Skocz do pozycji: 1.

Tytuł:

Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide.

Autorzy:

Nogi Y; Graduate School of Pharmaceutical Science, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan.
Saito-Tarashima N; Graduate School of Pharmaceutical Science, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan.
Karanjit S; Graduate School of Pharmaceutical Science, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan.
Minakawa N; Graduate School of Pharmaceutical Science, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2023 Apr 06; Vol. 28 (7). Date of Electronic Publication: 2023 Apr 06.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide*
DNA*
Base Pairing ; Nucleosides ; Nucleotides

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 2.

Tytuł:

Wide distribution of resistance to the fungicides fludioxonil and iprodione in Penicillium species.

Autorzy:

Oiki S; Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Yaguchi T; Medical Mycology Research Center, Chiba University, Chiba, Japan.
Urayama SI; Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.; Microbiology Research Center for Sustainability, University of Tsukuba, Tsukuba, Japan.
Hagiwara D; Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.; Microbiology Research Center for Sustainability, University of Tsukuba, Tsukuba, Japan.

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Źródło:

PloS one [PLoS One] 2022 Jan 31; Vol. 17 (1), pp. e0262521. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2022).

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Drug Resistance, Fungal*
Polymorphism, Single Nucleotide*
Aminoimidazole Carboxamide/*analogs & derivatives
Dioxoles/*pharmacology
Fungal Proteins/*genetics
Hydantoins/*pharmacology
Mycoses/*drug therapy
Penicillium/*isolation & purification
Pyrroles/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Cadaver ; Crops, Agricultural/microbiology ; Food Analysis ; Fungicides, Industrial/pharmacology ; Humans ; Mycoses/genetics ; Mycoses/microbiology ; Penicillium/drug effects ; Penicillium/genetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 3.

Tytuł:

AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess.

Autorzy:

Samsonov MV; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Podkuychenko NV; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Khapchaev AY; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Efremov EE; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Yanushevskaya EV; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Vlasik TN; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Lankin VZ; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Stafeev IS; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Skulachev MV; Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University, 119234 Moscow, Russia.
Shestakova MV; Diabetes Institute, Endocrinology Research Center, 117036 Moscow, Russia.
Vorotnikov AV; National Medical Research Center for Cardiology, 121552 Moscow, Russia.
Shirinsky VP; National Medical Research Center for Cardiology, 121552 Moscow, Russia.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2021 Dec 25; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 25.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Endothelium, Vascular/*drug effects
Human Umbilical Vein Endothelial Cells/*drug effects
Oxidative Stress/*drug effects
Palmitates/*metabolism
Ribonucleotides/*pharmacology
AMP-Activated Protein Kinases/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Apoptosis/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Endothelium, Vascular/metabolism ; Fatty Acids, Nonesterified/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Insulin/metabolism ; Insulin Resistance/physiology ; Lipid Peroxidation/drug effects ; Malondialdehyde/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 4.

Tytuł:

AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.

Autorzy:

Višnjić D; Laboratory of Cell Biology, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Lalić H; Laboratory of Cell Biology, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Dembitz V; Laboratory of Cell Biology, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Tomić B; Laboratory of Cell Biology, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Smoljo T; Laboratory of Cell Biology, Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.

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Źródło:

Cells [Cells] 2021 May 04; Vol. 10 (5). Date of Electronic Publication: 2021 May 04.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't; Systematic Review

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Hypoglycemic Agents/*pharmacology
Protein Kinases/*metabolism
Ribonucleotides/*pharmacology
AMP-Activated Protein Kinase Kinases ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Carcinogenesis/drug effects ; Cell Cycle/drug effects ; Energy Metabolism/drug effects ; Humans ; Myocytes, Cardiac/drug effects

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 5.

Tytuł:

Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.

Autorzy:

Efstathiou NE; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Moustafa GA; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Maidana DE; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Konstantinou EK; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Notomi S; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Barbisan PRT; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Georgakopoulos CD; Department of Ophthalmology, University of Patras, Medical School, Patras, Greece.
Miller JW; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Vavvas DG; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.

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Źródło:

PloS one [PLoS One] 2020 Dec 23; Vol. 15 (12), pp. e0244307. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).

Typ publikacji:

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Complement C3/*metabolism
Retinal Pigment Epithelium/*metabolism
Ribonucleosides/*pharmacology
AMP-Activated Protein Kinases/metabolism ; Adenosine/metabolism ; Aminoimidazole Carboxamide/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line ; Cells, Cultured ; Complement Activation/drug effects ; Complement C3/drug effects ; Humans ; Macular Degeneration/metabolism ; Phosphorylation ; Retinal Pigment Epithelium/drug effects ; Retinal Pigments/metabolism ; Ribonucleosides/metabolism ; Ribonucleotides/pharmacology ; Tumor Necrosis Factor-alpha/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 6.

Tytuł:

Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies.

Autorzy:

Hashempour S; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.; Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran.
Shahabadi N; Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran.; Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah 6714414971, Iran.
Adewoye A; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Murphy B; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Rouse C; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Salvatore BA; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Stratton C; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.
Mahdavian E; Department of Chemistry and Physics, Louisiana State University, Shreveport, LA 71115, USA.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2020 Nov 19; Vol. 25 (22). Date of Electronic Publication: 2020 Nov 19.

Typ publikacji:

Journal Article

MeSH Terms:

Molecular Docking Simulation*
Spectrum Analysis*
Aminoimidazole Carboxamide/*analogs & derivatives
Ribonucleotides/*metabolism
Serum Albumin, Human/*metabolism
Aminoimidazole Carboxamide/chemistry ; Aminoimidazole Carboxamide/metabolism ; Energy Transfer ; Humans ; Kinetics ; Protein Binding ; Ribonucleotides/chemistry ; Serum Albumin, Human/chemistry ; Spectrometry, Fluorescence ; Spectrophotometry, Ultraviolet ; Thermodynamics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 7.

Tytuł:

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts.

Autorzy:

Dembitz V; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Lalic H; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Kodvanj I; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Tomic B; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia.; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.
Batinic J; Division of Hematology, Department of Internal Medicine, University Hospital Center Zagreb, Zagreb, Croatia.
Dubravcic K; Department of Laboratory Immunology, University Hospital Center Zagreb, Zagreb, Croatia.
Batinic D; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia.; Department of Laboratory Immunology, University Hospital Center Zagreb, Zagreb, Croatia.
Bedalov A; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Visnjic D; Croatian Institute for Brain Research, University of Zagreb School of Medicine, 10 000, Zagreb, Croatia. .; Department of Physiology, University of Zagreb School of Medicine, Zagreb, Croatia. .

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Źródło:

BMC cancer [BMC Cancer] 2020 Nov 11; Vol. 20 (1), pp. 1090. Date of Electronic Publication: 2020 Nov 11.

Typ publikacji:

Journal Article

MeSH Terms:

Cell Differentiation*
Aminoimidazole Carboxamide/*analogs & derivatives
Biomarkers, Tumor/*metabolism
Blast Crisis/*drug therapy
Bone Marrow/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Leukemia, Myeloid, Acute/*drug therapy
Ribonucleosides/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Biomarkers, Tumor/genetics ; Blast Crisis/genetics ; Blast Crisis/metabolism ; Blast Crisis/pathology ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Case-Control Studies ; Cell Proliferation ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; RNA-Seq ; Tumor Cells, Cultured

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 8.

Tytuł:

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells.

Autorzy:

Khorraminejad-Shirazi M; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.; Cell and Molecular Medicine Student Research Group, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sani M; Tissue Engineering Department, School of Advanced Medical Science and Technology, Shiraz University of Medical Science, Shiraz, Iran.; Tissue Engineering Lab, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Talaei-Khozani T; Tissue Engineering Lab, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Dorvash M; Cell and Molecular Medicine Student Research Group, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mirzaei M; Persian BayanGene Research and Training Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Faghihi MA; Persian BayanGene Research and Training Center, Shiraz University of Medical Sciences, Shiraz, Iran.; Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Monabati A; Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Attar A; Department of Cardiovascular Medicine, Shiraz University of Medical Sciences, PO Box 71344-1864, Shiraz, Iran. .

