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Wyszukujesz frazę ""Aminoimidazole Carboxamide"" wg kryterium: Temat


Tytuł :
N-acetylcysteine reduced the immunotoxicity effects induced in vitro by azoxystrobin and iprodione fungicides in mice.
Autorzy :
Naasri S; Faculty of Pharmacy of Monastir, Laboratory of Transmissible Diseases and Biologically Active Substances, University of Monastir, Monastir, Tunisia.
Helali I; Faculty of Pharmacy of Monastir, Laboratory of Transmissible Diseases and Biologically Active Substances, University of Monastir, Monastir, Tunisia.
Aouni M; Faculty of Pharmacy of Monastir, Laboratory of Transmissible Diseases and Biologically Active Substances, University of Monastir, Monastir, Tunisia.
Mastouri M; Faculty of Pharmacy of Monastir, Laboratory of Transmissible Diseases and Biologically Active Substances, University of Monastir, Monastir, Tunisia.
Harizi H; Faculty of Pharmacy of Monastir, Laboratory of Transmissible Diseases and Biologically Active Substances, University of Monastir, Monastir, Tunisia.; Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Apr; Vol. 36 (4), pp. 562-571. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Macrophages, Peritoneal*/drug effects
Macrophages, Peritoneal*/immunology
Acetylcysteine/*pharmacology
Aminoimidazole Carboxamide/*analogs & derivatives
Environmental Pollutants/*toxicity
Fungicides, Industrial/*toxicity
Hydantoins/*toxicity
Pyrimidines/*toxicity
Strobilurins/*toxicity
Aminoimidazole Carboxamide/toxicity ; Animals ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cell Survival/immunology ; Cells, Cultured ; Cytokines/biosynthesis ; Dose-Response Relationship, Drug ; Male ; Mice ; Spleen/drug effects ; Spleen/immunology
Czasopismo naukowe
Tytuł :
Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.
Autorzy :
Efstathiou NE; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Moustafa GA; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Maidana DE; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Konstantinou EK; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Notomi S; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Barbisan PRT; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Georgakopoulos CD; Department of Ophthalmology, University of Patras, Medical School, Patras, Greece.
Miller JW; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Vavvas DG; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 23; Vol. 15 (12), pp. e0244307. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Complement C3/*metabolism
Retinal Pigment Epithelium/*metabolism
Ribonucleosides/*pharmacology
AMP-Activated Protein Kinases/metabolism ; Adenosine/metabolism ; Aminoimidazole Carboxamide/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line ; Cells, Cultured ; Complement Activation/drug effects ; Complement C3/drug effects ; Humans ; Macular Degeneration/metabolism ; Phosphorylation ; Retinal Pigment Epithelium/drug effects ; Retinal Pigments/metabolism ; Ribonucleosides/metabolism ; Ribonucleotides/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Construction of EVA/chitosan based PEG-PCL micelles nanocomposite films with controlled release of iprodione and its application in pre-harvest treatment of grapes.
Autorzy :
Xiao NY; College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China. Electronic address: .
Zhang XQ; College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China. Electronic address: .
Ma XY; Research Center of Chinese Herbal Resource Science and Engineering, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Luo WH; College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Li HQ; College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zeng QY; College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zhong L; College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Zhao WH; College of Light Industry and Food Science, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
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Źródło :
Food chemistry [Food Chem] 2020 Nov 30; Vol. 331, pp. 127277. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Hydantoins/*pharmacokinetics
Nanocomposites/*chemistry
Vitis/*drug effects
Aminoimidazole Carboxamide/administration & dosage ; Aminoimidazole Carboxamide/pharmacokinetics ; Chitosan/chemistry ; Delayed-Action Preparations ; Drug Carriers ; Food Microbiology ; Fungicides, Industrial/administration & dosage ; Fungicides, Industrial/pharmacokinetics ; Hydantoins/administration & dosage ; Lactones/chemistry ; Micelles ; Oxygen ; Permeability ; Polyethylene Glycols/chemistry ; Polyvinyls/chemistry ; Steam
Czasopismo naukowe
Tytuł :
Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies.
