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Wyszukujesz frazę ""Amino Acid Substitution"" wg kryterium: Temat


Tytuł :
p.Arg72Pro polymorphism of P53 and breast cancer risk: a meta-analysis of case-control studies.
Autorzy :
Diakite B; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali. .; Teaching Hospital Center of Point G, 333, Bamako, Mali. .; Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, IL, 60611, USA. .
Kassogue Y; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali.; Teaching Hospital Center of Point G, 333, Bamako, Mali.; Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, IL, 60611, USA.
Dolo G; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali.; Teaching Hospital Center of Point G, 333, Bamako, Mali.
Wang J; Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, IL, 60611, USA.; Institute for Global Health, Northwestern University, IL60611, Chicago, USA.
Neuschler E; Department of Radiology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Kassogue O; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali.; Teaching Hospital Center of Point G, 333, Bamako, Mali.
Keita ML; Teaching Hospital Center of Point G, 333, Bamako, Mali.
Traore CB; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali.; Teaching Hospital Center of Point G, 333, Bamako, Mali.
Kamate B; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali.; Teaching Hospital Center of Point G, 333, Bamako, Mali.
Dembele E; Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, IL, 60611, USA.; Institute for Global Health, Northwestern University, IL60611, Chicago, USA.
Nadifi S; Hassan II University Aïn chock, 20000, Casablanca,19, Rue Tarik Ibnou Ziad,, Morocco.
Murphy RL; Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, IL, 60611, USA.; Institute for Global Health, Northwestern University, IL60611, Chicago, USA.
Doumbia S; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali.; Teaching Hospital Center of Point G, 333, Bamako, Mali.
Hou L; Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, IL, 60611, USA.; Institute for Global Health, Northwestern University, IL60611, Chicago, USA.
Maiga M; Faculty of Medicine and Odontostomatology, 1805, Université des Sciences, des Techniques et des Technologies Sciences de Bamako (USTTB), Hamdallaye ACI, 2000, Bamako, Mali.; Preventive Medicine Department, Cancer Epidemiology and Prevention, Northwestern University, Chicago, IL, 60611, USA.; Institute for Global Health, Northwestern University, IL60611, Chicago, USA.
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Źródło :
BMC medical genetics [BMC Med Genet] 2020 Oct 19; Vol. 21 (1), pp. 206. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Polymorphism, Single Nucleotide*
Breast Neoplasms/*genetics
Genetic Predisposition to Disease/*genetics
Tumor Suppressor Protein p53/*genetics
Alleles ; Breast Neoplasms/diagnosis ; Case-Control Studies ; Female ; Gene Frequency ; Genotype ; Humans ; Risk Factors
Czasopismo naukowe
Tytuł :
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
Autorzy :
Hsieh CL; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Goldsmith JA; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Schaub JM; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
DiVenere AM; Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA.
Kuo HC; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Javanmardi K; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Le KC; Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA.
Wrapp D; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Lee AG; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Liu Y; Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA.
Chou CW; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Byrne PO; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Hjorth CK; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Johnson NV; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Ludes-Meyers J; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Nguyen AW; Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA.
Park J; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Wang N; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Amengor D; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.
Lavinder JJ; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.; Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA.
Ippolito GC; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA.; Department of Oncology, Dell Medical School, University of Texas, Austin, TX 78712, USA.
Maynard JA; Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA. .
Finkelstein IJ; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA. .; Center for Systems and Synthetic Biology, University of Texas, Austin, TX 78712, USA.
McLellan JS; Department of Molecular Biosciences, University of Texas, Austin, TX 78712, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Sep 18; Vol. 369 (6510), pp. 1501-1505. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Betacoronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*chemistry
Coronavirus Infections/prevention & control ; Cryoelectron Microscopy ; Humans ; Proline/chemistry ; Protein Domains ; Protein Stability ; Viral Vaccines/chemistry
SCR Organism :
severe acute respiratory syndrome coronavirus 2
Czasopismo naukowe
Tytuł :
The ranging of amino acids substitution matrices of various types in accordance with the alignment accuracy criterion.