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Źródło:

Stem cell research & therapy [Stem Cell Res Ther] 2020 Feb 03; Vol. 11 (1), pp. 45. Date of Electronic Publication: 2020 Feb 03.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Hypoglycemic Agents/*therapeutic use
Mesenchymal Stem Cells/*drug effects
Niacinamide/*therapeutic use
Ribonucleotides/*therapeutic use
Vitamin B Complex/*therapeutic use
Aminoimidazole Carboxamide/pharmacology ; Aminoimidazole Carboxamide/therapeutic use ; Cell Proliferation/drug effects ; Cellular Senescence/drug effects ; Humans ; Hypoglycemic Agents/pharmacology ; Niacinamide/pharmacology ; Ribonucleotides/pharmacology ; Vitamin B Complex/pharmacology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 9.

Tytuł:

Cytological and Gene Profile Expression Analysis Reveals Modification in Metabolic Pathways and Catalytic Activities Induce Resistance in Botrytis cinerea Against Iprodione Isolated From Tomato.

Autorzy:

Maqsood A; Guangxi Key Laboratory of Agric-Environment and Agric-Products Safety, Agricultural College of Guangxi University, Nanning 530004, Guangxi, China.; Department of Plant Pathology, University College of Agriculture and Environmental Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Wu C; Guangxi Key Laboratory of Agric-Environment and Agric-Products Safety, Agricultural College of Guangxi University, Nanning 530004, Guangxi, China.
Ahmar S; National Key Laboratory of Crop Improvement Genetics, College of Plant Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Wu H; Guangxi Key Laboratory of Agric-Environment and Agric-Products Safety, Agricultural College of Guangxi University, Nanning 530004, Guangxi, China.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2020 Jul 09; Vol. 21 (14). Date of Electronic Publication: 2020 Jul 09.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Botrytis/*drug effects
Botrytis/*genetics
Drug Resistance, Fungal/*genetics
Hydantoins/*pharmacology
Solanum lycopersicum/*microbiology
Metabolic Networks and Pathways/*genetics
Transcriptome/*genetics
Aminoimidazole Carboxamide/pharmacology ; Catalysis ; Drug Resistance, Fungal/drug effects ; Fruit/microbiology ; Fungicides, Industrial/pharmacology ; Mycelium/drug effects ; Mycelium/genetics ; Plant Diseases/microbiology ; Virulence/genetics

SCR Organism:

Botrytis cinerea

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 10.

Tytuł:

The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin.

Autorzy:

Kopel J; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Higuchi K; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Ristic B; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Sato T; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Ramachandran S; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States.
Ganapathy V; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, 79430, Texas, United States. .

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Źródło:

Scientific reports [Sci Rep] 2020 May 22; Vol. 10 (1), pp. 8536. Date of Electronic Publication: 2020 May 22.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Molecular Targeted Therapy*
Aminoimidazole Carboxamide/*analogs & derivatives
Carcinoma, Hepatocellular/*drug therapy
Gene Expression Regulation, Neoplastic/*drug effects
Liver Neoplasms/*drug therapy
Metformin/*pharmacology
Ribonucleotides/*pharmacology
Symporters/*antagonists & inhibitors
Aminoimidazole Carboxamide/pharmacology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Citric Acid/metabolism ; Glycolysis ; Hep G2 Cells ; Humans ; Hypoglycemic Agents/pharmacology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Signal Transduction ; Symporters/genetics ; Symporters/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 11.

Tytuł:

Acadesine Circumvents Azacitidine Resistance in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Autorzy:

Cluzeau T; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Furstoss N; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Savy C; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
El Manaa W; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Zerhouni M; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Blot L; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Calleja A; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Dufies M; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Dubois A; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Ginet C; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Mounier N; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Garnier G; Service de Médecine Interne, Centre Hospitalier Princesse Grace, Monaco 98000, Monaco.
Raynaud S; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Rohrlich PS; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.
Peterlin P; Service D'hématologie Clinique, CHU de Nantes, 44093 Nantes, France.
Stamatoullas A; Centre Henri Becquerel, 76038 Rouen, France.
Chermat F; Service Hématologie Seniors, Hopital Saint-Louis, 75010 Paris, France.
Fenaux P; Service Hématologie Seniors, Hopital Saint-Louis, 75010 Paris, France.
Jacquel A; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Robert G; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.
Auberger P; INSERM U1065, Université Côte d'Azur, C3M, 06204 Nice, France.; Equipe Labellisée par la Ligue Nationale Contre le Cancer, 75013 Paris, France.; CHU de Nice, Service d'hématologie Clinique, 06200 Nice, France.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2019 Dec 25; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 25.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Leukemia, Myeloid, Acute/*drug therapy
Myelodysplastic Syndromes/*drug therapy
Ribonucleosides/*therapeutic use
Aged ; Aminoimidazole Carboxamide/pharmacology ; Aminoimidazole Carboxamide/therapeutic use ; Apoptosis/drug effects ; Azacitidine/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Clinical Trials as Topic ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Leukemia, Myeloid, Acute/pathology ; Male ; Middle Aged ; Myelodysplastic Syndromes/pathology ; Recurrence ; Ribonucleosides/pharmacology ; Treatment Failure

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 12.

Tytuł:

Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle.

Autorzy:

Gu M; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.; College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China.
Wei Z; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Wang X; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Gao Y; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Wang D; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Liu X; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Bai C; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Su G; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Yang L; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Li G; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2022 Nov 08; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 08.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases*/metabolism
Myostatin*/genetics
Myostatin*/metabolism
Animals ; Mice ; Aminoimidazole Carboxamide/pharmacology ; Mice, Knockout ; Mitochondria/genetics ; Mitochondria/metabolism ; Muscle, Skeletal/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 13.

Tytuł:

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport.

Autorzy:

Knudsen JR; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.; Laboratory of Microsystems 2, Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
Madsen AB; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Persson KW; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Henríquez-Olguín C; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Li Z; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.
Jensen TE; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2020 Mar 28; Vol. 21 (7). Date of Electronic Publication: 2020 Mar 28.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Benzamides/*pharmacology
Glucose/*metabolism
Hypoglycemic Agents/*pharmacology
Insulin/*pharmacology
Pyrimidines/*pharmacology
Ribonucleotides/*pharmacology
AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Autophagy-Related Protein-1 Homolog/antagonists & inhibitors ; Autophagy-Related Protein-1 Homolog/metabolism ; Biological Transport/drug effects ; Female ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 14.

Tytuł:

Suppression of AMP-activated protein kinase reverses osteoprotegerin-induced inhibition of osteoclast differentiation by reducing autophagy.

Autorzy:

Tong X; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Zhang C; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.
Wang D; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Key Laboratory of Neurodegeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neurodegeneration, Nantong University, Nantong, Jiangsu, China.
Song R; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Ma Y; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Cao Y; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Zhao H; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Bian J; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Gu J; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.
Liu Z; College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.; Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China.

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Źródło:

Cell proliferation [Cell Prolif] 2020 Jan; Vol. 53 (1), pp. e12714. Date of Electronic Publication: 2019 Nov 07.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*antagonists & inhibitors
Aminoimidazole Carboxamide/*analogs & derivatives
Autophagic Cell Death/*drug effects
Cell Differentiation/*drug effects
Osteoclasts/*metabolism
Osteoprotegerin/*metabolism
Ribonucleotides/*pharmacology
AMP-Activated Protein Kinases/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Mice ; Mice, Inbred BALB C ; Osteoclasts/cytology ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 15.

Tytuł:

Accelerated decomposition of the fungicide, iprodione, on TiO 2 surface under solar irradiation: experimental study and DFT mechanisms.

Autorzy:

Gorbachev MY; Department of Quantum Chemistry, Institute of Chemistry, Academy of Sciences of Moldova, Kishinev, Republic of Moldova.
Gorinchoy NN; Department of Quantum Chemistry, Institute of Chemistry, Academy of Sciences of Moldova, Kishinev, Republic of Moldova.
Osipov I; Department of Quantum Chemistry, Institute of Chemistry, Academy of Sciences of Moldova, Kishinev, Republic of Moldova.

