyrans/chemistry ; Benzopyrans/metabolism ; Dose-Response Relationship, Drug ; Esters/chemistry ; Esters/metabolism ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Electron attachment to isolated and microhydrated favipiravir.
Autorzy :
Sedmidubská B; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 3, 18223 Prague, Czech Republic. .; Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, Břehová 7, 11519 Prague, Czech Republic.
Luxford TFM; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 3, 18223 Prague, Czech Republic. .
Kočišek J; J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 3, 18223 Prague, Czech Republic. .
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Źródło :
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2021 Oct 06; Vol. 23 (38), pp. 21501-21511. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Amides*/chemistry
Amides*/isolation & purification
Pyrazines*/chemistry
Pyrazines*/isolation & purification
Electrons ; Water/chemistry
Czasopismo naukowe
Tytuł :
Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.
Autorzy :
Zaręba P; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland. Electronic address: .
Sałat K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Höfner GC; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München Butenandtstr, 5-13, 81377, Munich, Germany.
Łątka K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Bajda M; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Latacz G; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Kotniewicz K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Rapacz A; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Podkowa A; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Maj M; Department of Biopharmacy, Medical University of Lublin, ul. W. Chodzki 4a, 20-093, Lublin, Poland.
Jóźwiak K; Department of Biopharmacy, Medical University of Lublin, ul. W. Chodzki 4a, 20-093, Lublin, Poland.
Filipek B; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Wanner KT; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München Butenandtstr, 5-13, 81377, Munich, Germany.
Malawska B; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
Kulig K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St, 30-688, Kraków, Poland.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113512. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Amides/*pharmacology
Analgesics/*pharmacology
Anticonvulsants/*pharmacology
Antidepressive Agents/*pharmacology
GABA Uptake Inhibitors/*pharmacology
Amides/chemical synthesis ; Amides/chemistry ; Analgesics/chemical synthesis ; Analgesics/chemistry ; Anticonvulsants/chemical synthesis ; Anticonvulsants/chemistry ; Antidepressive Agents/chemical synthesis ; Antidepressive Agents/chemistry ; Dose-Response Relationship, Drug ; GABA Uptake Inhibitors/chemical synthesis ; GABA Uptake Inhibitors/chemistry ; Humans ; Molecular Structure ; N-Acetylglucosaminyltransferases/antagonists & inhibitors ; N-Acetylglucosaminyltransferases/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors.
Autorzy :
Venkidath A; Centre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.
Oh JM; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Dev S; Centre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.
Amin E; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah 52571, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Rasheed SP; Centre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.
Vengamthodi A; Centre for Experimental Drug Design and Development, Department of Pharmaceutical Chemistry, Al-Shifa College of Pharmacy, Perinthalmanna 679325, India.
Gambacorta N; Dipartimento di Farmacia-Scienze del Farmaco, Università Degli Studi di Bari 'Aldo Moro', Via E. Orabona, 4, I-70125 Bari, Italy.
Khames A; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.
George G; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682041, India.
Nicolotti O; Dipartimento di Farmacia-Scienze del Farmaco, Università Degli Studi di Bari 'Aldo Moro', Via E. Orabona, 4, I-70125 Bari, Italy.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682041, India.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Oct 03; Vol. 26 (19). Date of Electronic Publication: 2021 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*chemistry
Amyloid Precursor Protein Secretases/*antagonists & inhibitors
Monoamine Oxidase/*chemistry
Monoamine Oxidase Inhibitors/*chemistry
Protease Inhibitors/*chemistry
Amides/chemical synthesis ; Amides/metabolism ; Blood-Brain Barrier/metabolism ; Membranes, Artificial ; Molecular Structure ; Monoamine Oxidase Inhibitors/metabolism ; Protease Inhibitors/metabolism
Czasopismo naukowe
Tytuł :
Metal-Free Photoredox-Catalyzed Hydrodefluorination of Fluoroarenes Utilizing Amide Solvent as Reductant.
Autorzy :
Toriumi N; Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Yamashita K; Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
Iwasawa N; Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Sep 01; Vol. 27 (49), pp. 12635-12641. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Amides*
Reducing Agents*
Catalysis ; Metals ; Solvents
Czasopismo naukowe
Tytuł :
Intrinsic Green Fluorescent Cross-Linked Poly(ester amide)s by Spontaneous Zwitterionic Copolymerization.
Autorzy :
Zia A; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Finnegan JR; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Morrow JP; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Yin W; Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Jasieniak JJ; Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Pentzer E; Department of Chemistry, Department of Materials Science and Engineering, Texas A&M University, College Station, Texas 77843, United States.
Thickett S; School of Natural Sciences, The University of Tasmania, Hobart, TAS 7005, Australia.