Autorzy :
Polyanovsky V; Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Vavilova 32, 119991, Moscow, Russia. .
Lifanov A; Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Vavilova 32, 119991, Moscow, Russia.
Esipova N; Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Vavilova 32, 119991, Moscow, Russia.
Tumanyan V; Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Vavilova 32, 119991, Moscow, Russia. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 Sep 14; Vol. 21 (Suppl 11), pp. 294. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Amino Acid Substitution*
Sequence Alignment*
Software*
Computational Biology/*methods
Sequence Analysis, Protein/*methods
Amino Acid Sequence ; Evolution, Molecular ; Proteins/chemistry ; Proteins/metabolism
Czasopismo naukowe
Tytuł :
A hemizygous mutation in the androgen receptor gene causes different phenotypes of androgen insensitivity syndrome in two siblings by disrupting the nuclear translocation.
Autorzy :
Liu C; Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China.
Lyu Y; Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China.
Li P; Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China. .
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Źródło :
Molecular genetics and genomics : MGG [Mol Genet Genomics] 2020 Sep; Vol. 295 (5), pp. 1103-1111. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Substitution*
Androgen-Insensitivity Syndrome/*genetics
Cell Nucleus/*metabolism
Receptors, Androgen/*genetics
Receptors, Androgen/*metabolism
Whole Exome Sequencing/*methods
Androgen-Insensitivity Syndrome/metabolism ; Animals ; COS Cells ; China ; Chlorocebus aethiops ; Female ; Hemizygote ; Humans ; Infant ; Male ; Pedigree ; Phenotype ; Protein Transport ; Receptors, Androgen/chemistry ; Siblings
Czasopismo naukowe
Tytuł :
Functional Impact of the G279S Substitution in the Adenosine A 1 -Receptor (A 1 R-G279S ), a Mutation Associated with Parkinson's Disease.
Autorzy :
Nasrollahi-Shirazi S; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Szöllösi D; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Yang Q; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Muratspahic E; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
El-Kasaby A; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Sucic S; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Stockner T; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Nanoff C; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Freissmuth M; Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Sep; Vol. 98 (3), pp. 250-266.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Parkinson Disease/*genetics
Receptor, Adenosine A1/*chemistry
Receptor, Adenosine A1/*metabolism
HEK293 Cells ; Humans ; Models, Molecular ; Molecular Dynamics Simulation ; Mutation ; Protein Binding ; Protein Conformation ; Protein Stability ; Receptor, Adenosine A1/genetics ; Thermodynamics
Czasopismo naukowe
Tytuł :
The D614G substitution in the S gene and clinical information for patients with COVID-19 detected in Hong Kong.
Autorzy :
Mak GCK; All from Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China. Electronic address: .
Lau AWL; All from Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
Chan AMY; All from Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
Chan DYW; All from Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
Tsang DNC; All from Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.
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Źródło :
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2020 Sep; Vol. 130, pp. 104550. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Substitution*
Betacoronavirus/*genetics
Coronavirus Infections/*diagnosis
Coronavirus Infections/*virology
Pneumonia, Viral/*diagnosis
Pneumonia, Viral/*virology
Spike Glycoprotein, Coronavirus/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Hong Kong ; Humans ; Male ; Middle Aged ; Mutation ; Pandemics ; Sequence Analysis, DNA ; Young Adult
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme.
Autorzy :
Egbe E; School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England, United Kingdom.
Levy CW; School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England, United Kingdom.
Tabernero L; School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England, United Kingdom.