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Źródło:

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes [J Environ Sci Health B] 2020; Vol. 55 (10), pp. 876-888. Date of Electronic Publication: 2020 Jul 12.

Typ publikacji:

Journal Article

MeSH Terms:

Photolysis*
Sunlight*
Aminoimidazole Carboxamide/*analogs & derivatives
Fungicides, Industrial/*analysis
Hydantoins/*analysis
Titanium/*analysis
Aminoimidazole Carboxamide/analysis ; Catalysis

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 16.

Tytuł:

Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells.

Autorzy:

Lee DM; Department of Food Science & Human Nutrition, Colorado State University, Fort Collins, CO, United States of America.
Sevits KJ; Department of Food Science & Human Nutrition, Colorado State University, Fort Collins, CO, United States of America.
Battson ML; Department of Food Science & Human Nutrition, Colorado State University, Fort Collins, CO, United States of America.
Wei Y; Department of Food Science & Human Nutrition, Colorado State University, Fort Collins, CO, United States of America.
Cox-York KA; Department of Food Science & Human Nutrition, Colorado State University, Fort Collins, CO, United States of America.
Gentile CL; Department of Food Science & Human Nutrition, Colorado State University, Fort Collins, CO, United States of America.

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Źródło:

PloS one [PLoS One] 2019 Dec 31; Vol. 14 (12), pp. e0226940. Date of Electronic Publication: 2019 Dec 31 (Print Publication: 2019).

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Apoptosis/*drug effects
Dietary Fats/*adverse effects
Fatty Acids, Monounsaturated/*administration & dosage
Palmitic Acid/*adverse effects
Ribonucleotides/*pharmacology
Adenylate Kinase/antagonists & inhibitors ; Adenylate Kinase/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/prevention & control ; Cell Survival/drug effects ; Dietary Fats/administration & dosage ; Dietary Fats/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Fatty Acids, Monounsaturated/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Palmitic Acid/metabolism ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 17.

Tytuł:

Multi-residue analysis of captan, captafol, folpet, and iprodione in cereals using liquid chromatography with tandem mass spectrometry.

Autorzy:

Shinde R; National Referral Laboratory, ICAR- National Research Centre for Grapes, Pune, India.; Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, India.
Shiragave P; Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, India.
Lakade A; National Referral Laboratory, ICAR- National Research Centre for Grapes, Pune, India.
Thorat P; National Referral Laboratory, ICAR- National Research Centre for Grapes, Pune, India.
Banerjee K; National Referral Laboratory, ICAR- National Research Centre for Grapes, Pune, India.

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Źródło:

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2019 Nov; Vol. 36 (11), pp. 1688-1695. Date of Electronic Publication: 2019 Sep 19.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Captan/*analogs & derivatives
Captan/*analysis
Cyclohexenes/*analysis
Food Contamination/*analysis
Hydantoins/*analysis
Pesticide Residues/*analysis
Phthalimides/*analysis
Aminoimidazole Carboxamide/analysis ; Chromatography, Liquid ; Edible Grain/chemistry ; Food Analysis ; Tandem Mass Spectrometry

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 18.

Tytuł:

A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice.

Autorzy:

Takemura H; Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
Choi JH; Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
Matsuzaki N; Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
Taniguchi Y; Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
Wu J; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
Hirai H; Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
Motohashi R; Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan.
Asakawa T; Institute of Innovative Science and Technology, Tokai University, 4-1-1 Kitakaname, Hiratsuka City, Kanagawa, 259-1292, Japan.
Ikeuchi K; Department of Chemistry, Faculty of Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, 060-0810, Japan.
Inai M; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Kan T; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Kawagishi H; Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan. .; Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan. .; Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, 422-8529, Japan. .

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Źródło:

Scientific reports [Sci Rep] 2019 Jul 09; Vol. 9 (1), pp. 9899. Date of Electronic Publication: 2019 Jul 09.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Arabidopsis/*metabolism
Metabolic Networks and Pathways/*genetics
Oryza/*metabolism
Purines/*metabolism
Aminoimidazole Carboxamide/metabolism ; Arabidopsis/genetics ; Arabidopsis/growth & development ; Gene Expression Profiling ; Oryza/genetics ; Oryza/growth & development

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 19.

Tytuł:

5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift.

Autorzy:

Martin LM; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Möller M; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Weiss U; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Russe OQ; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Scholich K; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Pierre S; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Geisslinger G; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Niederberger E; pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany. .

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2019 Jul 02; Vol. 20 (13). Date of Electronic Publication: 2019 Jul 02.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Anti-Inflammatory Agents/*therapeutic use
Inflammation/*drug therapy
Macrophages/*drug effects
Ribonucleotides/*therapeutic use
Aminoimidazole Carboxamide/therapeutic use ; Animals ; Cells, Cultured ; Edema/complications ; Edema/drug therapy ; Edema/immunology ; Hyperalgesia/complications ; Hyperalgesia/drug therapy ; Hyperalgesia/immunology ; Inflammation/complications ; Inflammation/immunology ; Macrophages/immunology ; Male ; Mice, Inbred C57BL

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 20.

Tytuł:

AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative stress and promoting mesothelial cell repair.

Autorzy:

Wu Y; The Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Duan X; The Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.; Affiliated Hospital of Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Gao Z; The Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Yang N; The Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Xue F; The Second Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.; Affiliated Hospital of Northwestern Polytechnical University, Xi'an, Shaanxi, China.

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Źródło:

PloS one [PLoS One] 2022 Sep 01; Vol. 17 (9), pp. e0272928. Date of Electronic Publication: 2022 Sep 01 (Print Publication: 2022).

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Ribonucleosides*/metabolism
Transforming Growth Factor beta1*/metabolism
Aminoimidazole Carboxamide/analogs & derivatives ; Animals ; Cadherins/metabolism ; Catalase/metabolism ; Hyaluronic Acid ; Inflammation ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; RNA, Messenger/metabolism ; Rats ; Reactive Oxygen Species/metabolism ; Ribonucleotides ; Superoxide Dismutase/metabolism ; Tissue Adhesions/drug therapy ; Tissue Adhesions/prevention & control ; Vimentin/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 21.

Tytuł:

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

Autorzy:

Blanco CL; Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Gastaldelli A; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.; Institute of Clinical Physiology Consiglio Nazionale delle Ricerche, Pisa Italy.
Anzueto DG; Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Winter LA; Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Seidner SR; Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
McCurnin DC; Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Liang H; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
Javors MA; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.; Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.
DeFronzo RA; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.; Texas Diabetes Institute, San Antonio, TX, United States of America.
Musi N; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States of America.; Texas Diabetes Institute, San Antonio, TX, United States of America.; Sam and Ann Barshop Institute for Longevity and Aging Studies, San Antonio, TX, United States of America.

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Źródło:

PloS one [PLoS One] 2018 Dec 12; Vol. 13 (12), pp. e0208757. Date of Electronic Publication: 2018 Dec 12 (Print Publication: 2018).

Typ publikacji:

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

MeSH Terms:

Insulin Resistance*
Aminoimidazole Carboxamide/*analogs & derivatives
Hypoglycemic Agents/*administration & dosage
Insulin/*metabolism
Ribonucleotides/*administration & dosage
Administration, Intravenous ; Aminoimidazole Carboxamide/administration & dosage ; Aminoimidazole Carboxamide/blood ; Animals ; Animals, Newborn ; Fatty Acids, Nonesterified/blood ; Female ; Glycogen/blood ; Hypoglycemic Agents/blood ; Liver/metabolism ; Male ; Muscle, Skeletal/metabolism ; Papio ; RNA, Messenger/metabolism ; Random Allocation ; Ribonucleotides/blood

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 22.

Tytuł:

Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.