Autorzy :
Hashempour S; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.; Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran.
Shahabadi N; Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran.; Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah 6714414971, Iran.
Adewoye A; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Murphy B; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Rouse C; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Salvatore BA; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Stratton C; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Mahdavian E; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 19; Vol. 25 (22). Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Spectrum Analysis*
Aminoimidazole Carboxamide/*analogs & derivatives
Ribonucleotides/*metabolism
Serum Albumin, Human/*metabolism
Aminoimidazole Carboxamide/chemistry ; Aminoimidazole Carboxamide/metabolism ; Energy Transfer ; Humans ; Kinetics ; Protein Binding ; Ribonucleotides/chemistry ; Serum Albumin, Human/chemistry ; Spectrometry, Fluorescence ; Spectrophotometry, Ultraviolet ; Thermodynamics
Czasopismo naukowe
Tytuł :
Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy.
Autorzy :
Tseng HH; Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.; Division of General Surgery, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
Huang WR; Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.; The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.
Cheng CY; Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.
Chiu HC; Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.; The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.
Liao TL; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.
Nielsen BL; Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Liu HJ; Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.; The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan.; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Nov 24; Vol. 11, pp. 556838. Date of Electronic Publication: 2020 Nov 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Aspirin/*pharmacology
Autophagy/*drug effects
Ephemeral Fever/*virology
Ephemeral Fever Virus, Bovine/*drug effects
Ephemeral Fever Virus, Bovine/*physiology
Ribonucleosides/*pharmacology
Virus Replication/*drug effects
Aminoimidazole Carboxamide/pharmacology ; Animals ; Biomarkers ; Cattle ; Cell Line ; Cell Survival/drug effects ; Cyclooxygenase 2/metabolism ; Ephemeral Fever/metabolism ; Gene Expression Regulation/drug effects ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Small Interfering
Czasopismo naukowe
Tytuł :
5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts.
Autorzy :
Dembitz V; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Lalic H; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Kodvanj I; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Tomic B; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Batinic J; Division of Hematology, Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia.
Dubravcic K; Department of Laboratory Immunology, University Hospital Center Zagreb, Zagreb, Croatia.
Batinic D; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.; Department of Laboratory Immunology, University Hospital Center Zagreb, Zagreb, Croatia.
Bedalov A; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Visnjic D; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia. .; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia. .
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Źródło :
BMC cancer [BMC Cancer] 2020 Nov 11; Vol. 20 (1), pp. 1090. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Aminoimidazole Carboxamide/*analogs & derivatives
Biomarkers, Tumor/*metabolism
Blast Crisis/*drug therapy
Bone Marrow/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Leukemia, Myeloid, Acute/*drug therapy
Ribonucleosides/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Biomarkers, Tumor/genetics ; Blast Crisis/genetics ; Blast Crisis/metabolism ; Blast Crisis/pathology ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Case-Control Studies ; Cell Proliferation ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; RNA-Seq ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Residue behavior and removal of iprodione in garlic, green garlic, and garlic shoot.
Autorzy :
Bian Y; College of Science, China Agricultural University, Beijing, China.
Wang J; College of Science, China Agricultural University, Beijing, China.
Liu F; College of Science, China Agricultural University, Beijing, China.
Mao B; College of Science, China Agricultural University, Beijing, China.
Huang H; College of Science, China Agricultural University, Beijing, China.
Xu J; College of Science, China Agricultural University, Beijing, China.
Li X; College of Science, China Agricultural University, Beijing, China.
Guo Y; College of Science, China Agricultural University, Beijing, China.