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Źródło :
PloS one [PLoS One] 2020 Jun 25; Vol. 15 (6), pp. e0235133. Date of Electronic Publication: 2020 Jun 25 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Computer Simulation*
Protein Folding*
Protein Tyrosine Phosphatases*/chemistry
Protein Tyrosine Phosphatases*/genetics
Phosphatidylinositols/*chemistry
Catalytic Domain ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Autorzy :
Unciuleac MC; Molecular Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
Goldgur Y; Structural Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
Shuman S; Molecular Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 04; Vol. 48 (10), pp. 5603-5615.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Alanine*
Amino Acid Substitution*
Lysine/*chemistry
RNA Ligase (ATP)/*chemistry
RNA Ligase (ATP)/*genetics
Adenosine Monophosphate/chemistry ; Adenosine Triphosphate/chemistry ; Catalytic Domain ; Lysine/metabolism ; Manganese/chemistry ; Models, Molecular ; Naegleria/enzymology ; RNA Ligase (ATP)/metabolism
Czasopismo naukowe
Tytuł :
Amino acid substitutions involved in the adaptation of a novel H7N7 avian influenza virus in mice.
Autorzy :
Wu H; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: .
Liu F; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Yang F; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Xiao Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Yao H; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Wu N; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: .
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Źródło :
Research in veterinary science [Res Vet Sci] 2020 Jun; Vol. 130, pp. 203-206. Date of Electronic Publication: 2020 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptation, Biological*
Amino Acid Substitution*
Chickens*
Influenza A Virus, H7N7 Subtype/*genetics
Influenza in Birds/*virology
Poultry Diseases/*virology
Animals ; Mice
Czasopismo naukowe
Tytuł :
Basic Amino Acid Substitution at Residue 367 of the Envelope Protein of Tembusu Virus Plays a Critical Role in Pathogenesis.
Autorzy :
Sun M; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhang L; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Cao Y; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Wang J; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yu Z; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Sun X; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Liu F; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Li Z; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Liu P; Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA .
Su J; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China .
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Źródło :
Journal of virology [J Virol] 2020 Mar 31; Vol. 94 (8). Date of Electronic Publication: 2020 Mar 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*/immunology
Flavivirus/*genetics
Flavivirus Infections/*immunology
Flavivirus Infections/*virology
Viral Envelope Proteins/*genetics
Animals ; Antibodies, Neutralizing ; Cell Line ; China/epidemiology ; Ducks/virology ; Female ; Flavivirus Infections/epidemiology ; Flavivirus Infections/pathology ; Mutagenesis, Site-Directed ; Mutation ; Poultry Diseases/immunology ; Poultry Diseases/mortality ; Poultry Diseases/pathology ; Poultry Diseases/virology ; Viral Load ; Virulence ; Virus Replication
SCR Organism :
Tembusu virus
Czasopismo naukowe
Tytuł :
Substitution matrix based color schemes for sequence alignment visualization.
Autorzy :
Kunzmann P; Department of Computational Biology and Simulation, TU Darmstadt, Schnittspahnstraße 2, Darmstadt, 64287, Germany. .
Mayer BE; Department of Computational Biology and Simulation, TU Darmstadt, Schnittspahnstraße 2, Darmstadt, 64287, Germany.
Hamacher K; Department of Computational Biology and Simulation, TU Darmstadt, Schnittspahnstraße 2, Darmstadt, 64287, Germany.
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 May 24; Vol. 21 (1), pp. 209. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Substitution*
Sequence Alignment/*methods
Algorithms ; Amino Acid Sequence ; Color ; Computer Simulation ; Humans
Czasopismo naukowe
Tytuł :
The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme.
Autorzy :
Norvil AB; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
AlAbdi L; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Liu B; Department of Epigenetics and Molecular Carcinogenesis, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
Tu YH; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Forstoffer NE; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Michie AR; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
Chen T; Department of Epigenetics and Molecular Carcinogenesis, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
Gowher H; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Apr 17; Vol. 48 (7), pp. 3761-3775.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amino Acid Substitution*
DNA (Cytosine-5-)-Methyltransferases/*genetics
DNA (Cytosine-5-)-Methyltransferases/*metabolism
Leukemia, Myeloid, Acute/*genetics
Animals ; Arginine ; CpG Islands ; DNA Methylation ; DNA, Satellite/metabolism ; Embryonic Stem Cells/metabolism ; Humans ; Kinetics ; Mice ; Mutation ; Myeloid Ecotropic Viral Integration Site 1 Protein/genetics ; Substrate Specificity
Czasopismo naukowe
Tytuł :
A single amino acid substitution in the FAD-binding domain causes the inactivation of Propionibacterium Acnes isomerase.
