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Tytuł :
Caspase-1 inhibition ameliorates murine acute graft versus host disease by modulating the Th1/Th17/Treg balance.
Autorzy :
Chen W; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Su G; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; The Third People's Hospital of Bengbu, Bengbu, Anhui, China.
Xu Y; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Guo W; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Bhansali R; Department of Medicine, Hospital of the University of Pennsylvania.
Pan B; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Kong Q; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; Department of Medicine, Hospital of the University of Pennsylvania.
Cheng H; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Cao J; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Qi K; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zhu F; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Li M; Xuzhou Children's Hospital, Xuzhou, Jiangsu, China.
Zhu S; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zeng L; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Li Z; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Wu Q; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xu K; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China; Blood Diseases Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China; Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 May; Vol. 94, pp. 107503. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Chloromethyl Ketones/*therapeutic use
Caspase 1/*immunology
Graft vs Host Disease/*drug therapy
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Colon/drug effects ; Colon/immunology ; Graft vs Host Disease/blood ; Graft vs Host Disease/genetics ; Graft vs Host Disease/immunology ; HMGB1 Protein/blood ; HMGB1 Protein/genetics ; HMGB1 Protein/immunology ; Interleukin-18/blood ; Interleukin-18/genetics ; Interleukin-18/immunology ; Interleukin-1beta/blood ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Liver/drug effects ; Liver/immunology ; Lung/drug effects ; Lung/immunology ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; T-Lymphocytes, Regulatory/immunology ; Th1 Cells/immunology ; Th17 Cells/immunology
Czasopismo naukowe
Tytuł :
Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry.
Autorzy :
Citarella A; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy.
Micale N; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Sep 03; Vol. 25 (17). Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Amino Acid Chloromethyl Ketones/*chemical synthesis
Phenylalanine/*analogs & derivatives
SARS Virus/*drug effects
Serine Proteinase Inhibitors/*chemical synthesis
Viral Nonstructural Proteins/*antagonists & inhibitors
Amino Acid Chloromethyl Ketones/pharmacology ; Chemistry, Pharmaceutical/methods ; Coronavirus 3C Proteases ; Cysteine Endopeptidases/chemistry ; Cysteine Endopeptidases/metabolism ; HIV/drug effects ; HIV/enzymology ; HIV Protease/chemistry ; HIV Protease/metabolism ; Humans ; Kinetics ; Phenylalanine/chemical synthesis ; Phenylalanine/pharmacology ; SARS Virus/enzymology ; Serine Proteinase Inhibitors/pharmacology ; Structure-Activity Relationship ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
Autorzy :
Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Zeisner TU; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Papageorgiou G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Joshi D; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Soudy C; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Wu M; High Throughput Screening STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Lim CT; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Tan KW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Fujisawa R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Deegan T; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Nagaraj H; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Bineva-Todd G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Basier C; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Curran JF; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Howell M; High Throughput Screening STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Labib K; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
O'Reilly N; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
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Źródło :
The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2499-2515.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Evaluation, Preclinical*
Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Coronavirus 3C Proteases/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Small Molecule Libraries/*pharmacology
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Azoles/pharmacology ; Chlorocebus aethiops ; Coronavirus 3C Proteases/genetics ; Coronavirus 3C Proteases/isolation & purification ; Coronavirus 3C Proteases/metabolism ; Enzyme Assays ; Fluorescence Resonance Energy Transfer ; High-Throughput Screening Assays ; Leupeptins/pharmacology ; Organoselenium Compounds/pharmacology ; Peptidomimetics ; RNA-Binding Proteins/metabolism ; Reproducibility of Results ; SARS-CoV-2/drug effects ; Small Molecule Libraries/chemistry ; Vero Cells ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Formulation and Characterization of Antithrombin Perfluorocarbon Nanoparticles.
Autorzy :
Wilson AJ; The USF Health Heart Institute, University of South Florida, Tampa, FL, USA.
Zhou Q; College of Pharmacy, University of South Florida, Tampa, FL, USA.