Autorzy:

Brooks HB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA. brooks_.
Meier TI; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Geeganage S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Fales KR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Thrasher KJ; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Konicek SA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Spencer CD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Thibodeaux S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Foreman RT; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Hui YH; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Roth KD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Qian YW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Wang T; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Luo S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Torrado A; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Si C; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Toth JL; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Mc Cowan JR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Frimpong K; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Lee MR; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Dally RD; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Shepherd TA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Durham TB; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Wang Y; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Wu Z; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Iversen PW; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.
Njoroge FG; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, 46285, USA.

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Źródło:

Scientific reports [Sci Rep] 2018 Oct 18; Vol. 8 (1), pp. 15458. Date of Electronic Publication: 2018 Oct 18.

Typ publikacji:

Journal Article

MeSH Terms:

Antineoplastic Agents*/pharmacokinetics
Antineoplastic Agents*/pharmacology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/enzymology
Lung Neoplasms*/pathology
Ribonucleotides*/pharmacokinetics
Ribonucleotides*/pharmacology
Aminoimidazole Carboxamide/*analogs & derivatives
Enzyme Inhibitors/*pharmacology
Hydroxymethyl and Formyl Transferases/*antagonists & inhibitors
Multienzyme Complexes/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Nucleotide Deaminases/*antagonists & inhibitors
Aminoimidazole Carboxamide/pharmacokinetics ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line, Tumor ; Female ; Humans ; Hydroxymethyl and Formyl Transferases/metabolism ; Mice ; Mice, Nude ; Multienzyme Complexes/metabolism ; Neoplasm Proteins/metabolism ; Nucleotide Deaminases/metabolism ; Xenograft Model Antitumor Assays

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 23.

Tytuł:

AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway.

Autorzy:

Su CC; Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan. .; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .; Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan. .
Hsieh KL; Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan. .
Liu PL; Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
Yeh HC; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .; Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan. .; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
Huang SP; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
Fang SH; Institute of Athletics, National Taiwan University of Sport, Taichung 40404, Taiwan. .
Cheng WC; Graduate Institute of Biomedical Sciences, and Research Center for Tumor Medical Science, China Medical University, Taichung 40402, Taiwan. .
Huang KH; Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan 71004, Taiwan. .
Chiu FY; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
Lin IL; Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
Huang MY; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan. .; Department of Radiation Oncology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .; Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
Li CY; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2019 Apr 03; Vol. 20 (7). Date of Electronic Publication: 2019 Apr 03.

Typ publikacji:

Journal Article

MeSH Terms:

Signal Transduction*/drug effects
AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Apoptosis/*drug effects
Cell Movement/*drug effects
Prostatic Neoplasms/*metabolism
Prostatic Neoplasms/*pathology
Ribonucleotides/*pharmacology
TOR Serine-Threonine Kinases/*metabolism
Aminoimidazole Carboxamide/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Docetaxel/pharmacology ; Drug Synergism ; Epithelial-Mesenchymal Transition/drug effects ; Humans ; Male ; Neoplasm Invasiveness ; Transforming Growth Factor beta/pharmacology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 24.

Tytuł:

AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression.

Autorzy:

Xiang HC; Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, People's Republic of China.
Lin LX; Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, People's Republic of China.
Hu XF; Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, People's Republic of China.
Zhu H; Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, People's Republic of China.
Li HP; Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, People's Republic of China.
Zhang RY; Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, People's Republic of China.
Hu L; Department of Pharmacology, School of Basic Medicine, Nanjing Medical University, Nanjing, 210000, China.
Liu WT; Department of Pharmacology, School of Basic Medicine, Nanjing Medical University, Nanjing, 210000, China.
Zhao YL; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Shu Y; Department of Central Laboratory, Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, China.
Pan HL; Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Li M; Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, People's Republic of China. .

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Źródło:

Journal of neuroinflammation [J Neuroinflammation] 2019 Feb 12; Vol. 16 (1), pp. 34. Date of Electronic Publication: 2019 Feb 12.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Hypoglycemic Agents/*therapeutic use
Interleukin-1beta/*metabolism
NF-kappa B/*metabolism
Pain/*metabolism
Ribonucleotides/*therapeutic use
Aminoimidazole Carboxamide/therapeutic use ; Animals ; Anti-Inflammatory Agents/therapeutic use ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; CX3C Chemokine Receptor 1/genetics ; CX3C Chemokine Receptor 1/metabolism ; Disease Models, Animal ; Enzyme Activation/drug effects ; Enzyme Activation/physiology ; Freund's Adjuvant/toxicity ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Inflammation/chemically induced ; Inflammation/complications ; Inflammation/drug therapy ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pain/drug therapy ; Pain/etiology ; Pain Threshold/drug effects ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Skin/drug effects ; Skin/metabolism ; Skin/pathology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 25.

Tytuł:

Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder.

Autorzy:

Wang Z; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.; Department of Pediatrics, First Affiliated Hospital of Xi'an Medical University, Xi'an Medical University, Xi'an, China.
Cao Y; Department of Heart Center, Airforce General Hospital, Beijing, China.
Yin Q; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Han Y; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Wang Y; Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Sun G; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhu H; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Xu M; Department of Physiology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Gu C; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

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Źródło:

Cardiovascular therapeutics [Cardiovasc Ther] 2018 Dec; Vol. 36 (6), pp. e12482.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Blood Glucose/*drug effects
Cardiopulmonary Bypass/*adverse effects
Enzyme Activators/*pharmacology
Glucose Metabolism Disorders/*prevention & control
Heart Diseases/*prevention & control
Myocardium/*enzymology
Ribonucleotides/*pharmacology
Adenosine Triphosphate/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Blood Glucose/metabolism ; Creatine Kinase, MB Form/blood ; Disease Models, Animal ; Enzyme Activation ; GTPase-Activating Proteins/metabolism ; Glucose Metabolism Disorders/blood ; Glucose Metabolism Disorders/enzymology ; Glucose Transporter Type 4/metabolism ; Heart Diseases/enzymology ; Heart Diseases/pathology ; Heart Diseases/physiopathology ; Male ; Myocardium/pathology ; Phosphorylation ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Troponin I/blood

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 26.

Tytuł:

Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old rats.

Autorzy:

Oki K; a Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Arias EB; a Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Kanzaki M; b Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi, 980-8579, Japan.
Cartee GD; a Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.; c Department of Molecular and Integrative Physiology and The Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA.

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Źródło:

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2018 Aug; Vol. 43 (8), pp. 795-805. Date of Electronic Publication: 2018 Mar 08.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Enzyme Activators/*pharmacology
Glucose/*metabolism
Muscle, Skeletal/*drug effects
Ribonucleotides/*pharmacology
Age Factors ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Enzyme Activation ; GTPase-Activating Proteins/metabolism ; Glucose Transporter Type 4/metabolism ; Hexokinase/metabolism ; In Vitro Techniques ; Insulin/pharmacology ; Male ; Muscle, Skeletal/enzymology ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Inbred BN ; Rats, Inbred F344 ; Signal Transduction/drug effects

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 27.

Tytuł:

The inhibitory effect of AMP-activated protein kinase (AMPK) on chemokine and prostaglandin production in human endometrial stromal cells.

Autorzy:

Kawano Y; Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan. .
Sato H; Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Goto K; Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Nishida M; Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Nasu K; Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.

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Źródło:

Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2021 Dec 20; Vol. 19 (1), pp. 188. Date of Electronic Publication: 2021 Dec 20.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Chemokines/*metabolism
Endometrium/*metabolism
Prostaglandins/*metabolism
Stromal Cells/*metabolism
Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Endometrium/drug effects ; Female ; Humans ; Hypoglycemic Agents/pharmacology ; Interleukin-1/pharmacology ; Interleukin-1beta/pharmacology ; Phosphorylation/drug effects ; Ribonucleotides/pharmacology ; Stromal Cells/drug effects

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 28.

Tytuł:

Medium & long-chain acylcarnitine's relation to lipid metabolism as potential predictors for diabetic cardiomyopathy: a metabolomic study.