Davis TP; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Kempe K; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology and Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
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Źródło :
Biomacromolecules [Biomacromolecules] 2021 Nov 08; Vol. 22 (11), pp. 4794-4804. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides*
Esters*
Fluorescence ; Polymerization ; Polymers
Czasopismo naukowe
Tytuł :
Mechanochemical Synthesis of Primary Amides.
Autorzy :
Gómez-Carpintero J; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Sánchez JD; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
González JF; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Menéndez JC; Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Oct 15; Vol. 86 (20), pp. 14232-14237. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides*
Esters*
Dipeptides
Czasopismo naukowe
Tytuł :
Continuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: a Telescoped Approach.
Autorzy :
Franco F; Dipartimento di Chimica e Biologia 'A. Zambelli', Università di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Meninno S; Dipartimento di Chimica e Biologia 'A. Zambelli', Università di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Lattanzi A; Dipartimento di Chimica e Biologia 'A. Zambelli', Università di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Puglisi A; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.
Benaglia M; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Oct 15; Vol. 86 (20), pp. 14207-14212. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides*
Carboxylic Acids*
Alcohols ; Esters ; Indicators and Reagents
Czasopismo naukowe
Tytuł :
Enyne Amides to Fused Pyridones: Scope and Limitations.
Autorzy :
Labadie SS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Thai K; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Grandner JM; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Liu Y; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Parr BT; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Oct 15; Vol. 86 (20), pp. 14177-14191. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Amides*
Pyridones*
Catalysis ; Cyclization ; Molecular Structure
Czasopismo naukowe
Tytuł :
Multipolar Force Fields for Amide-I Spectroscopy from Conformational Dynamics of the Alanine Trimer.
Autorzy :
Mondal P; Department of Chemistry, University of Basel, Klingelbergstrasse 80, Basel 4056, Switzerland.
Cazade PA; Department of Chemistry, University of Basel, Klingelbergstrasse 80, Basel 4056, Switzerland.
Das AK; Department of Chemistry, University of Basel, Klingelbergstrasse 80, Basel 4056, Switzerland.
Bereau T; Department of Chemistry, University of Basel, Klingelbergstrasse 80, Basel 4056, Switzerland.
Meuwly M; Department of Chemistry, University of Basel, Klingelbergstrasse 80, Basel 4056, Switzerland.; Department of Chemistry, Brown University, Providence/RI 02912, United States.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2021 Oct 07; Vol. 125 (39), pp. 10928-10938. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alanine*
Amides*
Bayes Theorem ; Molecular Conformation ; Molecular Dynamics Simulation ; Spectrum Analysis
Czasopismo naukowe
Tytuł :
New nimesulide derivatives with amide/sulfonamide moieties: Selective COX-2 inhibition and antitumor effects.
Autorzy :
Güngör T; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey. Electronic address: .
Ozleyen A; Graduate Program of Biomolecular Sciences, School of Graduate Studies, Canakkale Onsekiz Mart University, 17020, Çanakkale, Turkey; School of Chemistry, University of Leicester, LE1 7RH, Leicester, United Kingdom.
Yılmaz YB; Graduate Program of Biomolecular Sciences, School of Graduate Studies, Canakkale Onsekiz Mart University, 17020, Çanakkale, Turkey; Department of Molecular Biology and Genetics, Faculty of Arts and Science, Çanakkale Onsekiz Mart University, 17020, Çanakkale, Turkey.
Siyah P; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, 34353, Istanbul, Turkey.
Ay M; Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, 17020, Turkey.
Durdağı S; Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, 34353, Istanbul, Turkey.
Tumer TB; Department of Molecular Biology and Genetics, Faculty of Arts and Science, Çanakkale Onsekiz Mart University, 17020, Çanakkale, Turkey. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113566. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*pharmacology
Antineoplastic Agents/*pharmacology
Cyclooxygenase 2/*metabolism
Cyclooxygenase 2 Inhibitors/*pharmacology
Sulfonamides/*pharmacology
Amides/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model.
Autorzy :
Abdelnabi R; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Foo CS; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Kaptein SJF; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Zhang X; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Do TND; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Langendries L; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Vangeel L; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Breuer J; UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom.
Pang J; UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom.
Williams R; UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom.
Vergote V; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Heylen E; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Leyssen P; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Dallmeier K; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Coelmont L; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Chatterjee AK; Calibr at Scripps Research, La Jolla, CA 92037, USA.
Mols R; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery & Disposition, Box 921, 3000 Leuven, Belgium.
Augustijns P; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery & Disposition, Box 921, 3000 Leuven, Belgium.
De Jonghe S; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Jochmans D; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
Weynand B; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, Division of Translational Cell and Tissue Research, B-3000 Leuven, Belgium.
Neyts J; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium; Global Virus Network, GVN, Baltimore, MD 21201, USA.