Vargas I; The USF Health Heart Institute, University of South Florida, Tampa, FL, USA.
Palekar R; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Grabau R; The USF Health Heart Institute, University of South Florida, Tampa, FL, USA.
Pan H; The USF Health Heart Institute, University of South Florida, Tampa, FL, USA.
Wickline SA; The USF Health Heart Institute, University of South Florida, Tampa, FL, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2118, pp. 111-120.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Chloromethyl Ketones/*chemical synthesis
Antithrombins/*chemical synthesis
Fluorocarbons/*chemistry
Hirudins/*chemical synthesis
Peptide Fragments/*chemical synthesis
Amino Acid Chloromethyl Ketones/chemistry ; Amino Acid Chloromethyl Ketones/pharmacology ; Antithrombins/chemistry ; Antithrombins/pharmacology ; Hirudins/chemistry ; Hirudins/pharmacology ; Magnetic Iron Oxide Nanoparticles ; Nanoparticles ; Particle Size ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacology ; Polyhydroxyethyl Methacrylate ; Recombinant Proteins/chemical synthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
The Effectiveness of Anti-Apoptotic Agents to Preserve Primordial Follicles and Prevent Tissue Damage during Ovarian Tissue Cryopreservation and Xenotransplantation.
Autorzy :
Lee S; Department of Obstetrics and Gynecology, Korea University College of Medicine 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.
Cho HW; Department of Obstetrics and Gynecology, Korea University College of Medicine 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.
Kim B; Department of Obstetrics and Gynecology, Korea University College of Medicine 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.
Lee JK; Department of Obstetrics and Gynecology, Korea University College of Medicine 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.
Kim T; Department of Obstetrics and Gynecology, Korea University College of Medicine 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 03; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Heterografts/*drug effects
Ovarian Follicle/*drug effects
Adolescent ; Adult ; Amino Acid Chloromethyl Ketones/therapeutic use ; Animals ; Cryopreservation/methods ; Female ; Freezing ; Humans ; Lysophospholipids/metabolism ; Mice ; Mice, SCID ; Ovarian Follicle/metabolism ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Transplantation, Heterologous/methods ; Young Adult
Czasopismo naukowe
Tytuł :
Proprotein convertases blockage up-regulates specifically metallothioneins coding genes in human colon cancer stem cells.
Autorzy :
Gerovska D; Computational Biology and Systems Biomedicine Group, Biodonostia Health Research Institute, Calle Doctor 8 Beguiristain s/n, 20014 San Sebastián, Spain; Computational Biomedicine Data Analysis Platform, Biodonostia Health Research Institute, C/ Doctor 8 Beguiristain s/n, 20014 San Sebastián, Spain.
García-Gallastegi P; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Spain; Univ. Bordeaux, INSERM, LAMC, U1029, F-33600 Pessac, France.
Descarpentrie J; Univ. Bordeaux, INSERM, LAMC, U1029, F-33600 Pessac, France.
Crende O; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Spain.
Casado-Andrés M; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Spain; Univ. Bordeaux, INSERM, LAMC, U1029, F-33600 Pessac, France.
Martín A; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Spain.
Eguia J; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Spain.
Khatib AM; Univ. Bordeaux, INSERM, LAMC, U1029, F-33600 Pessac, France.
Araúzo-Bravo MJ; Computational Biology and Systems Biomedicine Group, Biodonostia Health Research Institute, Calle Doctor 8 Beguiristain s/n, 20014 San Sebastián, Spain; Computational Biomedicine Data Analysis Platform, Biodonostia Health Research Institute, C/ Doctor 8 Beguiristain s/n, 20014 San Sebastián, Spain; IKERBASQUE, Basque Foundation for Science, C/ María Díaz Harokoa 3, 48013 Bilbao, Spain; CIBER of Frailty and Healthy Aging (CIBERfes), Madrid, Spain. Electronic address: .