Autorzy :
Rao Y; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Li SL; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Li MJ; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Cui S; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Gou KM; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2020 Apr; Vol. 84 (4), pp. 789-796. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Substitution*
Flavin-Adenine Dinucleotide/*metabolism
Isomerases/*antagonists & inhibitors
Propionibacterium acnes/*enzymology
Blotting, Western ; Codon ; Crystallography, X-Ray ; Isomerases/chemistry ; Isomerases/genetics ; Isomerases/metabolism ; Linoleic Acids, Conjugated/metabolism ; Loss of Function Mutation ; Propionibacterium acnes/genetics ; Protein Conformation
Czasopismo naukowe
Tytuł :
Single amino acid mutation altered substrate specificity for L-glucose and inositol in scyllo -inositol dehydrogenase isolated from Paracoccus laeviglucosivorans .
Autorzy :
Suzuki M; Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
Koubara K; Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
Takenoya M; Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
Fukano K; Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
Ito S; Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
Sasaki Y; Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
Nakamura A; Faculty of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan.; Microbiology Research Center for Sustainability (MiCS), University of Tsukuba, Ibaraki, Japan.
Yajima S; Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2020 Apr; Vol. 84 (4), pp. 734-742. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Substitution*
Glucose/*metabolism
Inositol/*metabolism
Oxidoreductases/*metabolism
Paracoccus/*enzymology
Kinetics ; Oxidoreductases/isolation & purification ; Protein Conformation ; Substrate Specificity
SCR Organism :
Paracoccus laeviglucosivorans
Czasopismo naukowe
Tytuł :
Infantile restrictive cardiomyopathy: cTnI-R170G/W impair the interplay of sarcomeric proteins and the integrity of thin filaments.
Autorzy :
Cimiotti D; Department of Clinical Pharmacology and Molecular Cardiology, Ruhr-University of Bochum, Bochum, Germany.; Cardiology, Bergmannsheil and St. Josef Hospital, Clinics of the Ruhr-University Bochum, Bochum, Germany.
Fujita-Becker S; Cryoelectron Microscopy, BioQuant, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Möhner D; Vegetative Physiology, University of Cologne, Cologne, Germany.
Smolina N; Department of Molecular Biology and Genetics, Almazov Federal Medical Research Center, St. Petersburg, Russia.
Budde H; Department of Clinical Pharmacology and Molecular Cardiology, Ruhr-University of Bochum, Bochum, Germany.; Cardiology, Bergmannsheil and St. Josef Hospital, Clinics of the Ruhr-University Bochum, Bochum, Germany.
Wies A; Vegetative Physiology, University of Cologne, Cologne, Germany.
Morgenstern L; Department of Clinical Pharmacology and Molecular Cardiology, Ruhr-University of Bochum, Bochum, Germany.; Cardiology, Bergmannsheil and St. Josef Hospital, Clinics of the Ruhr-University Bochum, Bochum, Germany.
Gudkova A; Department of Molecular Biology and Genetics, Almazov Federal Medical Research Center, St. Petersburg, Russia.
Sejersen T; Department of Women's and Children's Health and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Sjöberg G; Department of Women's and Children's Health and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Mügge A; Cardiology, Bergmannsheil and St. Josef Hospital, Clinics of the Ruhr-University Bochum, Bochum, Germany.
Nowaczyk MM; Plant Biochemistry, Faculty of Biology and Biotechnology, Ruhr-University Bochum, Bochum, Germany.
Reusch P; Department of Clinical Pharmacology and Molecular Cardiology, Ruhr-University of Bochum, Bochum, Germany.
Pfitzer G; Vegetative Physiology, University of Cologne, Cologne, Germany.
