Temat: "Amino Acid Substitution" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses.
Autorzy :: Wang N; Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural Universitygrid.27871.3b, Nanjing, China.
Zhai X; Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural Universitygrid.27871.3b, Nanjing, China.
Li X; Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural Universitygrid.27871.3b, Nanjing, China.
Wang Y; Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural Universitygrid.27871.3b, Nanjing, China.
He WT; Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural Universitygrid.27871.3b, Nanjing, China.
Jiang Z; Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural Universitygrid.27871.3b, Nanjing, China.
Veit M; Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University Berlin, Berlin, Germany.
Su S; Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural Universitygrid.27871.3b, Nanjing, China.; Pokaż więcej
Źródło :: Journal of virology [J Virol] 2022 Mar 23; Vol. 96 (6), pp. e0175121. Date of Electronic Publication: 2022 Jan 05.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Alphavirus*/genetics
Alphavirus*/pathogenicity
Alphavirus Infections*/virology
Amino Acid Substitution*
Viral Envelope Proteins*/genetics
Viral Envelope Proteins*/metabolism
Animals ; Binding Sites/genetics ; Cells, Cultured ; Disease Models, Animal ; Heparitin Sulfate/metabolism ; Humans ; Mice
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Detection of SARS-CoV-2 and the L452R spike mutation using reverse transcription loop-mediated isothermal amplification plus bioluminescent assay in real-time (RT-LAMP-BART).
Autorzy :: Iijima T; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan.
Ando S; Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
Kanamori D; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan.
Kuroda K; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Nomura T; Division of Otolaryngology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry, Saitama, Japan.
Tisi L; Erba Molecular, Erba Molecular-Lumora, Ely, United Kingdom.
Kilgore PE; Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI, United States of America.
Percy N; 3M Company, St. Paul, MN, United States of America.
Kohase H; Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
Hayakawa S; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Seki M; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan.; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Hoshino T; Division of Pediatric Dentistry, Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan.; Pokaż więcej
Źródło :: PloS one [PLoS One] 2022 Mar 21; Vol. 17 (3), pp. e0265748. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022).
Typ publikacji :: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
COVID-19/*diagnosis
Peptide Nucleic Acids/*genetics
SARS-CoV-2/*classification
Spike Glycoprotein, Coronavirus/*genetics
Binding Sites ; California ; Early Diagnosis ; Humans ; India ; Limit of Detection ; Luminescent Measurements ; Molecular Diagnostic Techniques ; Mutation, Missense ; Nucleic Acid Amplification Techniques ; Real-Time Polymerase Chain Reaction ; Reverse Transcription ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity ; Spike Glycoprotein, Coronavirus/chemistry
SCR Protocol :: LAMP assay
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 3 3.