Badiola I; Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Spain. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Mar; Vol. 1868 (3), pp. 118912. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Amino Acid Chloromethyl Ketones/*pharmacology
Colonic Neoplasms/*enzymology
Gene Expression Profiling/*methods
Metallothionein/*genetics
Neoplastic Stem Cells/*enzymology
Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplastic Stem Cells/chemistry ; Neoplastic Stem Cells/drug effects ; Proprotein Convertases/antagonists & inhibitors ; Sequence Analysis, RNA ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Thermal shift assay to probe melting of thrombin, fibrinogen, fibrin monomer, and fibrin: Gly-Pro-Arg-Pro induces a fibrin monomer-like state in fibrinogen.
Autorzy :
Crossen J; Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, United States.. Electronic address: .
Diamond SL; Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, United States.. Electronic address: .
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Feb; Vol. 1865 (2), pp. 129805. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Fibrin/*chemistry
Fibrin Fibrinogen Degradation Products/*chemistry
Fibrinogen/*chemistry
Thrombin/*chemistry
Amino Acid Chloromethyl Ketones/chemistry ; Fibrinogens, Abnormal/chemistry ; Humans ; Oligopeptides/chemistry ; Protein Stability ; Transition Temperature
Czasopismo naukowe
Tytuł :
Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats.
Autorzy :
Liang H; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Sun Y; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China; Department of Neurosurgery, Xinyang Central Hospital, Xinyang, P.R. China.
Gao A; School of Life Science, Northeast Agricultural University, Harbin, P.R. China.
Zhang N; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P.R. China.
Jia Y; Department of Pathology, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Yang S; Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Na M; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Liu H; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Cheng X; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Fang X; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Ma W; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
Zhang X; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China. Electronic address: .
Wang F; Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P.R. China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2019 Oct; Vol. 75, pp. 105771. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Chloromethyl Ketones/*therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Caspase 1/*immunology
Caspase Inhibitors/*therapeutic use
Cerebral Hemorrhage/*drug therapy
Neuroprotective Agents/*therapeutic use
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacology ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/pathology ; Caspase Inhibitors/pharmacology ; Cells, Cultured ; Cerebral Hemorrhage/immunology ; Cerebral Hemorrhage/pathology ; Interleukin-18/genetics ; Interleukin-18/immunology ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Male ; Microglia ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/immunology ; Neuroprotective Agents/pharmacology ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction.
Autorzy :
Chen S; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Tian Q; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Shang C; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yang L; Department of Paediatrics, The Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Wei N; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Shang G; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Ji Y; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Kou H; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Lu S; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Liu H; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Dec 08; Vol. 2020, pp. 6976317. Date of Electronic Publication: 2020 Dec 08 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Chloromethyl Ketones/*pharmacology
Imidazoles/*pharmacology
Indoles/*pharmacology
Membrane Potential, Mitochondrial/*drug effects
Nucleus Pulposus/*drug effects
Oxidative Stress/*drug effects
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/metabolism ; Autophagy ; Cadaverine/analogs & derivatives ; Cadaverine/pharmacology ; Cell Death ; Cell Survival ; Compressive Strength ; L-Lactate Dehydrogenase/metabolism ; Mitochondria/metabolism ; Nucleus Pulposus/cytology ; Pressure ; Propidium/chemistry ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Eliminating the contribution of lipopolysaccharide to protein allergenicity in the human cell-line activation test (h-CLAT).
Autorzy :
Kobayashi-Tsukumo H; Department of Chemical and Energy Engineering, Yokohama National University.; Division of Risk Assessment, National Institute of Health Sciences.
Oiji K; College of Engineering Science, Yokohama National University.
Xie D; Department of Chemical and Energy Engineering, Yokohama National University.
Sawada Y; Department of Chemical and Energy Engineering, Yokohama National University.
Yamashita K; Corporate Research Center, Daicel Corporation.
Ogata S; Department of Environment and Information Sciences, Yokohama National University.
Kojima H; Division of Risk Assessment, National Institute of Health Sciences.
Itagaki H; Department of Chemical and Energy Engineering, Yokohama National University.