Stehle R; Vegetative Physiology, University of Cologne, Cologne, Germany.
Schröder RR; Cryoelectron Microscopy, BioQuant, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Mannherz HG; Department of Clinical Pharmacology and Molecular Cardiology, Ruhr-University of Bochum, Bochum, Germany.; Department of Anatomy and Embryology, Medical Faculty, Ruhr-University Bochum, Bochum, Germany.
Kostareva A; Department of Molecular Biology and Genetics, Almazov Federal Medical Research Center, St. Petersburg, Russia.; Department of Women's and Children's Health and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Jaquet K; Department of Clinical Pharmacology and Molecular Cardiology, Ruhr-University of Bochum, Bochum, Germany.; Cardiology, Bergmannsheil and St. Josef Hospital, Clinics of the Ruhr-University Bochum, Bochum, Germany.
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Źródło :
PloS one [PLoS One] 2020 Mar 17; Vol. 15 (3), pp. e0229227. Date of Electronic Publication: 2020 Mar 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Cardiomyopathy, Restrictive/*genetics
Myocardium/*metabolism
Sarcomeres/*metabolism
Troponin I/*genetics
Actins/metabolism ; Animals ; Calcium/metabolism ; Cardiomyopathy, Restrictive/metabolism ; Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Child, Preschool ; Guinea Pigs ; Humans ; Microscopy, Electron ; Models, Biological ; Protein Binding ; Tropomyosin/metabolism
Czasopismo naukowe
Tytuł :
R409K mutation prevents acid-induced aggregation of human IgG4.
Autorzy :
Namisaki H; Alliance Development Group, Open Innovation Department R&D Division, Kyowa Kirin Co., Ltd., Tokyo, Japan.; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
Saito S; Tokyo Research Park, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Hiraishi K; Tokyo Research Park, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Haba T; Tokyo Research Park, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Tanaka Y; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
Yoshida H; Tokyo Research Park, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Iida S; Tokyo Research Park, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Takahashi N; Research Functions Unit, R&D Division, Kyowa Kirin Co., Ltd., Tokyo, Japan.
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Źródło :
PloS one [PLoS One] 2020 Mar 17; Vol. 15 (3), pp. e0229027. Date of Electronic Publication: 2020 Mar 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Immunoglobulin G/*chemistry
Antibodies, Monoclonal/chemistry ; Calorimetry, Differential Scanning ; Cell Line ; Drug Design ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Immunoglobulin G/genetics ; Protein Aggregates/drug effects ; Protein Domains ; Protein Stability
Czasopismo naukowe
Tytuł :
Heart failure after pressure overload in autosomal-dominant desminopathies: Lessons from heterozygous DES-p.R349P knock-in mice.
Autorzy :
Stöckigt F; Department of Cardiology, University Hospital Bonn, Bonn, Germany.; Department of Cardiology, Krankenhaus Porz, Urbacher Weg, Cologne, Germany.
Eichhorn L; Department of Anesthesiology, University Hospital Bonn, Bonn, Germany.
Beiert T; Department of Cardiology, University Hospital Bonn, Bonn, Germany.
Knappe V; Department of Cardiology, University Hospital Bonn, Bonn, Germany.
Radecke T; Department of Cardiology, University Hospital Essen, Hufelandstraße, Essen, Germany.
Steinmetz M; Department of Cardiology, University Hospital Essen, Hufelandstraße, Essen, Germany.
Nickenig G; Department of Cardiology, University Hospital Bonn, Bonn, Germany.
Peeva V; Institute of Experimental Epileptology and Cognition Research, Bonn, Germany.; Department of Epileptology, University Hospital of Bonn, Bonn, Germany.
Kudin AP; Institute of Experimental Epileptology and Cognition Research, Bonn, Germany.; Department of Epileptology, University Hospital of Bonn, Bonn, Germany.
Kunz WS; Institute of Experimental Epileptology and Cognition Research, Bonn, Germany.; Department of Epileptology, University Hospital of Bonn, Bonn, Germany.