Autorzy:

Zheng DM; Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, section 5, Renmin Street Guta District, Jinzhou, Liaoning Province, China.
An ZN; Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, section 5, Renmin Street Guta District, Jinzhou, Liaoning Province, China.
Ge MH; Department of Orthopedic, The First Affiliated Hospital of Jinzhou Medical University, No. 2, section 5, Renmin Street Guta District, Jinzhou, Liaoning Province, China.
Wei DZ; Department of Endocrinology, Liaoning University of Traditional Chinese Medicine, No.79, Chongshan East Road, Huanggu District, Shenyang, Liaoning Province, China.
Jiang DW; Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, section 5, Renmin Street Guta District, Jinzhou, Liaoning Province, China.
Xing XJ; Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, section 5, Renmin Street Guta District, Jinzhou, Liaoning Province, China.
Shen XL; Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, section 5, Renmin Street Guta District, Jinzhou, Liaoning Province, China.
Liu C; Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, No. 2, section 5, Renmin Street Guta District, Jinzhou, Liaoning Province, China. .

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Źródło:

Lipids in health and disease [Lipids Health Dis] 2021 Nov 02; Vol. 20 (1), pp. 151. Date of Electronic Publication: 2021 Nov 02.

Typ publikacji:

Journal Article

MeSH Terms:

Lipid Metabolism*/drug effects
Carnitine/*analogs & derivatives
Diabetes Mellitus, Type 2/*complications
Diabetic Cardiomyopathies/*metabolism
Adult ; Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Biomarkers/blood ; Carnitine/blood ; Carnitine/chemistry ; Carnitine/pharmacology ; Cell Line ; Diabetes Mellitus, Type 2/metabolism ; Female ; Humans ; Male ; Mass Spectrometry ; Middle Aged ; Myoblasts, Cardiac/drug effects ; Myoblasts, Cardiac/metabolism ; Myristic Acids/pharmacology ; Rats ; Retrospective Studies ; Ribonucleosides/pharmacology ; Risk Factors

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 29.

Tytuł:

Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells.

Autorzy:

Lee KC; Department of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung 833, Taiwan. .
Lin CT; Center for General Education, National Formosa University, Yunlin 632, Taiwan. .; Department of Wood Based Materials and Design, National Chiayi University, Chiayi 600, Taiwan. .
Chang SF; Department of Medical Research and Development, Chang Gung Memorial Hospital Chiayi Branch, Chiayi 613, Taiwan. .
Chen CN; Department of Biochemical Science and Technology, National Chiayi University, Chiayi 600, Taiwan. .
Liu JL; Department of Pathology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi 600, Taiwan. .
Huang WS; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. .; Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan. .

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2017 Nov 08; Vol. 18 (11). Date of Electronic Publication: 2017 Nov 08.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
Fluorouracil/*agonists
Protein Kinases/*metabolism
Ribonucleotides/*pharmacology
X-ray Repair Cross Complementing Protein 1/*metabolism
AMP-Activated Protein Kinase Kinases ; Aminoimidazole Carboxamide/pharmacology ; Aminoimidazole Carboxamide/therapeutic use ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Synergism ; Drug Therapy, Combination ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; HCT116 Cells ; Humans ; Receptors, CXCR4/genetics ; Receptors, CXCR4/metabolism ; Ribonucleotides/therapeutic use ; X-ray Repair Cross Complementing Protein 1/genetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 30.

Tytuł:

The Fairy Chemical Imidazole-4-carboxamide Inhibits the Expression of Axl, PD-L1, and PD-L2 and Improves Response to Cisplatin in Melanoma.

Autorzy:

Inoue C; Department of Diabetes, Metabolism and Endocrinology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Yasuma T; Department of Diabetes, Metabolism and Endocrinology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
D'Alessandro-Gabazza CN; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Toda M; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Fridman D'Alessandro V; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Inoue R; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.; Central Institute for Experimental Animals, Kawasaki-ku, Kawasaki 210-0821, Japan.
Fujimoto H; Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Kobori H; Iwade-Research Institute of Mycology Co., Ltd., Tsu 514-0012, Japan.
Tharavecharak S; Department of Agriculture, Graduate School of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
Takeshita A; Department of Diabetes, Metabolism and Endocrinology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Nishihama K; Department of Diabetes, Metabolism and Endocrinology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Okano Y; Department of Diabetes, Metabolism and Endocrinology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Wu J; Research Institute of Green Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan.
Kobayashi T; Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Yano Y; Department of Diabetes, Metabolism and Endocrinology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.
Kawagishi H; Research Institute of Green Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan.
Gabazza EC; Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu 514-8507, Japan.

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Źródło:

Cells [Cells] 2022 Jan 22; Vol. 11 (3). Date of Electronic Publication: 2022 Jan 22.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Cisplatin*/pharmacology
Cisplatin*/therapeutic use
Melanoma*/drug therapy
Aminoimidazole Carboxamide/analogs & derivatives ; Animals ; B7-H1 Antigen ; Humans ; Immune Checkpoint Proteins ; Mice

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 31.

Tytuł:

Serum Is Not Necessary for Prior Pharmacological Activation of AMPK to Increase Insulin Sensitivity of Mouse Skeletal Muscle.

Autorzy:

Jørgensen NO; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark. .
Wojtaszewski JFP; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark. .
Kjøbsted R; Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark. .

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2018 Apr 15; Vol. 19 (4). Date of Electronic Publication: 2018 Apr 15.

Typ publikacji:

Journal Article

MeSH Terms:

Insulin Resistance*
AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Enzyme Activation/*drug effects
Glucose/*metabolism
Muscle, Skeletal/*drug effects
Ribonucleotides/*pharmacology
Serum/*metabolism
Aminoimidazole Carboxamide/pharmacology ; Animals ; Female ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 32.

Tytuł:

Specific features of L-histidine production by Escherichia coli concerned with feedback control of AICAR formation and inorganic phosphate/metal transport.

Autorzy:

Malykh EA; Ajinomoto-Genetika Research Institute, 1-st Dorozny pr., 1-1, Moscow, 117545, Russian Federation.
Butov IA; Ajinomoto-Genetika Research Institute, 1-st Dorozny pr., 1-1, Moscow, 117545, Russian Federation.
Ravcheeva AB; Ajinomoto-Genetika Research Institute, 1-st Dorozny pr., 1-1, Moscow, 117545, Russian Federation.
Krylov AA; Ajinomoto-Genetika Research Institute, 1-st Dorozny pr., 1-1, Moscow, 117545, Russian Federation.
Mashko SV; Ajinomoto-Genetika Research Institute, 1-st Dorozny pr., 1-1, Moscow, 117545, Russian Federation.
Stoynova NV; Ajinomoto-Genetika Research Institute, 1-st Dorozny pr., 1-1, Moscow, 117545, Russian Federation. nataliya_.

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Źródło:

Microbial cell factories [Microb Cell Fact] 2018 Mar 15; Vol. 17 (1), pp. 42. Date of Electronic Publication: 2018 Mar 15.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Escherichia coli/*metabolism
Histidine/*genetics
Ribonucleotides/*metabolism
Aminoimidazole Carboxamide/metabolism ; Metals

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 33.

Tytuł:

Isolation and characterization of a bacterium able to degrade high concentrations of iprodione.

Autorzy:

Cao L; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.
Shi W; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.
Shu R; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.
Pang J; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.
Liu Y; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.
Zhang X; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.
Lei Y; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.; College of Agriculture and Biotechnology, Hexi University, Zhangye, Gansu 734000, China.

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Źródło:

Canadian journal of microbiology [Can J Microbiol] 2018 Jan; Vol. 64 (1), pp. 49-56. Date of Electronic Publication: 2017 Dec 08.

Typ publikacji:

Journal Article

MeSH Terms:

Biodegradation, Environmental*
Aminoimidazole Carboxamide/*analogs & derivatives
Bacteria/*isolation & purification
Bacteria/*metabolism
Hydantoins/*metabolism
Aminoimidazole Carboxamide/metabolism ; Aniline Compounds/metabolism ; Bacteria/classification ; Bacteria/genetics ; Phylogeny ; RNA, Ribosomal, 16S/genetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 34.

Tytuł:

Aicar effect in early neuronal development.