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Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2019; Vol. 44 (4), pp. 283-297.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Chloromethyl Ketones/*pharmacology
Hypersensitivity/*etiology
Hypersensitivity/*immunology
Lipopolysaccharides/*antagonists & inhibitors
Lipopolysaccharides/*immunology
Polymyxin B/*pharmacology
Proteins/*adverse effects
Proteins/*immunology
Skin/*immunology
Skin Tests/*methods
Amino Acid Chloromethyl Ketones/administration & dosage ; Amino Acid Chloromethyl Ketones/metabolism ; B7-2 Antigen/genetics ; B7-2 Antigen/immunology ; B7-2 Antigen/metabolism ; Culture Media ; Gene Expression/drug effects ; Humans ; Immunization ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/immunology ; Intercellular Adhesion Molecule-1/metabolism ; Lipopolysaccharides/adverse effects ; Lipopolysaccharides/metabolism ; Muramidase ; Ovalbumin ; Ovomucin ; Polymyxin B/administration & dosage ; Polymyxin B/metabolism ; Protein Binding ; THP-1 Cells ; Temperature ; Time Factors
Czasopismo naukowe
Tytuł :
Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination.
Autorzy :
Chen H; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.
Tian J; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.
Guo L; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA.; Higuchi Biosciences Center, The University of Kansas, Lawrence, KS, 66045, USA.
Du H; Department of Biological Sciences, The University of Texas at Dallas, 800 west Campbell Rd, Richardson, TX, 75080, USA. .; Higuchi Biosciences Center, The University of Kansas, Lawrence, KS, 66045, USA. .; Department of Pharmacology & Toxicology, The University of Kansas, Lawrence, KS, 66045, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 16; Vol. 10 (1), pp. 17589. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendritic Spines/*metabolism
Mitochondria/*metabolism
Mitochondrial Proton-Translocating ATPases/*metabolism
Adenosine Triphosphate/metabolism ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Caspase 3/metabolism ; Caspase Inhibitors/pharmacology ; Cell Death ; Female ; Hippocampus/metabolism ; Male ; Membrane Potential, Mitochondrial ; Mice ; Mice, Inbred C57BL ; Mitochondrial Proton-Translocating ATPases/physiology ; Neurons/metabolism ; Oligomycins/metabolism ; Oligomycins/pharmacology ; Quinolines/pharmacology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects.
Autorzy :
Cheng YW; Department of Microbiology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Chao TL; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Li CL; Department of Microbiology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Chiu MF; Department of Microbiology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Kao HC; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Wang SH; Hepatitis Research Center, National Taiwan University Hospital, Taipei 100, Taiwan.
Pang YH; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Lin CH; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Tsai YM; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Lee WH; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Tao MH; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Ho TC; Department of Microbiology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Wu PY; Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Jang LT; Biomedical Resource Core at the First Core Labs, Branch Office of Research and Development, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Chen PJ; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan; National Taiwan University Center for Genomic Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Chang SY; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. Electronic address: .
Yeh SH; Department of Microbiology, National Taiwan University College of Medicine, Taipei 100, Taiwan; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan; National Taiwan University Center for Genomic Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Oct 13; Vol. 33 (2), pp. 108254. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Amino Acid Chloromethyl Ketones/*pharmacology
Antiviral Agents/*pharmacology
Fluoresceins/*pharmacology
Furin/*antagonists & inhibitors
Protease Inhibitors/*pharmacology
Spike Glycoprotein, Coronavirus/*metabolism
Animals ; Betacoronavirus/drug effects ; Betacoronavirus/metabolism ; Betacoronavirus/physiology ; Chlorocebus aethiops ; Humans ; Proteolysis ; SARS-CoV-2 ; Vero Cells
Czasopismo naukowe
Tytuł :
Absent in melanoma 2 enhances anti-tumour effects of CAIX promotor controlled conditionally replicative adenovirus in renal cancer.