Tytuł :: Improvement of thermostability of cholesterol oxidase from streptomyces Sp. SA-COO by random mutagenesis.
Autorzy :: Fazaeli A; Department of Clinical Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Fana SE; Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Golestani A; Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Aminian M; Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .; Pokaż więcej
Źródło :: Protein expression and purification [Protein Expr Purif] 2022 Mar; Vol. 191, pp. 106028. Date of Electronic Publication: 2021 Dec 01.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Cholesterol Oxidase*/chemistry
Cholesterol Oxidase*/genetics
Models, Molecular*
Mutagenesis*
Streptomyces*/enzymology
Streptomyces*/genetics
Enzyme Stability/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients.
Autorzy :: Na R; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
Wei J; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
Sample CJ; Duke University School of Medicine and Duke Cancer Institute, Durham, NC, USA.
Gielzak M; Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Choi S; Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Cooney KA; Duke University School of Medicine and Duke Cancer Institute, Durham, NC, USA.
Rabizadeh D; Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Walsh PC; Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Zheng LS; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
Xu J; Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.
Isaacs WB; Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA. .; Pokaż więcej
Źródło :: British journal of cancer [Br J Cancer] 2022 Mar; Vol. 126 (5), pp. 791-796. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: Amino Acid Substitution*
African Americans/*genetics
Homeodomain Proteins/*genetics
Prostatic Neoplasms/*surgery
Whole Exome Sequencing/*methods
Adult ; Age of Onset ; Genetic Predisposition to Disease ; Germ-Line Mutation ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Prostatectomy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Retrospective Studies
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Creation of photocyclic vertebrate rhodopsin by single amino acid substitution.
Autorzy :: Sakai K; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Shichida Y; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.; Research Organization for Science and technology, Ritsumeikan University, Kusatsu, Japan.
Imamoto Y; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Yamashita T; Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.; Pokaż więcej
Źródło :: ELife [Elife] 2022 Feb 24; Vol. 11. Date of Electronic Publication: 2022 Feb 24.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Rhodopsin/*genetics
Amino Acid Sequence ; Animals ; Cattle ; Light ; Mutation ; Opsins/genetics ; Opsins/metabolism ; Rhodopsin/metabolism ; Vertebrates/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Characterization of Amino Acid Substitution W20S in MgrB Involved in Polymyxin Resistance in Klebsiella pneumoniae.
Autorzy :: Roch M; Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Service of Infectious Diseases, Department of Medicine, Geneva University Hospitals and Medical School, Geneva, Switzerland.
Martins WMBS; Department of Medical Microbiology, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.; Universidade Federal de São Paulo - UNIFESP, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo, Brazil.
Sierra R; Service of Infectious Diseases, Department of Medicine, Geneva University Hospitals and Medical School, Geneva, Switzerland.; Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Gales AC; Universidade Federal de São Paulo - UNIFESP, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo, Brazil.
Andrey DO; Service of Infectious Diseases, Department of Medicine, Geneva University Hospitals and Medical School, Geneva, Switzerland.; Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Pokaż więcej
Źródło :: Microbiology spectrum [Microbiol Spectr] 2022 Feb 23; Vol. 10 (1), pp. e0176621. Date of Electronic Publication: 2022 Feb 16.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Drug Resistance, Bacterial*
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*genetics
Klebsiella pneumoniae/*drug effects
Klebsiella pneumoniae/*genetics
Bacterial Proteins/metabolism ; Humans ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/metabolism ; Microbial Sensitivity Tests ; Mutation, Missense ; Polymyxin B/pharmacology ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/ MT-ND4 Mutation Associated with Leber's Hereditary Optic Neuropathy.
Autorzy :: Musiani F; Dipartimento di Farmacia e Biotecnologie (FABIT), Università di Bologna, I-40126 Bologna, Italy.
Rigobello L; Dipartimento di Farmacia e Biotecnologie (FABIT), Università di Bologna, I-40126 Bologna, Italy.
Iommarini L; Dipartimento di Farmacia e Biotecnologie (FABIT), Università di Bologna, I-40126 Bologna, Italy.
Carelli V; Dipartimento di Scienze Biomediche e Neuromotorie (DIBINEM), Università di Bologna, I-40100 Bologna, Italy.; IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, I-40139 Bologna, Italy.
Degli Esposti M; Center for Genomic Sciences, Universidad Nacional Autónoma de México (UNAM), Cuernavaca 62210, Mexico.
Ghelli AM; Dipartimento di Farmacia e Biotecnologie (FABIT), Università di Bologna, I-40126 Bologna, Italy.; Pokaż więcej
Źródło :: Molecules (Basel, Switzerland) [Molecules] 2022 Feb 16; Vol. 27 (4). Date of Electronic Publication: 2022 Feb 16.
Typ publikacji :: Journal Article
MeSH Terms :: Alleles*
Amino Acid Substitution*
Mutation*
Drug Resistance/*genetics
Electron Transport Complex I/*genetics
Optic Atrophy, Hereditary, Leber/*genetics
Rotenone/*pharmacology
Amino Acid Sequence ; Binding Sites ; Conserved Sequence ; Electron Transport Complex I/chemistry ; Electron Transport Complex I/metabolism ; Models, Molecular ; Optic Atrophy, Hereditary, Leber/metabolism ; Protein Binding ; Protein Conformation ; Rotenone/chemistry ; Structure-Activity Relationship ; Uncoupling Agents/pharmacology
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 8 8.