Autorzy:

Torres RJ; a Department of Biochemistry , La Paz University Hospital , IdiPaz , Madrid , Spain and Center for Biomedical Network Research on Rare Diseases (CIBERER) , ISCIII , Spain.
Puig JG; b Department of Internal Medicine, Metabolic-Vascular Unit , La Paz University Hospital , IdiPaz , Madrid , Spain.

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Źródło:

Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2018; Vol. 37 (5), pp. 261-272. Date of Electronic Publication: 2018 Apr 10.

Typ publikacji:

Journal Article

MeSH Terms:

Ribonucleotides*/pharmacology
Aminoimidazole Carboxamide/*analogs & derivatives
Neurogenesis/*drug effects
Aminoimidazole Carboxamide/pharmacology ; Cell Differentiation/drug effects ; Gene Expression Regulation/drug effects ; Hedgehog Proteins/genetics ; Humans ; Microtubule-Associated Proteins/genetics ; Neurogenesis/genetics ; Neurons/cytology ; Signal Transduction ; Transforming Growth Factors/genetics ; beta Catenin/genetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 35.

Tytuł:

New synthetic AICAR derivatives with enhanced AMPK and ACC activation.

Autorzy:

Scudiero O; a CEINGE - Advanced Biotechnologies S.C a r.l. , Napoli , Italy .; b Department of Molecular Medicine and Medical Biotechnologies and.
Nigro E; a CEINGE - Advanced Biotechnologies S.C a r.l. , Napoli , Italy .
Monaco ML; a CEINGE - Advanced Biotechnologies S.C a r.l. , Napoli , Italy .
Oliviero G; c Department of Pharmacy , University of Naples Federico II , Napoli , Italy .
Polito R; a CEINGE - Advanced Biotechnologies S.C a r.l. , Napoli , Italy .
Borbone N; c Department of Pharmacy , University of Naples Federico II , Napoli , Italy .
D'Errico S; c Department of Pharmacy , University of Naples Federico II , Napoli , Italy .
Mayol L; c Department of Pharmacy , University of Naples Federico II , Napoli , Italy .
Daniele A; a CEINGE - Advanced Biotechnologies S.C a r.l. , Napoli , Italy .; d Department of Environmental Biological and Pharmaceutical Sciences and Technologies , Second University of Naples , Caserta , Italy , and.
Piccialli G; c Department of Pharmacy , University of Naples Federico II , Napoli , Italy .; e Institute of Protein Biochemistry , Napoli , Italy.

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Źródło:

Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2016 Oct; Vol. 31 (5), pp. 748-53. Date of Electronic Publication: 2015 Oct 08.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Acetyl-CoA Carboxylase/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Gene Expression Regulation, Enzymologic/*drug effects
Ribonucleotides/*chemical synthesis
Ribonucleotides/*pharmacology
AMP-Activated Protein Kinases/genetics ; Acetyl-CoA Carboxylase/genetics ; Aminoimidazole Carboxamide/chemical synthesis ; Aminoimidazole Carboxamide/chemistry ; Aminoimidazole Carboxamide/pharmacology ; Blotting, Western ; Cell Line, Tumor ; Enzyme Activation/drug effects ; Humans ; MAP Kinase Signaling System/genetics ; Molecular Structure ; Ribonucleotides/chemistry

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 36.

Tytuł:

Design, Synthesis, and Biological Evaluation of Novel PARP-1 Inhibitors Based on a 1H-Thieno[3,4-d] Imidazole-4-Carboxamide Scaffold.

Autorzy:

Wang L; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. .
Liu F; Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. .
Jiang N; Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. .
Zhou W; Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. .
Zhou X; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. .
Zheng Z; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. .

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2016 Jun 13; Vol. 21 (6). Date of Electronic Publication: 2016 Jun 13.

Typ publikacji:

Journal Article

MeSH Terms:

Structure-Activity Relationship*
Aminoimidazole Carboxamide/*analogs & derivatives
Poly (ADP-Ribose) Polymerase-1/*antagonists & inhibitors
Aminoimidazole Carboxamide/administration & dosage ; Aminoimidazole Carboxamide/chemical synthesis ; Aminoimidazole Carboxamide/chemistry ; Cell Line ; Cell Proliferation/drug effects ; Humans ; Phthalazines/administration & dosage ; Piperazines/administration & dosage ; Poly (ADP-Ribose) Polymerase-1/chemistry

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 37.

Tytuł:

TP63 Is Significantly Upregulated in Diabetic Kidney.

Autorzy:

Liang S; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Nayak BK; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Vogel KS; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
Habib SL; Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, TX 78229, USA.; South Texas, Veterans Healthcare System, San Antonio, TX 78229, USA.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2021 Apr 15; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 15.

Typ publikacji:

Journal Article

MeSH Terms:

Diabetic Nephropathies/*genetics
Trans-Activators/*genetics
Up-Regulation/*genetics
Adenylate Kinase/metabolism ; Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Blood Glucose/metabolism ; Cells, Cultured ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/genetics ; Diabetic Nephropathies/blood ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Insulin Receptor Substrate Proteins/genetics ; Insulin Receptor Substrate Proteins/metabolism ; Kidney Tubules, Proximal/pathology ; Models, Biological ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribonucleotides/pharmacology ; Signal Transduction/drug effects ; Trans-Activators/metabolism ; Tuberous Sclerosis Complex 2 Protein/pharmacology ; Up-Regulation/drug effects

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 38.

Tytuł:

miR-22-3p regulates muscle fiber-type conversion through inhibiting AMPK/SIRT1/PGC-1α pathway.

Autorzy:

Wen W; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Chen X; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Huang Z; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Chen D; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Zheng P; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
He J; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Chen H; College of Food Science, Sichuan Agricultural University, Yaan, Sichuan, P. R. China.
Yu J; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Luo Y; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Yu B; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.

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Źródło:

Animal biotechnology [Anim Biotechnol] 2021 Apr; Vol. 32 (2), pp. 254-261. Date of Electronic Publication: 2020 May 14.

Typ publikacji:

Journal Article

MeSH Terms:

MicroRNAs/*metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
Protein Kinases/*metabolism
Sirtuin 1/*metabolism
AMP-Activated Protein Kinase Kinases ; Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Mice ; MicroRNAs/genetics ; Myoblasts ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Protein Kinases/genetics ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Ribonucleotides/pharmacology ; Sirtuin 1/genetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 39.

Tytuł:

PGC1 α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control.

Autorzy:

Lee SY; Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Kang JM; Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Kim DJ; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.
Park SH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.
Jeong HY; Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Lee YH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.
Kim YG; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.
Yang DH; Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Lee SH; Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Republic of Korea.

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Źródło:

Journal of diabetes research [J Diabetes Res] 2017; Vol. 2017, pp. 6483572. Date of Electronic Publication: 2017 Mar 20.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Autophagy/*drug effects
Diabetes Mellitus, Experimental/*metabolism
Diabetic Nephropathies/*metabolism
Hypoglycemic Agents/*pharmacology
Kidney Tubules, Proximal/*drug effects
Metformin/*pharmacology
Mitochondrial Dynamics/*drug effects
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*drug effects
Ribonucleotides/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Animals ; Apoptosis/drug effects ; Cell Line ; Glucose/pharmacology ; Humans ; Kidney Tubules, Proximal/cytology ; Male ; Mice ; Sweetening Agents/pharmacology

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 40.

Tytuł:

Iprodione and chlorpyrifos induce testicular damage, oxidative stress, apoptosis and suppression of steroidogenic- and spermatogenic-related genes in immature male albino rats.

Autorzy:

Hassan MA; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
El Bohy KM; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
El Sharkawy NI; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Imam TS; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
El-Metwally AE; Department of Pathology, Animal Reproduction Research Institute, Giza, Egypt.
Hamed Arisha A; Department of Animal Physiology and Biochemistry, Faculty of Veterinary Medicine, Badr University in Cairo (BUC), Badr city, Egypt.; Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Mohammed HA; Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Abd-Elhakim YM; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

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Źródło:

Andrologia [Andrologia] 2021 May; Vol. 53 (4), pp. e13978. Date of Electronic Publication: 2021 Feb 14.