Autorzy :
Chai D; Cancer Institute, Xuzhou Medical University, Xuzhou, China.; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Qiu D; Department of Urology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Zhang Z; Cancer Institute, Xuzhou Medical University, Xuzhou, China.; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Yuchen Shi S; Department of Radiation Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Wang G; Cancer Institute, Xuzhou Medical University, Xuzhou, China.; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Fang L; Cancer Institute, Xuzhou Medical University, Xuzhou, China.; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Li H; Cancer Institute, Xuzhou Medical University, Xuzhou, China.; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Li H; Department of Urology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Tian H; Cancer Institute, Xuzhou Medical University, Xuzhou, China.; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
Zheng J; Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Sep; Vol. 24 (18), pp. 10744-10755. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*
Adenoviruses, Human/*physiology
Carbonic Anhydrase IX/*genetics
Carcinoma, Renal Cell/*therapy
DNA-Binding Proteins/*physiology
Kidney Neoplasms/*therapy
Promoter Regions, Genetic/*genetics
Adenovirus E1A Proteins/biosynthesis ; Adenovirus E1A Proteins/genetics ; Adenoviruses, Human/genetics ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Carcinoma, Renal Cell/secondary ; Caspase 1/analysis ; Cell Line ; Cell Line, Tumor ; Cytokines/analysis ; DNA-Binding Proteins/genetics ; Genes, Synthetic ; Humans ; Inflammasomes/drug effects ; Kidney Neoplasms/pathology ; Kidney Tubules/cytology ; Lung Neoplasms/prevention & control ; Lung Neoplasms/secondary ; Lung Neoplasms/therapy ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Tumor Stem Cell Assay ; Virus Replication ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma.
Autorzy :
Lan W; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France; Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, «Equipe Labellisée Ligue Contre le Cancer», Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France.
Santofimia-Castaño P; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France.
Xia Y; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, No.55 Daxuecheng South Road, Chongqing, 401331, PR China.
Zhou Z; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, No.55 Daxuecheng South Road, Chongqing, 401331, PR China.
Huang C; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France.
Fraunhoffer N; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France; Consejo Nacional de Investigaciones Científicas y Técnicas, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Facultad de Medicina, Buenos Aires, Argentina.
Barea D; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France.
Cervello M; Consiglio Nazionale Delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedicale (IRIB), Palermo, Italy.
Giannitrapani L; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Montalto G; Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Peng L; Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, «Equipe Labellisée Ligue Contre le Cancer», Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France.
Iovanna J; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288, Marseille, France. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Aug 28; Vol. 486, pp. 8-17. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*antagonists & inhibitors
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Neoplasm Proteins/*antagonists & inhibitors
Piperazines/*pharmacology
Thiazines/*pharmacology
Adenosine Triphosphate/metabolism ; Adult ; Aged ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Apoptosis/drug effects ; Basic Helix-Loop-Helix Transcription Factors/analysis ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Female ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neoplasm Proteins/analysis ; Piperazines/therapeutic use ; Thiazines/therapeutic use
Czasopismo naukowe
Tytuł :
Activation of the NLRP3 Inflammasome by Particles from the Echinococcus granulosus Laminated Layer.
Autorzy :
Casaravilla C; Área Inmunología, Departamento de Biociencias (Facultad de Química) and Cátedra de Inmunología, Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay.
Pittini Á; Área Inmunología, Departamento de Biociencias (Facultad de Química) and Cátedra de Inmunología, Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay.
Rückerl D; Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom.
Allen JE; Faculty of Biology, Medicine and Health, School of Biological Sciences, University of Manchester, Manchester, United Kingdom.
Díaz Á; Área Inmunología, Departamento de Biociencias (Facultad de Química) and Cátedra de Inmunología, Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay .
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Źródło :
Infection and immunity [Infect Immun] 2020 Aug 19; Vol. 88 (9). Date of Electronic Publication: 2020 Aug 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell-Derived Microparticles/*chemistry
Dendritic Cells/*drug effects
Echinococcus granulosus/*chemistry
Gene Expression Regulation/*drug effects
Host-Parasite Interactions/*immunology
NLR Family, Pyrin Domain-Containing 3 Protein/*immunology
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Caspase 1/genetics ; Caspase 1/immunology ; Cell-Derived Microparticles/immunology ; Dendritic Cells/immunology ; Echinococcus granulosus/immunology ; Female ; Gene Expression Regulation/immunology ; Host-Parasite Interactions/genetics ; Indazoles/pharmacology ; Inflammasomes/drug effects ; Inflammasomes/genetics ; Inflammasomes/immunology ; Interleukin-12/genetics ; Interleukin-12/immunology ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/agonists ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Phagocytosis/drug effects ; Phosphatidylinositol 3-Kinase/genetics ; Phosphatidylinositol 3-Kinase/immunology ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/immunology ; Signal Transduction ; Stilbenes/pharmacology ; Sulfonamides/pharmacology ; Wortmannin/pharmacology
Czasopismo naukowe
Tytuł :
Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro .
Autorzy :
Liu CY; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University , Guangzhou, China.; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University , Guangzhou, China.
Wang M; Department of Pharmacy, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) , Haikou, China.
Yu HM; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University , Guangzhou, China.; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University , Guangzhou, China.
Han FX; Department of Pharmacy, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) , Haikou, China.
Wu QS; Department of Pharmacy, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) , Haikou, China.
Cai XJ; Department of Respiratory and Critical Care Medicine, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) , Haikou, China.
Kurihara H; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University , Guangzhou, China.; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University , Guangzhou, China.
Chen YX; Department of Respiratory and Critical Care Medicine, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) , Haikou, China.
Li YF; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University , Guangzhou, China.; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University , Guangzhou, China.
He RR; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University , Guangzhou, China.; Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University , Guangzhou, China.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2020 Aug; Vol. 84 (8), pp. 1621-1628. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclohexylamines/*pharmacology
Ethanol/*toxicity
Ferroptosis/*drug effects
Iron/*metabolism
Liver/*drug effects
Liver Diseases, Alcoholic/*genetics
Phenylenediamines/*pharmacology
Adenine/analogs & derivatives ; Adenine/pharmacology ; Amino Acid Chloromethyl Ketones/pharmacology ; Amino Acid Transport System y+/genetics ; Amino Acid Transport System y+/metabolism ; Animals ; Autophagy/drug effects ; Autophagy/genetics ; Cell Line ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Disease Models, Animal ; Female ; Ferroptosis/genetics ; Gene Expression Regulation ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; Lipid Peroxidation/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Diseases, Alcoholic/etiology ; Liver Diseases, Alcoholic/pathology ; Liver Diseases, Alcoholic/prevention & control ; Mice ; Mice, Inbred C57BL ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Signal Transduction ; Vitamin E/pharmacology
Czasopismo naukowe
Tytuł :
Caspase inhibitor z-VAD-FMK increases the survival of hair cells after Actinomycin-D-induced damage in vitro.
Autorzy :
Chang H; Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an Medical University, Xi'an, 710077, China.
Sun F; Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China.
Tian K; Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China.
Wang W; Department of Otolaryngology Head and Neck Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710038, China.
Zhou K; Center of Clinical Laboratory Medicine of PLA, Department of Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China.
Zha D; Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China. Electronic address: .
Qiu J; Department of Otolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China. Electronic address: .
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Źródło :
Neuroscience letters [Neurosci Lett] 2020 Jul 27; Vol. 732, pp. 135089. Date of Electronic Publication: 2020 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Chloromethyl Ketones/*pharmacology
Dactinomycin/*toxicity
Hair Cells, Auditory/*drug effects
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase Inhibitors ; Cell Survival/drug effects ; Cochlear Nerve/drug effects ; Culture ; Cysteine Proteinase Inhibitors/pharmacology ; Humans ; Infant, Newborn ; Organ of Corti/drug effects ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species ; Spiral Ganglion/drug effects
Czasopismo naukowe
Tytuł :
Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors.