Tytuł :: Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.
Autorzy :: Zagare A; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg.
Barmpa K; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg.
Smajic S; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg.
Smits LM; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg.
Grzyb K; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg.
Grünewald A; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg.
Skupin A; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg.
Nickels SL; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address: .
Schwamborn JC; University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 6, Avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address: .; Pokaż więcej
Źródło :: American journal of human genetics [Am J Hum Genet] 2022 Feb 03; Vol. 109 (2), pp. 311-327. Date of Electronic Publication: 2022 Jan 24.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*genetics
Neurogenesis/*genetics
Organoids/*metabolism
Parkinson Disease/*genetics
Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Differentiation ; Cytokines/genetics ; Cytokines/metabolism ; Embryo, Mammalian ; GATA3 Transcription Factor/genetics ; GATA3 Transcription Factor/metabolism ; Gene Expression Regulation, Developmental ; Glycine/chemistry ; Glycine/metabolism ; HSP40 Heat-Shock Proteins/genetics ; HSP40 Heat-Shock Proteins/metabolism ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Mesencephalon ; Models, Biological ; Mutation ; Organoids/pathology ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Sequence Analysis, RNA ; Serine/chemistry ; Serine/metabolism ; Single-Cell Analysis/methods ; Transcriptome
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: The N501Y spike substitution enhances SARS-CoV-2 infection and transmission.
Autorzy :: Liu Y; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
Liu J; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Plante KS; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Plante JA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Zhang X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Ku Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
An Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Scharton D; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Schindewolf C; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Widen SG; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Menachery VD; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. .; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA. .
Weaver SC; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA. .; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA. .; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. .; Pokaż więcej
Źródło :: Nature [Nature] 2022 Feb; Vol. 602 (7896), pp. 294-299. Date of Electronic Publication: 2021 Nov 24.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
COVID-19/*transmission
COVID-19/*virology
SARS-CoV-2/*pathogenicity
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Binding, Competitive ; Bronchi/cytology ; Cells, Cultured ; Cricetinae ; Humans ; Male ; Mesocricetus ; Models, Molecular ; Mutation ; Protein Binding ; SARS-CoV-2/chemistry ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Virus Replication
SCR Organism :: SARS-CoV-2 variants
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Effects of removing a highly conserved disulfide bond in ubiquitin-associated domain of human HOIP on biochemical characteristics.
Autorzy :: Ma W; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Lu Y; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Zuo Y; Heilongjiang Institute of Animal Health Inspection, Harbin, 150006, China.
Wang C; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
Liu J; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Harbin Medical University-Daqing, No 39, Xin Yang Road, Daqing, Heilongjiang, 163319, China. Electronic address: .; Pokaż więcej
Źródło :: Protein expression and purification [Protein Expr Purif] 2022 Feb; Vol. 190, pp. 106005. Date of Electronic Publication: 2021 Oct 22.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Mutation, Missense*
Cysteine/*chemistry
Disulfides/*chemistry
Ubiquitin-Protein Ligases/*chemistry
Cysteine/genetics ; Humans ; Protein Domains ; Ubiquitin-Protein Ligases/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies.
Autorzy :: Fonin AV; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Silonov SA; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Fefilova AS; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Stepanenko OV; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Gavrilova AA; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Petukhov AV; Almazov National Medical Research Centre, Institute of Hematology, 197341 St. Petersburg, Russia.
Romanovich AE; Resource Center of Molecular and Cell Technologies, St-Petersburg State University Research Park, Universitetskaya Emb. 7-9, 199034 St. Petersburg, Russia.
Modina AL; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Zueva TS; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Nedelyaev EM; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Pleskach NM; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Kuranova ML; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Kuznetsova IM; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.
Uversky VN; Department of Molecular Medicine, Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Turoverov KK; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 30; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 30.
Typ publikacji :: Comparative Study; Journal Article
MeSH Terms :: Amino Acid Substitution*
Promyelocytic Leukemia Nuclear Bodies/*metabolism
Promyelocytic Leukemia Protein/*chemistry
Promyelocytic Leukemia Protein/*metabolism
Amino Acid Sequence ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Gene Knockout Techniques ; HeLa Cells ; Humans ; Promyelocytic Leukemia Protein/genetics ; Protein Domains ; Protein Isoforms/chemistry ; Protein Isoforms/metabolism ; Sumoylation
: Czasopismo naukowe

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Skocz do pozycji: 12 12.

Tytuł :: Overexpression of the dystrophins Dp40 and Dp40 L170P modifies neurite outgrowth and the protein expression profile of PC12 cells.
Autorzy :: García-Cruz C; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
Merino-Jiménez C; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
Aragón J; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
Ceja V; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
González-Assad B; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico.
Reyes-Grajeda JP; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Montanez C; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Mexico City, Mexico. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2022 Jan 26; Vol. 12 (1), pp. 1410. Date of Electronic Publication: 2022 Jan 26.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Dystrophin/*genetics
Intermediate Filaments/*metabolism
Neuronal Outgrowth/*genetics
Neurons/*metabolism
Synaptic Vesicles/*metabolism
Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Cytoskeleton/metabolism ; Cytoskeleton/ultrastructure ; Dystrophin/metabolism ; Exocytosis ; Gene Expression Regulation ; Intermediate Filament Proteins/genetics ; Intermediate Filament Proteins/metabolism ; Intermediate Filaments/ultrastructure ; Neurofilament Proteins/genetics ; Neurofilament Proteins/metabolism ; Neurons/cytology ; PC12 Cells ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Rats ; S100 Calcium Binding Protein A6/genetics ; S100 Calcium Binding Protein A6/metabolism ; Signal Transduction ; Synaptic Vesicles/ultrastructure
: Czasopismo naukowe

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Skocz do pozycji: 13 13.