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Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2020 Oct; Vol. 100 (13), pp. 4705-4713. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Fungicides, Industrial/*chemistry
Garlic/*chemistry
Hydantoins/*chemistry
Pesticide Residues/*chemistry
Plant Shoots/*chemistry
Aminoimidazole Carboxamide/chemistry ; Food Contamination/analysis ; Garlic/growth & development ; Half-Life ; Plant Leaves/chemistry ; Plant Shoots/growth & development
Czasopismo naukowe
Tytuł :
Cytological and Gene Profile Expression Analysis Reveals Modification in Metabolic Pathways and Catalytic Activities Induce Resistance in Botrytis cinerea Against Iprodione Isolated From Tomato.
Autorzy :
Maqsood A; Guangxi Key Laboratory of Agric-Environment and Agric-Products Safety, Agricultural College of Guangxi University, Nanning 530004, Guangxi, China.; Department of Plant Pathology, University College of Agriculture and Environmental Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Wu C; Guangxi Key Laboratory of Agric-Environment and Agric-Products Safety, Agricultural College of Guangxi University, Nanning 530004, Guangxi, China.
Ahmar S; National Key Laboratory of Crop Improvement Genetics, College of Plant Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Wu H; Guangxi Key Laboratory of Agric-Environment and Agric-Products Safety, Agricultural College of Guangxi University, Nanning 530004, Guangxi, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 09; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Botrytis/*drug effects
Botrytis/*genetics
Drug Resistance, Fungal/*genetics
Hydantoins/*pharmacology
Lycopersicon esculentum/*microbiology
Metabolic Networks and Pathways/*genetics
Transcriptome/*genetics
Aminoimidazole Carboxamide/pharmacology ; Catalysis ; Drug Resistance, Fungal/drug effects ; Fruit/microbiology ; Fungicides, Industrial/pharmacology ; Mycelium/drug effects ; Mycelium/genetics ; Plant Diseases/microbiology ; Virulence/genetics
SCR Organism :
Botrytis cinerea
Czasopismo naukowe
Tytuł :
AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis.
Autorzy :
Nuwormegbe SA; .
Kim SW; .
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Źródło :
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Jun 03; Vol. 61 (6), pp. 43.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Cornea/*pathology
Eye Burns/*complications
Fibroblasts/*metabolism
AMP-Activated Protein Kinases/drug effects ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cells, Cultured ; Cornea/drug effects ; Cornea/metabolism ; Disease Models, Animal ; Eye Burns/drug therapy ; Eye Burns/metabolism ; Fibroblasts/pathology ; Fibrosis/drug therapy ; Fibrosis/metabolism ; Fibrosis/pathology ; Humans ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
TP63 Is Significantly Upregulated in Diabetic Kidney.
Autorzy :
Liang S; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Nayak BK; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Vogel KS; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Habib SL; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.; South Texas, Veterans Healthcare System, San Antonio, TX 78229, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 15; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetic Nephropathies/*genetics
Trans-Activators/*genetics
Up-Regulation/*genetics
Adenylate Kinase/metabolism ; Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Blood Glucose/metabolism ; Cells, Cultured ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/genetics ; Diabetic Nephropathies/blood ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Insulin Receptor Substrate Proteins/genetics ; Insulin Receptor Substrate Proteins/metabolism ; Kidney Tubules, Proximal/pathology ; Models, Biological ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribonucleotides/pharmacology ; Signal Transduction/drug effects ; Trans-Activators/metabolism ; Tuberous Sclerosis Complex 2 Protein/pharmacology ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Autorzy :
Liu Y; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA. .; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. .; The McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA. .
Jurczak MJ; Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA.
Lear TB; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Lin B; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
Larsen MB; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
Kennerdell JR; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
Chen Y; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
Huckestein BR; Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA.
Nguyen MK; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
Tuncer F; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
Jiang Y; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Monga SP; Department of Pathology and Medicine, and Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
O'Donnell CP; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Finkel T; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Chen BB; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, PA, USA. .; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. .; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA. .