Autorzy :
Mei S; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia.
Ayala R; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia.
Ramarathinam SH; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia.
Illing PT; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia.
Faridi P; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia.
Song J; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia.
Purcell AW; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia. Electronic address: .
Croft NP; Biomedicine Discovery Institute and Department of Biochemistry & Molecular Biology, Monash University, Melbourne, VIC, Australia. Electronic address: .
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Źródło :
Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2020 Jul; Vol. 19 (7), pp. 1236-1247. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asparagine/*metabolism
Glycoproteins/*metabolism
Histocompatibility Antigens Class I/*metabolism
Histocompatibility Antigens Class II/*metabolism
Peptides/*metabolism
Amino Acid Chloromethyl Ketones/pharmacology ; Amino Acid Motifs ; Cell Line ; Chromatography, Liquid ; Deamination ; Endoplasmic Reticulum-Associated Degradation ; Epitopes, T-Lymphocyte/metabolism ; Glycosylation ; Humans ; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/antagonists & inhibitors ; Protein Processing, Post-Translational ; Proteomics ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Cartilage Trauma Induces Necroptotic Chondrocyte Death and Expulsion of Cellular Contents.
Autorzy :
Stolberg-Stolberg J; Institute for Musculoskeletal Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building D 3, 48149 Muenster, Germany, (M.S.).; Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building W1, 48149 Muenster, Germany.
Sambale M; Institute for Musculoskeletal Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building D 3, 48149 Muenster, Germany, (M.S.).
Hansen U; Institute for Musculoskeletal Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building D 3, 48149 Muenster, Germany, (M.S.).
Raschke ASM; Institute for Musculoskeletal Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building D 3, 48149 Muenster, Germany, (M.S.).; Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building W1, 48149 Muenster, Germany.
Bertrand J; Department of Orthopaedic Surgery, Otto-von-Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany, .
Pap T; Institute for Musculoskeletal Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building D 3, 48149 Muenster, Germany, (M.S.).
Sherwood J; Institute for Musculoskeletal Medicine, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building D 3, 48149 Muenster, Germany, (M.S.).
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 12; Vol. 21 (12). Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Necroptosis*
Chondrocytes/*cytology
Intra-Articular Fractures/*pathology
Protein Kinases/*metabolism
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Cell Survival/drug effects ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Disease Models, Animal ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; Intra-Articular Fractures/metabolism ; Mice ; Phosphorylation/drug effects ; Primary Cell Culture ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Hsp90 inhibition aggravates adriamycin-induced podocyte injury through intrinsic apoptosis pathway.
Autorzy :
Dong J; Department of Paediatrics, The First Affiliated Hospital of Henan University of Science & Technology, Luoyang, Henan, 471000, China.
Jiang Z; Department of Paediatrics, The First Affiliated Hospital of Henan University of Science & Technology, Luoyang, Henan, 471000, China. Electronic address: .
Ma G; Department of Paediatrics, The First Affiliated Hospital of Henan University of Science & Technology, Luoyang, Henan, 471000, China.
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Źródło :
Experimental cell research [Exp Cell Res] 2020 May 15; Vol. 390 (2), pp. 111928. Date of Electronic Publication: 2020 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antibiotics, Antineoplastic/*administration & dosage
Apoptosis/*drug effects
Doxorubicin/*administration & dosage
HSP90 Heat-Shock Proteins/*genetics
Nephrotic Syndrome/*genetics
Podocytes/*drug effects
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Apoptosis/genetics ; Benzodioxoles/pharmacology ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cell Line ; Cytosol/drug effects ; Cytosol/metabolism ; Gene Expression Regulation ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mitochondria/drug effects ; Mitochondria/metabolism ; Nephrotic Syndrome/chemically induced ; Nephrotic Syndrome/metabolism ; Nephrotic Syndrome/pathology ; Podocytes/metabolism ; Podocytes/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Purines/pharmacology ; Signal Transduction ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
SCR Disease Name :
Nephrosis, congenital
Czasopismo naukowe

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