Tytuł :: Insights into the Potential Mechanisms of JAK2V617F Somatic Mutation Contributing Distinct Phenotypes in Myeloproliferative Neoplasms.
Autorzy :: Gou P; Laboratoire UMRS-1131, Ecole doctorale 561, Université de Paris, 75010 Paris, France.; INSERM UMR-S1131, Hôpital Saint-Louis, 75010 Paris, France.
Zhang W; BFA, UMR 8251, CNRS, Université de Paris, 75013 Paris, France.
Giraudier S; Laboratoire UMRS-1131, Ecole doctorale 561, Université de Paris, 75010 Paris, France.; INSERM UMR-S1131, Hôpital Saint-Louis, 75010 Paris, France.; Service de Biologie Cellulaire, Hôpital Saint-Louis, AP-HP, 75010 Paris, France.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 18; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 18.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Amino Acid Substitution*
Janus Kinase 2/*metabolism
Myeloproliferative Disorders/*pathology
Epigenesis, Genetic ; Humans ; Janus Kinase 2/chemistry ; Janus Kinase 2/genetics ; MAP Kinase Signaling System ; Models, Molecular ; Myeloproliferative Disorders/genetics ; Protein Domains
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 14 14.

Tytuł :: Biochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase.
Autorzy :: Bough R; Department of Agricultural Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Dayan FE; Department of Agricultural Biology, Colorado State University, Fort Collins, CO, 80523, USA. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2022 Jan 13; Vol. 12 (1), pp. 679. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: Amino Acid Substitution*
Acetyl-CoA Carboxylase/*chemistry
Acetyl-CoA Carboxylase/*genetics
Herbicide Resistance/*genetics
Herbicides/*pharmacology
Propionates/*pharmacology
Quinoxalines/*pharmacology
Triticum/*drug effects
Acetyltransferases/genetics ; Alanine ; Mutation ; Plant Proteins ; Poaceae ; Pyridines/pharmacology ; Valine
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 15 15.

Tytuł :: A novel fluorescent reporter sensitive to serine mis-incorporation.
Autorzy :: Rozik P; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Szabla R; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Lant JT; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Kiri R; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Wright DE; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.
Junop M; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.
O'Donoghue P; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.; Department of Chemistry, The University of Western Ontario, London, Ontario, Canada.; Pokaż więcej
Źródło :: RNA biology [RNA Biol] 2022; Vol. 19 (1), pp. 221-233. Date of Electronic Publication: 2021 Dec 31.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Biosensing Techniques*
Gene Expression*
Genes, Reporter*
Luminescent Proteins/*genetics
Serine/*genetics
Escherichia coli/genetics ; Escherichia coli/metabolism ; Fluorescent Antibody Technique ; Humans ; Luminescent Proteins/metabolism ; Mass Spectrometry ; Mutation ; Optical Imaging/methods ; Protein Biosynthesis ; RNA, Transfer/genetics ; Serine/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3.
Autorzy :: Hewitt CS; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Das C; Department of Chemistry, College of Science, Purdue University, West Lafayette, IN 47907, USA.
Flaherty DP; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.; Purdue Center for Cancer Research, Hanson Life Sciences Research Building, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Pokaż więcej
Źródło :: Biomolecules [Biomolecules] 2022 Jan 01; Vol. 12 (1). Date of Electronic Publication: 2022 Jan 01.
Typ publikacji :: Journal Article
MeSH Terms :: Amino Acid Substitution*
Mutation, Missense*
Ubiquitin*/chemistry
Ubiquitin*/genetics
Ubiquitin*/metabolism
Ubiquitin Thiolesterase*/chemistry
Ubiquitin Thiolesterase*/genetics
Ubiquitin Thiolesterase*/metabolism
Cell Line, Tumor ; Humans
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 17 17.