Mallampalli RK; Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Mar; Vol. 17 (3), pp. 298-306. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
AMP-Activated Protein Kinases/*genetics
Hypoglycemic Agents/*pharmacology
Obesity/*drug therapy
Proteasome Endopeptidase Complex/*drug effects
Protein Processing, Post-Translational/*drug effects
Ubiquitin-Protein Ligases/*genetics
AMP-Activated Protein Kinases/metabolism ; Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line, Transformed ; Diet, High-Fat ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Hypoglycemic Agents/chemical synthesis ; Insulin Resistance ; Metformin/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Mitochondrial Dynamics/drug effects ; Obesity/etiology ; Obesity/genetics ; Obesity/metabolism ; Phosphorylation ; Polyubiquitin/genetics ; Polyubiquitin/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Protein Stability/drug effects ; Proteolysis/drug effects ; Ribonucleotides/pharmacology ; Ubiquitin-Protein Ligases/antagonists & inhibitors ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Tytuł :
Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator.
Autorzy :
Kawashima H; Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Ozawa Y; Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Toda E; Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.
Homma K; Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.
Osada H; Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.
Narimatsu T; Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Nagai N; Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan.; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Tsubota K; Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Apr; Vol. 34 (4), pp. 5016-5026. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Macular Degeneration/*drug therapy
Neuroprotective Agents/*pharmacology
Protein Kinases/*metabolism
Ribonucleotides/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Aminoimidazole Carboxamide/therapeutic use ; Animals ; Cell Line ; Electron Transport Complex IV/metabolism ; Macular Degeneration/etiology ; Macular Degeneration/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Neuroprotective Agents/therapeutic use ; Oxygen Consumption ; Protein Kinases/genetics ; Retina/drug effects ; Retina/metabolism ; Retina/radiation effects ; Ribonucleotides/therapeutic use ; Ultraviolet Rays/adverse effects
Czasopismo naukowe
Tytuł :
The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin.
Autorzy :
Kopel J; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Higuchi K; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Ristic B; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Sato T; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Ramachandran S; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Ganapathy V; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 22; Vol. 10 (1), pp. 8536. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Targeted Therapy*
Aminoimidazole Carboxamide/*analogs & derivatives
Carcinoma, Hepatocellular/*drug therapy
Gene Expression Regulation, Neoplastic/*drug effects
Liver Neoplasms/*drug therapy
Metformin/*pharmacology
Ribonucleotides/*pharmacology
Symporters/*antagonists & inhibitors
Aminoimidazole Carboxamide/pharmacology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Citric Acid/metabolism ; Glycolysis ; Hep G2 Cells ; Humans ; Hypoglycemic Agents/pharmacology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Signal Transduction ; Symporters/genetics ; Symporters/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport.
Autorzy :
Knudsen JR; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.; Laboratory of Microsystems 2, Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Madsen AB; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Persson KW; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Henríquez-Olguín C; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Li Z; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Jensen TE; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 28; Vol. 21 (7). Date of Electronic Publication: 2020 Mar 28.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Benzamides/*pharmacology
Glucose/*metabolism
Hypoglycemic Agents/*pharmacology
Insulin/*pharmacology
Pyrimidines/*pharmacology
Ribonucleotides/*pharmacology
AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Autophagy-Related Protein-1 Homolog/antagonists & inhibitors ; Autophagy-Related Protein-1 Homolog/metabolism ; Biological Transport/drug effects ; Female ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism
Czasopismo naukowe
Tytuł :
Low-cost sugarcane bagasse and peanut shell magnetic-composites applied in the removal of carbofuran and iprodione pesticides.
Autorzy :
Toledo-Jaldin HP; Posgrado en Ciencia de Materiales, Facultad de Química, Universidad Autónoma del Estado de México Paseo Colón y Tollocan, 50110, Toluca, México, Mexico.; Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, (CCIQS), Carretera Toluca-Atlacomulco Km 14.5, Unidad El Rosedal C.P., 50200, Toluca, Estado de México, Mexico.