Berwanger C; Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Cologne, Germany.
Kamm L; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage, Erlangen, Germany.
Schultheis D; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage, Erlangen, Germany.
Schlötzer-Schrehardt U; Department of Opthalmology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage, Erlangen, Germany.
Clemen CS; Institute of Aerospace Medicine, German Aerospace Center (DLR), Linder Höhe, Cologne, Germany.; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage, Erlangen, Germany.; Center for Biochemistry, Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany.; Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, Medical Faculty, University of Cologne, Cologne, Germany.
Schröder R; Institute of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage, Erlangen, Germany.
Schrickel JW; Department of Cardiology, University Hospital Bonn, Bonn, Germany.
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Źródło :
PloS one [PLoS One] 2020 Mar 03; Vol. 15 (3), pp. e0228913. Date of Electronic Publication: 2020 Mar 03 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Amino Acid Substitution*
Atrioventricular Block/*physiopathology
Cardiomyopathies/*physiopathology
Desmin/*genetics
Animals ; Atrioventricular Block/genetics ; Cardiomyopathies/genetics ; DNA Copy Number Variations ; DNA, Mitochondrial/genetics ; Disease Models, Animal ; Female ; Gene Knock-In Techniques ; Heterozygote ; Humans ; Male ; Mice ; Stroke Volume
Czasopismo naukowe
Tytuł :
Equiprobable discrete models of site-specific substitution rates underestimate the extent of rate variability.
Autorzy :
Mannino F; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America.
Wisotsky S; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America.; Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, United States of America.
Kosakovsky Pond SL; Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, United States of America.
Muse SV; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, United States of America.; Department of Statistics, North Carolina State University, Raleigh, NC, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Mar 02; Vol. 15 (3), pp. e0229493. Date of Electronic Publication: 2020 Mar 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amino Acid Substitution*
Models, Genetic*
Sequence Analysis, DNA/*methods
Algorithms ; Evolution, Molecular ; Likelihood Functions ; Mutation Rate ; Phylogeny ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Evolution of Listeria monocytogenes in a Food Processing Plant Involves Limited Single-Nucleotide Substitutions but Considerable Diversification by Gain and Loss of Prophages.
Autorzy :
Harrand AS; Department of Food Science, Cornell University, Ithaca, New York, USA.
Jagadeesan B; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Vers-chez-les-Blanc, Lausanne, Switzerland.
Baert L; Nestlé Institute of Food Safety and Analytical Sciences, Nestlé Research, Vers-chez-les-Blanc, Lausanne, Switzerland.
Wiedmann M; Department of Food Science, Cornell University, Ithaca, New York, USA.
Orsi RH; Department of Food Science, Cornell University, Ithaca, New York, USA .
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Źródło :
Applied and environmental microbiology [Appl Environ Microbiol] 2020 Mar 02; Vol. 86 (6). Date of Electronic Publication: 2020 Mar 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Evolution, Molecular*
Food Handling*
Food Microbiology*
Listeria monocytogenes/*genetics
Prophages/*physiology
Genome, Bacterial ; Listeria monocytogenes/virology ; Phylogeny ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Amino acid charge and epidermolysis bullosa simplex severity: genotype-phenotype correlations.
Autorzy :
Ansai O; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Shinkuma S; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Kabata Y; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Katsumi T; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Hagiwara R; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Tomii K; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Fujikawa H; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Matsubara M; Division of Dermatology, Shirone General Hospital, Niigata, Japan.
Abe R; Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
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Źródło :
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2020 Feb; Vol. 34 (2), pp. e87-e90. Date of Electronic Publication: 2019 Oct 29.
Typ publikacji :
Case Reports; Letter
MeSH Terms :
Amino Acid Substitution*
Genetic Association Studies*
Epidermolysis Bullosa Simplex/*pathology
Adolescent ; Epidermolysis Bullosa Simplex/genetics ; Epidermolysis Bullosa Simplex/metabolism ; Humans ; Male
Raport

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