Typ publikacji:

Journal Article

MeSH Terms:

Chlorpyrifos*/metabolism
Chlorpyrifos*/toxicity
Insecticides*/toxicity
Aminoimidazole Carboxamide/analogs & derivatives ; Animals ; Apoptosis ; Hydantoins ; Male ; Oxidative Stress ; Rats ; Testis/metabolism

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 41.

Tytuł:

5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis.

Autorzy:

Kumar A; Department of Ophthalmology/Kresge Eye Institute, Wayne State University, Detroit, MI, USA.
Giri S; Department of Neurology, Henry Ford Health System, Detroit, MI, USA.
Kumar A; Department of Ophthalmology/Kresge Eye Institute, Wayne State University, Detroit, MI, USA.; Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI, USA.; Department of Immunology and Microbiology, Wayne State University, Detroit, MI, USA.

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Źródło:

Cellular microbiology [Cell Microbiol] 2016 Dec; Vol. 18 (12), pp. 1815-1830. Date of Electronic Publication: 2016 Jul 26.

Typ publikacji:

Journal Article

MeSH Terms:

Host-Pathogen Interactions*
AMP-Activated Protein Kinases/*immunology
Aminoimidazole Carboxamide/*analogs & derivatives
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Endophthalmitis/*drug therapy
Retina/*drug effects
Ribonucleotides/*pharmacology
Staphylococcal Infections/*drug therapy
AMP-Activated Protein Kinases/genetics ; Acetyl-CoA Carboxylase/genetics ; Acetyl-CoA Carboxylase/immunology ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Bacterial Load/drug effects ; Disease Models, Animal ; Endophthalmitis/immunology ; Endophthalmitis/microbiology ; Female ; Gene Expression Regulation ; Glycolysis/drug effects ; Immunity, Innate ; Intravitreal Injections ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase 4/immunology ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Microglia/cytology ; Microglia/drug effects ; Microglia/immunology ; NF-kappa B/genetics ; NF-kappa B/immunology ; Phagocytosis/drug effects ; Retina/immunology ; Retina/microbiology ; Signal Transduction ; Staphylococcal Infections/immunology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/growth & development ; Staphylococcus aureus/pathogenicity ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/immunology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 42.

Tytuł:

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function.

Autorzy:

Kang SW; Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
Haydar G; Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
Taniane C; Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
Farrell G; Liver Research Group, Australian National University Medical School, Canberra, Australia.
Arias IM; National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.
Lippincott-Schwartz J; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America.
Fu D; Faculty of Pharmacy, The University of Sydney, Sydney, NSW, Australia.

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Źródło:

PloS one [PLoS One] 2016 Oct 28; Vol. 11 (10), pp. e0165638. Date of Electronic Publication: 2016 Oct 28 (Print Publication: 2016).

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Chemical and Drug Induced Liver Injury/*pathology
Chemical and Drug Induced Liver Injury/*prevention & control
Hepatocytes/*drug effects
Mitochondria/*drug effects
Mitochondrial Dynamics/*drug effects
Ribonucleotides/*pharmacology
Acetaminophen/pharmacology ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Autophagy/drug effects ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/enzymology ; Diclofenac/pharmacology ; Enzyme Activation/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Male ; Mitochondria/metabolism ; Rats ; Rats, Sprague-Dawley

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 43.

Tytuł:

Methotrexate reduces HbA1c concentration but does not produce chronic accumulation of ZMP in patients with rheumatoid or psoriatic arthritis.

Autorzy:

Perdan-Pirkmajer K; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.
Pirkmajer S; b Institute of Pathophysiology, Faculty of Medicine , University of Ljubljana , Slovenia.
Thevis M; c Institute of Biochemistry, Centre for Preventive Doping Research , German Sport University Cologne , Germany.
Thomas A; c Institute of Biochemistry, Centre for Preventive Doping Research , German Sport University Cologne , Germany.
Praprotnik S; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.
Hočevar A; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.
Rotar Ž; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.
Gašperšič N; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.
Sodin-Šemrl S; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.
Žibert J; d Faculty of Health Sciences , University of Ljubljana , Slovenia.
Omersel J; e Faculty of Pharmacy , University of Ljubljana , Slovenia.
Chibalin AV; f Department of Molecular Medicine and Surgery, Integrative Physiology , Karolinska Institutet , Stockholm , Sweden.
Tomšič M; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.
Ambrožič A; a Department of Rheumatology , University Medical Centre Ljubljana , Slovenia.

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Źródło:

Scandinavian journal of rheumatology [Scand J Rheumatol] 2016 Oct; Vol. 45 (5), pp. 347-55. Date of Electronic Publication: 2016 Jan 04.

Typ publikacji:

Journal Article

MeSH Terms:

Aminoimidazole Carboxamide/*analogs & derivatives
Antirheumatic Agents/*therapeutic use
Arthritis, Psoriatic/*drug therapy
Arthritis, Rheumatoid/*drug therapy
Blood Glucose/*metabolism
Glycated Hemoglobin/*metabolism
Insulin/*metabolism
Methotrexate/*therapeutic use
Ribonucleotides/*metabolism
Adult ; Aged ; Aminoimidazole Carboxamide/metabolism ; Arthritis, Psoriatic/metabolism ; Arthritis, Rheumatoid/metabolism ; Chromatography, Liquid ; Erythrocytes/metabolism ; Female ; Humans ; Insulin Resistance ; Male ; Middle Aged ; Prospective Studies ; Tandem Mass Spectrometry

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 44.

Tytuł:

AMPK-independent inhibition of human macrophage ER stress response by AICAR.

Autorzy:

Boß M; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.
Newbatt Y; Division of Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Gupta S; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.
Collins I; Division of Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.
Brüne B; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.
Namgaladze D; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt, Germany.

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Źródło:

Scientific reports [Sci Rep] 2016 Aug 26; Vol. 6, pp. 32111. Date of Electronic Publication: 2016 Aug 26.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Endoplasmic Reticulum Stress/*drug effects
Macrophages/*metabolism
Ribonucleotides/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Cytokines/metabolism ; Endoribonucleases/metabolism ; Equilibrative Nucleoside Transporter 1/metabolism ; Humans ; Macrophage Activation/drug effects ; Macrophages/pathology ; Membrane Transport Proteins/metabolism ; Obesity/metabolism ; Obesity/pathology ; Phosphorylation/drug effects ; Protein Serine-Threonine Kinases/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 45.

Tytuł:

AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype.

Autorzy:

Abdul-Rahman O; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.; MTA-DE Cell Biology and Signaling Research Group, Debrecen, H-4032, Hungary.
Kristóf E; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Doan-Xuan QM; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Vida A; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.; MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, H-4032, Hungary.
Nagy L; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.; MTA-DE Cell Biology and Signaling Research Group, Debrecen, H-4032, Hungary.
Horváth A; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Simon J; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Maros T; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Szentkirályi I; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Palotás L; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Debreceni T; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Csizmadia P; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Szerafin T; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Fodor T; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Szántó M; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.; MTA-DE Cell Biology and Signaling Research Group, Debrecen, H-4032, Hungary.
Tóth A; Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Kiss B; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Bacsó Z; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
Bai P; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.; MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, H-4032, Hungary.; Research Center for Molecular Medicine, University of Debrecen, Debrecen, H-4032, Hungary.

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Źródło:

PloS one [PLoS One] 2016 Jun 20; Vol. 11 (6), pp. e0157644. Date of Electronic Publication: 2016 Jun 20 (Print Publication: 2016).

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Adipocytes, Beige/*cytology
Adipocytes, White/*enzymology
Adipose Tissue, White/*cytology
Aminoimidazole Carboxamide/*analogs & derivatives
Pericardium/*cytology
Ribonucleotides/*pharmacology
Stem Cells/*enzymology
Adipocytes, Beige/drug effects ; Adipocytes, Beige/enzymology ; Aminoimidazole Carboxamide/pharmacology ; Cell Shape/drug effects ; Enzyme Activation/drug effects ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Dynamics/drug effects ; Phenotype ; Stem Cells/cytology ; Stem Cells/drug effects

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 46.

Tytuł:

Neuroprotective effect of activated 5'-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation.