Sánchez-Mendieta V; Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, (CCIQS), Carretera Toluca-Atlacomulco Km 14.5, Unidad El Rosedal C.P., 50200, Toluca, Estado de México, Mexico.
Blanco-Flores A; Tecnológico de Estudios Superiores de Tianguistenco, División de Ingeniería Mecánica, Carretera Tenango-La Marqueza km 22, Santiago Tilapa, C.P., 52650, Santiago de Tianguistenco, Mexico. .
López-Téllez G; Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, (CCIQS), Carretera Toluca-Atlacomulco Km 14.5, Unidad El Rosedal C.P., 50200, Toluca, Estado de México, Mexico. .
Vilchis-Nestor AR; Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, (CCIQS), Carretera Toluca-Atlacomulco Km 14.5, Unidad El Rosedal C.P., 50200, Toluca, Estado de México, Mexico.
Martín-Hernández O; Síntesis y Formulaciones de Alta Tecnología, S.A. De C.V. (SIFATEC), Álamo 101, Habitacional Valle de Los Pinos 2a. Sección, 54040, Tlalnepantla, Mexico.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2020 Mar; Vol. 27 (8), pp. 7872-7885. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Carbofuran*/chemistry
Pesticides*
Saccharum*
Water Pollutants, Chemical*
Aminoimidazole Carboxamide/*analogs & derivatives
Arachis/*chemistry
Hydantoins/*chemistry
Adsorption ; Aminoimidazole Carboxamide/chemistry ; Cellulose ; Magnetic Phenomena
Czasopismo naukowe
Tytuł :
Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study.
Autorzy :
Tsai WL; Department of Pediatrics, Chiayi Chang Gung Memorial Hospital, Chiayi County, Puzi City 613, Taiwan.
Hsu CN; Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Tain YL; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
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Źródło :
Nutrients [Nutrients] 2020 Feb 11; Vol. 12 (2). Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Animal Nutritional Physiological Phenomena*/drug effects
Animal Nutritional Physiological Phenomena*/physiology
Aminoimidazole Carboxamide/*analogs & derivatives
Diet, High-Fat/*adverse effects
Fatty Acids/*adverse effects
Hypertension/*etiology
Hypertension/*prevention & control
Ribonucleotides/*administration & dosage
AMP-Activated Protein Kinases/metabolism ; AMP-Activated Protein Kinases/physiology ; Aminoimidazole Carboxamide/administration & dosage ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Female ; Kidney/metabolism ; Lactation/metabolism ; Male ; Nitric Oxide/metabolism ; Obesity/etiology ; Obesity/prevention & control ; Oxidative Stress/drug effects ; Pilot Projects ; Pregnancy ; Rats, Sprague-Dawley ; Ribonucleotides/pharmacology ; Signal Transduction/drug effects ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells.
Autorzy :
Khorraminejad-Shirazi M; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Cell and Molecular Medicine Student Research Group, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sani M; Tissue Engineering Department, School of Advanced Medical Science and Technology, Shiraz University of Medical Science, Shiraz, Iran.; Tissue Engineering Lab, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Talaei-Khozani T; Tissue Engineering Lab, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Dorvash M; Cell and Molecular Medicine Student Research Group, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mirzaei M; Persian BayanGene Research and Training Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Faghihi MA; Persian BayanGene Research and Training Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Monabati A; Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Attar A; Department of Cardiovascular Medicine, Shiraz University of Medical Sciences, PO Box 71344-1864, Shiraz, Iran. .