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Źródło :
EBioMedicine [EBioMedicine] 2021 Oct; Vol. 72, pp. 103595. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article
MeSH Terms :
Amides/*therapeutic use
COVID-19/*drug therapy
Cytidine/*analogs & derivatives
Hydroxylamines/*therapeutic use
Lung/*virology
Pyrazines/*therapeutic use
Amides/pharmacology ; Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/transmission ; Cytidine/pharmacology ; Cytidine/therapeutic use ; Disease Models, Animal ; Drug Therapy, Combination ; Female ; Hydroxylamines/pharmacology ; Mesocricetus ; Pyrazines/pharmacology ; RNA, Viral ; Treatment Outcome ; Viral Load
Czasopismo naukowe
Tytuł :
New amide alkaloids and carbazole alkaloid from the stems of Clausena lansium.
Autorzy :
Sun X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Li C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Ma J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Zang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Huang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Chen N; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Wang X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Zhang D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: .
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Źródło :
Fitoterapia [Fitoterapia] 2021 Oct; Vol. 154, pp. 104999. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Amides/*pharmacology
Carbazoles/*pharmacology
Clausena/*chemistry
Neuroprotective Agents/*pharmacology
Alkaloids/isolation & purification ; Amides/isolation & purification ; Animals ; Carbazoles/isolation & purification ; China ; Molecular Structure ; Neuroprotective Agents/isolation & purification ; PC12 Cells ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Stems/chemistry ; Rats
Czasopismo naukowe
Tytuł :
Population pharmacokinetics of favipiravir in patients with COVID-19.
Autorzy :
Irie K; Department of Pharmacy, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.; Faculty of Pharmaceutical Science, Kobe Gakuin University, Kobe, Japan.
Nakagawa A; Department of Respiratory Medicine, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Fujita H; Department of Pharmacy, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Tamura R; Department of Pharmacy, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Eto M; Department of Clinical Laboratory, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Ikesue H; Department of Pharmacy, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Muroi N; Department of Pharmacy, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Fukushima S; Faculty of Pharmaceutical Science, Kobe Gakuin University, Kobe, Japan.
Tomii K; Department of Respiratory Medicine, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
Hashida T; Department of Pharmacy, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
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Źródło :
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Oct; Vol. 10 (10), pp. 1161-1170. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Amides/*administration & dosage
Antiviral Agents/*administration & dosage
COVID-19/*drug therapy
Pyrazines/*administration & dosage
Adult ; Aged ; Aged, 80 and over ; Amides/pharmacokinetics ; Antiviral Agents/pharmacokinetics ; COVID-19/blood ; Chromatography, Liquid ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Models, Theoretical ; Pyrazines/pharmacokinetics ; Retrospective Studies ; Tandem Mass Spectrometry ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Optimization of Analytical Procedure for In-hospital Rapid Quantification of Serum Level of Favipiravir in the Pharmacological Treatment of COVID-19.
Autorzy :
Moriiwa Y; Department of Biomedical Analysis, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
Morikawa G; Department of Pharmacy, Hokushin General Hospital.
Okazawa K; Department of Pharmacy, Hokushin General Hospital.
Yanagida A; Department of Biomedical Analysis, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
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Źródło :
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry [Anal Sci] 2021 Sep 10; Vol. 37 (9), pp. 1301-1304. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Hospitals*
Amides/*blood
Blood Chemical Analysis/*methods
COVID-19/*drug therapy
Pyrazines/*blood
Amides/therapeutic use ; COVID-19/blood ; Chromatography, High Pressure Liquid ; Humans ; Pyrazines/therapeutic use ; Time Factors
Czasopismo naukowe
Tytuł :
Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media.
Autorzy :
Stenholm Å; Cytiva, Uppsala, Sweden.; Analytical Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Backlund A; Pharmacognosy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Holmström S; Cytiva, Uppsala, Sweden.
Backlund M; SLU Artdatabanken, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Hedeland M; Analytical Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Fransson P; Uppsala BioCenter, Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
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Źródło :
PloS one [PLoS One] 2021 Sep 01; Vol. 16 (9), pp. e0244910. Date of Electronic Publication: 2021 Sep 01 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amides*
Amines*
Ammonium Compounds*
Mycorrhizae*
Agaricales
SCR Organism :
Hygrophorus camarophyllus
Czasopismo naukowe
Tytuł :
Molecular and structural characterization of agmatine coumaroyltransferase in Triticeae, the key regulator of hydroxycinnamic acid amide accumulation.
Autorzy :
Yamane M; Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502, Japan.
Takenoya M; Department of Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502, Japan.
Yajima S; Department of Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502, Japan.
Sue M; Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagaya, Tokyo, 156-8502, Japan. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2021 Sep; Vol. 189, pp. 112825. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Amides*
Coumaric Acids*
Acyltransferases/genetics ; Poaceae
Czasopismo naukowe

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