Autorzy:

Kamoshita M; Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Fujinami K; Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Toda E; Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Tsubota K; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Ozawa Y; Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. .; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. .

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Źródło:

BMC neuroscience [BMC Neurosci] 2016 Jun 10; Vol. 17 (1), pp. 32. Date of Electronic Publication: 2016 Jun 10.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Neuroprotective Agents/*pharmacology
Retinal Cone Photoreceptor Cells/*drug effects
Retinitis/*drug therapy
Ribonucleosides/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line, Tumor ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Lipopolysaccharides ; Male ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; RNA, Messenger/metabolism ; Random Allocation ; Retinal Cone Photoreceptor Cells/enzymology ; Retinal Cone Photoreceptor Cells/immunology ; Retinitis/enzymology ; Retinitis/immunology ; Retinitis/pathology ; Tumor Necrosis Factor-alpha/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 47.

Tytuł:

Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer.

Autorzy:

Pigna E; DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Italy.
Berardi E; DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Italy.; Department of Kinesiology, Research Group in Exercise Physiology, KU Leuven, Belgium.
Aulino P; DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Italy.
Rizzuto E; Department of Mechanical &Aerospace Engineering, Sapienza University of Rome, Italy.
Zampieri S; Department of Biomedical Sciences, University of Padua, Italy.; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Department of Physical Medicine and Rehabilitation, Wilhelminenspital Wien, Austria.
Carraro U; IRCCS Fondazione Ospedale San Camillo, Venezia, Italy.
Kern H; Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Department of Physical Medicine and Rehabilitation, Wilhelminenspital Wien, Austria.
Merigliano S; Department of Surgical and Gastroenterological Sciences, University of Padua, Italy.
Gruppo M; Department of Surgical and Gastroenterological Sciences, University of Padua, Italy.
Mericskay M; Department of Biological Adaptation and Ageing B2A (CNRS UMR 8256 - INSERM ERL U1164 - UPMC P6), Pierre et Marie Curie University, Paris 6, France.
Li Z; Department of Biological Adaptation and Ageing B2A (CNRS UMR 8256 - INSERM ERL U1164 - UPMC P6), Pierre et Marie Curie University, Paris 6, France.
Rocchi M; Department of Biomolecular Sciences, Unit of Biostatistics, 'Carlo Bo' University of Urbino, Italy.
Barone R; Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy.
Macaluso F; Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy.
Di Felice V; Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy.
Adamo S; DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Italy.
Coletti D; DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Italy.; Department of Biological Adaptation and Ageing B2A (CNRS UMR 8256 - INSERM ERL U1164 - UPMC P6), Pierre et Marie Curie University, Paris 6, France.
Moresi V; DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Italy.

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Źródło:

Scientific reports [Sci Rep] 2016 May 31; Vol. 6, pp. 26991. Date of Electronic Publication: 2016 May 31.

Typ publikacji:

Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

MeSH Terms:

Physical Conditioning, Animal*
Aminoimidazole Carboxamide/*analogs & derivatives
Autophagy/*drug effects
Cachexia/*drug therapy
Colonic Neoplasms/*drug therapy
Muscle Weakness/*prevention & control
Ribonucleotides/*pharmacology
Sirolimus/*pharmacology
Aminoimidazole Carboxamide/pharmacology ; Animals ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagy/genetics ; Cachexia/metabolism ; Cachexia/mortality ; Cachexia/physiopathology ; Cell Line, Tumor ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/mortality ; Colonic Neoplasms/physiopathology ; Female ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism ; Mice ; Mice, Inbred BALB C ; Muscle Fibers, Skeletal/cytology ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/metabolism ; Muscle Weakness/metabolism ; Muscle Weakness/physiopathology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Neoplasm Transplantation ; Survival Analysis

Czasopismo naukowe

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Skocz do pozycji: 48.

Tytuł:

Identification and function prediction of novel microRNAs in adenosine monophosphate activated protein kinase-activated Sertoli cells of immature boar.

Autorzy:

Zhang JJ; Chongqing Key Laboratory of Forage and Herbivore, College of Veterinary Medicine, Southwest University, Chongqing, China.
Wang YS; Chongqing Key Laboratory of Forage and Herbivore, College of Veterinary Medicine, Southwest University, Chongqing, China.
Li YQ; Chongqing Key Laboratory of Forage and Herbivore, College of Veterinary Medicine, Southwest University, Chongqing, China.
Chen L; Department of Dermatology and Sexually Transmitted Disease, The Fifth People's Hospital of Chongqing, Chongqing, China.
Wang XZ; Chongqing Key Laboratory of Forage and Herbivore, College of Veterinary Medicine, Southwest University, Chongqing, China.

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Źródło:

Animal science journal = Nihon chikusan Gakkaiho [Anim Sci J] 2021 Jan-Dec; Vol. 92 (1), pp. e13622.

Typ publikacji:

Journal Article

MeSH Terms:

AMP-Activated Protein Kinases/*metabolism
Biological Phenomena/*genetics
MicroRNAs/*genetics
MicroRNAs/*physiology
Sertoli Cells/*metabolism
Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Energy Metabolism/genetics ; Gene Library ; High-Throughput Nucleotide Sequencing/veterinary ; Homeostasis/genetics ; Male ; MicroRNAs/isolation & purification ; Ribonucleotides/pharmacology ; Swine

Czasopismo naukowe

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Skocz do pozycji: 49.

Tytuł:

AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane.

Autorzy:

Liu L; Department of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.
Liu C; Institute of Cardiovascular Diseases, Tianjin Chest Hospital, Tianjin 300457, P.R. China.
Fang L; Department of Thyroid and Breast Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China.

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Źródło:

Molecular medicine reports [Mol Med Rep] 2021 Jan; Vol. 23 (1). Date of Electronic Publication: 2020 Nov 17.

Typ publikacji:

Journal Article

MeSH Terms:

Signal Transduction*
AMP-Activated Protein Kinases/*metabolism
Apoptosis/*drug effects
Cognitive Dysfunction/*metabolism
Neurons/*metabolism
Sevoflurane/*toxicity
Sirtuin 1/*metabolism
Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Behavior, Animal/drug effects ; Cognition/drug effects ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/prevention & control ; Hippocampus/metabolism ; Male ; Neurons/cytology ; Neuroprotective Agents/pharmacology ; PC12 Cells ; Rats ; Rats, Sprague-Dawley ; Ribonucleotides/pharmacology

Czasopismo naukowe

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Skocz do pozycji: 50.

Tytuł:

Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein.

Autorzy:

Spanò V; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Barreca M; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Cilibrasi V; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Genovese M; Telethon Institute of Genetics and Medicine (TIGEM), Campi Flegrei 34, 80078 Naples, Italy.
Renda M; Telethon Institute of Genetics and Medicine (TIGEM), Campi Flegrei 34, 80078 Naples, Italy.
Montalbano A; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.
Galietta LJV; Telethon Institute of Genetics and Medicine (TIGEM), Campi Flegrei 34, 80078 Naples, Italy.; Department of Translational Medical Sciences (DISMET), University of Naples, 'Federico II', Via Sergio Pansini 5, 80131 Naples, Italy.
Barraja P; Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Via Archirafi 32, 90123 Palermo, Italy.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2021 Feb 26; Vol. 26 (5). Date of Electronic Publication: 2021 Feb 26.

Typ publikacji:

Journal Article

MeSH Terms:

Benzodioxoles/*pharmacology
Cystic Fibrosis/*drug therapy
Cystic Fibrosis Transmembrane Conductance Regulator/*genetics
Mutant Proteins/*genetics
Aminoimidazole Carboxamide/chemistry ; Benzodioxoles/chemistry ; Cystic Fibrosis/genetics ; Cystic Fibrosis/pathology ; Cystic Fibrosis Transmembrane Conductance Regulator/drug effects ; Humans ; Mutation/drug effects ; Mutation/genetics ; Protein Folding/drug effects ; Thiazoles/chemistry

Czasopismo naukowe

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Pełny tekst  Link otwiera się w nowym oknieSzczegóły