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2020 Feb 03; Vol. 11 (1), pp. 45. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Hypoglycemic Agents/*therapeutic use
Mesenchymal Stem Cells/*drug effects
Niacinamide/*therapeutic use
Ribonucleotides/*therapeutic use
Vitamin B Complex/*therapeutic use
Aminoimidazole Carboxamide/pharmacology ; Aminoimidazole Carboxamide/therapeutic use ; Cell Proliferation/drug effects ; Cellular Senescence/drug effects ; Humans ; Hypoglycemic Agents/pharmacology ; Niacinamide/pharmacology ; Ribonucleotides/pharmacology ; Vitamin B Complex/pharmacology
Czasopismo naukowe
Tytuł :
Acadesine Circumvents Azacitidine Resistance in Myelodysplastic Syndrome and Acute Myeloid Leukemia.
Autorzy :
Cluzeau T; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Furstoss N; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Savy C; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
El Manaa W; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Zerhouni M; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Blot L; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Calleja A; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Dufies M; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Dubois A; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Ginet C; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Mounier N; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Garnier G; Service de Médecine Interne, Centre Hospitalier Princesse Grace, Monaco 98000, Monaco.
Raynaud S; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Rohrlich PS; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Peterlin P; Service D'hématologie Clinique, CHU de Nantes, 44093 Nantes, France.
Stamatoullas A; Centre Henri Becquerel, 76038 Rouen, France.
Chermat F; Service Hématologie Seniors, Hopital Saint-Louis, 75010 Paris, France.
Fenaux P; Service Hématologie Seniors, Hopital Saint-Louis, 75010 Paris, France.
Jacquel A; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Robert G; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Auberger P; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 25; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Leukemia, Myeloid, Acute/*drug therapy
Myelodysplastic Syndromes/*drug therapy
Ribonucleosides/*therapeutic use
Aged ; Aminoimidazole Carboxamide/pharmacology ; Aminoimidazole Carboxamide/therapeutic use ; Apoptosis/drug effects ; Azacitidine/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Clinical Trials as Topic ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Leukemia, Myeloid, Acute/pathology ; Male ; Middle Aged ; Myelodysplastic Syndromes/pathology ; Recurrence ; Ribonucleosides/pharmacology ; Treatment Failure
Czasopismo naukowe
Tytuł :
AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane.
Autorzy :
Liu L; Department of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
Liu C; Institute of Cardiovascular Diseases, Tianjin Chest Hospital, Tianjin 300457, P.R. China.
Fang L; Department of Thyroid and Breast Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
AMP-Activated Protein Kinases/*metabolism
Apoptosis/*drug effects
Cognitive Dysfunction/*metabolism
Neurons/*metabolism
Sevoflurane/*toxicity
Sirtuin 1/*metabolism
Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Behavior, Animal/drug effects ; Cognition/drug effects ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/prevention & control ; Hippocampus/metabolism ; Male ; Neurons/cytology ; Neuroprotective Agents/pharmacology ; PC12 Cells ; Rats ; Rats, Sprague-Dawley ; Ribonucleotides/pharmacology
Czasopismo naukowe
Tytuł :
The fungicide iprodione affects midgut cells of non-target honey bee Apis mellifera workers.
Autorzy :
Carneiro LS; Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900, Viçosa, Minas Gerais, Brazil.
Martínez LC; Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900, Viçosa, Minas Gerais, Brazil.
Gonçalves WG; Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900, Viçosa, Minas Gerais, Brazil.
Santana LM; Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900, Viçosa, Minas Gerais, Brazil.
Serrão JE; Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900, Viçosa, Minas Gerais, Brazil. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Feb; Vol. 189, pp. 109991. Date of Electronic Publication: 2019 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Aminoimidazole Carboxamide/*analogs & derivatives
Bees/*drug effects
Fungicides, Industrial/*toxicity
Hydantoins/*toxicity
Aminoimidazole Carboxamide/toxicity ; Animals ; Apoptosis/drug effects ; Bees/cytology ; Digestive System/cytology ; Digestive System/drug effects ; Pesticides/analysis ; Pollen/chemistry
Czasopismo naukowe

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