Tytuł :: Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases.
Autorzy :: Cheng Q; State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong.
Cheung YC; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong.
Chan EWC; State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.
Wong KY; State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.
Chen S; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong. Electronic address: .; Pokaż więcej
Źródło :: International journal of antimicrobial agents [Int J Antimicrob Agents] 2022 Jan; Vol. 59 (1), pp. 106498. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :: Journal Article
MeSH Terms :: Amino Acid Substitution*
Evolution, Molecular*
Escherichia coli/*genetics
Escherichia coli/*metabolism
beta-Lactamases/*genetics
beta-Lactamases/*metabolism
Genetic Variation ; Genotype ; Microbial Sensitivity Tests ; Mutation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Analysis of the ARTIC Version 3 and Version 4 SARS-CoV-2 Primers and Their Impact on the Detection of the G142D Amino Acid Substitution in the Spike Protein.
Autorzy :: Davis JJ; Division of Data Science and Learning, Argonne National Laboratorygrid.187073.a, Lemont, Illinois, USA.; University of Chicago Consortium for Advanced Science and Engineering, Chicago, Illinois, USA.
Long SW; Center for Infectious Diseases, Laboratory of Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.; Departments of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.; Departments of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Christensen PA; Center for Infectious Diseases, Laboratory of Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.; Departments of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.; Departments of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Olsen RJ; Center for Infectious Diseases, Laboratory of Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.; Departments of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.; Departments of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Olson R; Division of Data Science and Learning, Argonne National Laboratorygrid.187073.a, Lemont, Illinois, USA.; University of Chicago Consortium for Advanced Science and Engineering, Chicago, Illinois, USA.
Shukla M; Division of Data Science and Learning, Argonne National Laboratorygrid.187073.a, Lemont, Illinois, USA.; University of Chicago Consortium for Advanced Science and Engineering, Chicago, Illinois, USA.
Subedi S; Center for Infectious Diseases, Laboratory of Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.; Departments of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.; Departments of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
Stevens R; Computing, Environment and Life Sciences Directorate, Argonne National Laboratorygrid.187073.a, Argonne, Illinois, USA.; Department of Computer Science, University of Chicago, Chicago, Illinois, USA.
Musser JM; Center for Infectious Diseases, Laboratory of Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.; Departments of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.; Departments of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.; Pokaż więcej
Źródło :: Microbiology spectrum [Microbiol Spectr] 2021 Dec 22; Vol. 9 (3), pp. e0180321. Date of Electronic Publication: 2021 Dec 08.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
COVID-19/*virology
SARS-CoV-2/*classification
SARS-CoV-2/*genetics
SARS-CoV-2/*isolation & purification
Spike Glycoprotein, Coronavirus/*genetics
Base Sequence ; Genome, Viral ; Humans ; Mutation ; Whole Genome Sequencing
SCR Organism :: SARS-CoV-2 variants
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Multiple rereads of single proteins at single-amino acid resolution using nanopores.
Autorzy :: Brinkerhoff H; Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.
Kang ASW; Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.
Liu J; Center for Biophysics and Quantitative Biology and Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Aksimentiev A; Center for Biophysics and Quantitative Biology and Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Dekker C; Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, 2629 HZ Delft, Netherlands.; Pokaż więcej
Źródło :: Science (New York, N.Y.) [Science] 2021 Dec 17; Vol. 374 (6574), pp. 1509-1513. Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Nanopores*
Sequence Analysis, Protein*
Amino Acids/*chemistry
Peptides/*chemistry
Proteomics/*methods
DNA Helicases ; Molecular Dynamics Simulation
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 20 20.

Tytuł :: New Variants of the Cytochrome P450 2R1 ( CYP2R1 ) Gene in Individuals with Severe Vitamin D-Activating Enzyme 25(OH)D Deficiency.
Autorzy :: Fronczek M; Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.; Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Strzelczyk JK; Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Biernacki K; Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Salatino S; Molecular Biology, Core Research Laboratories, Natural History Museum, London SW7 5BD, UK.
Osadnik T; Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Ostrowska Z; Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.; Pokaż więcej
Źródło :: Biomolecules [Biomolecules] 2021 Dec 12; Vol. 11 (12). Date of Electronic Publication: 2021 Dec 12.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Amino Acid Substitution*
Cholestanetriol 26-Monooxygenase/*genetics
Cytochrome P450 Family 2/*genetics
Sequence Analysis, DNA/*methods
Vitamin D Deficiency/*genetics
Adult ; Binding Sites ; Case-Control Studies ; Cholestanetriol 26-Monooxygenase/chemistry ; Cholestanetriol 26-Monooxygenase/metabolism ; Cytochrome P450 Family 2/chemistry ; Cytochrome P450 Family 2/metabolism ; Female ; Humans ; Male ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Young Adult
: Czasopismo naukowe

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